EcoR1 Capital, LLC Quant / Systematic

Location: San Francisco, CA

CIK: 0001587114 · Show all filings

Period: Q3 2017 (← Previous) (Next →)

Filing Date: Nov 14, 2017

Total Value: $750M (100.0% shares, 0.0% debt)

Holdings (39)

— ASSEMBLY BIOSCIENCES INC 13.7%

Value $103M Shares 2,943,164 Est. Cost $8.38 Unrealized —

— FIBROGEN INC 12.4%

Value $93.38M Shares 1,735,677 Est. Cost $33.98 Unrealized —

IRWD IRONWOOD PHARMACEUTICALS INC 11.5%

Value $86.1M Shares 5,459,583 Est. Cost $11.59 Unrealized +18.8%

ASND ASCENDIS PHARMA A S 10.2%

Value $76.4M Shares 2,107,600 Est. Cost $26.79 Unrealized —

KURA KURA ONCOLOGY INC COM 7.5%

Value $56.31M Shares 3,766,852 Est. Cost $9.78 Unrealized -4.0%

— IMMUNOMEDICS INC 5.3%

Value $39.98M Shares 2,860,019 Est. Cost $13.98 Unrealized —

— MYOKARDIA INC 3.9%

Value $29.57M Shares 689,986 Est. Cost $42.85 Unrealized —

GLPG GALAPAGOS NV SPON ADR 3.3%

Value $24.5M Shares 240,776 Est. Cost $58.59 Unrealized —

— MARINUS PHARMACEUTICALS INC 2.8%

Value $21.26M Shares 3,622,271 Est. Cost $5.87 Unrealized —

— ATYR PHARMA INC 2.6%

Value $19.87M Shares 3,934,849 Est. Cost $3.81 Unrealized —

— TOCAGEN INC 2.5%

Value $18.72M Shares 1,502,373 Est. Cost $12.03 Unrealized —

— ARRAY BIOPHARMA INC 2.0%

Value $15.38M Shares 1,250,000 Est. Cost $12.30 Unrealized —

CTMX CYTOMX THERAPEUTICS INC 2.0%

Value $15.08M Shares 829,771 Est. Cost $13.26 Unrealized +17.6%

CRVS CORVUS PHARMACEUTICALS INC 1.9%

Value $14.48M Shares 908,525 Est. Cost $11.04 Unrealized +25.4%

— INTEC PHARMA LTD JERUSALEM 1.8%

Value $13.43M Shares 1,500,000 Est. Cost $8.95 Unrealized —

INSM INSMED INC 1.7%

Value $12.65M Shares 405,400 Est. Cost $19.05 Unrealized 0.0%

WVE WAVE LIFE SCIENCES LTD 1.6%

Value $12.27M Shares 564,248 Est. Cost $20.10 Unrealized 0.0%

— CASCADIAN THERAPEUTICS INC 1.6%

Value $12.27M Shares 3,000,000 Est. Cost $4.14 Unrealized —

— VERTEX PHARMACEUTICALS INC 1.4%

Value $10.28M Shares 67,600 Est. Cost — Unrealized —

— IRONWOOD PHARMACEUTICALS INC 1.3%

Value $9.777M Shares 620,000 Est. Cost — Unrealized —

OMER OMEROS CORP 1.3%

Value $9.729M Shares 450,000 Est. Cost $21.19 Unrealized 0.0%

FATE FATE THERAPEUTICS INC 1.2%

Value $8.96M Shares 2,262,678 Est. Cost $3.66 Unrealized -7.1%

— REGULUS THERAPEUTICS INC 0.9%

Value $6.549M Shares 5,239,225 Est. Cost $1.25 Unrealized —

— DICERNA PHARMACEUTICALS INC 0.7%

Value $5.508M Shares 957,992 Est. Cost $3.77 Unrealized —

— OVASCIENCE INC 0.7%

Value $4.988M Shares 3,512,332 Est. Cost $1.87 Unrealized —

ZLAB ZAI LAB LIMITED 0.6%

Value $4.307M Shares 159,535 Est. Cost $27.00 Unrealized —

— KINDRED BIOSCIENCES INC 0.6%

Value $4.277M Shares 544,880 Est. Cost $7.10 Unrealized —

SGMO SANGAMO BIOSCIENCES INC 0.4%

Value $3.336M Shares 222,388 Est. Cost $6.42 Unrealized +72.3%

— CLEMENTIA PHARMACEUTICALS INC 0.4%

Value $3.279M Shares 194,166 Est. Cost $16.89 Unrealized —

— ADVERUM BIOTECHNOLOGIES INC 0.4%

Value $2.785M Shares 762,947 Est. Cost $4.11 Unrealized —

— CLOVIS ONCOLOGY INC 0.3%

Value $2.123M Shares 25,765 Est. Cost $86.75 Unrealized —

XNCR XENCOR INC 0.3%

Value $2.065M Shares 90,114 Est. Cost $22.20 Unrealized 0.0%

— SEATTLE GENETICS INC 0.2%

Value $1.632M Shares 30,000 Est. Cost $53.07 Unrealized —

ACRS ACLARIS THERAPEUTICS INC 0.2%

Value $1.549M Shares 60,000 Est. Cost $26.78 Unrealized +0.1%

— SYROS PHARMACEUTICALS INC 0.2%

Value $1.531M Shares 104,000 Est. Cost $14.72 Unrealized —

BMY BRISTOL MYERS SQUIBB CO 0.1%

Value $1.087M Shares 17,060 Est. Cost $39.73 Unrealized +8.5%

ONC BEIGENE LTD SPONSORED ADR 0.1%

Value $1.009M Shares 9,800 Est. Cost $102.96 Unrealized —

— DECIPHERA PHARMACEUTICALS INC 0.1%

Value $855K Shares 45,000 Est. Cost $19.00 Unrealized —

— SPRING BK PHARMACEUTICALS INC 0.0%

Value $269K Shares 16,000 Est. Cost $16.81 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	ASSEMBLY BIOSCIENCES INC	2,943,164	$103M	13.7%	$8.38	—	COM	045396108
—	FIBROGEN INC	1,735,677	$93.38M	12.4%	$33.98	—	COM	31572Q808
IRWD	IRONWOOD PHARMACEUTICALS INC	5,459,583	$86.1M	11.5%	$11.59	+18.8%	COM	46333X108
ASND	ASCENDIS PHARMA A S	2,107,600	$76.4M	10.2%	$26.79	—	SPONSORED ADR	04351P101
KURA	KURA ONCOLOGY INC COM	3,766,852	$56.31M	7.5%	$9.78	-4.0%	COM	50127T109
—	IMMUNOMEDICS INC	2,860,019	$39.98M	5.3%	$13.98	—	COM	452907108
—	MYOKARDIA INC	689,986	$29.57M	3.9%	$42.85	—	COM	62857M105
GLPG	GALAPAGOS NV SPON ADR	240,776	$24.5M	3.3%	$58.59	—	SPONSORED ADR	36315X101
—	MARINUS PHARMACEUTICALS INC	3,622,271	$21.26M	2.8%	$5.87	—	COM	56854Q101
—	ATYR PHARMA INC	3,934,849	$19.87M	2.6%	$3.81	—	COM	002120103
—	TOCAGEN INC	1,502,373	$18.72M	2.5%	$12.03	—	COM	888846102
—	ARRAY BIOPHARMA INC	1,250,000	$15.38M	2.0%	$12.30	—	COM	04269X105
CTMX	CYTOMX THERAPEUTICS INC	829,771	$15.08M	2.0%	$13.26	+17.6%	COM	23284F105
CRVS	CORVUS PHARMACEUTICALS INC	908,525	$14.48M	1.9%	$11.04	+25.4%	COM	221015100
—	INTEC PHARMA LTD JERUSALEM	1,500,000	$13.43M	1.8%	$8.95	—	COM	M53644106
INSM	INSMED INC	405,400	$12.65M	1.7%	$19.05	0.0%	COM	457669307
WVE	WAVE LIFE SCIENCES LTD	564,248	$12.27M	1.6%	$20.10	0.0%	COM	Y95308105
—	CASCADIAN THERAPEUTICS INC	3,000,000	$12.27M	1.6%	$4.14	—	COM	14740B606
—	VERTEX PHARMACEUTICALS INC	67,600	$10.28M	1.4%	—	—	Call	92532F900
—	IRONWOOD PHARMACEUTICALS INC	620,000	$9.777M	1.3%	—	—	Call	46333X908
OMER	OMEROS CORP	450,000	$9.729M	1.3%	$21.19	0.0%	COM	682143102
FATE	FATE THERAPEUTICS INC	2,262,678	$8.96M	1.2%	$3.66	-7.1%	COM	31189P102
—	REGULUS THERAPEUTICS INC	5,239,225	$6.549M	0.9%	$1.25	—	COM	75915K101
—	DICERNA PHARMACEUTICALS INC	957,992	$5.508M	0.7%	$3.77	—	COM	253031108
—	OVASCIENCE INC	3,512,332	$4.988M	0.7%	$1.87	—	COM	69014Q101
ZLAB	ZAI LAB LIMITED	159,535	$4.307M	0.6%	$27.00	—	SPONSORED ADR	98887Q104
—	KINDRED BIOSCIENCES INC	544,880	$4.277M	0.6%	$7.10	—	COM	494577109
SGMO	SANGAMO BIOSCIENCES INC	222,388	$3.336M	0.4%	$6.42	+72.3%	COM	800677106
—	CLEMENTIA PHARMACEUTICALS INC	194,166	$3.279M	0.4%	$16.89	—	COM	185575107
—	ADVERUM BIOTECHNOLOGIES INC	762,947	$2.785M	0.4%	$4.11	—	COM	00773U108
—	CLOVIS ONCOLOGY INC	25,765	$2.123M	0.3%	$86.75	—	COM	189464100
XNCR	XENCOR INC	90,114	$2.065M	0.3%	$22.20	0.0%	COM	98401F105
—	SEATTLE GENETICS INC	30,000	$1.632M	0.2%	$53.07	—	COM	812578102
ACRS	ACLARIS THERAPEUTICS INC	60,000	$1.549M	0.2%	$26.78	+0.1%	COM	00461U105
—	SYROS PHARMACEUTICALS INC	104,000	$1.531M	0.2%	$14.72	—	COM	87184Q107
BMY	BRISTOL MYERS SQUIBB CO	17,060	$1.087M	0.1%	$39.73	+8.5%	COM	110122108
ONC	BEIGENE LTD SPONSORED ADR	9,800	$1.009M	0.1%	$102.96	—	SPONSORED ADR	07725L102
—	DECIPHERA PHARMACEUTICALS INC	45,000	$855K	0.1%	$19.00	—	COM	24344T101
—	SPRING BK PHARMACEUTICALS INC	16,000	$269K	0.0%	$16.81	—	COM	849431101