Avoro Capital Advisors LLC Diversified Active

Location: New York, NY

CIK: 0001633313 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 14, 2025

Total Value: $7.737B (100.0% shares, 0.0% debt)

Holdings (32)

ASND ASCENDIS PHARMA 13.1%

Value $1.016B Shares 5,110,000 Est. Cost $129.64 Unrealized —

UTHR UNITED THERAPEUTICS CORP 11.0%

Value $848M Shares 2,022,222 Est. Cost $134.94 Unrealized +149.2%

MDGL MADRIGAL PHARMACEUTICALS INC 10.9%

Value $841M Shares 1,833,000 Est. Cost $138.83 Unrealized +168.7%

ARGX ARGENX SE 9.4%

Value $730M Shares 990,000 Est. Cost $186.36 Unrealized —

KRYS KRYSTAL BIOTECH INC 6.3%

Value $490M Shares 2,777,777 Est. Cost $91.68 Unrealized +63.3%

ARWR ARROWHEAD PHARMACEUTICALS INC. 4.9%

Value $376M Shares 10,900,000 Est. Cost $29.07 Unrealized -24.4%

KYMR KYMERA THERAPEUTICS INC 4.6%

Value $359M Shares 6,350,000 Est. Cost $35.30 Unrealized +27.8%

— MERUS N V 4.3%

Value $334M Shares 3,542,500 Est. Cost $46.32 Unrealized —

RNAM AVIDITY BIOSCIENCES INC 4.3%

Value $333M Shares 7,645,000 Est. Cost $23.88 Unrealized +69.3%

APLS APELLIS PHARMACEUTICALS INC. 3.6%

Value $277M Shares 12,222,222 Est. Cost $47.01 Unrealized -50.4%

CNTA CENTESSA PHARMACEUTICALS PLC 3.4%

Value $262M Shares 10,808,080 Est. Cost $19.57 Unrealized —

QURE UNIQURE NV 3.4%

Value $259M Shares 4,444,444 Est. Cost $11.96 Unrealized +51.8%

XENE XENON PHARMACEUTICALS INC 2.8%

Value $217M Shares 5,400,000 Est. Cost $19.12 Unrealized +84.2%

— AKERO THERAPEUTICS INC 2.4%

Value $188M Shares 3,955,555 Est. Cost $52.68 Unrealized —

VERA VERA THERAPEUTICS INC 2.3%

Value $180M Shares 6,210,000 Est. Cost $36.12 Unrealized -36.0%

SLNO SOLENO THERAPEUTICS INC 2.3%

Value $174M Shares 2,577,777 Est. Cost $47.37 Unrealized +56.5%

GPCR STRUCTURE THERAPEUTICS INC. 1.9%

Value $144M Shares 5,155,555 Est. Cost $28.00 Unrealized —

— TOURMALINE BIO INC 1.6%

Value $122M Shares 2,555,555 Est. Cost $23.05 Unrealized —

OCUL OCULAR THERAPEUTIX INC 1.5%

Value $120M Shares 10,250,000 Est. Cost $8.37 Unrealized +42.8%

FOLD AMICUS THERAPEUTICS INC. 1.5%

Value $118M Shares 15,025,000 Est. Cost $10.47 Unrealized -32.0%

— 89BIO INC 1.2%

Value $93.9M Shares 6,387,790 Est. Cost $7.76 Unrealized —

TSHA TAYSHA GENE THERAPIES INC 0.9%

Value $70.96M Shares 21,700,000 Est. Cost $2.05 Unrealized +38.2%

ALKS ALKERMES PLC 0.9%

Value $67.2M Shares 2,240,000 Est. Cost $28.91 Unrealized -2.5%

ORKA ORUKA THERAPEUTICS INC 0.3%

Value $25.64M Shares 1,333,340 Est. Cost $14.82 Unrealized 0.0%

SEPN SEPTERNA INC 0.3%

Value $25.16M Shares 1,337,500 Est. Cost $20.93 Unrealized -37.3%

MNKD MANNKIND CORP 0.3%

Value $24M Shares 4,468,877 Est. Cost $3.56 Unrealized +23.4%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 0.2%

Value $14.34M Shares 2,000,000 Est. Cost $37.53 Unrealized +38.9%

BCRX BIOCRYST PHARMACEUTICALS INC 0.1%

Value $9.488M Shares 1,250,000 Est. Cost $10.72 Unrealized -22.3%

WHWK WHITEHAWK THERAPEUTICS INC 0.1%

Value $5.414M Shares 2,849,402 Est. Cost $24.27 Unrealized -92.4%

TNGX TANGO THERAPEUTICS INC 0.1%

Value $4.578M Shares 545,000 Est. Cost $6.77 Unrealized 0.0%

UTHR UNITED THERAPEUTICS CORP 0.1%

Value $4.44M Shares 200,000 Est. Cost $134.94 Unrealized +149.2%

GPCR STRUCTURE THERAPEUTICS INC. 0.0%

Value $2.237M Shares 250,000 Est. Cost $28.00 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ASND	ASCENDIS PHARMA	5,110,000	$1.016B	13.1%	$129.64	—	Sponsored ADR	04351P101
UTHR	UNITED THERAPEUTICS CORP	2,022,222	$848M	11.0%	$134.94	+149.2%	Common	91307C102
MDGL	MADRIGAL PHARMACEUTICALS INC	1,833,000	$841M	10.9%	$138.83	+168.7%	Common	558868105
ARGX	ARGENX SE	990,000	$730M	9.4%	$186.36	—	Sponsored ADR	04016X101
KRYS	KRYSTAL BIOTECH INC	2,777,777	$490M	6.3%	$91.68	+63.3%	Common	501147102
ARWR	ARROWHEAD PHARMACEUTICALS INC.	10,900,000	$376M	4.9%	$29.07	-24.4%	Common	04280A100
KYMR	KYMERA THERAPEUTICS INC	6,350,000	$359M	4.6%	$35.30	+27.8%	Common	501575104
—	MERUS N V	3,542,500	$334M	4.3%	$46.32	—	Common	N5749R100
RNAM	AVIDITY BIOSCIENCES INC	7,645,000	$333M	4.3%	$23.88	+69.3%	Common	05370A108
APLS	APELLIS PHARMACEUTICALS INC.	12,222,222	$277M	3.6%	$47.01	-50.4%	Common	03753U106
CNTA	CENTESSA PHARMACEUTICALS PLC	10,808,080	$262M	3.4%	$19.57	—	SPONSORED ADR	152309100
QURE	UNIQURE NV	4,444,444	$259M	3.4%	$11.96	+51.8%	Common	N90064101
XENE	XENON PHARMACEUTICALS INC	5,400,000	$217M	2.8%	$19.12	+84.2%	Common	98420N105
—	AKERO THERAPEUTICS INC	3,955,555	$188M	2.4%	$52.68	—	Common	00973Y108
VERA	VERA THERAPEUTICS INC	6,210,000	$180M	2.3%	$36.12	-36.0%	Common	92337R101
SLNO	SOLENO THERAPEUTICS INC	2,577,777	$174M	2.3%	$47.37	+56.5%	Common	834203309
GPCR	STRUCTURE THERAPEUTICS INC.	5,155,555	$144M	1.9%	$28.00	—	SPONSORED ADS	86366E106
—	TOURMALINE BIO INC	2,555,555	$122M	1.6%	$23.05	—	Common	89157D105
OCUL	OCULAR THERAPEUTIX INC	10,250,000	$120M	1.5%	$8.37	+42.8%	Common	67576A100
FOLD	AMICUS THERAPEUTICS INC.	15,025,000	$118M	1.5%	$10.47	-32.0%	Common	03152W109
—	89BIO INC	6,387,790	$93.9M	1.2%	$7.76	—	Common	282559103
TSHA	TAYSHA GENE THERAPIES INC	21,700,000	$70.96M	0.9%	$2.05	+38.2%	Common	877619106
ALKS	ALKERMES PLC	2,240,000	$67.2M	0.9%	$28.91	-2.5%	Common	G01767105
ORKA	ORUKA THERAPEUTICS INC	1,333,340	$25.64M	0.3%	$14.82	0.0%	Common	687604108
SEPN	SEPTERNA INC	1,337,500	$25.16M	0.3%	$20.93	-37.3%	Common	81734D104
MNKD	MANNKIND CORP	4,468,877	$24M	0.3%	$3.56	+23.4%	Common	56400P706
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	2,000,000	$14.34M	0.2%	$37.53	+38.9%	CLASS A ORD	61559X104
BCRX	BIOCRYST PHARMACEUTICALS INC	1,250,000	$9.488M	0.1%	$10.72	-22.3%	Common	09058V103
WHWK	WHITEHAWK THERAPEUTICS INC	2,849,402	$5.414M	0.1%	$24.27	-92.4%	Common	00032Q104
TNGX	TANGO THERAPEUTICS INC	545,000	$4.578M	0.1%	$6.77	0.0%	Common	87583X109
UTHR	UNITED THERAPEUTICS CORP	200,000	$4.44M	0.1%	$134.94	+149.2%	Call	91307C102
GPCR	STRUCTURE THERAPEUTICS INC.	250,000	$2.237M	0.0%	$28.00	—	Call	86366E106