| BlackRock, Inc. | 28,272,412 | $791,062 |
| VANGUARD GROUP INC | 18,007,364 | $503,846 |
| BAKER BROS. ADVISORS LP | 10,012,267 | $280,143 |
| STATE STREET CORP | 9,472,858 | $265,051 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,998,963 | $252 |
| RENAISSANCE TECHNOLOGIES LLC | 6,668,028 | $186,571 |
| AMERICAN CENTURY COMPANIES INC | 5,956,824 | $166,672 |
| JPMORGAN CHASE & CO | 5,184,547 | $145,064 |
| DIMENSIONAL FUND ADVISORS LP | 4,412,783 | $123,467 |
| GEODE CAPITAL MANAGEMENT, LLC | 4,080,776 | $114,198 |
| Commodore Capital LP | 3,550,000 | $99,329 |
| WELLINGTON MANAGEMENT GROUP LLP | 3,020,442 | $84,512 |
| PRIMECAP MANAGEMENT CO/CA/ | 2,564,300 | $71,749 |
| UBS Group AG | 2,544,895 | $71,206 |
| Nuveen, LLC | 2,427,028 | $67,908 |
| GOLDMAN SACHS GROUP INC | 2,267,588 | $63,447 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,152,756 | $60,234 |
| Deep Track Capital, LP | 2,000,000 | $55,960 |
| NORGES BANK | 1,945,734 | $54,442 |
| LOOMIS SAYLES & CO L P | 1,902,522 | $53,233 |
| MORGAN STANLEY | 1,888,487 | $52,840 |
| RTW INVESTMENTS, LP | 1,672,356 | $46,793 |
| NORTHERN TRUST CORP | 1,653,475 | $46,264 |
| Pictet Asset Management Holding SA | 1,477,214 | $41,344 |
| FIRST TRUST ADVISORS LP | 1,454,002 | $40,683 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,450,841 | $40,595 |
| Avoro Capital Advisors LLC | 1,400,000 | $39,172 |
| FMR LLC | 1,355,253 | $37,920 |
| Artisan Partners Limited Partnership | 1,349,122 | $37,748 |
| BANK OF AMERICA CORP /DE/ | 1,333,105 | $37,300 |
| Soleus Capital Management, L.P. | 1,322,364 | $37,000 |
| TWO SIGMA INVESTMENTS, LP | 1,213,397 | $33,951 |
| CITADEL ADVISORS LLC | 1,198,268 | $33,528 |
| Squarepoint Ops LLC | 1,095,846 | $30,662 |
| Bank of New York Mellon Corp | 1,074,087 | $30,053 |
| Affinity Asset Advisors, LLC | 1,000,000 | $27,980 |
| VIRGINIA RETIREMENT SYSTEMS ET AL | 976,483 | $27,322 |
| PRINCIPAL FINANCIAL GROUP INC | 947,623 | $26,514 |
| PANAGORA ASSET MANAGEMENT INC | 928,964 | $25,992 |
| D. E. Shaw & Co., Inc. | 911,272 | $25,497 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 796,968 | $22,299 |
| Frazier Life Sciences Management, L.P. | 700,647 | $19,604 |
| BALYASNY ASSET MANAGEMENT L.P. | 679,633 | $19,016 |
| Pacer Advisors, Inc. | 674,874 | $18,883 |
| Public Sector Pension Investment Board | 671,170 | $18,779 |
| SEGALL BRYANT & HAMILL, LLC | 615,292 | $17,216 |
| BARCLAYS PLC | 565,033 | $15,810 |
| TWO SIGMA ADVISERS, LP | 562,587 | $15,741 |
| Woodline Partners LP | 558,567 | $15,629 |
| Invesco Ltd. | 538,716 | $15,073 |
| AMERIPRISE FINANCIAL INC | 531,362 | $14,868 |
| MetLife Investment Management, LLC | 530,379 | $14,840 |
| ACADIAN ASSET MANAGEMENT LLC | 522,097 | $15 |
| AQR CAPITAL MANAGEMENT LLC | 514,324 | $14,391 |
| Voya Investment Management LLC | 501,807 | $14,041 |
| Opaleye Management Inc. | 490,000 | $13,710 |
| RHUMBLINE ADVISERS | 439,195 | $12,289 |
| BNP PARIBAS ARBITRAGE, SA | 430,330 | $12,041 |
| Legal & General Group Plc | 429,497 | $12,017 |
| GLENMEDE TRUST CO NA | 412,920 | $11,554 |
| VICTORY CAPITAL MANAGEMENT INC | 402,578 | $11,264 |
| UBS ASSET MANAGEMENT AMERICAS INC | 394,853 | $11,048 |
| Fisher Asset Management, LLC | 390,493 | $10,926 |
| RICE HALL JAMES & ASSOCIATES, LLC | 379,458 | $10,617 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 361,387 | $10,112 |
| Allianz Asset Management GmbH | 347,308 | $9,718 |
| Bridgewater Associates, LP | 344,452 | $9,638 |
| RAYMOND JAMES FINANCIAL INC | 328,205 | $9,141 |
| ROYAL BANK OF CANADA | 325,496 | $9,107 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 324,578 | $9,082 |
| Man Group plc | 312,512 | $8,744 |
| CANADA PENSION PLAN INVESTMENT BOARD | 310,600 | $8,691 |
| Swiss National Bank | 309,200 | $8,651 |
| Edgestream Partners, L.P. | 291,299 | $8,151 |
| Robeco Institutional Asset Management B.V. | 285,670 | $7,993 |
| Qube Research & Technologies Ltd | 276,558 | $7,738 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 273,158 | $7,643 |
| PEREGRINE CAPITAL MANAGEMENT LLC | 254,333 | $7,116 |
| C WorldWide Group Holding A/S | 250,000 | $7 |
| Palo Alto Investors LP | 242,560 | $6,787 |
| HealthInvest Partners AB | 242,473 | $6,784 |
| BNP Paribas Investment Partners S.A. | 241,133 | $7 |
| WELLS FARGO & COMPANY/MN | 232,987 | $6,519 |
| FCF Advisors LLC | 219,495 | $6,141 |
| ALLIANCEBERNSTEIN L.P. | 215,854 | $6,040 |
| Rafferty Asset Management, LLC | 203,264 | $5,687 |
| HRT FINANCIAL LP | 200,224 | $6 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 194,530 | $5,442 |
| PRUDENTIAL FINANCIAL INC | 194,505 | $5,442 |
| FRANKLIN RESOURCES INC | 192,807 | $5,395 |
| SEI INVESTMENTS CO | 190,717 | $5,336 |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 172,250 | $4,820 |
| MARTINGALE ASSET MANAGEMENT L P | 170,267 | $4,764 |
| INTECH INVESTMENT MANAGEMENT LLC | 159,581 | $4,465 |
| BESSEMER GROUP INC | 157,640 | $4 |
| Russell Investments Group, Ltd. | 157,359 | $4,393 |
| NEUBERGER BERMAN GROUP LLC | 152,772 | $4,275 |
| CAPITAL FUND MANAGEMENT S.A. | 150,775 | $4,219 |
| NEW YORK STATE COMMON RETIREMENT FUND | 149,284 | $4,177 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 148,793 | $4,163 |
| 261 other institutions | 7,667,683 | $190,940 |