UNIQURE NV

Ticker: QURE CUSIP: N90064101 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 24,900 Value ($000) $1,453 Avg Close $18.16 Range $12.33 - $60.70

Q3 2023

Shares 148,734 Value ($000) $998 Avg Close $9.00 Range $6.64 - $11.95

Q2 2023

Shares 148,734 Value ($000) $1,704 Avg Close $18.95 Range $10.51 - $22.48

Q1 2023

Shares 62,000 Value ($000) $1,249 Avg Close $20.98 Range $18.01 - $23.46

Q3 2021

Shares 172,000 Value ($000) $5,506 Avg Close $30.48 Range $25.80 - $38.80

Q2 2021

Shares 172,000 Value ($000) $5,298 Avg Close $33.51 Range $29.85 - $37.78

Q4 2020

Shares 216,000 Value ($000) $7,804 Avg Close $42.18 Range $34.38 - $52.19

Q3 2020

Shares 126,000 Value ($000) $4,641 Avg Close $40.97 Range $35.76 - $48.50

Q2 2020

Shares 110,000 Value ($000) $4,957 Avg Close $59.06 Range $44.63 - $71.45

Q1 2020

Shares 201,107 Value ($000) $9,543 Avg Close $57.46 Range $37.50 - $76.69

Q4 2019

Shares 139,514 Value ($000) $9,998 Avg Close $54.91 Range $36.20 - $76.09

Q3 2019

Shares 177,500 Value ($000) $6,986 Avg Close $57.69 Range $38.07 - $77.46

Q2 2019

Shares 60,149 Value ($000) $4,701 Avg Close $63.72 Range $51.85 - $82.49

Q1 2019

Shares 77,349 Value ($000) $4,614 Avg Close $44.67 Range $26.94 - $69.60

Q4 2018

Shares 232,849 Value ($000) $6,711 Avg Close $27.83 Range $21.98 - $37.30

Q3 2018

Shares 177,849 Value ($000) $6,472 Avg Close $37.20 Range $28.00 - $43.23

Q2 2018

Shares 152,490 Value ($000) $5,764 Avg Close $32.02 Range $21.57 - $40.98

Q1 2018

Shares 127,600 Value ($000) $2,999 Avg Close $21.81 Range $16.77 - $27.19

Q4 2015

Shares 153,500 Value ($000) $2,539 Avg Close $18.53 Range $15.05 - $22.93

Q3 2015

Shares 115,000 Value ($000) $2,352 Avg Close $26.34 Range $18.51 - $36.38

Q2 2015

Shares 115,000 Value ($000) $3,105 Avg Close $28.48 Range $22.51 - $35.50

Q1 2015

Shares 102,415 Value ($000) $2,491 Avg Close $21.81 Range $14.67 - $28.00

Q4 2014

Shares 168,415 Value ($000) $2,494 Avg Close $12.24 Range $9.17 - $17.33

Q1 2014

Shares 100,000 Value ($000) $1,555 Avg Close $15.95 Range $13.10 - $18.75

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	24,900	$1,453	$18.16	$12.33 - $60.70
Q3 2023	148,734	$998	$9.00	$6.64 - $11.95
Q2 2023	148,734	$1,704	$18.95	$10.51 - $22.48
Q1 2023	62,000	$1,249	$20.98	$18.01 - $23.46
Q3 2021	172,000	$5,506	$30.48	$25.80 - $38.80
Q2 2021	172,000	$5,298	$33.51	$29.85 - $37.78
Q4 2020	216,000	$7,804	$42.18	$34.38 - $52.19
Q3 2020	126,000	$4,641	$40.97	$35.76 - $48.50
Q2 2020	110,000	$4,957	$59.06	$44.63 - $71.45
Q1 2020	201,107	$9,543	$57.46	$37.50 - $76.69
Q4 2019	139,514	$9,998	$54.91	$36.20 - $76.09
Q3 2019	177,500	$6,986	$57.69	$38.07 - $77.46
Q2 2019	60,149	$4,701	$63.72	$51.85 - $82.49
Q1 2019	77,349	$4,614	$44.67	$26.94 - $69.60
Q4 2018	232,849	$6,711	$27.83	$21.98 - $37.30
Q3 2018	177,849	$6,472	$37.20	$28.00 - $43.23
Q2 2018	152,490	$5,764	$32.02	$21.57 - $40.98
Q1 2018	127,600	$2,999	$21.81	$16.77 - $27.19
Q4 2015	153,500	$2,539	$18.53	$15.05 - $22.93
Q3 2015	115,000	$2,352	$26.34	$18.51 - $36.38
Q2 2015	115,000	$3,105	$28.48	$22.51 - $35.50
Q1 2015	102,415	$2,491	$21.81	$14.67 - $28.00
Q4 2014	168,415	$2,494	$12.24	$9.17 - $17.33
Q1 2014	100,000	$1,555	$15.95	$13.10 - $18.75