| Redmile Group, LLC | 15,666,731 | $55,304 |
| TCG Crossover Management, LLC | 11,390,175 | $40,207 |
| Prosight Management, LP | 8,477,338 | $29,925 |
| ORBIMED ADVISORS LLC | 5,822,854 | $20,555 |
| Nantahala Capital Management, LLC | 5,475,433 | $19,328 |
| BlackRock, Inc. | 5,427,309 | $19,158 |
| Point72 Asset Management, L.P. | 5,014,617 | $17,702 |
| MORGAN STANLEY | 3,769,743 | $13,307 |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,364,067 | $11,875 |
| GOLDMAN SACHS GROUP INC | 1,640,872 | $5,792 |
| STATE STREET CORP | 1,407,325 | $4,968 |
| BANK OF AMERICA CORP /DE/ | 1,298,584 | $4,584 |
| VANGUARD GROUP INC | 1,129,587 | $3,987 |
| GEODE CAPITAL MANAGEMENT, LLC | 996,523 | $3,518 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 990,778 | $3,497 |
| BNP PARIBAS ARBITRAGE, SA | 830,903 | $2,933 |
| Blue Owl Capital Holdings LP | 733,568 | $2,934 |
| Vantage Consulting Group Inc | 682,998 | $2,411 |
| PANAGORA ASSET MANAGEMENT INC | 594,256 | $2,098 |
| ACADIAN ASSET MANAGEMENT LLC | 528,965 | $2 |
| STEMPOINT CAPITAL LP | 502,570 | $1,774 |
| JPMORGAN CHASE & CO | 471,693 | $1,665 |
| Voleon Capital Management LP | 464,159 | $1,638 |
| NORTHERN TRUST CORP | 437,551 | $1,545 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 418,782 | $1,466 |
| MILLENNIUM MANAGEMENT LLC | 328,429 | $1,159 |
| WELLS FARGO & COMPANY/MN | 320,048 | $1,130 |
| CITADEL ADVISORS LLC | 298,218 | $1,053 |
| D. E. Shaw & Co., Inc. | 263,071 | $929 |
| UBS Group AG | 215,212 | $760 |
| WELLINGTON MANAGEMENT GROUP LLP | 212,915 | $752 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 212,668 | $751 |
| AQR CAPITAL MANAGEMENT LLC | 206,576 | $729 |
| JANE STREET GROUP, LLC | 199,764 | $705 |
| Squarepoint Ops LLC | 173,867 | $614 |
| Bank of New York Mellon Corp | 172,987 | $611 |
| Jump Financial, LLC | 162,250 | $573 |
| BARCLAYS PLC | 161,386 | $570 |
| FMR LLC | 133,797 | $472 |
| TWO SIGMA ADVISERS, LP | 120,567 | $426 |
| TWO SIGMA INVESTMENTS, LP | 119,461 | $422 |
| Nuveen, LLC | 118,915 | $420 |
| STATE OF WISCONSIN INVESTMENT BOARD | 113,369 | $400 |
| Creative Planning | 113,247 | $400 |
| Florida Trust Wealth Management Co | 113,000 | $399 |
| KINGSWOOD WEALTH ADVISORS, LLC | 105,000 | $371 |
| BRYN MAWR TRUST Co | 100,000 | $353 |
| CANTOR FITZGERALD, L. P. | 100,000 | $353 |
| RHUMBLINE ADVISERS | 90,683 | $320 |
| XTX Topco Ltd | 82,871 | $293 |
| DAFNA Capital Management LLC | 77,081 | $272 |
| DEUTSCHE BANK AG\ | 70,774 | $250 |
| Susquehanna Portfolio Strategies, LLC | 64,523 | $228 |
| ExodusPoint Capital Management, LP | 56,783 | $200 |
| MetLife Investment Management, LLC | 49,682 | $175 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 46,750 | $0 |
| ALLIANCEBERNSTEIN L.P. | 41,850 | $148 |
| Invesco Ltd. | 40,211 | $142 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,027 | $141 |
| Magnetar Financial LLC | 39,092 | $138 |
| INTECH INVESTMENT MANAGEMENT LLC | 36,940 | $130 |
| LPL Financial LLC | 31,900 | $113 |
| DLK Investment Management, LLC | 25,305 | $89 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,758 | $87 |
| Russell Investments Group, Ltd. | 24,532 | $87 |
| SG Americas Securities, LLC | 24,448 | $0 |
| Callan Family Office, LLC | 23,842 | $84 |
| Saxony Capital Management, LLC | 23,768 | $84 |
| SEI INVESTMENTS CO | 22,989 | $81 |
| Police & Firemen's Retirement System of New Jersey | 22,819 | $81 |
| GSA CAPITAL PARTNERS LLP | 20,889 | $0 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,178 | $71 |
| Henrickson Nauta Wealth Advisors, Inc. | 19,411 | $69 |
| COMMONWEALTH EQUITY SERVICES, LLC | 17,809 | $63 |
| CITIGROUP INC | 16,109 | $57 |
| AXQ CAPITAL, LP | 16,078 | $57 |
| IEQ CAPITAL, LLC | 16,067 | $57 |
| ProShare Advisors LLC | 15,727 | $56 |
| Voya Investment Management LLC | 14,375 | $51 |
| Ethic Inc. | 12,100 | $43 |
| Engineers Gate Manager LP | 12,071 | $43 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 11,722 | $41 |
| Quantinno Capital Management LP | 10,825 | $38 |
| HSBC HOLDINGS PLC | 10,521 | $38 |
| CWM, LLC | 10,370 | $0 |
| AVISO WEALTH MANAGEMENT | 10,343 | $37 |
| ROYAL BANK OF CANADA | 10,263 | $36 |
| OSAIC HOLDINGS, INC. | 9,324 | $33 |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,100 | $32 |
| Legal & General Group Plc | 8,924 | $32 |
| Ameritas Investment Partners, Inc. | 6,859 | $24 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,308 | $19 |
| Tower Research Capital LLC (TRC) | 3,995 | $14 |
| JONES FINANCIAL COMPANIES LLLP | 3,000 | $11 |
| AMALGAMATED BANK | 2,710 | $0 |
| SIMPLEX TRADING, LLC | 2,687 | $9 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 1,725 | $8 |
| EverSource Wealth Advisors, LLC | 958 | $3 |
| Optiver Holding B.V. | 586 | $2 |
| GAMMA Investing LLC | 492 | $2 |
| 14 other institutions | 2,075 | $7 |