Avoro Capital Advisors LLC Diversified Active

Location: New York, NY

CIK: 0001633313 · Show all filings

Period: Q2 2022 (← Previous) (Next →)

Filing Date: Aug 15, 2022

Total Value: $5.061B (100.0% shares, 0.0% debt)

Holdings (40)

UTHR UNITED THERAPEUTICS CORP 13.8%

Value $700M Shares 2,970,000 Est. Cost $133.73 Unrealized +52.0%

ARGX ARGENX SE 9.5%

Value $479M Shares 1,265,555 Est. Cost $136.82 Unrealized —

APLS APELLIS PHARMACEUTICALS INC 8.8%

Value $443M Shares 9,805,000 Est. Cost $47.70 Unrealized -4.4%

— HORIZON THERAPEUTICS PLC 7.9%

Value $399M Shares 5,000,000 Est. Cost $48.54 Unrealized —

— MIRATI THERAPEUTICS INC 7.4%

Value $373M Shares 5,550,555 Est. Cost $53.82 Unrealized —

FOLD AMICUS THERAPEUTICS INC 5.7%

Value $288M Shares 26,800,000 Est. Cost $10.43 Unrealized -21.1%

BMRN BIOMARIN PHARMACEUTICAL INC 5.4%

Value $272M Shares 3,284,000 Est. Cost $83.20 Unrealized -4.3%

— SEAGEN INC 5.3%

Value $270M Shares 1,525,000 Est. Cost $148.58 Unrealized —

SRPT SAREPTA THERAPEUTICS INC 5.0%

Value $254M Shares 3,390,000 Est. Cost $97.25 Unrealized -24.3%

ASND ASCENDIS PHARMA 4.2%

Value $211M Shares 2,275,000 Est. Cost $130.04 Unrealized —

ALNY ALNYLAM PHARMACEUTICALS INC 3.9%

Value $198M Shares 1,360,000 Est. Cost $153.75 Unrealized -7.7%

XENE XENON PHARMACEUTICALS INC 2.9%

Value $149M Shares 4,900,000 Est. Cost $16.29 Unrealized +85.6%

MDGL MADRIGAL PHARMACEUTICALS INC 2.2%

Value $110M Shares 1,535,000 Est. Cost $120.44 Unrealized -39.0%

IOVA IOVANCE BIOTHERAPEUTICS INC 2.0%

Value $102M Shares 9,220,000 Est. Cost $16.40 Unrealized -20.1%

KURA KURA ONCOLOGY INC 1.7%

Value $87.98M Shares 4,800,000 Est. Cost $23.38 Unrealized -38.5%

KRYS KRYSTAL BIOTECH INC 1.4%

Value $70.58M Shares 1,075,000 Est. Cost $60.54 Unrealized +2.7%

BCRX BIOCRYST PHARMACEUTICALS INC 1.4%

Value $68.77M Shares 6,500,000 Est. Cost $11.97 Unrealized -13.8%

— IVERIC BIO INC 1.4%

Value $68.49M Shares 7,120,000 Est. Cost $6.39 Unrealized —

XBI SPDR SERIES TRUST - S&P BIOTECH 1.3%

Value $66.84M Shares 900,000 Est. Cost $97.48 Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL INC 0.9%

Value $44.74M Shares 750,000 Est. Cost $64.00 Unrealized -3.9%

PMVP PMV PHARMACEUTICALS INC 0.9%

Value $44.17M Shares 3,100,000 Est. Cost $25.09 Unrealized -42.0%

SNDX SYNDAX PHARMACEUTICALS INC 0.8%

Value $42.76M Shares 2,222,222 Est. Cost $20.62 Unrealized -19.2%

— MERSANA THERAPEUTICS INC 0.7%

Value $34.88M Shares 7,550,000 Est. Cost $21.34 Unrealized —

MNKD MANNKIND CORP 0.7%

Value $34.67M Shares 9,100,000 Est. Cost $3.56 Unrealized +3.3%

GLUE MONTE ROSA THERAPEUTICS INC 0.6%

Value $32.02M Shares 3,311,536 Est. Cost $20.37 Unrealized -50.7%

DSGN DESIGN THERAPEUTICS INC 0.6%

Value $31.11M Shares 2,222,222 Est. Cost $25.91 Unrealized -47.9%

— CYMABAY THERAPEUTICS INC 0.6%

Value $30.39M Shares 10,300,000 Est. Cost $6.26 Unrealized —

KYMR KYMERA THERAPEUTICS INC 0.5%

Value $24.81M Shares 1,260,000 Est. Cost $42.48 Unrealized -45.0%

WHWK AADI BIOSCIENCES INC 0.4%

Value $22.54M Shares 1,829,402 Est. Cost $30.48 Unrealized -51.3%

RNAM AVIDITY BIOSCIENCES INC 0.4%

Value $18.89M Shares 1,300,000 Est. Cost $24.59 Unrealized -39.5%

— DICE THERAPEUTICS INC 0.3%

Value $16.68M Shares 1,075,000 Est. Cost $26.26 Unrealized —

— MARINUS PHARMACEUTICALS INC 0.3%

Value $15.25M Shares 3,150,000 Est. Cost $12.20 Unrealized —

NUVL NUVALENT INC 0.3%

Value $14.23M Shares 1,049,471 Est. Cost $29.01 Unrealized -63.5%

IOBT IO BIOTECH INC 0.2%

Value $9.601M Shares 2,055,883 Est. Cost $9.66 Unrealized -36.6%

— AMARIN CORP PLC 0.2%

Value $8.94M Shares 6,000,000 Est. Cost $8.22 Unrealized —

TNGX TANGO THERAPEUTICS INC 0.1%

Value $7.022M Shares 1,550,000 Est. Cost $11.99 Unrealized -49.5%

FENC FENNEC PHARMACEUTICALS INC 0.1%

Value $6.78M Shares 1,200,000 Est. Cost $9.85 Unrealized -41.1%

RLAY RELAY THERAPEUTICS INC 0.1%

Value $6.7M Shares 400,000 Est. Cost $21.43 Unrealized 0.0%

— APPLIED MOLECULAR TRANS INC 0.1%

Value $2.997M Shares 1,030,000 Est. Cost $7.52 Unrealized —

GNCAQ GENOCEA BIOSCIENCES INC 0.0%

Value $86,000 Shares 5,084,184 Est. Cost $2.62 Unrealized -89.3%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
UTHR	UNITED THERAPEUTICS CORP	2,970,000	$700M	13.8%	$133.73	+52.0%	Common	91307C102
ARGX	ARGENX SE	1,265,555	$479M	9.5%	$136.82	—	Sponsored ADR	04016X101
APLS	APELLIS PHARMACEUTICALS INC	9,805,000	$443M	8.8%	$47.70	-4.4%	Common	03753U106
—	HORIZON THERAPEUTICS PLC	5,000,000	$399M	7.9%	$48.54	—	Common	G46188101
—	MIRATI THERAPEUTICS INC	5,550,555	$373M	7.4%	$53.82	—	Common	60468T105
FOLD	AMICUS THERAPEUTICS INC	26,800,000	$288M	5.7%	$10.43	-21.1%	Common	03152W109
BMRN	BIOMARIN PHARMACEUTICAL INC	3,284,000	$272M	5.4%	$83.20	-4.3%	Common	09061G101
—	SEAGEN INC	1,525,000	$270M	5.3%	$148.58	—	Common	81181C104
SRPT	SAREPTA THERAPEUTICS INC	3,390,000	$254M	5.0%	$97.25	-24.3%	Common	803607100
ASND	ASCENDIS PHARMA	2,275,000	$211M	4.2%	$130.04	—	Sponsored ADR	04351P101
ALNY	ALNYLAM PHARMACEUTICALS INC	1,360,000	$198M	3.9%	$153.75	-7.7%	Common	02043Q107
XENE	XENON PHARMACEUTICALS INC	4,900,000	$149M	2.9%	$16.29	+85.6%	Common	98420N105
MDGL	MADRIGAL PHARMACEUTICALS INC	1,535,000	$110M	2.2%	$120.44	-39.0%	Common	558868105
IOVA	IOVANCE BIOTHERAPEUTICS INC	9,220,000	$102M	2.0%	$16.40	-20.1%	Common	462260100
KURA	KURA ONCOLOGY INC	4,800,000	$87.98M	1.7%	$23.38	-38.5%	Common	50127T109
KRYS	KRYSTAL BIOTECH INC	1,075,000	$70.58M	1.4%	$60.54	+2.7%	Common	501147102
BCRX	BIOCRYST PHARMACEUTICALS INC	6,500,000	$68.77M	1.4%	$11.97	-13.8%	Common	09058V103
—	IVERIC BIO INC	7,120,000	$68.49M	1.4%	$6.39	—	Common	46583P102
XBI	SPDR SERIES TRUST - S&P BIOTECH	900,000	$66.84M	1.3%	$97.48	—	ETF	78464A870
RARE	ULTRAGENYX PHARMACEUTICAL INC	750,000	$44.74M	0.9%	$64.00	-3.9%	Common	90400D108
PMVP	PMV PHARMACEUTICALS INC	3,100,000	$44.17M	0.9%	$25.09	-42.0%	Common	69353Y103
SNDX	SYNDAX PHARMACEUTICALS INC	2,222,222	$42.76M	0.8%	$20.62	-19.2%	Common	87164F105
—	MERSANA THERAPEUTICS INC	7,550,000	$34.88M	0.7%	$21.34	—	Common	59045L106
MNKD	MANNKIND CORP	9,100,000	$34.67M	0.7%	$3.56	+3.3%	Common	56400P706
GLUE	MONTE ROSA THERAPEUTICS INC	3,311,536	$32.02M	0.6%	$20.37	-50.7%	Common	61225M102
DSGN	DESIGN THERAPEUTICS INC	2,222,222	$31.11M	0.6%	$25.91	-47.9%	Common	25056L103
—	CYMABAY THERAPEUTICS INC	10,300,000	$30.39M	0.6%	$6.26	—	Common	23257D103
KYMR	KYMERA THERAPEUTICS INC	1,260,000	$24.81M	0.5%	$42.48	-45.0%	Common	501575104
WHWK	AADI BIOSCIENCES INC	1,829,402	$22.54M	0.4%	$30.48	-51.3%	Common	00032Q104
RNAM	AVIDITY BIOSCIENCES INC	1,300,000	$18.89M	0.4%	$24.59	-39.5%	Common	05370A108
—	DICE THERAPEUTICS INC	1,075,000	$16.68M	0.3%	$26.26	—	Common	23345J104
—	MARINUS PHARMACEUTICALS INC	3,150,000	$15.25M	0.3%	$12.20	—	Common	56854Q200
NUVL	NUVALENT INC	1,049,471	$14.23M	0.3%	$29.01	-63.5%	Common	670703107
IOBT	IO BIOTECH INC	2,055,883	$9.601M	0.2%	$9.66	-36.6%	Common	449778109
—	AMARIN CORP PLC	6,000,000	$8.94M	0.2%	$8.22	—	Sponsored ADR	023111206
TNGX	TANGO THERAPEUTICS INC	1,550,000	$7.022M	0.1%	$11.99	-49.5%	Common	87583X109
FENC	FENNEC PHARMACEUTICALS INC	1,200,000	$6.78M	0.1%	$9.85	-41.1%	Common	31447P100
RLAY	RELAY THERAPEUTICS INC	400,000	$6.7M	0.1%	$21.43	0.0%	Common	75943R102
—	APPLIED MOLECULAR TRANS INC	1,030,000	$2.997M	0.1%	$7.52	—	Common	03824M109
GNCAQ	GENOCEA BIOSCIENCES INC	5,084,184	$86,000	0.0%	$2.62	-89.3%	Common	372427401