| FMR LLC | 14,384,456 | $447,644 |
| BlackRock, Inc. | 6,431,923 | $200,161 |
| VANGUARD GROUP INC | 5,612,144 | $174,650 |
| Bellevue Group AG | 4,358,527 | $135,637 |
| Fairmount Funds Management LLC | 3,914,458 | $121,818 |
| VR Adviser, LLC | 3,882,709 | $120,830 |
| STATE STREET CORP | 3,466,560 | $107,879 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,439,414 | $107 |
| PERCEPTIVE ADVISORS LLC | 3,042,703 | $94,689 |
| Deep Track Capital, LP | 2,524,833 | $78,573 |
| Novo Holdings A/S | 2,380,000 | $74,066 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,992,174 | $62,007 |
| BAKER BROS. ADVISORS LP | 1,971,678 | $61,359 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,971,411 | $61,350 |
| TANG CAPITAL MANAGEMENT LLC | 1,792,626 | $55,787 |
| Eversept Partners, LP | 1,782,235 | $55,463 |
| Fisher Asset Management, LLC | 1,780,284 | $55,402 |
| MORGAN STANLEY | 1,738,225 | $54,094 |
| Avoro Capital Advisors LLC | 1,500,000 | $46,680 |
| LOOMIS SAYLES & CO L P | 1,481,135 | $46,093 |
| Kynam Capital Management, LP | 1,470,541 | $45,763 |
| Paradigm Biocapital Advisors LP | 1,443,102 | $44,909 |
| ALLIANCEBERNSTEIN L.P. | 1,414,181 | $44,009 |
| MARSHALL WACE, LLP | 1,375,739 | $42,813 |
| GOLDMAN SACHS GROUP INC | 1,264,047 | $39,337 |
| JENNISON ASSOCIATES LLC | 1,154,080 | $35,915 |
| Woodline Partners LP | 1,115,929 | $34,728 |
| JPMORGAN CHASE & CO | 1,010,260 | $31,439 |
| D. E. Shaw & Co., Inc. | 1,000,717 | $31,142 |
| BANK OF AMERICA CORP /DE/ | 990,117 | $30,812 |
| Vivo Capital, LLC | 982,576 | $30,578 |
| Pictet Asset Management Holding SA | 922,767 | $28,717 |
| RICE HALL JAMES & ASSOCIATES, LLC | 884,532 | $27,527 |
| Elmind Capital, LP | 858,631 | $26,721 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 790,018 | $24,585 |
| Parkman Healthcare Partners LLC | 788,076 | $24,525 |
| Candriam S.C.A. | 785,098 | $24,433 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 748,961 | $23,308 |
| Nuveen, LLC | 742,337 | $23,102 |
| 5AM Venture Management, LLC | 736,595 | $22,923 |
| First Turn Management, LLC | 690,528 | $21,489 |
| CITADEL ADVISORS LLC | 679,694 | $21,152 |
| NORTHERN TRUST CORP | 668,417 | $20,801 |
| DIMENSIONAL FUND ADVISORS LP | 555,594 | $17,289 |
| BNP PARIBAS ARBITRAGE, SA | 517,398 | $16,101 |
| BALYASNY ASSET MANAGEMENT L.P. | 503,868 | $15,680 |
| DEUTSCHE BANK AG\ | 479,758 | $14,930 |
| MILLENNIUM MANAGEMENT LLC | 460,125 | $14,319 |
| Rosalind Advisors, Inc. | 450,000 | $14,004 |
| ALGERT GLOBAL LLC | 425,039 | $13 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 423,272 | $13,172 |
| FEDERATED HERMES, INC. | 416,358 | $12,957 |
| HighVista Strategies LLC | 372,472 | $11,591 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 348,569 | $10,847 |
| Voleon Capital Management LP | 345,713 | $10,759 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 341,258 | $10,620 |
| PANAGORA ASSET MANAGEMENT INC | 324,746 | $10,106 |
| RAYMOND JAMES FINANCIAL INC | 303,774 | $9,424 |
| Skandinaviska Enskilda Banken AB (publ) | 286,320 | $8,910 |
| Propel Bio Management, LLC | 282,531 | $8,792 |
| JANE STREET GROUP, LLC | 279,607 | $8,701 |
| Davern Capital Partners, LP | 261,615 | $8,141 |
| Point72 Asset Management, L.P. | 254,285 | $7,913 |
| Affinity Asset Advisors, LLC | 250,000 | $7,780 |
| BARCLAYS PLC | 244,273 | $7,602 |
| VICTORY CAPITAL MANAGEMENT INC | 226,817 | $7,059 |
| Schonfeld Strategic Advisors LLC | 217,434 | $6,561 |
| Bank of New York Mellon Corp | 215,866 | $6,718 |
| Yiheng Capital Management, L.P. | 208,735 | $6,496 |
| Russell Investments Group, Ltd. | 193,479 | $6,021 |
| Invesco Ltd. | 183,468 | $5,710 |
| PRINCIPAL FINANCIAL GROUP INC | 175,930 | $5,475 |
| Privium Fund Management B.V. | 173,516 | $5,400 |
| Kopp Family Office, LLC | 173,173 | $5,389 |
| Hennion & Walsh Asset Management, Inc. | 169,167 | $5,264 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 167,934 | $5,226 |
| UBS Group AG | 164,820 | $5,129 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 154,739 | $4,815 |
| STEMPOINT CAPITAL LP | 154,320 | $4,802 |
| Hudson Bay Capital Management LP | 151,464 | $4,714 |
| MOORE CAPITAL MANAGEMENT, LP | 150,000 | $4,668 |
| WELLS FARGO & COMPANY/MN | 147,316 | $4,584 |
| Knott David M Jr | 145,000 | $4,512 |
| UBS ASSET MANAGEMENT AMERICAS INC | 139,360 | $4,337 |
| CenterBook Partners LP | 136,717 | $4,255 |
| Qube Research & Technologies Ltd | 129,532 | $4,031 |
| Swiss National Bank | 128,600 | $4,002 |
| NORGES BANK | 122,790 | $3,821 |
| FIRST TRUST ADVISORS LP | 119,892 | $3,731 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 116,524 | $3,626 |
| TD Asset Management Inc | 114,002 | $3,548 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 112,682 | $3,500 |
| Simplify Asset Management Inc. | 103,531 | $3,222 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 101,083 | $3,146 |
| SEVEN GRAND MANAGERS, LLC | 100,000 | $3,112 |
| Rafferty Asset Management, LLC | 99,750 | $3,104 |
| RHUMBLINE ADVISERS | 97,451 | $3,033 |
| Moody Aldrich Partners LLC | 96,187 | $2,993 |
| Merck & Co., Inc. | 93,414 | $2,907 |
| ExodusPoint Capital Management, LP | 92,697 | $2,885 |
| 128 other institutions | 2,633,344 | $77,687 |