EcoR1 Capital, LLC Quant / Systematic

Location: San Francisco, CA

CIK: 0001587114 · Show all filings

Period: Q2 2025 (← Previous) (Next →)

Filing Date: Aug 14, 2025

Total Value: $1.689B (100.0% shares, 0.0% debt)

Holdings (37)

ZYME ZYMEWORKS INC 17.1%

Value $288M Shares 22,970,388 Est. Cost $9.83 Unrealized +21.2%

APLS APELLIS PHARMACEUTICALS INC 12.2%

Value $206M Shares 11,895,808 Est. Cost $43.04 Unrealized -57.0%

JAZZ JAZZ PHARMACEUTICALS PLC 10.7%

Value $181M Shares 1,706,469 Est. Cost $120.72 Unrealized -10.0%

ANAB ANAPTYSBIO INC 10.4%

Value $175M Shares 7,880,094 Est. Cost $23.54 Unrealized -11.1%

CRNX CRINETICS PHARMACEUTICALS IN 7.3%

Value $123M Shares 4,288,120 Est. Cost $32.41 Unrealized -4.7%

— ITEOS THERAPEUTICS INC 6.3%

Value $107M Shares 10,688,978 Est. Cost $9.97 Unrealized —

CRSP CRISPR THERAPEUTICS AG 4.0%

Value $67.57M Shares 1,389,276 Est. Cost $71.59 Unrealized -45.9%

QURE UNIQURE NV 3.3%

Value $55.61M Shares 3,988,971 Est. Cost $9.43 Unrealized +42.7%

TNGX TANGO THERAPEUTICS INC 3.2%

Value $54.43M Shares 10,630,736 Est. Cost $7.06 Unrealized -65.0%

XNCR XENCOR INC 2.9%

Value $48.3M Shares 6,144,767 Est. Cost $32.11 Unrealized -72.0%

IMNM IMMUNOME INC 2.2%

Value $37.94M Shares 4,079,415 Est. Cost $8.38 Unrealized -2.1%

JANX JANUX THERAPEUTICS INC 2.0%

Value $33.95M Shares 1,469,818 Est. Cost $46.95 Unrealized -43.9%

GLPG GALAPAGOS NV 1.7%

Value $29.02M Shares 1,036,945 Est. Cost $31.18 Unrealized —

ETON ETON PHARMACEUTICALS INC 1.7%

Value $28.94M Shares 2,030,544 Est. Cost $9.01 Unrealized +75.4%

KURA KURA ONCOLOGY INC 1.4%

Value $24.23M Shares 4,200,000 Est. Cost $14.07 Unrealized -56.5%

— AKERO THERAPEUTICS INC 1.4%

Value $23.48M Shares 440,000 Est. Cost $40.48 Unrealized —

MDGL MADRIGAL PHARMACEUTICALS INC 1.3%

Value $22.7M Shares 75,000 Est. Cost $235.62 Unrealized +26.5%

NGNE NEUROGENE INC 1.1%

Value $19.01M Shares 1,271,342 Est. Cost $14.32 Unrealized +9.6%

— VERONA PHARMA PLC 1.1%

Value $18.92M Shares 200,000 Est. Cost $94.58 Unrealized —

TECX TECTONIC THERAPEUTIC INC 1.1%

Value $18.58M Shares 935,121 Est. Cost $17.32 Unrealized +17.1%

ORIC ORIC PHARMACEUTICALS INC 1.0%

Value $16.42M Shares 1,618,068 Est. Cost $30.24 Unrealized -77.8%

ALKS ALKERMES PLC 0.8%

Value $14.3M Shares 500,000 Est. Cost $29.76 Unrealized 0.0%

RNAM AVIDITY BIOSCIENCES INC 0.8%

Value $14.2M Shares 500,000 Est. Cost $15.67 Unrealized +90.2%

MBX MBX BIOSCIENCES INC 0.8%

Value $13.12M Shares 1,149,794 Est. Cost $22.77 Unrealized -55.2%

VYGR VOYAGER THERAPEUTICS INC 0.7%

Value $12.18M Shares 3,917,546 Est. Cost $3.61 Unrealized —

PCRX PACIRA BIOSCIENCES INC 0.6%

Value $10.93M Shares 457,471 Est. Cost $25.21 Unrealized 0.0%

REPL REPLIMUNE GROUP INC 0.5%

Value $7.9M Shares 850,341 Est. Cost $6.97 Unrealized +25.2%

— METSERA INC 0.5%

Value $7.725M Shares 271,529 Est. Cost $28.22 Unrealized —

ADAPY ADAPTIMMUNE THERAPEUTICS PLC 0.4%

Value $6.569M Shares 27,404,070 Est. Cost $1.58 Unrealized —

DAWN DAY ONE BIOPHARMACEUTICALS I 0.3%

Value $5.603M Shares 862,068 Est. Cost $14.27 Unrealized -51.8%

— HILLEVAX INC 0.3%

Value $4.816M Shares 2,420,243 Est. Cost $1.99 Unrealized —

ATRA ATARA BIOTHERAPEUTICS INC 0.3%

Value $4.425M Shares 573,183 Est. Cost $13.39 Unrealized -45.5%

WHWK WHITEHAWK THERAPEUTICS INC 0.1%

Value $2.041M Shares 1,091,417 Est. Cost $2.45 Unrealized -28.9%

MGNX MACROGENICS INC 0.1%

Value $1.939M Shares 1,602,717 Est. Cost $1.45 Unrealized 0.0%

QURE UNIQURE NV 0.1%

Value $1.882M Shares 135,000 Est. Cost $9.43 Unrealized +42.7%

— NUVATION BIO INC 0.1%

Value $1.878M Shares 963,333 Est. Cost $10.45 Unrealized —

SRZNW SURROZEN INC 0.0%

Value $596K Shares 66,665 Est. Cost $7.07 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ZYME	ZYMEWORKS INC	22,970,388	$288M	17.1%	$9.83	+21.2%	COM	98985Y108
APLS	APELLIS PHARMACEUTICALS INC	11,895,808	$206M	12.2%	$43.04	-57.0%	COM	03753U106
JAZZ	JAZZ PHARMACEUTICALS PLC	1,706,469	$181M	10.7%	$120.72	-10.0%	SHS USD	G50871105
ANAB	ANAPTYSBIO INC	7,880,094	$175M	10.4%	$23.54	-11.1%	COM	032724106
CRNX	CRINETICS PHARMACEUTICALS IN	4,288,120	$123M	7.3%	$32.41	-4.7%	COM	22663K107
—	ITEOS THERAPEUTICS INC	10,688,978	$107M	6.3%	$9.97	—	COM	46565G104
CRSP	CRISPR THERAPEUTICS AG	1,389,276	$67.57M	4.0%	$71.59	-45.9%	NAMEN AKT	H17182108
QURE	UNIQURE NV	3,988,971	$55.61M	3.3%	$9.43	+42.7%	SHS	N90064101
TNGX	TANGO THERAPEUTICS INC	10,630,736	$54.43M	3.2%	$7.06	-65.0%	COM	87583X109
XNCR	XENCOR INC	6,144,767	$48.3M	2.9%	$32.11	-72.0%	COM	98401F105
IMNM	IMMUNOME INC	4,079,415	$37.94M	2.2%	$8.38	-2.1%	COM	45257U108
JANX	JANUX THERAPEUTICS INC	1,469,818	$33.95M	2.0%	$46.95	-43.9%	COM	47103J105
GLPG	GALAPAGOS NV	1,036,945	$29.02M	1.7%	$31.18	—	SPON ADR	36315X101
ETON	ETON PHARMACEUTICALS INC	2,030,544	$28.94M	1.7%	$9.01	+75.4%	COM	29772L108
KURA	KURA ONCOLOGY INC	4,200,000	$24.23M	1.4%	$14.07	-56.5%	COM	50127T109
—	AKERO THERAPEUTICS INC	440,000	$23.48M	1.4%	$40.48	—	COM	00973Y108
MDGL	MADRIGAL PHARMACEUTICALS INC	75,000	$22.7M	1.3%	$235.62	+26.5%	COM	558868105
NGNE	NEUROGENE INC	1,271,342	$19.01M	1.1%	$14.32	+9.6%	COM	64135M105
—	VERONA PHARMA PLC	200,000	$18.92M	1.1%	$94.58	—	SPONSORED ADS	925050106
TECX	TECTONIC THERAPEUTIC INC	935,121	$18.58M	1.1%	$17.32	+17.1%	COM	878972108
ORIC	ORIC PHARMACEUTICALS INC	1,618,068	$16.42M	1.0%	$30.24	-77.8%	COM	68622P109
ALKS	ALKERMES PLC	500,000	$14.3M	0.8%	$29.76	0.0%	SHS	G01767105
RNAM	AVIDITY BIOSCIENCES INC	500,000	$14.2M	0.8%	$15.67	+90.2%	COM	05370A108
MBX	MBX BIOSCIENCES INC	1,149,794	$13.12M	0.8%	$22.77	-55.2%	COM	55287L101
VYGR	VOYAGER THERAPEUTICS INC	3,917,546	$12.18M	0.7%	$3.61	—	COM	92915B106
PCRX	PACIRA BIOSCIENCES INC	457,471	$10.93M	0.6%	$25.21	0.0%	COM	695127100
REPL	REPLIMUNE GROUP INC	850,341	$7.9M	0.5%	$6.97	+25.2%	COM	76029N106
—	METSERA INC	271,529	$7.725M	0.5%	$28.22	—	COM	59267L107
ADAPY	ADAPTIMMUNE THERAPEUTICS PLC	27,404,070	$6.569M	0.4%	$1.58	—	SPONDS ADS	00653A107
DAWN	DAY ONE BIOPHARMACEUTICALS I	862,068	$5.603M	0.3%	$14.27	-51.8%	COM	23954D109
—	HILLEVAX INC	2,420,243	$4.816M	0.3%	$1.99	—	COM	43157M102
ATRA	ATARA BIOTHERAPEUTICS INC	573,183	$4.425M	0.3%	$13.39	-45.5%	COM NEW	046513206
WHWK	WHITEHAWK THERAPEUTICS INC	1,091,417	$2.041M	0.1%	$2.45	-28.9%	COM	00032Q104
MGNX	MACROGENICS INC	1,602,717	$1.939M	0.1%	$1.45	0.0%	COM	556099109
QURE	UNIQURE NV	135,000	$1.882M	0.1%	$9.43	+42.7%	Call	N90064101
—	NUVATION BIO INC	963,333	$1.878M	0.1%	$10.45	—	*W EXP 02/10/202	67080N119
SRZNW	SURROZEN INC	66,665	$596K	0.0%	$7.07	—	*W EXP 08/01/203	86889P117