EcoR1 Capital, LLC Quant / Systematic

Location: San Francisco, CA

CIK: 0001587114 · Show all filings

Period: Q1 2018 (← Previous) (Next →)

Filing Date: May 15, 2018

Total Value: $997M (100.0% shares, 0.0% debt)

Holdings (31)

— ASSEMBLY BIOSCIENCES INC 14.5%

Value $145M Shares 2,943,165 Est. Cost $8.38 Unrealized —

ASND ASCENDIS PHARMA 12.0%

Value $119M Shares 1,822,575 Est. Cost $26.79 Unrealized —

— FIBROGEN INC 9.3%

Value $92.51M Shares 2,002,437 Est. Cost $36.02 Unrealized —

IRWD IRONWOOD PHARMACEUTICALS INC 9.1%

Value $90.81M Shares 5,885,583 Est. Cost $11.69 Unrealized +6.6%

KURA KURA ONCOLOGY INC 7.1%

Value $70.63M Shares 3,766,852 Est. Cost $9.78 Unrealized +99.0%

WVE WAVE LIFE SCIENCES LTD 5.9%

Value $58.51M Shares 1,459,072 Est. Cost $30.27 Unrealized +38.9%

— ARRAY BIOPHARMA INC 5.0%

Value $49.77M Shares 3,049,312 Est. Cost $12.79 Unrealized —

— DICERNA PHARMACEUTICALS ORD 4.6%

Value $45.55M Shares 4,764,447 Est. Cost $7.99 Unrealized —

MGNX MACROGENICS INC 3.7%

Value $36.5M Shares 1,450,606 Est. Cost $19.87 Unrealized +22.3%

RCUS ARCUS BIOSCIENCES ORD 3.5%

Value $34.53M Shares 2,236,387 Est. Cost $16.66 Unrealized 0.0%

— CELGENE CORPORATION 3.4%

Value $34.35M Shares 385,000 Est. Cost — Unrealized —

APLS APELLIS PHARMACEUTICALS INC 2.3%

Value $23.36M Shares 1,056,348 Est. Cost $14.72 Unrealized +33.5%

— FIVE PRIME THERAPEUTICS ORD 2.1%

Value $21.31M Shares 1,240,470 Est. Cost $17.18 Unrealized —

URGN UROGEN PHARMA ORD 2.0%

Value $19.99M Shares 402,300 Est. Cost $50.09 Unrealized 0.0%

— FIBROGEN INC 1.5%

Value $15.02M Shares 325,000 Est. Cost — Unrealized —

— IMMUNE DESIGN CORP 1.4%

Value $14.42M Shares 4,437,600 Est. Cost $3.77 Unrealized —

AGIO AGIOS PHARMACEUTICALS ORD 1.4%

Value $14.14M Shares 172,952 Est. Cost $77.29 Unrealized 0.0%

AKBA AKEBIA THERAPEUTICS ORD 1.4%

Value $13.58M Shares 1,425,000 Est. Cost $13.99 Unrealized 0.0%

— ACHILLION PHARMACEUTICALS INC 1.4%

Value $13.57M Shares 3,668,307 Est. Cost $3.29 Unrealized —

— DOVA PHARMACEUTICALS ORD 1.2%

Value $11.65M Shares 429,729 Est. Cost $27.12 Unrealized —

— ATYR PHARMA INC 1.1%

Value $10.58M Shares 3,917,972 Est. Cost $3.81 Unrealized —

— DBV TECHNOLOGIES ADR REP 0.5 ORD 1.0%

Value $10.38M Shares 450,000 Est. Cost $23.07 Unrealized —

— IRONWOOD PHARMACEUTICALS INC 1.0%

Value $10.3M Shares 667,800 Est. Cost — Unrealized —

PTGX PROTAGONIST THERAPEUTICS ORD 0.9%

Value $9.308M Shares 1,083,567 Est. Cost $18.83 Unrealized 0.0%

— SYNLOGIC ORD 0.7%

Value $6.566M Shares 700,000 Est. Cost $9.38 Unrealized —

DNLI DENALI THERAPEUTICS INC 0.6%

Value $6.399M Shares 325,000 Est. Cost $18.97 Unrealized +8.4%

RYTM RHYTHM PHARMACEUTICALS INC 0.6%

Value $6.339M Shares 318,564 Est. Cost $26.40 Unrealized +0.6%

CRVS CORVUS PHARMACEUTICALS INC 0.5%

Value $5.416M Shares 469,700 Est. Cost $11.04 Unrealized -14.3%

— NEWLINK GENETICS CORP 0.4%

Value $4.06M Shares 560,000 Est. Cost — Unrealized —

— KINDRED BIOSCIENCES INC 0.2%

Value $2.151M Shares 248,680 Est. Cost $7.10 Unrealized —

GERN GERON ORD 0.1%

Value $1.488M Shares 350,000 Est. Cost $2.70 Unrealized 0.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	ASSEMBLY BIOSCIENCES INC	2,943,165	$145M	14.5%	$8.38	—	COM	045396108
ASND	ASCENDIS PHARMA	1,822,575	$119M	12.0%	$26.79	—	SPONSORED ADR	04351P101
—	FIBROGEN INC	2,002,437	$92.51M	9.3%	$36.02	—	COM	31572Q808
IRWD	IRONWOOD PHARMACEUTICALS INC	5,885,583	$90.81M	9.1%	$11.69	+6.6%	COM	46333X108
KURA	KURA ONCOLOGY INC	3,766,852	$70.63M	7.1%	$9.78	+99.0%	COM	50127T109
WVE	WAVE LIFE SCIENCES LTD	1,459,072	$58.51M	5.9%	$30.27	+38.9%	COM	Y95308105
—	ARRAY BIOPHARMA INC	3,049,312	$49.77M	5.0%	$12.79	—	COM	04269X105
—	DICERNA PHARMACEUTICALS ORD	4,764,447	$45.55M	4.6%	$7.99	—	COM	253031108
MGNX	MACROGENICS INC	1,450,606	$36.5M	3.7%	$19.87	+22.3%	COM	556099109
RCUS	ARCUS BIOSCIENCES ORD	2,236,387	$34.53M	3.5%	$16.66	0.0%	COM	03969F109
—	CELGENE CORPORATION	385,000	$34.35M	3.4%	—	—	Call	151020904
APLS	APELLIS PHARMACEUTICALS INC	1,056,348	$23.36M	2.3%	$14.72	+33.5%	COM	03753U106
—	FIVE PRIME THERAPEUTICS ORD	1,240,470	$21.31M	2.1%	$17.18	—	COM	33830X104
URGN	UROGEN PHARMA ORD	402,300	$19.99M	2.0%	$50.09	0.0%	COM	M96088105
—	FIBROGEN INC	325,000	$15.02M	1.5%	—	—	Call	31572Q908
—	IMMUNE DESIGN CORP	4,437,600	$14.42M	1.4%	$3.77	—	COM	45252L103
AGIO	AGIOS PHARMACEUTICALS ORD	172,952	$14.14M	1.4%	$77.29	0.0%	COM	00847X104
AKBA	AKEBIA THERAPEUTICS ORD	1,425,000	$13.58M	1.4%	$13.99	0.0%	COM	00972D105
—	ACHILLION PHARMACEUTICALS INC	3,668,307	$13.57M	1.4%	$3.29	—	COM	00448Q201
—	DOVA PHARMACEUTICALS ORD	429,729	$11.65M	1.2%	$27.12	—	COM	25985T102
—	ATYR PHARMA INC	3,917,972	$10.58M	1.1%	$3.81	—	COM	002120103
—	DBV TECHNOLOGIES ADR REP 0.5 ORD	450,000	$10.38M	1.0%	$23.07	—	SPONSORED ADR	23306J101
—	IRONWOOD PHARMACEUTICALS INC	667,800	$10.3M	1.0%	—	—	Call	46333X908
PTGX	PROTAGONIST THERAPEUTICS ORD	1,083,567	$9.308M	0.9%	$18.83	0.0%	COM	74366E102
—	SYNLOGIC ORD	700,000	$6.566M	0.7%	$9.38	—	COM	87166L100
DNLI	DENALI THERAPEUTICS INC	325,000	$6.399M	0.6%	$18.97	+8.4%	COM	24823R105
RYTM	RHYTHM PHARMACEUTICALS INC	318,564	$6.339M	0.6%	$26.40	+0.6%	COM	76243J105
CRVS	CORVUS PHARMACEUTICALS INC	469,700	$5.416M	0.5%	$11.04	-14.3%	COM	221015100
—	NEWLINK GENETICS CORP	560,000	$4.06M	0.4%	—	—	Call	651511907
—	KINDRED BIOSCIENCES INC	248,680	$2.151M	0.2%	$7.10	—	COM	494577109
GERN	GERON ORD	350,000	$1.488M	0.1%	$2.70	0.0%	COM	374163103