UNIQURE NV

Ticker: QURE CUSIP: N90064101 Class: Common Stock

ORBIMED ADVISORS LLC's Holding History (CIK: 0001055951)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 737,400 Value ($000) $17,646 Avg Close $38.59 Range $19.29 - $71.50

Q3 2025

Shares 458,500 Value ($000) $26,763 Avg Close $18.16 Range $12.33 - $60.70

Q4 2023

Shares 1,347,900 Value ($000) $9,125 Avg Close $6.61 Range $5.49 - $8.66

Q3 2023

Shares 2,064,455 Value ($000) $13,852 Avg Close $9.00 Range $6.64 - $11.95

Q2 2023

Shares 2,064,455 Value ($000) $23,659 Avg Close $18.95 Range $10.51 - $22.48

Q1 2023

Shares 2,064,455 Value ($000) $41,578 Avg Close $20.98 Range $18.01 - $23.46

Q4 2022

Shares 1,747,555 Value ($000) $39,617 Avg Close $21.57 Range $17.85 - $28.25

Q3 2022

Shares 1,597,000 Value ($000) $29,960 Avg Close $21.02 Range $16.75 - $25.81

Q2 2022

Shares 874,849 Value ($000) $16,307 Avg Close $15.91 Range $12.52 - $20.72

Q1 2022

Shares 919,249 Value ($000) $16,611 Avg Close $17.46 Range $14.29 - $21.85

Q4 2021

Shares 585,574 Value ($000) $12,145 Avg Close $28.68 Range $19.50 - $36.55

Q3 2021

Shares 585,574 Value ($000) $18,744 Avg Close $30.48 Range $25.80 - $38.80

Q2 2021

Shares 471,174 Value ($000) $14,512 Avg Close $33.51 Range $29.85 - $37.78

Q1 2021

Shares 969,079 Value ($000) $32,648 Avg Close $35.84 Range $28.58 - $42.27

Q4 2020

Shares 969,079 Value ($000) $35,013 Avg Close $42.18 Range $34.38 - $52.19

Q3 2020

Shares 969,079 Value ($000) $35,691 Avg Close $40.97 Range $35.76 - $48.50

Q2 2020

Shares 969,079 Value ($000) $43,667 Avg Close $59.06 Range $44.63 - $71.45

Q1 2020

Shares 983,979 Value ($000) $46,690 Avg Close $57.46 Range $37.50 - $76.69

Q4 2019

Shares 1,081,765 Value ($000) $77,519 Avg Close $54.91 Range $36.20 - $76.09

Q3 2019

Shares 839,600 Value ($000) $33,047 Avg Close $57.69 Range $38.07 - $77.46

Q2 2019

Shares 897,800 Value ($000) $70,163 Avg Close $63.72 Range $51.85 - $82.49

Q3 2016

Shares 489,000 Value ($000) $3,741 Avg Close $7.93 Range $6.68 - $9.72

Q2 2016

Shares 195,400 Value ($000) $1,440 Avg Close $11.96 Range $6.75 - $15.00

Q1 2016

Shares 184,800 Value ($000) $2,195 Avg Close $14.77 Range $10.61 - $19.40

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	737,400	$17,646	$38.59	$19.29 - $71.50
Q3 2025	458,500	$26,763	$18.16	$12.33 - $60.70
Q4 2023	1,347,900	$9,125	$6.61	$5.49 - $8.66
Q3 2023	2,064,455	$13,852	$9.00	$6.64 - $11.95
Q2 2023	2,064,455	$23,659	$18.95	$10.51 - $22.48
Q1 2023	2,064,455	$41,578	$20.98	$18.01 - $23.46
Q4 2022	1,747,555	$39,617	$21.57	$17.85 - $28.25
Q3 2022	1,597,000	$29,960	$21.02	$16.75 - $25.81
Q2 2022	874,849	$16,307	$15.91	$12.52 - $20.72
Q1 2022	919,249	$16,611	$17.46	$14.29 - $21.85
Q4 2021	585,574	$12,145	$28.68	$19.50 - $36.55
Q3 2021	585,574	$18,744	$30.48	$25.80 - $38.80
Q2 2021	471,174	$14,512	$33.51	$29.85 - $37.78
Q1 2021	969,079	$32,648	$35.84	$28.58 - $42.27
Q4 2020	969,079	$35,013	$42.18	$34.38 - $52.19
Q3 2020	969,079	$35,691	$40.97	$35.76 - $48.50
Q2 2020	969,079	$43,667	$59.06	$44.63 - $71.45
Q1 2020	983,979	$46,690	$57.46	$37.50 - $76.69
Q4 2019	1,081,765	$77,519	$54.91	$36.20 - $76.09
Q3 2019	839,600	$33,047	$57.69	$38.07 - $77.46
Q2 2019	897,800	$70,163	$63.72	$51.85 - $82.49
Q3 2016	489,000	$3,741	$7.93	$6.68 - $9.72
Q2 2016	195,400	$1,440	$11.96	$6.75 - $15.00
Q1 2016	184,800	$2,195	$14.77	$10.61 - $19.40