ZYMEWORKS INC

Ticker: ZYME CUSIP: 98985Y108 Class: Common Stock

Frazier Life Sciences Management, L.P.'s Holding History (CIK: 0001892134)

Note: Option positions (PUT/CALL) are excluded.

Q1 2023

Shares 610,000 Value ($000) $5,514 Avg Close $8.72 Range $7.31 - $10.80

Q4 2022

Shares 610,000 Value ($000) $4,795 Avg Close $7.03 Range $4.86 - $9.28

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2023	610,000	$5,514	$8.72	$7.31 - $10.80
Q4 2022	610,000	$4,795	$7.03	$4.86 - $9.28