ADC THERAPEUTICS SA

Institution	Shares	Value ($000)
EVENTIDE ASSET MANAGEMENT, LLC	3,364,067	$11,875
KINGSWOOD WEALTH ADVISORS, LLC	105,000	$371
AXQ CAPITAL, LP	16,078	$57
Henrickson Nauta Wealth Advisors, Inc.	19,411	$69
CANTOR FITZGERALD, L. P.	100,000	$353
SCHRODER INVESTMENT MANAGEMENT GROUP	418,782	$1,466
D. E. Shaw & Co., Inc.	263,071	$929
TWO SIGMA ADVISERS, LP	120,567	$426
STATE OF WISCONSIN INVESTMENT BOARD	113,369	$400
Callan Family Office, LLC	23,842	$84
SUSQUEHANNA INTERNATIONAL GROUP, LLP	20,178	$71
Engineers Gate Manager LP	12,071	$43
Quantinno Capital Management LP	10,825	$38
LOS ANGELES CAPITAL MANAGEMENT LLC	1,725	$8
GSA CAPITAL PARTNERS LLP	20,889	$0
GAMMA Investing LLC	492	$2
GROUP ONE TRADING, L.P.	100	$0
Farther Finance Advisors, LLC	57	$0
SG Americas Securities, LLC	24,448	$0
MAI Capital Management	16	$0

Increased Positions (46)

Prosight Management, LP

Value ($000) $29,925 (+0.1%) Shares 8,477,338 (+13.5%)

TCG Crossover Management, LLC

Value ($000) $40,207 (+623.1%) Shares 11,390,175 (+719.3%)

Nantahala Capital Management, LLC

Value ($000) $19,328 (+113.2%) Shares 5,475,433 (+141.6%)

STEMPOINT CAPITAL LP

Value ($000) $1,774 (+56.6%) Shares 502,570 (+77.4%)

Voleon Capital Management LP

Value ($000) $1,638 (+482.6%) Shares 464,159 (+560.2%)

Jump Financial, LLC

Value ($000) $573 (+1135.3%) Shares 162,250 (+1299.8%)

BlackRock, Inc.

Value ($000) $19,158 (+6.2%) Shares 5,427,309 (+20.3%)

VANGUARD GROUP INC

Value ($000) $3,987 (+67.8%) Shares 1,129,587 (+90.2%)

WELLS FARGO & COMPANY/MN

Value ($000) $1,130 (+306.4%) Shares 320,048 (+360.5%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $2,933 (+6.5%) Shares 830,903 (+20.7%)

JPMORGAN CHASE & CO

Value ($000) $1,665 (+25.9%) Shares 471,693 (+42.7%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $3,518 (+1.9%) Shares 996,523 (+15.5%)

STATE STREET CORP

Value ($000) $4,968 (-4.2%) Shares 1,407,325 (+8.6%)

MORGAN STANLEY

Value ($000) $13,307 (-9.3%) Shares 3,769,743 (+2.7%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $422 (+131.9%) Shares 119,461 (+162.8%)

PANAGORA ASSET MANAGEMENT INC

Value ($000) $2,098 (-3.6%) Shares 594,256 (+9.2%)

AQR CAPITAL MANAGEMENT LLC

Value ($000) $729 (+25.5%) Shares 206,576 (+42.2%)

GOLDMAN SACHS GROUP INC

Value ($000) $5,792 (-9.2%) Shares 1,640,872 (+2.9%)

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

Value ($000) $751 (+3.1%) Shares 212,668 (+16.8%)

BARCLAYS PLC

Value ($000) $570 (+41.6%) Shares 161,386 (+26.3%)

Institution	Prev Shares	Curr Shares	Change
Prosight Management, LP	7,472,303	8,477,338	+1,005,035 (+13.5%)
TCG Crossover Management, LLC	1,390,175	11,390,175	+10,000,000 (+719.3%)
Nantahala Capital Management, LLC	2,266,289	5,475,433	+3,209,144 (+141.6%)
STEMPOINT CAPITAL LP	283,286	502,570	+219,284 (+77.4%)
Voleon Capital Management LP	70,311	464,159	+393,848 (+560.2%)
Jump Financial, LLC	11,591	162,250	+150,659 (+1299.8%)
BlackRock, Inc.	4,511,699	5,427,309	+915,610 (+20.3%)
VANGUARD GROUP INC	593,954	1,129,587	+535,633 (+90.2%)
WELLS FARGO & COMPANY/MN	69,501	320,048	+250,547 (+360.5%)
BNP PARIBAS ARBITRAGE, SA	688,471	830,903	+142,432 (+20.7%)
JPMORGAN CHASE & CO	330,597	471,693	+141,096 (+42.7%)
GEODE CAPITAL MANAGEMENT, LLC	862,934	996,523	+133,589 (+15.5%)
STATE STREET CORP	1,295,941	1,407,325	+111,384 (+8.6%)
MORGAN STANLEY	3,669,067	3,769,743	+100,676 (+2.7%)
TWO SIGMA INVESTMENTS, LP	45,458	119,461	+74,003 (+162.8%)
PANAGORA ASSET MANAGEMENT INC	544,261	594,256	+49,995 (+9.2%)
AQR CAPITAL MANAGEMENT LLC	145,252	206,576	+61,324 (+42.2%)
GOLDMAN SACHS GROUP INC	1,594,434	1,640,872	+46,438 (+2.9%)
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	182,012	212,668	+30,656 (+16.8%)
BARCLAYS PLC	127,739	161,386	+33,647 (+26.3%)

Decreased Positions (26)

PLATINUM INVESTMENT MANAGEMENT LTD

Value ($000) $3,497 (-24.4%) Shares 990,778 (-14.3%)

DAFNA Capital Management LLC

Value ($000) $272 (-44.3%) Shares 77,081 (-36.9%)

Point72 Asset Management, L.P.

Value ($000) $17,702 (-45.6%) Shares 5,014,617 (-38.4%)

ORBIMED ADVISORS LLC

Value ($000) $20,555 (-13.0%) Shares 5,822,854 (-1.4%)

CITADEL ADVISORS LLC

Value ($000) $1,053 (-67.9%) Shares 298,218 (-63.7%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $1,159 (-58.7%) Shares 328,429 (-53.2%)

JANE STREET GROUP, LLC

Value ($000) $705 (-63.9%) Shares 199,764 (-59.1%)

BANK OF AMERICA CORP /DE/

Value ($000) $4,584 (-15.8%) Shares 1,298,584 (-4.6%)

Nuveen, LLC

Value ($000) $420 (-38.7%) Shares 118,915 (-30.6%)

UBS Group AG

Value ($000) $760 (-27.6%) Shares 215,212 (-17.9%)

WELLINGTON MANAGEMENT GROUP LLP

Value ($000) $752 (-24.9%) Shares 212,915 (-14.9%)

XTX Topco Ltd

Value ($000) $293 (-20.1%) Shares 82,871 (-9.5%)

LPL Financial LLC

Value ($000) $113 (-37.6%) Shares 31,900 (-29.3%)

RHUMBLINE ADVISERS

Value ($000) $320 (-20.4%) Shares 90,683 (-9.7%)

Russell Investments Group, Ltd.

Value ($000) $87 (-33.4%) Shares 24,532 (-24.5%)

ALLIANCEBERNSTEIN L.P.

Value ($000) $148 (-25.5%) Shares 41,850 (-15.6%)

DEUTSCHE BANK AG\

Value ($000) $250 (-19.4%) Shares 70,774 (-8.7%)

IEQ CAPITAL, LLC

Value ($000) $57 (-31.2%) Shares 16,067 (-22.0%)

Ethic Inc.

Value ($000) $43 (-29.8%) Shares 12,100 (-20.4%)

SIMPLEX TRADING, LLC

Value ($000) $9 (+29540.6%) Shares 2,687 (-67.0%)

Institution	Prev Shares	Curr Shares	Change
PLATINUM INVESTMENT MANAGEMENT LTD	1,156,721	990,778	-165,943 (-14.3%)
DAFNA Capital Management LLC	122,081	77,081	-45,000 (-36.9%)
Point72 Asset Management, L.P.	8,135,651	5,014,617	-3,121,034 (-38.4%)
ORBIMED ADVISORS LLC	5,907,351	5,822,854	-84,497 (-1.4%)
CITADEL ADVISORS LLC	820,715	298,218	-522,497 (-63.7%)
MILLENNIUM MANAGEMENT LLC	701,619	328,429	-373,190 (-53.2%)
JANE STREET GROUP, LLC	487,868	199,764	-288,104 (-59.1%)
BANK OF AMERICA CORP /DE/	1,361,290	1,298,584	-62,706 (-4.6%)
Nuveen, LLC	171,230	118,915	-52,315 (-30.6%)
UBS Group AG	262,261	215,212	-47,049 (-17.9%)
WELLINGTON MANAGEMENT GROUP LLP	250,084	212,915	-37,169 (-14.9%)
XTX Topco Ltd	91,579	82,871	-8,708 (-9.5%)
LPL Financial LLC	45,100	31,900	-13,200 (-29.3%)
RHUMBLINE ADVISERS	100,474	90,683	-9,791 (-9.7%)
Russell Investments Group, Ltd.	32,502	24,532	-7,970 (-24.5%)
ALLIANCEBERNSTEIN L.P.	49,590	41,850	-7,740 (-15.6%)
DEUTSCHE BANK AG\	77,524	70,774	-6,750 (-8.7%)
IEQ CAPITAL, LLC	20,598	16,067	-4,531 (-22.0%)
Ethic Inc.	15,207	12,100	-3,107 (-20.4%)
SIMPLEX TRADING, LLC	8,143	2,687	-5,456 (-67.0%)

Exited Positions (12)

Lynx1 Capital Management LP

Value ($000) $5,303 Shares 1,325,848

Opaleye Management Inc.

Value ($000) $2,730 Shares 682,529

HEIGHTS CAPITAL MANAGEMENT, INC

Value ($000) $1,307 Shares 326,766

R Squared Ltd

Value ($000) $59 Shares 14,714

Walleye Capital LLC

Value ($000) $708 Shares 177,032

MARSHALL WACE, LLP

Value ($000) $640 Shares 159,993

Atom Investors LP

Value ($000) $53 Shares 13,131

Diversified Trust Co

Value ($000) $56 Shares 14,115

Physician Wealth Advisors, Inc.

Value ($000) $1 Shares 228

HRT FINANCIAL LP

Value ($000) $0 Shares 27,531

Clearstead Advisors, LLC

Value ($000) $0 Shares 1

TSFG, LLC

Value ($000) $0 Shares 100

Institution	Prev Shares	Prev Value ($000)
Lynx1 Capital Management LP	1,325,848	$5,303
Opaleye Management Inc.	682,529	$2,730
HEIGHTS CAPITAL MANAGEMENT, INC	326,766	$1,307
R Squared Ltd	14,714	$59
Walleye Capital LLC	177,032	$708
MARSHALL WACE, LLP	159,993	$640
Atom Investors LP	13,131	$53
Diversified Trust Co	14,115	$56
Physician Wealth Advisors, Inc.	228	$1
HRT FINANCIAL LP	27,531	$0
Clearstead Advisors, LLC	1	$0
TSFG, LLC	100	$0