EcoR1 Capital, LLC Quant / Systematic

CIK: 0001587114 · Show all filings

Period: Q4 2017 (← Previous) (Next →)

Filing Date: Feb 14, 2018

Total Value ($000): $888,086 (100.0% shares, 0.0% debt)

Holdings (30)

— ASSEMBLY BIOSCIENCES INC 15.0%

Value ($000) $133,178 Shares 2,943,164 Est. Cost $8.38 Unrealized —

— FIBROGEN INC 10.9%

Value ($000) $97,063 Shares 2,047,737 Est. Cost $36.02 Unrealized —

— CELGENE CORPORATION 10.3%

Value ($000) $91,315 Shares 875,000 Est. Cost — Unrealized —

IRWD IRONWOOD PHARMACEUTICALS INC 9.9%

Value ($000) $88,225 Shares 5,885,583 Est. Cost $11.69 Unrealized +11.7%

ASND ASCENDIS PHARMA 9.5%

Value ($000) $84,430 Shares 2,107,600 Est. Cost $26.79 Unrealized —

KURA KURA ONCOLOGY INC 6.5%

Value ($000) $57,633 Shares 3,766,852 Est. Cost $9.78 Unrealized +50.6%

— DICERNA PHARMACEUTICALS INC 4.9%

Value ($000) $43,674 Shares 4,836,547 Est. Cost $7.99 Unrealized —

— ARRAY BIOPHARMA INC 4.2%

Value ($000) $36,899 Shares 2,882,712 Est. Cost $12.58 Unrealized —

WVE WAVE LIFE SCIENCES LTD 3.7%

Value ($000) $32,859 Shares 936,163 Est. Cost $23.69 Unrealized +23.0%

— MYOKARDIA INC 3.7%

Value ($000) $32,770 Shares 778,393 Est. Cost $42.76 Unrealized —

APLS APELLIS PHARMACEUTICALS INC 2.8%

Value ($000) $24,837 Shares 1,144,558 Est. Cost $14.72 Unrealized 0.0%

— SPARK THERAPEUTICS INC 2.6%

Value ($000) $23,422 Shares 455,500 Est. Cost — Unrealized —

MGNX MACROGENICS INC 2.4%

Value ($000) $21,675 Shares 1,140,794 Est. Cost $18.67 Unrealized 0.0%

RYTM RHYTHM PHARMACEUTICALS INC 1.7%

Value ($000) $15,406 Shares 530,161 Est. Cost $26.40 Unrealized 0.0%

— IMMUNE DESIGN CORP 1.6%

Value ($000) $13,894 Shares 3,562,600 Est. Cost $3.90 Unrealized —

— ATYR PHARMA INC 1.5%

Value ($000) $13,713 Shares 3,917,972 Est. Cost $3.81 Unrealized —

— FIBROGEN INC 1.5%

Value ($000) $13,528 Shares 285,400 Est. Cost — Unrealized —

GLPG GALAPAGOS NV (ADR) 1.2%

Value ($000) $10,350 Shares 110,384 Est. Cost $58.59 Unrealized —

ONC BEIGENE LTD 0.9%

Value ($000) $8,176 Shares 83,667 Est. Cost $98.33 Unrealized —

— IRONWOOD PHARMACEUTICALS INC 0.8%

Value ($000) $7,495 Shares 500,000 Est. Cost — Unrealized —

CRVS CORVUS PHARMACEUTICALS INC 0.7%

Value ($000) $6,096 Shares 588,432 Est. Cost $11.04 Unrealized +16.0%

— ACHILLION PHARMACEUTICALS INC 0.6%

Value ($000) $5,301 Shares 1,840,725 Est. Cost $2.88 Unrealized —

— UNIQURE NV 0.6%

Value ($000) $5,170 Shares 263,900 Est. Cost — Unrealized —

— KINDRED BIOSCIENCES INC 0.6%

Value ($000) $5,149 Shares 544,880 Est. Cost $7.10 Unrealized —

— CLEMENTIA PHARMACEUTICALS 0.4%

Value ($000) $3,685 Shares 194,166 Est. Cost $16.89 Unrealized —

MDGL MADRIGAL PHARMACEUTICALS INC 0.4%

Value ($000) $3,213 Shares 35,000 Est. Cost $57.12 Unrealized 0.0%

DNLI DENALI THERAPEUTICS INC 0.4%

Value ($000) $3,128 Shares 200,000 Est. Cost $17.97 Unrealized 0.0%

XNCR XENCOR INC 0.3%

Value ($000) $2,476 Shares 112,976 Est. Cost $22.10 Unrealized -1.9%

— MIRATI THERAPEUTICS INC 0.2%

Value ($000) $1,884 Shares 103,240 Est. Cost $18.25 Unrealized —

— INTELLIA THERAPEUTICS INC 0.2%

Value ($000) $1,442 Shares 75,000 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	ASSEMBLY BIOSCIENCES INC	2,943,164	$133,178	15.0%	$8.38	—	COM	045396108
—	FIBROGEN INC	2,047,737	$97,063	10.9%	$36.02	—	COM	31572Q808
—	CELGENE CORPORATION	875,000	$91,315	10.3%	—	—	Call	151020904
IRWD	IRONWOOD PHARMACEUTICALS INC	5,885,583	$88,225	9.9%	$11.69	+11.7%	COM	46333X108
ASND	ASCENDIS PHARMA	2,107,600	$84,430	9.5%	$26.79	—	SPONSORED ADR	04351P101
KURA	KURA ONCOLOGY INC	3,766,852	$57,633	6.5%	$9.78	+50.6%	COM	50127T109
—	DICERNA PHARMACEUTICALS INC	4,836,547	$43,674	4.9%	$7.99	—	COM	253031108
—	ARRAY BIOPHARMA INC	2,882,712	$36,899	4.2%	$12.58	—	COM	04269X105
WVE	WAVE LIFE SCIENCES LTD	936,163	$32,859	3.7%	$23.69	+23.0%	COM	Y95308105
—	MYOKARDIA INC	778,393	$32,770	3.7%	$42.76	—	COM	62857M105
APLS	APELLIS PHARMACEUTICALS INC	1,144,558	$24,837	2.8%	$14.72	0.0%	COM	03753U106
—	SPARK THERAPEUTICS INC	455,500	$23,422	2.6%	—	—	Call	84652J903
MGNX	MACROGENICS INC	1,140,794	$21,675	2.4%	$18.67	0.0%	COM	556099109
RYTM	RHYTHM PHARMACEUTICALS INC	530,161	$15,406	1.7%	$26.40	0.0%	COM	76243J105
—	IMMUNE DESIGN CORP	3,562,600	$13,894	1.6%	$3.90	—	COM	45252L103
—	ATYR PHARMA INC	3,917,972	$13,713	1.5%	$3.81	—	COM	002120103
—	FIBROGEN INC	285,400	$13,528	1.5%	—	—	Call	31572Q908
GLPG	GALAPAGOS NV (ADR)	110,384	$10,350	1.2%	$58.59	—	SPONSORED ADR	36315X101
ONC	BEIGENE LTD	83,667	$8,176	0.9%	$98.33	—	SPONSORED ADR	07725L102
—	IRONWOOD PHARMACEUTICALS INC	500,000	$7,495	0.8%	—	—	Call	46333X908
CRVS	CORVUS PHARMACEUTICALS INC	588,432	$6,096	0.7%	$11.04	+16.0%	COM	221015100
—	ACHILLION PHARMACEUTICALS INC	1,840,725	$5,301	0.6%	$2.88	—	COM	00448Q201
—	UNIQURE NV	263,900	$5,170	0.6%	—	—	Call	N90064901
—	KINDRED BIOSCIENCES INC	544,880	$5,149	0.6%	$7.10	—	COM	494577109
—	CLEMENTIA PHARMACEUTICALS	194,166	$3,685	0.4%	$16.89	—	COM	185575107
MDGL	MADRIGAL PHARMACEUTICALS INC	35,000	$3,213	0.4%	$57.12	0.0%	COM	558868105
DNLI	DENALI THERAPEUTICS INC	200,000	$3,128	0.4%	$17.97	0.0%	COM	24823R105
XNCR	XENCOR INC	112,976	$2,476	0.3%	$22.10	-1.9%	COM	98401F105
—	MIRATI THERAPEUTICS INC	103,240	$1,884	0.2%	$18.25	—	COM	60468T105
—	INTELLIA THERAPEUTICS INC	75,000	$1,442	0.2%	—	—	Call	45826J905