VOYAGER THERAPEUTICS INC

Institution	Shares	Value ($000)
Opaleye Management Inc.	1,196,904	$4,704
Palumbo Wealth Management LLC	38,487	$151
Altshuler Shaham Ltd	203,740	$801
Pinnacle Wealth Planning Services, Inc.	9,446	$37
Point72 Asset Management, L.P.	95,351	$375
Jump Financial, LLC	36,320	$143
Walleye Capital LLC	55,840	$219
Quadrature Capital Ltd	30,425	$120
Quantinno Capital Management LP	31,298	$123
DEUTSCHE BANK AG\	31,669	$124
Assenagon Asset Management S.A.	16,381	$64
CIBC Asset Management Inc	11,335	$45
ProShare Advisors LLC	11,116	$44
SIMPLEX TRADING, LLC	8,135	$32
GROUP ONE TRADING, L.P.	2,074	$8
Versant Capital Management, Inc	1,019	$4
Federation des caisses Desjardins du Quebec	709	$3
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	28	$0

Increased Positions (25)

EcoR1 Capital, LLC

Value ($000) $15,731 (+402.5%) Shares 4,002,847 (+497.2%)

SPHERA FUNDS MANAGEMENT LTD.

Value ($000) $1,335 (+43.1%) Shares 339,761 (+70.1%)

Privium Fund Management B.V.

Value ($000) $373 (+77.7%) Shares 95,000 (+111.1%)

Caitong International Asset Management Co., Ltd

Value ($000) $62 (+35631.2%) Shares 15,729 (+42410.8%)

Erste Asset Management GmbH

Value ($000) $4,718 (-10.3%) Shares 1,195,141 (+7.0%)

CITADEL ADVISORS LLC

Value ($000) $2,188 (+17.6%) Shares 556,646 (+39.8%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $875 (+33.2%) Shares 222,713 (+58.3%)

JPMORGAN CHASE & CO

Value ($000) $1,282 (+26.3%) Shares 326,230 (+50.1%)

BARCLAYS PLC

Value ($000) $637 (+4.3%) Shares 162,112 (+55.2%)

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $1,165 (-4.9%) Shares 296,450 (+13.0%)

WELLS FARGO & COMPANY/MN

Value ($000) $521 (+6.6%) Shares 132,663 (+26.7%)

Invesco Ltd.

Value ($000) $456 (+7.9%) Shares 116,000 (+28.2%)

FMR LLC

Value ($000) $557 (+0.5%) Shares 141,737 (+19.4%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $252 (+27.6%) Shares 64,195 (+51.6%)

OMERS ADMINISTRATION Corp

Value ($000) $326 (-2.9%) Shares 83,012 (+15.4%)

STATE STREET CORP

Value ($000) $3,680 (-14.9%) Shares 936,266 (+1.2%)

SUSQUEHANNA INTERNATIONAL GROUP, LLP

Value ($000) $256 (-0.7%) Shares 65,182 (+18.0%)

Allspring Global Investments Holdings, LLC

Value ($000) $249 (-5.4%) Shares 61,775 (+9.6%)

GOLDMAN SACHS GROUP INC

Value ($000) $1,191 (-14.3%) Shares 303,133 (+1.9%)

TWO SIGMA ADVISERS, LP

Value ($000) $246 (-10.1%) Shares 62,600 (+6.8%)

Institution	Prev Shares	Curr Shares	Change
EcoR1 Capital, LLC	670,303	4,002,847	+3,332,544 (+497.2%)
SPHERA FUNDS MANAGEMENT LTD.	199,761	339,761	+140,000 (+70.1%)
Privium Fund Management B.V.	45,000	95,000	+50,000 (+111.1%)
Caitong International Asset Management Co., Ltd	37	15,729	+15,692 (+42410.8%)
Erste Asset Management GmbH	1,116,793	1,195,141	+78,348 (+7.0%)
CITADEL ADVISORS LLC	398,226	556,646	+158,420 (+39.8%)
TWO SIGMA INVESTMENTS, LP	140,715	222,713	+81,998 (+58.3%)
JPMORGAN CHASE & CO	217,411	326,230	+108,819 (+50.1%)
BARCLAYS PLC	104,462	162,112	+57,650 (+55.2%)
RENAISSANCE TECHNOLOGIES LLC	262,450	296,450	+34,000 (+13.0%)
WELLS FARGO & COMPANY/MN	104,699	132,663	+27,964 (+26.7%)
Invesco Ltd.	90,478	116,000	+25,522 (+28.2%)
FMR LLC	118,705	141,737	+23,032 (+19.4%)
BNP PARIBAS ARBITRAGE, SA	42,339	64,195	+21,856 (+51.6%)
OMERS ADMINISTRATION Corp	71,950	83,012	+11,062 (+15.4%)
STATE STREET CORP	925,358	936,266	+10,908 (+1.2%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP	55,225	65,182	+9,957 (+18.0%)
Allspring Global Investments Holdings, LLC	56,353	61,775	+5,422 (+9.6%)
GOLDMAN SACHS GROUP INC	297,573	303,133	+5,560 (+1.9%)
TWO SIGMA ADVISERS, LP	58,600	62,600	+4,000 (+6.8%)

Decreased Positions (41)

Birchview Capital, LP

Value ($000) $294 (-53.3%) Shares 74,918 (-44.5%)

ARMISTICE CAPITAL, LLC

Value ($000) $15,720 (-19.9%) Shares 4,000,000 (-4.8%)

Hunter Perkins Capital Management, LLC

Value ($000) $0 (-67.3%) Shares 20,965 (-61.1%)

Patriot Financial Group Insurance Agency, LLC

Value ($000) $404 (-26.3%) Shares 102,716 (-12.4%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $7,391 (-31.0%) Shares 1,880,760 (-18.0%)

ROYAL BANK OF CANADA

Value ($000) $5 (-99.6%) Shares 1,304 (-99.5%)

BANK OF AMERICA CORP /DE/

Value ($000) $692 (-65.3%) Shares 176,097 (-58.8%)

DIMENSIONAL FUND ADVISORS LP

Value ($000) $4,262 (-28.9%) Shares 1,084,499 (-15.5%)

UBS Group AG

Value ($000) $1,056 (-52.2%) Shares 268,793 (-43.2%)

HSBC HOLDINGS PLC

Value ($000) $206 (-69.4%) Shares 52,636 (-64.4%)

MORGAN STANLEY

Value ($000) $2,138 (-23.6%) Shares 544,114 (-9.3%)

Bank of New York Mellon Corp

Value ($000) $548 (-39.4%) Shares 139,332 (-28.0%)

NORTHERN TRUST CORP

Value ($000) $1,448 (-21.4%) Shares 368,546 (-6.6%)

XTX Topco Ltd

Value ($000) $57 (-47.3%) Shares 14,417 (-37.3%)

Jain Global LLC

Value ($000) $42 (-68.1%) Shares 10,669 (-62.0%)

AQR CAPITAL MANAGEMENT LLC

Value ($000) $629 (-23.6%) Shares 160,037 (-9.2%)

STRS OHIO

Value ($000) $149 (-36.9%) Shares 38,000 (-25.0%)

MetLife Investment Management, LLC

Value ($000) $60 (-52.2%) Shares 15,208 (-43.2%)

Tower Research Capital LLC (TRC)

Value ($000) $11 (-77.2%) Shares 2,736 (-72.9%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $4,462 (-16.8%) Shares 1,135,188 (-1.2%)

Institution	Prev Shares	Curr Shares	Change
Birchview Capital, LP	134,918	74,918	-60,000 (-44.5%)
ARMISTICE CAPITAL, LLC	4,200,000	4,000,000	-200,000 (-4.8%)
Hunter Perkins Capital Management, LLC	53,840	20,965	-32,875 (-61.1%)
Patriot Financial Group Insurance Agency, LLC	117,284	102,716	-14,568 (-12.4%)
MILLENNIUM MANAGEMENT LLC	2,292,703	1,880,760	-411,943 (-18.0%)
ROYAL BANK OF CANADA	242,672	1,304	-241,368 (-99.5%)
BANK OF AMERICA CORP /DE/	427,430	176,097	-251,333 (-58.8%)
DIMENSIONAL FUND ADVISORS LP	1,283,156	1,084,499	-198,657 (-15.5%)
UBS Group AG	473,100	268,793	-204,307 (-43.2%)
HSBC HOLDINGS PLC	148,055	52,636	-95,419 (-64.4%)
MORGAN STANLEY	599,688	544,114	-55,574 (-9.3%)
Bank of New York Mellon Corp	193,415	139,332	-54,083 (-28.0%)
NORTHERN TRUST CORP	394,751	368,546	-26,205 (-6.6%)
XTX Topco Ltd	23,002	14,417	-8,585 (-37.3%)
Jain Global LLC	28,104	10,669	-17,435 (-62.0%)
AQR CAPITAL MANAGEMENT LLC	176,216	160,037	-16,179 (-9.2%)
STRS OHIO	50,700	38,000	-12,700 (-25.0%)
MetLife Investment Management, LLC	26,753	15,208	-11,545 (-43.2%)
Tower Research Capital LLC (TRC)	10,107	2,736	-7,371 (-72.9%)
GEODE CAPITAL MANAGEMENT, LLC	1,148,612	1,135,188	-13,424 (-1.2%)

Exited Positions (9)

EHP Funds Inc.

Value ($000) $58 Shares 12,375

AXQ CAPITAL, LP

Value ($000) $128 Shares 27,360

GSA CAPITAL PARTNERS LLP

Value ($000) $1 Shares 184,203

WEXFORD CAPITAL LP

Value ($000) $42 Shares 9,007

nVerses Capital, LLC

Value ($000) $11 Shares 1,900

BOOTHBAY FUND MANAGEMENT, LLC

Value ($000) $57 Shares 12,144

MACQUARIE GROUP LTD

Value ($000) $27 Shares 5,700

CIBC Private Wealth Group, LLC

Value ($000) $9 Shares 2,000

Virtu Financial LLC

Value ($000) $0 Shares 19,937

Institution	Prev Shares	Prev Value ($000)
EHP Funds Inc.	12,375	$58
AXQ CAPITAL, LP	27,360	$128
GSA CAPITAL PARTNERS LLP	184,203	$1
WEXFORD CAPITAL LP	9,007	$42
nVerses Capital, LLC	1,900	$11
BOOTHBAY FUND MANAGEMENT, LLC	12,144	$57
MACQUARIE GROUP LTD	5,700	$27
CIBC Private Wealth Group, LLC	2,000	$9
Virtu Financial LLC	19,937	$0