Avoro Capital Advisors LLC Diversified Active

Location: NEW YORK, NY

CIK: 0001633313 · Show all filings

Period: Q3 2022 (← Previous) (Next →)

Filing Date: Nov 14, 2022

Total Value ($000): $5,412,850 (100.0% shares, 0.0% debt)

Holdings (39)

APLS APELLIS PHARMACEUTICALS INC 12.8%

Value ($000) $691,538 Shares 10,125,000 Est. Cost $48.06 Unrealized +23.1%

UTHR UNITED THERAPEUTICS CORP 11.3%

Value ($000) $612,751 Shares 2,926,500 Est. Cost $133.73 Unrealized +67.2%

ARGX ARGENX SE 8.3%

Value ($000) $446,804 Shares 1,265,555 Est. Cost $136.82 Unrealized —

— MIRATI THERAPEUTICS INC 7.2%

Value ($000) $387,651 Shares 5,550,555 Est. Cost $53.82 Unrealized —

SRPT SAREPTA THERAPEUTICS INC 6.5%

Value ($000) $350,965 Shares 3,175,000 Est. Cost $97.25 Unrealized +3.6%

— HORIZON THERAPEUTICS PLC 5.9%

Value ($000) $317,186 Shares 5,125,000 Est. Cost $48.87 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 5.6%

Value ($000) $301,404 Shares 3,555,555 Est. Cost $83.64 Unrealized +6.5%

ASND ASCENDIS PHARMA 5.4%

Value ($000) $294,291 Shares 2,850,000 Est. Cost $124.63 Unrealized —

FOLD AMICUS THERAPEUTICS INC 5.2%

Value ($000) $279,792 Shares 26,800,000 Est. Cost $10.43 Unrealized +6.8%

— SEAGEN INC 4.7%

Value ($000) $255,188 Shares 1,865,000 Est. Cost $146.44 Unrealized —

ALNY ALNYLAM PHARMACEUTICALS INC 4.1%

Value ($000) $221,177 Shares 1,105,000 Est. Cost $153.75 Unrealized +24.1%

XENE XENON PHARMACEUTICALS INC 3.3%

Value ($000) $176,890 Shares 4,900,000 Est. Cost $16.29 Unrealized +120.7%

BCRX BIOCRYST PHARMACEUTICALS INC 2.1%

Value ($000) $114,030 Shares 9,050,000 Est. Cost $12.22 Unrealized +5.3%

— IVERIC BIO INC 2.0%

Value ($000) $105,846 Shares 5,900,000 Est. Cost $6.39 Unrealized —

MDGL MADRIGAL PHARMACEUTICALS INC 1.8%

Value ($000) $99,760 Shares 1,535,000 Est. Cost $120.44 Unrealized -42.3%

KRYS KRYSTAL BIOTECH INC 1.6%

Value ($000) $88,868 Shares 1,275,000 Est. Cost $62.38 Unrealized +15.8%

IOVA IOVANCE BIOTHERAPEUTICS INC 1.6%

Value ($000) $86,412 Shares 9,020,000 Est. Cost $16.40 Unrealized -29.7%

SNDX SYNDAX PHARMACEUTICALS INC 1.0%

Value ($000) $53,400 Shares 2,222,222 Est. Cost $20.62 Unrealized +8.8%

— MERSANA THERAPEUTICS INC 0.9%

Value ($000) $51,038 Shares 7,550,000 Est. Cost $21.34 Unrealized —

KURA KURA ONCOLOGY INC 0.9%

Value ($000) $48,152 Shares 3,525,000 Est. Cost $23.38 Unrealized -34.0%

KYMR KYMERA THERAPEUTICS INC 0.9%

Value ($000) $47,224 Shares 2,169,230 Est. Cost $35.72 Unrealized -26.2%

WHWK AADI BIOSCIENCES INC 0.7%

Value ($000) $40,262 Shares 2,849,402 Est. Cost $24.27 Unrealized -45.9%

DSGN DESIGN THERAPEUTICS INC 0.7%

Value ($000) $37,156 Shares 2,222,222 Est. Cost $25.91 Unrealized -23.2%

PMVP PMV PHARMACEUTICALS INC 0.7%

Value ($000) $36,414 Shares 3,060,000 Est. Cost $25.09 Unrealized -42.4%

— CYMABAY THERAPEUTICS INC 0.7%

Value ($000) $36,050 Shares 10,300,000 Est. Cost $6.26 Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL INC 0.6%

Value ($000) $31,058 Shares 750,000 Est. Cost $64.00 Unrealized -19.7%

MNKD MANNKIND CORP 0.5%

Value ($000) $28,119 Shares 9,100,000 Est. Cost $3.56 Unrealized +6.0%

GLUE MONTE ROSA THERAPEUTICS INC 0.5%

Value ($000) $27,478 Shares 3,363,333 Est. Cost $20.20 Unrealized -54.5%

RNAM AVIDITY BIOSCIENCES INC 0.4%

Value ($000) $23,679 Shares 1,450,000 Est. Cost $24.02 Unrealized -20.4%

— DICE THERAPEUTICS INC 0.4%

Value ($000) $21,801 Shares 1,075,000 Est. Cost $26.26 Unrealized —

— MARINUS PHARMACEUTICALS INC 0.4%

Value ($000) $20,948 Shares 3,150,000 Est. Cost $12.20 Unrealized —

NUVL NUVALENT INC 0.4%

Value ($000) $20,402 Shares 1,049,471 Est. Cost $29.01 Unrealized -42.3%

AMLX AMYLYX PHARMACEUTICALS INC 0.3%

Value ($000) $18,298 Shares 650,000 Est. Cost $24.95 Unrealized 0.0%

FENC FENNEC PHARMACEUTICALS INC 0.2%

Value ($000) $9,720 Shares 1,200,000 Est. Cost $9.85 Unrealized -30.3%

RLAY RELAY THERAPEUTICS INC 0.2%

Value ($000) $8,948 Shares 400,000 Est. Cost $21.43 Unrealized +2.4%

— AMARIN CORP PLC 0.1%

Value ($000) $6,540 Shares 6,000,000 Est. Cost $8.22 Unrealized —

TNGX TANGO THERAPEUTICS INC 0.1%

Value ($000) $5,611 Shares 1,550,000 Est. Cost $11.99 Unrealized -64.4%

IOBT IO BIOTECH INC 0.1%

Value ($000) $5,571 Shares 2,055,883 Est. Cost $9.66 Unrealized -61.6%

BCAB BIOATLA INC 0.1%

Value ($000) $4,428 Shares 575,000 Est. Cost $6.55 Unrealized 0.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
APLS	APELLIS PHARMACEUTICALS INC	10,125,000	$691,538	12.8%	$48.06	+23.1%	Common	03753U106
UTHR	UNITED THERAPEUTICS CORP	2,926,500	$612,751	11.3%	$133.73	+67.2%	Common	91307C102
ARGX	ARGENX SE	1,265,555	$446,804	8.3%	$136.82	—	Sponsored ADR	04016X101
—	MIRATI THERAPEUTICS INC	5,550,555	$387,651	7.2%	$53.82	—	Common	60468T105
SRPT	SAREPTA THERAPEUTICS INC	3,175,000	$350,965	6.5%	$97.25	+3.6%	Common	803607100
—	HORIZON THERAPEUTICS PLC	5,125,000	$317,186	5.9%	$48.87	—	Common	G46188101
BMRN	BIOMARIN PHARMACEUTICAL INC	3,555,555	$301,404	5.6%	$83.64	+6.5%	Common	09061G101
ASND	ASCENDIS PHARMA	2,850,000	$294,291	5.4%	$124.63	—	Sponsored ADR	04351P101
FOLD	AMICUS THERAPEUTICS INC	26,800,000	$279,792	5.2%	$10.43	+6.8%	Common	03152W109
—	SEAGEN INC	1,865,000	$255,188	4.7%	$146.44	—	Common	81181C104
ALNY	ALNYLAM PHARMACEUTICALS INC	1,105,000	$221,177	4.1%	$153.75	+24.1%	Common	02043Q107
XENE	XENON PHARMACEUTICALS INC	4,900,000	$176,890	3.3%	$16.29	+120.7%	Common	98420N105
BCRX	BIOCRYST PHARMACEUTICALS INC	9,050,000	$114,030	2.1%	$12.22	+5.3%	Common	09058V103
—	IVERIC BIO INC	5,900,000	$105,846	2.0%	$6.39	—	Common	46583P102
MDGL	MADRIGAL PHARMACEUTICALS INC	1,535,000	$99,760	1.8%	$120.44	-42.3%	Common	558868105
KRYS	KRYSTAL BIOTECH INC	1,275,000	$88,868	1.6%	$62.38	+15.8%	Common	501147102
IOVA	IOVANCE BIOTHERAPEUTICS INC	9,020,000	$86,412	1.6%	$16.40	-29.7%	Common	462260100
SNDX	SYNDAX PHARMACEUTICALS INC	2,222,222	$53,400	1.0%	$20.62	+8.8%	Common	87164F105
—	MERSANA THERAPEUTICS INC	7,550,000	$51,038	0.9%	$21.34	—	Common	59045L106
KURA	KURA ONCOLOGY INC	3,525,000	$48,152	0.9%	$23.38	-34.0%	Common	50127T109
KYMR	KYMERA THERAPEUTICS INC	2,169,230	$47,224	0.9%	$35.72	-26.2%	Common	501575104
WHWK	AADI BIOSCIENCES INC	2,849,402	$40,262	0.7%	$24.27	-45.9%	Common	00032Q104
DSGN	DESIGN THERAPEUTICS INC	2,222,222	$37,156	0.7%	$25.91	-23.2%	Common	25056L103
PMVP	PMV PHARMACEUTICALS INC	3,060,000	$36,414	0.7%	$25.09	-42.4%	Common	69353Y103
—	CYMABAY THERAPEUTICS INC	10,300,000	$36,050	0.7%	$6.26	—	Common	23257D103
RARE	ULTRAGENYX PHARMACEUTICAL INC	750,000	$31,058	0.6%	$64.00	-19.7%	Common	90400D108
MNKD	MANNKIND CORP	9,100,000	$28,119	0.5%	$3.56	+6.0%	Common	56400P706
GLUE	MONTE ROSA THERAPEUTICS INC	3,363,333	$27,478	0.5%	$20.20	-54.5%	Common	61225M102
RNAM	AVIDITY BIOSCIENCES INC	1,450,000	$23,679	0.4%	$24.02	-20.4%	Common	05370A108
—	DICE THERAPEUTICS INC	1,075,000	$21,801	0.4%	$26.26	—	Common	23345J104
—	MARINUS PHARMACEUTICALS INC	3,150,000	$20,948	0.4%	$12.20	—	Common	56854Q200
NUVL	NUVALENT INC	1,049,471	$20,402	0.4%	$29.01	-42.3%	Common	670703107
AMLX	AMYLYX PHARMACEUTICALS INC	650,000	$18,298	0.3%	$24.95	0.0%	Common	03237H101
FENC	FENNEC PHARMACEUTICALS INC	1,200,000	$9,720	0.2%	$9.85	-30.3%	Common	31447P100
RLAY	RELAY THERAPEUTICS INC	400,000	$8,948	0.2%	$21.43	+2.4%	Common	75943R102
—	AMARIN CORP PLC	6,000,000	$6,540	0.1%	$8.22	—	Sponsored ADR	023111206
TNGX	TANGO THERAPEUTICS INC	1,550,000	$5,611	0.1%	$11.99	-64.4%	Common	87583X109
IOBT	IO BIOTECH INC	2,055,883	$5,571	0.1%	$9.66	-61.6%	Common	449778109
BCAB	BIOATLA INC	575,000	$4,428	0.1%	$6.55	0.0%	Common	09077B104