Avoro Capital Advisors LLC Diversified Active

Location: NEW YORK, NY

CIK: 0001633313 · Show all filings

Period: Q2 2022 (← Previous) (Next →)

Filing Date: Aug 15, 2022

Total Value ($000): $5,060,568 (100.0% shares, 0.0% debt)

Holdings (40)

UTHR UNITED THERAPEUTICS CORP 13.8%

Value ($000) $699,851 Shares 2,970,000 Est. Cost $133.73 Unrealized +52.0%

ARGX ARGENX SE 9.5%

Value ($000) $479,493 Shares 1,265,555 Est. Cost $136.82 Unrealized —

APLS APELLIS PHARMACEUTICALS INC 8.8%

Value ($000) $443,382 Shares 9,805,000 Est. Cost $47.70 Unrealized -4.4%

— HORIZON THERAPEUTICS PLC 7.9%

Value ($000) $398,800 Shares 5,000,000 Est. Cost $48.54 Unrealized —

— MIRATI THERAPEUTICS INC 7.4%

Value ($000) $372,609 Shares 5,550,555 Est. Cost $53.82 Unrealized —

FOLD AMICUS THERAPEUTICS INC 5.7%

Value ($000) $287,832 Shares 26,800,000 Est. Cost $10.43 Unrealized -21.1%

BMRN BIOMARIN PHARMACEUTICAL INC 5.4%

Value ($000) $272,145 Shares 3,284,000 Est. Cost $83.20 Unrealized -4.3%

— SEAGEN INC 5.3%

Value ($000) $269,834 Shares 1,525,000 Est. Cost $148.58 Unrealized —

SRPT SAREPTA THERAPEUTICS INC 5.0%

Value ($000) $254,114 Shares 3,390,000 Est. Cost $97.25 Unrealized -24.3%

ASND ASCENDIS PHARMA 4.2%

Value ($000) $211,484 Shares 2,275,000 Est. Cost $130.04 Unrealized —

ALNY ALNYLAM PHARMACEUTICALS INC 3.9%

Value ($000) $198,356 Shares 1,360,000 Est. Cost $153.75 Unrealized -7.7%

XENE XENON PHARMACEUTICALS INC 2.9%

Value ($000) $149,058 Shares 4,900,000 Est. Cost $16.29 Unrealized +85.6%

MDGL MADRIGAL PHARMACEUTICALS INC 2.2%

Value ($000) $109,875 Shares 1,535,000 Est. Cost $120.44 Unrealized -39.0%

IOVA IOVANCE BIOTHERAPEUTICS INC 2.0%

Value ($000) $101,789 Shares 9,220,000 Est. Cost $16.40 Unrealized -20.1%

KURA KURA ONCOLOGY INC 1.7%

Value ($000) $87,984 Shares 4,800,000 Est. Cost $23.38 Unrealized -38.5%

KRYS KRYSTAL BIOTECH INC 1.4%

Value ($000) $70,585 Shares 1,075,000 Est. Cost $60.54 Unrealized +2.7%

BCRX BIOCRYST PHARMACEUTICALS INC 1.4%

Value ($000) $68,770 Shares 6,500,000 Est. Cost $11.97 Unrealized -13.8%

— IVERIC BIO INC 1.4%

Value ($000) $68,494 Shares 7,120,000 Est. Cost $6.39 Unrealized —

XBI SPDR SERIES TRUST - S&P BIOTECH 1.3%

Value ($000) $66,843 Shares 900,000 Est. Cost $97.48 Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL INC 0.9%

Value ($000) $44,745 Shares 750,000 Est. Cost $64.00 Unrealized -3.9%

PMVP PMV PHARMACEUTICALS INC 0.9%

Value ($000) $44,175 Shares 3,100,000 Est. Cost $25.09 Unrealized -42.0%

SNDX SYNDAX PHARMACEUTICALS INC 0.8%

Value ($000) $42,756 Shares 2,222,222 Est. Cost $20.62 Unrealized -19.2%

— MERSANA THERAPEUTICS INC 0.7%

Value ($000) $34,881 Shares 7,550,000 Est. Cost $21.34 Unrealized —

MNKD MANNKIND CORP 0.7%

Value ($000) $34,671 Shares 9,100,000 Est. Cost $3.56 Unrealized +3.3%

GLUE MONTE ROSA THERAPEUTICS INC 0.6%

Value ($000) $32,023 Shares 3,311,536 Est. Cost $20.37 Unrealized -50.7%

DSGN DESIGN THERAPEUTICS INC 0.6%

Value ($000) $31,111 Shares 2,222,222 Est. Cost $25.91 Unrealized -47.9%

— CYMABAY THERAPEUTICS INC 0.6%

Value ($000) $30,385 Shares 10,300,000 Est. Cost $6.26 Unrealized —

KYMR KYMERA THERAPEUTICS INC 0.5%

Value ($000) $24,809 Shares 1,260,000 Est. Cost $42.48 Unrealized -45.0%

WHWK AADI BIOSCIENCES INC 0.4%

Value ($000) $22,538 Shares 1,829,402 Est. Cost $30.48 Unrealized -51.3%

RNAM AVIDITY BIOSCIENCES INC 0.4%

Value ($000) $18,889 Shares 1,300,000 Est. Cost $24.59 Unrealized -39.5%

— DICE THERAPEUTICS INC 0.3%

Value ($000) $16,684 Shares 1,075,000 Est. Cost $26.26 Unrealized —

— MARINUS PHARMACEUTICALS INC 0.3%

Value ($000) $15,246 Shares 3,150,000 Est. Cost $12.20 Unrealized —

NUVL NUVALENT INC 0.3%

Value ($000) $14,231 Shares 1,049,471 Est. Cost $29.01 Unrealized -63.5%

IOBT IO BIOTECH INC 0.2%

Value ($000) $9,601 Shares 2,055,883 Est. Cost $9.66 Unrealized -36.6%

— AMARIN CORP PLC 0.2%

Value ($000) $8,940 Shares 6,000,000 Est. Cost $8.22 Unrealized —

TNGX TANGO THERAPEUTICS INC 0.1%

Value ($000) $7,022 Shares 1,550,000 Est. Cost $11.99 Unrealized -49.5%

FENC FENNEC PHARMACEUTICALS INC 0.1%

Value ($000) $6,780 Shares 1,200,000 Est. Cost $9.85 Unrealized -41.1%

RLAY RELAY THERAPEUTICS INC 0.1%

Value ($000) $6,700 Shares 400,000 Est. Cost $21.43 Unrealized 0.0%

— APPLIED MOLECULAR TRANS INC 0.1%

Value ($000) $2,997 Shares 1,030,000 Est. Cost $7.52 Unrealized —

GNCAQ GENOCEA BIOSCIENCES INC 0.0%

Value ($000) $86 Shares 5,084,184 Est. Cost $2.62 Unrealized -89.3%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
UTHR	UNITED THERAPEUTICS CORP	2,970,000	$699,851	13.8%	$133.73	+52.0%	Common	91307C102
ARGX	ARGENX SE	1,265,555	$479,493	9.5%	$136.82	—	Sponsored ADR	04016X101
APLS	APELLIS PHARMACEUTICALS INC	9,805,000	$443,382	8.8%	$47.70	-4.4%	Common	03753U106
—	HORIZON THERAPEUTICS PLC	5,000,000	$398,800	7.9%	$48.54	—	Common	G46188101
—	MIRATI THERAPEUTICS INC	5,550,555	$372,609	7.4%	$53.82	—	Common	60468T105
FOLD	AMICUS THERAPEUTICS INC	26,800,000	$287,832	5.7%	$10.43	-21.1%	Common	03152W109
BMRN	BIOMARIN PHARMACEUTICAL INC	3,284,000	$272,145	5.4%	$83.20	-4.3%	Common	09061G101
—	SEAGEN INC	1,525,000	$269,834	5.3%	$148.58	—	Common	81181C104
SRPT	SAREPTA THERAPEUTICS INC	3,390,000	$254,114	5.0%	$97.25	-24.3%	Common	803607100
ASND	ASCENDIS PHARMA	2,275,000	$211,484	4.2%	$130.04	—	Sponsored ADR	04351P101
ALNY	ALNYLAM PHARMACEUTICALS INC	1,360,000	$198,356	3.9%	$153.75	-7.7%	Common	02043Q107
XENE	XENON PHARMACEUTICALS INC	4,900,000	$149,058	2.9%	$16.29	+85.6%	Common	98420N105
MDGL	MADRIGAL PHARMACEUTICALS INC	1,535,000	$109,875	2.2%	$120.44	-39.0%	Common	558868105
IOVA	IOVANCE BIOTHERAPEUTICS INC	9,220,000	$101,789	2.0%	$16.40	-20.1%	Common	462260100
KURA	KURA ONCOLOGY INC	4,800,000	$87,984	1.7%	$23.38	-38.5%	Common	50127T109
KRYS	KRYSTAL BIOTECH INC	1,075,000	$70,585	1.4%	$60.54	+2.7%	Common	501147102
BCRX	BIOCRYST PHARMACEUTICALS INC	6,500,000	$68,770	1.4%	$11.97	-13.8%	Common	09058V103
—	IVERIC BIO INC	7,120,000	$68,494	1.4%	$6.39	—	Common	46583P102
XBI	SPDR SERIES TRUST - S&P BIOTECH	900,000	$66,843	1.3%	$97.48	—	ETF	78464A870
RARE	ULTRAGENYX PHARMACEUTICAL INC	750,000	$44,745	0.9%	$64.00	-3.9%	Common	90400D108
PMVP	PMV PHARMACEUTICALS INC	3,100,000	$44,175	0.9%	$25.09	-42.0%	Common	69353Y103
SNDX	SYNDAX PHARMACEUTICALS INC	2,222,222	$42,756	0.8%	$20.62	-19.2%	Common	87164F105
—	MERSANA THERAPEUTICS INC	7,550,000	$34,881	0.7%	$21.34	—	Common	59045L106
MNKD	MANNKIND CORP	9,100,000	$34,671	0.7%	$3.56	+3.3%	Common	56400P706
GLUE	MONTE ROSA THERAPEUTICS INC	3,311,536	$32,023	0.6%	$20.37	-50.7%	Common	61225M102
DSGN	DESIGN THERAPEUTICS INC	2,222,222	$31,111	0.6%	$25.91	-47.9%	Common	25056L103
—	CYMABAY THERAPEUTICS INC	10,300,000	$30,385	0.6%	$6.26	—	Common	23257D103
KYMR	KYMERA THERAPEUTICS INC	1,260,000	$24,809	0.5%	$42.48	-45.0%	Common	501575104
WHWK	AADI BIOSCIENCES INC	1,829,402	$22,538	0.4%	$30.48	-51.3%	Common	00032Q104
RNAM	AVIDITY BIOSCIENCES INC	1,300,000	$18,889	0.4%	$24.59	-39.5%	Common	05370A108
—	DICE THERAPEUTICS INC	1,075,000	$16,684	0.3%	$26.26	—	Common	23345J104
—	MARINUS PHARMACEUTICALS INC	3,150,000	$15,246	0.3%	$12.20	—	Common	56854Q200
NUVL	NUVALENT INC	1,049,471	$14,231	0.3%	$29.01	-63.5%	Common	670703107
IOBT	IO BIOTECH INC	2,055,883	$9,601	0.2%	$9.66	-36.6%	Common	449778109
—	AMARIN CORP PLC	6,000,000	$8,940	0.2%	$8.22	—	Sponsored ADR	023111206
TNGX	TANGO THERAPEUTICS INC	1,550,000	$7,022	0.1%	$11.99	-49.5%	Common	87583X109
FENC	FENNEC PHARMACEUTICALS INC	1,200,000	$6,780	0.1%	$9.85	-41.1%	Common	31447P100
RLAY	RELAY THERAPEUTICS INC	400,000	$6,700	0.1%	$21.43	0.0%	Common	75943R102
—	APPLIED MOLECULAR TRANS INC	1,030,000	$2,997	0.1%	$7.52	—	Common	03824M109
GNCAQ	GENOCEA BIOSCIENCES INC	5,084,184	$86	0.0%	$2.62	-89.3%	Common	372427401