GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q3 2022 (← Previous) (Next →)

Filing Date: Nov 14, 2022

Total Value ($000): $415,311 (100.0% shares, 0.0% debt)

Holdings (40)

XENE XENON PHARMACEUTICALS INC 7.4%

Value ($000) $30,685 Shares 850,000 Est. Cost $22.27 Unrealized +61.5%

JAZZ JAZZ PHARMACEUTICALS PLC 6.9%

Value ($000) $28,657 Shares 215,000 Est. Cost $147.36 Unrealized +3.2%

— POINT BIOPHARMA GLOBAL INC 6.6%

Value ($000) $27,526 Shares 3,560,984 Est. Cost $7.65 Unrealized —

— ALPINE IMMUNE SCIENCES INC 6.0%

Value ($000) $24,829 Shares 3,448,521 Est. Cost $7.40 Unrealized —

TVTX TRAVERE THERAPEUTICS INC 5.7%

Value ($000) $23,805 Shares 966,108 Est. Cost $25.28 Unrealized +2.2%

HRTX HERON THERAPEUTICS INC 5.7%

Value ($000) $23,484 Shares 5,645,161 Est. Cost $3.91 Unrealized 0.0%

KALV KALVISTA PHARMACEUTICALS INC 5.4%

Value ($000) $22,515 Shares 1,551,719 Est. Cost $13.36 Unrealized +4.6%

PLRX PLIANT THERAPEUTICS INC 5.2%

Value ($000) $21,762 Shares 1,041,737 Est. Cost $14.77 Unrealized +29.6%

RLMD RELMADA THERAPEUTICS INC 4.5%

Value ($000) $18,880 Shares 510,000 Est. Cost $22.09 Unrealized +25.4%

ACRS ACLARIS THERAPEUTICS INC 3.9%

Value ($000) $16,043 Shares 1,019,282 Est. Cost $15.21 Unrealized +3.6%

PCVX VAXCYTE INC 3.5%

Value ($000) $14,400 Shares 600,000 Est. Cost $22.79 Unrealized +11.2%

GLPG GALAPAGOS NV 3.1%

Value ($000) $13,065 Shares 306,411 Est. Cost $56.28 Unrealized —

ABOS ACUMEN PHARMACEUTICALS INC 2.9%

Value ($000) $12,036 Shares 1,200,000 Est. Cost $4.79 Unrealized +19.8%

ALKS ALKERMES PLC 2.7%

Value ($000) $11,332 Shares 507,500 Est. Cost $27.94 Unrealized -6.9%

— SEAGEN INC 2.5%

Value ($000) $10,467 Shares 76,500 Est. Cost $136.82 Unrealized —

BBIO BRIDGEBIO PHARMA INC 2.5%

Value ($000) $10,437 Shares 1,050,000 Est. Cost $10.39 Unrealized 0.0%

— CINCOR PHARMA INC 2.4%

Value ($000) $9,889 Shares 301,324 Est. Cost $18.68 Unrealized —

VTYX VENTYX BIOSCIENCES INC 2.3%

Value ($000) $9,425 Shares 269,967 Est. Cost $13.58 Unrealized +63.1%

— TRICIDA INC 2.2%

Value ($000) $9,118 Shares 870,000 Est. Cost $4.49 Unrealized —

— RAPT THERAPEUTICS INC 1.8%

Value ($000) $7,579 Shares 315,000 Est. Cost $24.06 Unrealized —

URGN UROGEN PHARMA LTD 1.7%

Value ($000) $7,267 Shares 873,424 Est. Cost $15.60 Unrealized -47.0%

REPL REPLIMUNE GROUP INC 1.6%

Value ($000) $6,735 Shares 390,000 Est. Cost $19.07 Unrealized 0.0%

MDGL MADRIGAL PHARMACEUTICALS INC 1.5%

Value ($000) $6,207 Shares 95,500 Est. Cost $69.48 Unrealized 0.0%

MIST MILESTONE PHARMACEUTICALS IN 1.5%

Value ($000) $6,200 Shares 674,656 Est. Cost $7.58 Unrealized 0.0%

— 89BIO INC 1.3%

Value ($000) $5,529 Shares 955,000 Est. Cost $3.22 Unrealized —

— GENERATION BIO CO 1.1%

Value ($000) $4,381 Shares 825,077 Est. Cost $5.31 Unrealized —

— NGM BIOPHARMACEUTICALS INC 1.0%

Value ($000) $4,137 Shares 316,256 Est. Cost $13.08 Unrealized —

MLTX MOONLAKE IMMUNOTHERAPEUTICS 0.9%

Value ($000) $3,818 Shares 492,000 Est. Cost $6.38 Unrealized +10.4%

IMCR IMMUNOCORE HLDGS PLC 0.9%

Value ($000) $3,686 Shares 78,527 Est. Cost $46.94 Unrealized —

LRMR LARIMAR THERAPEUTICS INC 0.9%

Value ($000) $3,632 Shares 1,135,000 Est. Cost $2.51 Unrealized 0.0%

— PRECISION BIOSCIENCES INC 0.8%

Value ($000) $3,524 Shares 2,710,805 Est. Cost $1.60 Unrealized —

— CYMABAY THERAPEUTICS INC 0.7%

Value ($000) $2,798 Shares 799,439 Est. Cost $3.50 Unrealized —

— PIERIS PHARMACEUTICALS INC 0.5%

Value ($000) $2,260 Shares 1,965,449 Est. Cost $3.35 Unrealized —

— INTERCEPT PHARMACEUTICALS IN 0.4%

Value ($000) $1,465 Shares 105,000 Est. Cost $13.95 Unrealized —

— GRACELL BIOTECHNOLOGIES INC 0.3%

Value ($000) $1,446 Shares 449,049 Est. Cost $3.22 Unrealized —

— MAGENTA THERAPEUTICS INC 0.3%

Value ($000) $1,437 Shares 1,019,091 Est. Cost $9.65 Unrealized —

— NEKTAR THERAPEUTICS 0.3%

Value ($000) $1,433 Shares 447,820 Est. Cost $3.80 Unrealized —

DAWN DAY ONE BIOPHARMACEUTICALS I 0.3%

Value ($000) $1,415 Shares 70,621 Est. Cost $21.27 Unrealized 0.0%

— AEGLEA BIOTHERAPEUTICS INC 0.3%

Value ($000) $1,315 Shares 2,500,000 Est. Cost $0.51 Unrealized —

SLN SILENCE THERAPEUTICS PLC 0.2%

Value ($000) $692 Shares 68,915 Est. Cost $23.89 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
XENE	XENON PHARMACEUTICALS INC	850,000	$30,685	7.4%	$22.27	+61.5%	COM	98420N105
JAZZ	JAZZ PHARMACEUTICALS PLC	215,000	$28,657	6.9%	$147.36	+3.2%	SHS USD	G50871105
—	POINT BIOPHARMA GLOBAL INC	3,560,984	$27,526	6.6%	$7.65	—	COM	730541109
—	ALPINE IMMUNE SCIENCES INC	3,448,521	$24,829	6.0%	$7.40	—	COM	02083G100
TVTX	TRAVERE THERAPEUTICS INC	966,108	$23,805	5.7%	$25.28	+2.2%	COM	89422G107
HRTX	HERON THERAPEUTICS INC	5,645,161	$23,484	5.7%	$3.91	0.0%	COM	427746102
KALV	KALVISTA PHARMACEUTICALS INC	1,551,719	$22,515	5.4%	$13.36	+4.6%	COM	483497103
PLRX	PLIANT THERAPEUTICS INC	1,041,737	$21,762	5.2%	$14.77	+29.6%	COM	729139105
RLMD	RELMADA THERAPEUTICS INC	510,000	$18,880	4.5%	$22.09	+25.4%	COM	75955J402
ACRS	ACLARIS THERAPEUTICS INC	1,019,282	$16,043	3.9%	$15.21	+3.6%	COM	00461U105
PCVX	VAXCYTE INC	600,000	$14,400	3.5%	$22.79	+11.2%	COM	92243G108
GLPG	GALAPAGOS NV	306,411	$13,065	3.1%	$56.28	—	SPON ADR	36315X101
ABOS	ACUMEN PHARMACEUTICALS INC	1,200,000	$12,036	2.9%	$4.79	+19.8%	COM	00509G209
ALKS	ALKERMES PLC	507,500	$11,332	2.7%	$27.94	-6.9%	SHS	G01767105
—	SEAGEN INC	76,500	$10,467	2.5%	$136.82	—	COM	81181C104
BBIO	BRIDGEBIO PHARMA INC	1,050,000	$10,437	2.5%	$10.39	0.0%	COM	10806X102
—	CINCOR PHARMA INC	301,324	$9,889	2.4%	$18.68	—	COM	17240Y109
VTYX	VENTYX BIOSCIENCES INC	269,967	$9,425	2.3%	$13.58	+63.1%	COM	92332V107
—	TRICIDA INC	870,000	$9,118	2.2%	$4.49	—	COM	89610F101
—	RAPT THERAPEUTICS INC	315,000	$7,579	1.8%	$24.06	—	COM	75382E109
URGN	UROGEN PHARMA LTD	873,424	$7,267	1.7%	$15.60	-47.0%	COM	M96088105
REPL	REPLIMUNE GROUP INC	390,000	$6,735	1.6%	$19.07	0.0%	COM	76029N106
MDGL	MADRIGAL PHARMACEUTICALS INC	95,500	$6,207	1.5%	$69.48	0.0%	COM	558868105
MIST	MILESTONE PHARMACEUTICALS IN	674,656	$6,200	1.5%	$7.58	0.0%	COM	59935V107
—	89BIO INC	955,000	$5,529	1.3%	$3.22	—	COM	282559103
—	GENERATION BIO CO	825,077	$4,381	1.1%	$5.31	—	COM	37148K100
—	NGM BIOPHARMACEUTICALS INC	316,256	$4,137	1.0%	$13.08	—	COM	62921N105
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	492,000	$3,818	0.9%	$6.38	+10.4%	CLASS A ORD	61559X104
IMCR	IMMUNOCORE HLDGS PLC	78,527	$3,686	0.9%	$46.94	—	ADS	45258D105
LRMR	LARIMAR THERAPEUTICS INC	1,135,000	$3,632	0.9%	$2.51	0.0%	COM	517125100
—	PRECISION BIOSCIENCES INC	2,710,805	$3,524	0.8%	$1.60	—	COM	74019P108
—	CYMABAY THERAPEUTICS INC	799,439	$2,798	0.7%	$3.50	—	COM	23257D103
—	PIERIS PHARMACEUTICALS INC	1,965,449	$2,260	0.5%	$3.35	—	COM	720795103
—	INTERCEPT PHARMACEUTICALS IN	105,000	$1,465	0.4%	$13.95	—	COM	45845P108
—	GRACELL BIOTECHNOLOGIES INC	449,049	$1,446	0.3%	$3.22	—	SPONSORED ADS	38406L103
—	MAGENTA THERAPEUTICS INC	1,019,091	$1,437	0.3%	$9.65	—	COM	55910K108
—	NEKTAR THERAPEUTICS	447,820	$1,433	0.3%	$3.80	—	COM	640268108
DAWN	DAY ONE BIOPHARMACEUTICALS I	70,621	$1,415	0.3%	$21.27	0.0%	COM	23954D109
—	AEGLEA BIOTHERAPEUTICS INC	2,500,000	$1,315	0.3%	$0.51	—	COM	00773J103
SLN	SILENCE THERAPEUTICS PLC	68,915	$692	0.2%	$23.89	—	ADS	82686Q101