ZYMEWORKS INC

Ticker: ZYME CUSIP: 98985Y108 Class: Common Stock

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 108,929 Value ($000) $2,868 Avg Close $21.81 Range $16.00 - $28.49

Q3 2025

Shares 100,000 Value ($000) $1,708 Avg Close $14.31 Range $11.51 - $17.60

Q2 2025

Shares 210,000 Value ($000) $2,636 Avg Close $11.91 Range $9.03 - $13.44

Q1 2025

Shares 175,000 Value ($000) $2,084 Avg Close $13.64 Range $10.96 - $17.07

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	108,929	$2,868	$21.81	$16.00 - $28.49
Q3 2025	100,000	$1,708	$14.31	$11.51 - $17.60
Q2 2025	210,000	$2,636	$11.91	$9.03 - $13.44
Q1 2025	175,000	$2,084	$13.64	$10.96 - $17.07