EcoR1 Capital, LLC Quant / Systematic

Location: San Francisco, CA

CIK: 0001587114 · Show all filings

Period: Q4 2017 (← Previous) (Next →)

Filing Date: Feb 14, 2018

Total Value: $888M (100.0% shares, 0.0% debt)

Holdings (30)

— ASSEMBLY BIOSCIENCES INC 15.0%

Value $133M Shares 2,943,164 Est. Cost $8.38 Unrealized —

— FIBROGEN INC 10.9%

Value $97.06M Shares 2,047,737 Est. Cost $36.02 Unrealized —

— CELGENE CORPORATION 10.3%

Value $91.31M Shares 875,000 Est. Cost — Unrealized —

IRWD IRONWOOD PHARMACEUTICALS INC 9.9%

Value $88.22M Shares 5,885,583 Est. Cost $11.69 Unrealized +11.7%

ASND ASCENDIS PHARMA 9.5%

Value $84.43M Shares 2,107,600 Est. Cost $26.79 Unrealized —

KURA KURA ONCOLOGY INC 6.5%

Value $57.63M Shares 3,766,852 Est. Cost $9.78 Unrealized +50.6%

— DICERNA PHARMACEUTICALS INC 4.9%

Value $43.67M Shares 4,836,547 Est. Cost $7.99 Unrealized —

— ARRAY BIOPHARMA INC 4.2%

Value $36.9M Shares 2,882,712 Est. Cost $12.58 Unrealized —

WVE WAVE LIFE SCIENCES LTD 3.7%

Value $32.86M Shares 936,163 Est. Cost $23.69 Unrealized +23.0%

— MYOKARDIA INC 3.7%

Value $32.77M Shares 778,393 Est. Cost $42.76 Unrealized —

APLS APELLIS PHARMACEUTICALS INC 2.8%

Value $24.84M Shares 1,144,558 Est. Cost $14.72 Unrealized 0.0%

— SPARK THERAPEUTICS INC 2.6%

Value $23.42M Shares 455,500 Est. Cost — Unrealized —

MGNX MACROGENICS INC 2.4%

Value $21.68M Shares 1,140,794 Est. Cost $18.67 Unrealized 0.0%

RYTM RHYTHM PHARMACEUTICALS INC 1.7%

Value $15.41M Shares 530,161 Est. Cost $26.40 Unrealized 0.0%

— IMMUNE DESIGN CORP 1.6%

Value $13.89M Shares 3,562,600 Est. Cost $3.90 Unrealized —

— ATYR PHARMA INC 1.5%

Value $13.71M Shares 3,917,972 Est. Cost $3.81 Unrealized —

— FIBROGEN INC 1.5%

Value $13.53M Shares 285,400 Est. Cost — Unrealized —

GLPG GALAPAGOS NV (ADR) 1.2%

Value $10.35M Shares 110,384 Est. Cost $58.59 Unrealized —

ONC BEIGENE LTD 0.9%

Value $8.176M Shares 83,667 Est. Cost $98.33 Unrealized —

— IRONWOOD PHARMACEUTICALS INC 0.8%

Value $7.495M Shares 500,000 Est. Cost — Unrealized —

CRVS CORVUS PHARMACEUTICALS INC 0.7%

Value $6.096M Shares 588,432 Est. Cost $11.04 Unrealized +16.0%

— ACHILLION PHARMACEUTICALS INC 0.6%

Value $5.301M Shares 1,840,725 Est. Cost $2.88 Unrealized —

— UNIQURE NV 0.6%

Value $5.17M Shares 263,900 Est. Cost — Unrealized —

— KINDRED BIOSCIENCES INC 0.6%

Value $5.149M Shares 544,880 Est. Cost $7.10 Unrealized —

— CLEMENTIA PHARMACEUTICALS 0.4%

Value $3.685M Shares 194,166 Est. Cost $16.89 Unrealized —

MDGL MADRIGAL PHARMACEUTICALS INC 0.4%

Value $3.213M Shares 35,000 Est. Cost $57.12 Unrealized 0.0%

DNLI DENALI THERAPEUTICS INC 0.4%

Value $3.128M Shares 200,000 Est. Cost $17.97 Unrealized 0.0%

XNCR XENCOR INC 0.3%

Value $2.476M Shares 112,976 Est. Cost $22.10 Unrealized -1.9%

— MIRATI THERAPEUTICS INC 0.2%

Value $1.884M Shares 103,240 Est. Cost $18.25 Unrealized —

— INTELLIA THERAPEUTICS INC 0.2%

Value $1.442M Shares 75,000 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	ASSEMBLY BIOSCIENCES INC	2,943,164	$133M	15.0%	$8.38	—	COM	045396108
—	FIBROGEN INC	2,047,737	$97.06M	10.9%	$36.02	—	COM	31572Q808
—	CELGENE CORPORATION	875,000	$91.31M	10.3%	—	—	Call	151020904
IRWD	IRONWOOD PHARMACEUTICALS INC	5,885,583	$88.22M	9.9%	$11.69	+11.7%	COM	46333X108
ASND	ASCENDIS PHARMA	2,107,600	$84.43M	9.5%	$26.79	—	SPONSORED ADR	04351P101
KURA	KURA ONCOLOGY INC	3,766,852	$57.63M	6.5%	$9.78	+50.6%	COM	50127T109
—	DICERNA PHARMACEUTICALS INC	4,836,547	$43.67M	4.9%	$7.99	—	COM	253031108
—	ARRAY BIOPHARMA INC	2,882,712	$36.9M	4.2%	$12.58	—	COM	04269X105
WVE	WAVE LIFE SCIENCES LTD	936,163	$32.86M	3.7%	$23.69	+23.0%	COM	Y95308105
—	MYOKARDIA INC	778,393	$32.77M	3.7%	$42.76	—	COM	62857M105
APLS	APELLIS PHARMACEUTICALS INC	1,144,558	$24.84M	2.8%	$14.72	0.0%	COM	03753U106
—	SPARK THERAPEUTICS INC	455,500	$23.42M	2.6%	—	—	Call	84652J903
MGNX	MACROGENICS INC	1,140,794	$21.68M	2.4%	$18.67	0.0%	COM	556099109
RYTM	RHYTHM PHARMACEUTICALS INC	530,161	$15.41M	1.7%	$26.40	0.0%	COM	76243J105
—	IMMUNE DESIGN CORP	3,562,600	$13.89M	1.6%	$3.90	—	COM	45252L103
—	ATYR PHARMA INC	3,917,972	$13.71M	1.5%	$3.81	—	COM	002120103
—	FIBROGEN INC	285,400	$13.53M	1.5%	—	—	Call	31572Q908
GLPG	GALAPAGOS NV (ADR)	110,384	$10.35M	1.2%	$58.59	—	SPONSORED ADR	36315X101
ONC	BEIGENE LTD	83,667	$8.176M	0.9%	$98.33	—	SPONSORED ADR	07725L102
—	IRONWOOD PHARMACEUTICALS INC	500,000	$7.495M	0.8%	—	—	Call	46333X908
CRVS	CORVUS PHARMACEUTICALS INC	588,432	$6.096M	0.7%	$11.04	+16.0%	COM	221015100
—	ACHILLION PHARMACEUTICALS INC	1,840,725	$5.301M	0.6%	$2.88	—	COM	00448Q201
—	UNIQURE NV	263,900	$5.17M	0.6%	—	—	Call	N90064901
—	KINDRED BIOSCIENCES INC	544,880	$5.149M	0.6%	$7.10	—	COM	494577109
—	CLEMENTIA PHARMACEUTICALS	194,166	$3.685M	0.4%	$16.89	—	COM	185575107
MDGL	MADRIGAL PHARMACEUTICALS INC	35,000	$3.213M	0.4%	$57.12	0.0%	COM	558868105
DNLI	DENALI THERAPEUTICS INC	200,000	$3.128M	0.4%	$17.97	0.0%	COM	24823R105
XNCR	XENCOR INC	112,976	$2.476M	0.3%	$22.10	-1.9%	COM	98401F105
—	MIRATI THERAPEUTICS INC	103,240	$1.884M	0.2%	$18.25	—	COM	60468T105
—	INTELLIA THERAPEUTICS INC	75,000	$1.442M	0.2%	—	—	Call	45826J905