| BlackRock, Inc. | 5,618,365 | $22,080 |
| EcoR1 Capital, LLC | 4,002,847 | $15,731 |
| ARMISTICE CAPITAL, LLC | 4,000,000 | $15,720 |
| VANGUARD GROUP INC | 3,266,484 | $12,837 |
| MILLENNIUM MANAGEMENT LLC | 1,880,760 | $7,391 |
| Vestal Point Capital, LP | 1,475,000 | $5,797 |
| Opaleye Management Inc. | 1,196,904 | $4,704 |
| Erste Asset Management GmbH | 1,195,141 | $4,718 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,135,188 | $4,462 |
| DIMENSIONAL FUND ADVISORS LP | 1,084,499 | $4,262 |
| STATE STREET CORP | 936,266 | $3,680 |
| CITADEL ADVISORS LLC | 556,646 | $2,188 |
| MORGAN STANLEY | 544,114 | $2,138 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 521,651 | $2 |
| NORTHERN TRUST CORP | 368,546 | $1,448 |
| SPHERA FUNDS MANAGEMENT LTD. | 339,761 | $1,335 |
| Fiduciary Trust Co | 334,397 | $1,314 |
| JPMORGAN CHASE & CO | 326,230 | $1,282 |
| GOLDMAN SACHS GROUP INC | 303,133 | $1,191 |
| RENAISSANCE TECHNOLOGIES LLC | 296,450 | $1,165 |
| UBS Group AG | 268,793 | $1,056 |
| TWO SIGMA INVESTMENTS, LP | 222,713 | $875 |
| Altshuler Shaham Ltd | 203,740 | $801 |
| BANK OF AMERICA CORP /DE/ | 176,097 | $692 |
| BARCLAYS PLC | 162,112 | $637 |
| AQR CAPITAL MANAGEMENT LLC | 160,037 | $629 |
| AMERICAN CENTURY COMPANIES INC | 150,405 | $591 |
| JANE STREET GROUP, LLC | 149,747 | $589 |
| FMR LLC | 141,737 | $557 |
| Bank of New York Mellon Corp | 139,332 | $548 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 137,888 | $542 |
| WELLS FARGO & COMPANY/MN | 132,663 | $521 |
| Invesco Ltd. | 116,000 | $456 |
| CAPTRUST FINANCIAL ADVISORS | 103,649 | $407 |
| Patriot Financial Group Insurance Agency, LLC | 102,716 | $404 |
| ACADIAN ASSET MANAGEMENT LLC | 100,483 | $0 |
| Point72 Asset Management, L.P. | 95,351 | $375 |
| Privium Fund Management B.V. | 95,000 | $373 |
| Nuveen, LLC | 93,161 | $366 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 91,746 | $361 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 87,459 | $344 |
| OMERS ADMINISTRATION Corp | 83,012 | $326 |
| Birchview Capital, LP | 74,918 | $294 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 65,182 | $256 |
| BNP PARIBAS ARBITRAGE, SA | 64,195 | $252 |
| TWO SIGMA ADVISERS, LP | 62,600 | $246 |
| Allspring Global Investments Holdings, LLC | 61,775 | $249 |
| RHUMBLINE ADVISERS | 58,921 | $232 |
| ALLIANCEBERNSTEIN L.P. | 58,830 | $231 |
| Walleye Capital LLC | 55,840 | $219 |
| Ikarian Capital, LLC | 53,063 | $209 |
| HSBC HOLDINGS PLC | 52,636 | $206 |
| TD Asset Management Inc | 44,350 | $174 |
| Palumbo Wealth Management LLC | 38,487 | $151 |
| Marex Group plc | 38,322 | $151 |
| STRS OHIO | 38,000 | $149 |
| Ethic Inc. | 36,738 | $144 |
| Jump Financial, LLC | 36,320 | $143 |
| ADAR1 Capital Management, LLC | 35,000 | $138 |
| DEUTSCHE BANK AG\ | 31,669 | $124 |
| Quantinno Capital Management LP | 31,298 | $123 |
| Quadrature Capital Ltd | 30,425 | $120 |
| RAYMOND JAMES FINANCIAL INC | 25,067 | $99 |
| Vestcor Inc | 22,874 | $0 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,586 | $85 |
| Hunter Perkins Capital Management, LLC | 20,965 | $0 |
| INTECH INVESTMENT MANAGEMENT LLC | 18,972 | $75 |
| Assenagon Asset Management S.A. | 16,381 | $64 |
| Caitong International Asset Management Co., Ltd | 15,729 | $62 |
| HRT FINANCIAL LP | 15,508 | $0 |
| MetLife Investment Management, LLC | 15,208 | $60 |
| XTX Topco Ltd | 14,417 | $57 |
| Police & Firemen's Retirement System of New Jersey | 14,195 | $56 |
| Cetera Investment Advisers | 14,164 | $56 |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,732 | $50 |
| COLDSTREAM CAPITAL MANAGEMENT INC | 11,749 | $46 |
| BANK OF MONTREAL /CAN/ | 11,499 | $45 |
| CIBC Asset Management Inc | 11,335 | $45 |
| COMMONWEALTH EQUITY SERVICES, LLC | 11,254 | $44 |
| ProShare Advisors LLC | 11,116 | $44 |
| Jain Global LLC | 10,669 | $42 |
| China Universal Asset Management Co., Ltd. | 9,603 | $38 |
| Pinnacle Wealth Planning Services, Inc. | 9,446 | $37 |
| SIMPLEX TRADING, LLC | 8,135 | $32 |
| CWM, LLC | 5,957 | $0 |
| Russell Investments Group, Ltd. | 4,054 | $16 |
| Legal & General Group Plc | 3,969 | $16 |
| Ameritas Investment Partners, Inc. | 3,923 | $15 |
| BESSEMER GROUP INC | 3,513 | $0 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,865 | $11 |
| Mirae Asset Global Investments Co., Ltd. | 2,864 | $11 |
| Tower Research Capital LLC (TRC) | 2,736 | $11 |
| CITIGROUP INC | 2,699 | $11 |
| Sterling Capital Management LLC | 2,685 | $11 |
| OSAIC HOLDINGS, INC. | 2,145 | $8 |
| GROUP ONE TRADING, L.P. | 2,074 | $8 |
| AMALGAMATED BANK | 1,463 | $0 |
| SBI Securities Co., Ltd. | 1,402 | $6 |
| ROYAL BANK OF CANADA | 1,304 | $5 |
| GF FUND MANAGEMENT CO. LTD. | 1,178 | $5 |
| 23 other institutions | 9,903 | $37 |