ALKERMES PLC

Ticker: ALKS CUSIP: G01767105 Class: Common Stock

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 490,000 Value ($000) $13,710 Avg Close $29.95 Range $27.49 - $36.32

Q3 2025

Shares 450,000 Value ($000) $13,500 Avg Close $28.20 Range $25.17 - $31.69

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	490,000	$13,710	$29.95	$27.49 - $36.32
Q3 2025	450,000	$13,500	$28.20	$25.17 - $31.69