XENON PHARMACEUTICALS INC

Ticker: XENE CUSIP: 98420N105 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q1 2025

Shares 26,097 Value ($000) $876 Avg Close $37.97 Range $32.70 - $42.23

Q4 2024

Shares 52,097 Value ($000) $2,042 Avg Close $41.35 Range $37.34 - $46.00

Q3 2023

Shares 38,959 Value ($000) $1,331 Avg Close $37.40 Range $33.93 - $40.13

Q3 2021

Shares 373,510 Value ($000) $5,707 Avg Close $17.38 Range $14.65 - $19.64

Q2 2021

Shares 276,130 Value ($000) $51,412 Avg Close $18.43 Range $16.30 - $21.52

Q1 2019

Shares 533,655 Value ($000) $5,422 Avg Close $8.48 Range $6.17 - $10.74

Q4 2018

Shares 449,484 Value ($000) $2,836 Avg Close $8.89 Range $5.41 - $13.49

Q3 2018

Shares 379,484 Value ($000) $5,009 Avg Close $11.59 Range $8.85 - $15.92

Q2 2018

Shares 439,034 Value ($000) $4,039 Avg Close $6.21 Range $4.50 - $11.00

Q3 2017

Shares 228,029 Value ($000) $673 Avg Close $3.09 Range $2.25 - $3.50

Q2 2017

Shares 228,029 Value ($000) $718 Avg Close $3.91 Range $2.85 - $4.45

Q1 2017

Shares 328,029 Value ($000) $1,312 Avg Close $7.86 Range $3.95 - $9.95

Q4 2016

Shares 328,029 Value ($000) $2,526 Avg Close $8.03 Range $7.35 - $8.75

Q3 2016

Shares 228,029 Value ($000) $1,847 Avg Close $7.72 Range $5.88 - $8.56

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2025	26,097	$876	$37.97	$32.70 - $42.23
Q4 2024	52,097	$2,042	$41.35	$37.34 - $46.00
Q3 2023	38,959	$1,331	$37.40	$33.93 - $40.13
Q3 2021	373,510	$5,707	$17.38	$14.65 - $19.64
Q2 2021	276,130	$51,412	$18.43	$16.30 - $21.52
Q1 2019	533,655	$5,422	$8.48	$6.17 - $10.74
Q4 2018	449,484	$2,836	$8.89	$5.41 - $13.49
Q3 2018	379,484	$5,009	$11.59	$8.85 - $15.92
Q2 2018	439,034	$4,039	$6.21	$4.50 - $11.00
Q3 2017	228,029	$673	$3.09	$2.25 - $3.50
Q2 2017	228,029	$718	$3.91	$2.85 - $4.45
Q1 2017	328,029	$1,312	$7.86	$3.95 - $9.95
Q4 2016	328,029	$2,526	$8.03	$7.35 - $8.75
Q3 2016	228,029	$1,847	$7.72	$5.88 - $8.56