UNIQURE NV

Ticker: QURE CUSIP: N90064101 Class: Common Stock

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q2 2020

Shares 270,400 Value ($000) $8,547 Avg Close $59.06 Range $44.63 - $71.45

Q1 2020

Shares 210,000 Value ($000) $9,965 Avg Close $57.46 Range $37.50 - $76.69

Q4 2019

Shares 210,000 Value ($000) $15,049 Avg Close $54.91 Range $36.20 - $76.09

Q3 2019

Shares 205,000 Value ($000) $8,069 Avg Close $57.69 Range $38.07 - $77.46

Q2 2019

Shares 205,000 Value ($000) $16,021 Avg Close $63.72 Range $51.85 - $82.49

Q1 2019

Shares 205,000 Value ($000) $12,228 Avg Close $44.67 Range $26.94 - $69.60

Q4 2017

Shares 90,801 Value ($000) $1,778 Avg Close $15.23 Range $9.47 - $21.35

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2020	270,400	$8,547	$59.06	$44.63 - $71.45
Q1 2020	210,000	$9,965	$57.46	$37.50 - $76.69
Q4 2019	210,000	$15,049	$54.91	$36.20 - $76.09
Q3 2019	205,000	$8,069	$57.69	$38.07 - $77.46
Q2 2019	205,000	$16,021	$63.72	$51.85 - $82.49
Q1 2019	205,000	$12,228	$44.67	$26.94 - $69.60
Q4 2017	90,801	$1,778	$15.23	$9.47 - $21.35