CRISPR THERAPEUTICS AG

Ticker: CRSP CUSIP: H17182108 Class: NAMEN AKT

Novo Holdings A/S's Holding History (CIK: 0001388325)

Note: Option positions (PUT/CALL) are excluded.

Q1 2018

Shares 223,317 Value ($000) $10,208 Avg Close $41.27 Range $23.01 - $61.24

Q4 2017

Shares 223,317 Value ($000) $5,243 Avg Close $19.00 Range $16.51 - $25.00

Q3 2017

Shares 223,317 Value ($000) $3,991 Avg Close $18.13 Range $15.55 - $21.32

Q2 2017

Shares 223,317 Value ($000) $3,578 Avg Close $16.52 Range $13.50 - $22.22

Q1 2017

Shares 223,317 Value ($000) $4,862 Avg Close $19.63 Range $11.63 - $25.00

Q4 2016

Shares 223,317 Value ($000) $4,524 Avg Close $18.69 Range $13.75 - $23.97

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2018	223,317	$10,208	$41.27	$23.01 - $61.24
Q4 2017	223,317	$5,243	$19.00	$16.51 - $25.00
Q3 2017	223,317	$3,991	$18.13	$15.55 - $21.32
Q2 2017	223,317	$3,578	$16.52	$13.50 - $22.22
Q1 2017	223,317	$4,862	$19.63	$11.63 - $25.00
Q4 2016	223,317	$4,524	$18.69	$13.75 - $23.97