Avoro Capital Advisors LLC Diversified Active

Location: New York, NY

CIK: 0001633313 · Show all filings

Period: Q3 2022 (← Previous) (Next →)

Filing Date: Nov 14, 2022

Total Value: $5.413B (100.0% shares, 0.0% debt)

Holdings (39)

APLS APELLIS PHARMACEUTICALS INC 12.8%

Value $692M Shares 10,125,000 Est. Cost $48.06 Unrealized +23.1%

UTHR UNITED THERAPEUTICS CORP 11.3%

Value $613M Shares 2,926,500 Est. Cost $133.73 Unrealized +67.2%

ARGX ARGENX SE 8.3%

Value $447M Shares 1,265,555 Est. Cost $136.82 Unrealized —

— MIRATI THERAPEUTICS INC 7.2%

Value $388M Shares 5,550,555 Est. Cost $53.82 Unrealized —

SRPT SAREPTA THERAPEUTICS INC 6.5%

Value $351M Shares 3,175,000 Est. Cost $97.25 Unrealized +3.6%

— HORIZON THERAPEUTICS PLC 5.9%

Value $317M Shares 5,125,000 Est. Cost $48.87 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 5.6%

Value $301M Shares 3,555,555 Est. Cost $83.64 Unrealized +6.5%

ASND ASCENDIS PHARMA 5.4%

Value $294M Shares 2,850,000 Est. Cost $124.63 Unrealized —

FOLD AMICUS THERAPEUTICS INC 5.2%

Value $280M Shares 26,800,000 Est. Cost $10.43 Unrealized +6.8%

— SEAGEN INC 4.7%

Value $255M Shares 1,865,000 Est. Cost $146.44 Unrealized —

ALNY ALNYLAM PHARMACEUTICALS INC 4.1%

Value $221M Shares 1,105,000 Est. Cost $153.75 Unrealized +24.1%

XENE XENON PHARMACEUTICALS INC 3.3%

Value $177M Shares 4,900,000 Est. Cost $16.29 Unrealized +120.7%

BCRX BIOCRYST PHARMACEUTICALS INC 2.1%

Value $114M Shares 9,050,000 Est. Cost $12.22 Unrealized +5.3%

— IVERIC BIO INC 2.0%

Value $106M Shares 5,900,000 Est. Cost $6.39 Unrealized —

MDGL MADRIGAL PHARMACEUTICALS INC 1.8%

Value $99.76M Shares 1,535,000 Est. Cost $120.44 Unrealized -42.3%

KRYS KRYSTAL BIOTECH INC 1.6%

Value $88.87M Shares 1,275,000 Est. Cost $62.38 Unrealized +15.8%

IOVA IOVANCE BIOTHERAPEUTICS INC 1.6%

Value $86.41M Shares 9,020,000 Est. Cost $16.40 Unrealized -29.7%

SNDX SYNDAX PHARMACEUTICALS INC 1.0%

Value $53.4M Shares 2,222,222 Est. Cost $20.62 Unrealized +8.8%

— MERSANA THERAPEUTICS INC 0.9%

Value $51.04M Shares 7,550,000 Est. Cost $21.34 Unrealized —

KURA KURA ONCOLOGY INC 0.9%

Value $48.15M Shares 3,525,000 Est. Cost $23.38 Unrealized -34.0%

KYMR KYMERA THERAPEUTICS INC 0.9%

Value $47.22M Shares 2,169,230 Est. Cost $35.72 Unrealized -26.2%

WHWK AADI BIOSCIENCES INC 0.7%

Value $40.26M Shares 2,849,402 Est. Cost $24.27 Unrealized -45.9%

DSGN DESIGN THERAPEUTICS INC 0.7%

Value $37.16M Shares 2,222,222 Est. Cost $25.91 Unrealized -23.2%

PMVP PMV PHARMACEUTICALS INC 0.7%

Value $36.41M Shares 3,060,000 Est. Cost $25.09 Unrealized -42.4%

— CYMABAY THERAPEUTICS INC 0.7%

Value $36.05M Shares 10,300,000 Est. Cost $6.26 Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL INC 0.6%

Value $31.06M Shares 750,000 Est. Cost $64.00 Unrealized -19.7%

MNKD MANNKIND CORP 0.5%

Value $28.12M Shares 9,100,000 Est. Cost $3.56 Unrealized +6.0%

GLUE MONTE ROSA THERAPEUTICS INC 0.5%

Value $27.48M Shares 3,363,333 Est. Cost $20.20 Unrealized -54.5%

RNAM AVIDITY BIOSCIENCES INC 0.4%

Value $23.68M Shares 1,450,000 Est. Cost $24.02 Unrealized -20.4%

— DICE THERAPEUTICS INC 0.4%

Value $21.8M Shares 1,075,000 Est. Cost $26.26 Unrealized —

— MARINUS PHARMACEUTICALS INC 0.4%

Value $20.95M Shares 3,150,000 Est. Cost $12.20 Unrealized —

NUVL NUVALENT INC 0.4%

Value $20.4M Shares 1,049,471 Est. Cost $29.01 Unrealized -42.3%

AMLX AMYLYX PHARMACEUTICALS INC 0.3%

Value $18.3M Shares 650,000 Est. Cost $24.95 Unrealized 0.0%

FENC FENNEC PHARMACEUTICALS INC 0.2%

Value $9.72M Shares 1,200,000 Est. Cost $9.85 Unrealized -30.3%

RLAY RELAY THERAPEUTICS INC 0.2%

Value $8.948M Shares 400,000 Est. Cost $21.43 Unrealized +2.4%

— AMARIN CORP PLC 0.1%

Value $6.54M Shares 6,000,000 Est. Cost $8.22 Unrealized —

TNGX TANGO THERAPEUTICS INC 0.1%

Value $5.611M Shares 1,550,000 Est. Cost $11.99 Unrealized -64.4%

IOBT IO BIOTECH INC 0.1%

Value $5.571M Shares 2,055,883 Est. Cost $9.66 Unrealized -61.6%

BCAB BIOATLA INC 0.1%

Value $4.428M Shares 575,000 Est. Cost $6.55 Unrealized 0.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
APLS	APELLIS PHARMACEUTICALS INC	10,125,000	$692M	12.8%	$48.06	+23.1%	Common	03753U106
UTHR	UNITED THERAPEUTICS CORP	2,926,500	$613M	11.3%	$133.73	+67.2%	Common	91307C102
ARGX	ARGENX SE	1,265,555	$447M	8.3%	$136.82	—	Sponsored ADR	04016X101
—	MIRATI THERAPEUTICS INC	5,550,555	$388M	7.2%	$53.82	—	Common	60468T105
SRPT	SAREPTA THERAPEUTICS INC	3,175,000	$351M	6.5%	$97.25	+3.6%	Common	803607100
—	HORIZON THERAPEUTICS PLC	5,125,000	$317M	5.9%	$48.87	—	Common	G46188101
BMRN	BIOMARIN PHARMACEUTICAL INC	3,555,555	$301M	5.6%	$83.64	+6.5%	Common	09061G101
ASND	ASCENDIS PHARMA	2,850,000	$294M	5.4%	$124.63	—	Sponsored ADR	04351P101
FOLD	AMICUS THERAPEUTICS INC	26,800,000	$280M	5.2%	$10.43	+6.8%	Common	03152W109
—	SEAGEN INC	1,865,000	$255M	4.7%	$146.44	—	Common	81181C104
ALNY	ALNYLAM PHARMACEUTICALS INC	1,105,000	$221M	4.1%	$153.75	+24.1%	Common	02043Q107
XENE	XENON PHARMACEUTICALS INC	4,900,000	$177M	3.3%	$16.29	+120.7%	Common	98420N105
BCRX	BIOCRYST PHARMACEUTICALS INC	9,050,000	$114M	2.1%	$12.22	+5.3%	Common	09058V103
—	IVERIC BIO INC	5,900,000	$106M	2.0%	$6.39	—	Common	46583P102
MDGL	MADRIGAL PHARMACEUTICALS INC	1,535,000	$99.76M	1.8%	$120.44	-42.3%	Common	558868105
KRYS	KRYSTAL BIOTECH INC	1,275,000	$88.87M	1.6%	$62.38	+15.8%	Common	501147102
IOVA	IOVANCE BIOTHERAPEUTICS INC	9,020,000	$86.41M	1.6%	$16.40	-29.7%	Common	462260100
SNDX	SYNDAX PHARMACEUTICALS INC	2,222,222	$53.4M	1.0%	$20.62	+8.8%	Common	87164F105
—	MERSANA THERAPEUTICS INC	7,550,000	$51.04M	0.9%	$21.34	—	Common	59045L106
KURA	KURA ONCOLOGY INC	3,525,000	$48.15M	0.9%	$23.38	-34.0%	Common	50127T109
KYMR	KYMERA THERAPEUTICS INC	2,169,230	$47.22M	0.9%	$35.72	-26.2%	Common	501575104
WHWK	AADI BIOSCIENCES INC	2,849,402	$40.26M	0.7%	$24.27	-45.9%	Common	00032Q104
DSGN	DESIGN THERAPEUTICS INC	2,222,222	$37.16M	0.7%	$25.91	-23.2%	Common	25056L103
PMVP	PMV PHARMACEUTICALS INC	3,060,000	$36.41M	0.7%	$25.09	-42.4%	Common	69353Y103
—	CYMABAY THERAPEUTICS INC	10,300,000	$36.05M	0.7%	$6.26	—	Common	23257D103
RARE	ULTRAGENYX PHARMACEUTICAL INC	750,000	$31.06M	0.6%	$64.00	-19.7%	Common	90400D108
MNKD	MANNKIND CORP	9,100,000	$28.12M	0.5%	$3.56	+6.0%	Common	56400P706
GLUE	MONTE ROSA THERAPEUTICS INC	3,363,333	$27.48M	0.5%	$20.20	-54.5%	Common	61225M102
RNAM	AVIDITY BIOSCIENCES INC	1,450,000	$23.68M	0.4%	$24.02	-20.4%	Common	05370A108
—	DICE THERAPEUTICS INC	1,075,000	$21.8M	0.4%	$26.26	—	Common	23345J104
—	MARINUS PHARMACEUTICALS INC	3,150,000	$20.95M	0.4%	$12.20	—	Common	56854Q200
NUVL	NUVALENT INC	1,049,471	$20.4M	0.4%	$29.01	-42.3%	Common	670703107
AMLX	AMYLYX PHARMACEUTICALS INC	650,000	$18.3M	0.3%	$24.95	0.0%	Common	03237H101
FENC	FENNEC PHARMACEUTICALS INC	1,200,000	$9.72M	0.2%	$9.85	-30.3%	Common	31447P100
RLAY	RELAY THERAPEUTICS INC	400,000	$8.948M	0.2%	$21.43	+2.4%	Common	75943R102
—	AMARIN CORP PLC	6,000,000	$6.54M	0.1%	$8.22	—	Sponsored ADR	023111206
TNGX	TANGO THERAPEUTICS INC	1,550,000	$5.611M	0.1%	$11.99	-64.4%	Common	87583X109
IOBT	IO BIOTECH INC	2,055,883	$5.571M	0.1%	$9.66	-61.6%	Common	449778109
BCAB	BIOATLA INC	575,000	$4.428M	0.1%	$6.55	0.0%	Common	09077B104