XENON PHARMACEUTICALS INC

Ticker: XENE CUSIP: 98420N105 Class: Common Stock

Siren, L.L.C.'s Holding History (CIK: 0002005245)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 812,761 Value ($000) $36,428 Avg Close $42.00 Range $37.23 - $46.60

Q3 2025

Shares 812,761 Value ($000) $32,632 Avg Close $35.22 Range $30.00 - $40.35

Q2 2025

Shares 812,761 Value ($000) $25,439 Avg Close $32.62 Range $26.74 - $39.01

Q1 2025

Shares 732,761 Value ($000) $24,584 Avg Close $37.97 Range $32.70 - $42.23

Q4 2024

Shares 743,769 Value ($000) $29,156 Avg Close $41.35 Range $37.34 - $46.00

Q3 2024

Shares 743,769 Value ($000) $29,282 Avg Close $40.32 Range $35.73 - $44.74

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	812,761	$36,428	$42.00	$37.23 - $46.60
Q3 2025	812,761	$32,632	$35.22	$30.00 - $40.35
Q2 2025	812,761	$25,439	$32.62	$26.74 - $39.01
Q1 2025	732,761	$24,584	$37.97	$32.70 - $42.23
Q4 2024	743,769	$29,156	$41.35	$37.34 - $46.00
Q3 2024	743,769	$29,282	$40.32	$35.73 - $44.74