| FMR LLC | 7,704,255 | $279,742 |
| SR ONE CAPITAL MANAGEMENT, LP | 5,037,854 | $182,924 |
| Enavate Sciences GP, LLC | 3,919,159 | $142,305 |
| NEA Management Company, LLC | 3,523,219 | $127,928 |
| FEDERATED HERMES, INC. | 2,715,578 | $98,603 |
| Fairmount Funds Management LLC | 2,209,025 | $80,210 |
| NVP Associates, LLC | 1,838,482 | $66,755 |
| BlackRock, Inc. | 1,767,518 | $64,179 |
| VANGUARD GROUP INC | 1,453,065 | $52,761 |
| Novo Holdings A/S | 1,450,000 | $52,650 |
| Polar Capital Holdings Plc | 1,057,609 | $38,402 |
| WELLINGTON MANAGEMENT GROUP LLP | 855,334 | $31,057 |
| Vivo Capital, LLC | 853,495 | $30,990 |
| EcoR1 Capital, LLC | 789,500 | $28,667 |
| ArrowMark Colorado Holdings LLC | 751,161 | $27,275 |
| Pivotal bioVenture Partners Investment Advisor LLC | 591,991 | $21,495 |
| GEODE CAPITAL MANAGEMENT, LLC | 588,393 | $21,371 |
| Rock Springs Capital Management LP | 502,077 | $18,230 |
| STATE STREET CORP | 438,294 | $15,914 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 369,248 | $13 |
| Point72 Asset Management, L.P. | 368,400 | $9,214 |
| NEXTBio Capital Management LP | 321,983 | $11,691 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 213,193 | $7,741 |
| BALYASNY ASSET MANAGEMENT L.P. | 193,153 | $7,013 |
| Invesco Ltd. | 187,968 | $6,825 |
| Skandinaviska Enskilda Banken AB (publ) | 163,860 | $5,950 |
| NORTHERN TRUST CORP | 155,366 | $5,641 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 133,439 | $4,845 |
| GOLDMAN SACHS GROUP INC | 130,698 | $4,746 |
| MORGAN STANLEY | 128,335 | $4,660 |
| Eversept Partners, LP | 121,016 | $4,394 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 83,353 | $3,027 |
| AQR CAPITAL MANAGEMENT LLC | 78,220 | $2,840 |
| UBS Group AG | 69,495 | $2,523 |
| Bank of New York Mellon Corp | 51,802 | $1,881 |
| Nuveen, LLC | 50,850 | $1,846 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 50,636 | $1,852 |
| MILLENNIUM MANAGEMENT LLC | 49,160 | $1,785 |
| BANK OF AMERICA CORP /DE/ | 47,160 | $1,712 |
| ALPS ADVISORS INC | 44,077 | $1,600 |
| BARCLAYS PLC | 34,377 | $1,248 |
| Swiss National Bank | 31,600 | $1,147 |
| CITADEL ADVISORS LLC | 24,459 | $888 |
| RHUMBLINE ADVISERS | 21,946 | $797 |
| JPMORGAN CHASE & CO | 21,726 | $789 |
| WELLS FARGO & COMPANY/MN | 21,151 | $768 |
| ALLIANCEBERNSTEIN L.P. | 18,350 | $666 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,701 | $570 |
| Squarepoint Ops LLC | 15,541 | $564 |
| TWO SIGMA INVESTMENTS, LP | 15,100 | $548 |
| Voya Investment Management LLC | 14,725 | $535 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 14,447 | $432 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13,678 | $497 |
| China Universal Asset Management Co., Ltd. | 13,314 | $483 |
| Legal & General Group Plc | 13,027 | $473 |
| DEUTSCHE BANK AG\ | 12,781 | $464 |
| Creative Planning | 12,273 | $446 |
| XTX Topco Ltd | 12,183 | $442 |
| STATE OF WISCONSIN INVESTMENT BOARD | 10,221 | $371 |
| Voleon Capital Management LP | 10,187 | $370 |
| MetLife Investment Management, LLC | 10,100 | $367 |
| Schonfeld Strategic Advisors LLC | 9,127 | $331 |
| GSA CAPITAL PARTNERS LLP | 8,956 | $0 |
| INTECH INVESTMENT MANAGEMENT LLC | 8,863 | $322 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,780 | $319 |
| UBS ASSET MANAGEMENT AMERICAS INC | 8,400 | $305 |
| JANUS HENDERSON GROUP PLC | 7,900 | $287 |
| Mariner, LLC | 7,676 | $279 |
| VARCOV Co. | 7,335 | $266 |
| BNP PARIBAS ARBITRAGE, SA | 7,138 | $259 |
| MARSHALL WACE, LLP | 7,100 | $258 |
| Virtus Investment Advisers, LLC | 6,554 | $238 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 6,256 | $227 |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,200 | $225 |
| Brevan Howard Capital Management LP | 6,173 | $224 |
| PNC Financial Services Group, Inc. | 5,824 | $211 |
| ProShare Advisors LLC | 5,820 | $211 |
| Police & Firemen's Retirement System of New Jersey | 4,499 | $163 |
| KLP KAPITALFORVALTNING AS | 3,400 | $123 |
| STRS OHIO | 2,800 | $102 |
| Mirae Asset Global Investments Co., Ltd. | 2,608 | $95 |
| CITIGROUP INC | 2,351 | $85 |
| CWM, LLC | 2,178 | $0 |
| SIMPLEX TRADING, LLC | 1,974 | $72 |
| Ameritas Investment Partners, Inc. | 1,368 | $50 |
| Russell Investments Group, Ltd. | 1,345 | $49 |
| Sterling Capital Management LLC | 1,087 | $39 |
| GF FUND MANAGEMENT CO. LTD. | 1,054 | $38 |
| US BANCORP \DE\ | 884 | $32 |
| Tower Research Capital LLC (TRC) | 795 | $29 |
| AMALGAMATED BANK | 593 | $0 |
| ROYAL BANK OF CANADA | 544 | $20 |
| SIGNATUREFD, LLC | 389 | $14 |
| Daiwa Securities Group Inc. | 179 | $0 |
| GAMMA Investing LLC | 179 | $6 |
| NISA INVESTMENT ADVISORS, LLC | 115 | $4 |
| Torren Management, LLC | 95 | $3 |
| J.Safra Asset Management Corp | 92 | $3 |
| Farther Finance Advisors, LLC | 86 | $3 |
| EverSource Wealth Advisors, LLC | 73 | $3 |
| 17 other institutions | 266 | $10 |