ZYMEWORKS INC

Ticker: ZYME CUSIP: 98985Y108 Class: Common Stock

Siren, L.L.C.'s Holding History (CIK: 0002005245)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,680,121 Value ($000) $44,238 Avg Close $21.81 Range $16.00 - $28.49

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,680,121	$44,238	$21.81	$16.00 - $28.49