GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q4 2022 (← Previous) (Next →)

Filing Date: Feb 14, 2023

Total Value ($000): $510,185 (100.0% shares, 0.0% debt)

Holdings (42)

PCVX VAXCYTE INC 7.5%

Value ($000) $38,360 Shares 800,000 Est. Cost $26.90 Unrealized +45.9%

XENE XENON PHARMACEUTICALS INC 6.6%

Value ($000) $33,516 Shares 850,000 Est. Cost $22.27 Unrealized +63.6%

— RAPT THERAPEUTICS INC 5.6%

Value ($000) $28,444 Shares 1,436,569 Est. Cost $20.73 Unrealized —

— ALPINE IMMUNE SCIENCES INC 5.2%

Value ($000) $26,737 Shares 3,637,718 Est. Cost $7.40 Unrealized —

PLRX PLIANT THERAPEUTICS INC 5.0%

Value ($000) $25,571 Shares 1,322,870 Est. Cost $16.07 Unrealized +30.1%

JAZZ JAZZ PHARMACEUTICALS PLC 5.0%

Value ($000) $25,490 Shares 160,000 Est. Cost $147.36 Unrealized -0.5%

— SEAGEN INC 4.0%

Value ($000) $20,626 Shares 160,500 Est. Cost $132.47 Unrealized —

— POINT BIOPHARMA GLOBAL INC 3.6%

Value ($000) $18,530 Shares 2,541,779 Est. Cost $7.65 Unrealized —

NVCR NOVOCURE LTD 3.5%

Value ($000) $17,677 Shares 241,000 Est. Cost — Unrealized —

— IVERIC BIO INC 3.5%

Value ($000) $17,663 Shares 825,000 Est. Cost $21.41 Unrealized —

ACRS ACLARIS THERAPEUTICS INC 3.1%

Value ($000) $16,054 Shares 1,019,282 Est. Cost $15.21 Unrealized +5.8%

HRTX HERON THERAPEUTICS INC 3.1%

Value ($000) $15,900 Shares 6,360,161 Est. Cost $3.84 Unrealized -16.0%

RARE ULTRAGENYX PHARMACEUTICAL IN 3.1%

Value ($000) $15,859 Shares 342,300 Est. Cost $39.33 Unrealized 0.0%

— OPTINOSE INC 2.9%

Value ($000) $14,605 Shares 7,894,736 Est. Cost $1.85 Unrealized —

VTYX VENTYX BIOSCIENCES INC 2.6%

Value ($000) $13,139 Shares 400,695 Est. Cost $18.81 Unrealized +57.5%

— CINCOR PHARMA INC 2.5%

Value ($000) $12,525 Shares 1,019,153 Est. Cost $14.18 Unrealized —

VKTX VIKING THERAPEUTICS INC 2.4%

Value ($000) $12,173 Shares 1,295,034 Est. Cost $4.46 Unrealized 0.0%

DAWN DAY ONE BIOPHARMACEUTICALS I 2.3%

Value ($000) $11,717 Shares 544,451 Est. Cost $20.61 Unrealized -0.5%

PTCT PTC THERAPEUTICS INC 2.3%

Value ($000) $11,532 Shares 302,135 Est. Cost $41.57 Unrealized 0.0%

— AEROVATE THERAPEUTICS INC 2.2%

Value ($000) $11,091 Shares 378,522 Est. Cost $29.30 Unrealized —

TVTX TRAVERE THERAPEUTICS INC 2.0%

Value ($000) $9,989 Shares 475,000 Est. Cost $25.28 Unrealized -16.2%

— CYMABAY THERAPEUTICS INC 1.9%

Value ($000) $9,719 Shares 1,550,000 Est. Cost $4.84 Unrealized —

SRPT SAREPTA THERAPEUTICS INC 1.9%

Value ($000) $9,459 Shares 73,000 Est. Cost $115.88 Unrealized 0.0%

RCKT ROCKET PHARMACEUTICALS INC 1.7%

Value ($000) $8,826 Shares 451,000 Est. Cost — Unrealized —

KALV KALVISTA PHARMACEUTICALS INC 1.4%

Value ($000) $7,137 Shares 1,055,801 Est. Cost $13.36 Unrealized -59.9%

AMLX AMYLYX PHARMACEUTICALS INC 1.4%

Value ($000) $7,021 Shares 190,000 Est. Cost $35.49 Unrealized 0.0%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 1.3%

Value ($000) $6,747 Shares 642,566 Est. Cost $6.97 Unrealized +27.6%

ERAS ERASCA INC 1.3%

Value ($000) $6,631 Shares 1,538,461 Est. Cost $6.78 Unrealized 0.0%

— INTERCEPT PHARMACEUTICALS IN 1.3%

Value ($000) $6,542 Shares 528,850 Est. Cost $12.68 Unrealized —

ABOS ACUMEN PHARMACEUTICALS INC 1.2%

Value ($000) $6,030 Shares 1,116,581 Est. Cost $4.79 Unrealized +40.3%

— MIRATI THERAPEUTICS INC 1.2%

Value ($000) $6,026 Shares 133,000 Est. Cost $45.31 Unrealized —

— VERVE THERAPEUTICS INC 1.1%

Value ($000) $5,805 Shares 300,000 Est. Cost $19.35 Unrealized —

— ALBIREO PHARMA INC 1.1%

Value ($000) $5,776 Shares 267,283 Est. Cost $21.61 Unrealized —

LRMR LARIMAR THERAPEUTICS INC 1.0%

Value ($000) $5,260 Shares 1,273,635 Est. Cost $2.60 Unrealized +31.1%

URGN UROGEN PHARMA LTD 1.0%

Value ($000) $4,967 Shares 560,000 Est. Cost $15.60 Unrealized -39.3%

— PRECISION BIOSCIENCES INC 0.9%

Value ($000) $4,524 Shares 3,801,305 Est. Cost $1.48 Unrealized —

— GRACELL BIOTECHNOLOGIES INC 0.9%

Value ($000) $4,514 Shares 1,962,399 Est. Cost $2.51 Unrealized —

— GENERATION BIO CO 0.8%

Value ($000) $4,019 Shares 1,022,537 Est. Cost $5.04 Unrealized —

EOLS EVOLUS INC 0.3%

Value ($000) $1,429 Shares 190,329 Est. Cost $7.74 Unrealized 0.0%

ALKS ALKERMES PLC 0.2%

Value ($000) $1,207 Shares 46,185 Est. Cost $27.94 Unrealized -14.4%

IMUX IMMUNIC INC 0.2%

Value ($000) $885 Shares 632,184 Est. Cost $2.73 Unrealized 0.0%

ANAB ANAPTYSBIO INC 0.1%

Value ($000) $465 Shares 15,000 Est. Cost $28.24 Unrealized 0.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
PCVX	VAXCYTE INC	800,000	$38,360	7.5%	$26.90	+45.9%	COM	92243G108
XENE	XENON PHARMACEUTICALS INC	850,000	$33,516	6.6%	$22.27	+63.6%	COM	98420N105
—	RAPT THERAPEUTICS INC	1,436,569	$28,444	5.6%	$20.73	—	COM	75382E109
—	ALPINE IMMUNE SCIENCES INC	3,637,718	$26,737	5.2%	$7.40	—	COM	02083G100
PLRX	PLIANT THERAPEUTICS INC	1,322,870	$25,571	5.0%	$16.07	+30.1%	COM	729139105
JAZZ	JAZZ PHARMACEUTICALS PLC	160,000	$25,490	5.0%	$147.36	-0.5%	SHS USD	G50871105
—	SEAGEN INC	160,500	$20,626	4.0%	$132.47	—	COM	81181C104
—	POINT BIOPHARMA GLOBAL INC	2,541,779	$18,530	3.6%	$7.65	—	COM	730541109
NVCR	NOVOCURE LTD	241,000	$17,677	3.5%	—	—	Put	G6674U108
—	IVERIC BIO INC	825,000	$17,663	3.5%	$21.41	—	COM	46583P102
ACRS	ACLARIS THERAPEUTICS INC	1,019,282	$16,054	3.1%	$15.21	+5.8%	COM	00461U105
HRTX	HERON THERAPEUTICS INC	6,360,161	$15,900	3.1%	$3.84	-16.0%	COM	427746102
RARE	ULTRAGENYX PHARMACEUTICAL IN	342,300	$15,859	3.1%	$39.33	0.0%	COM	90400D108
—	OPTINOSE INC	7,894,736	$14,605	2.9%	$1.85	—	COM	68404V100
VTYX	VENTYX BIOSCIENCES INC	400,695	$13,139	2.6%	$18.81	+57.5%	COM	92332V107
—	CINCOR PHARMA INC	1,019,153	$12,525	2.5%	$14.18	—	COM	17240Y109
VKTX	VIKING THERAPEUTICS INC	1,295,034	$12,173	2.4%	$4.46	0.0%	COM	92686J106
DAWN	DAY ONE BIOPHARMACEUTICALS I	544,451	$11,717	2.3%	$20.61	-0.5%	COM	23954D109
PTCT	PTC THERAPEUTICS INC	302,135	$11,532	2.3%	$41.57	0.0%	COM	69366J200
—	AEROVATE THERAPEUTICS INC	378,522	$11,091	2.2%	$29.30	—	COM	008064107
TVTX	TRAVERE THERAPEUTICS INC	475,000	$9,989	2.0%	$25.28	-16.2%	COM	89422G107
—	CYMABAY THERAPEUTICS INC	1,550,000	$9,719	1.9%	$4.84	—	COM	23257D103
SRPT	SAREPTA THERAPEUTICS INC	73,000	$9,459	1.9%	$115.88	0.0%	COM	803607100
RCKT	ROCKET PHARMACEUTICALS INC	451,000	$8,826	1.7%	—	—	Call	77313F106
KALV	KALVISTA PHARMACEUTICALS INC	1,055,801	$7,137	1.4%	$13.36	-59.9%	COM	483497103
AMLX	AMYLYX PHARMACEUTICALS INC	190,000	$7,021	1.4%	$35.49	0.0%	COM	03237H101
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	642,566	$6,747	1.3%	$6.97	+27.6%	CLASS A ORD	61559X104
ERAS	ERASCA INC	1,538,461	$6,631	1.3%	$6.78	0.0%	COM	29479A108
—	INTERCEPT PHARMACEUTICALS IN	528,850	$6,542	1.3%	$12.68	—	COM	45845P108
ABOS	ACUMEN PHARMACEUTICALS INC	1,116,581	$6,030	1.2%	$4.79	+40.3%	COM	00509G209
—	MIRATI THERAPEUTICS INC	133,000	$6,026	1.2%	$45.31	—	COM	60468T105
—	VERVE THERAPEUTICS INC	300,000	$5,805	1.1%	$19.35	—	COM	92539P101
—	ALBIREO PHARMA INC	267,283	$5,776	1.1%	$21.61	—	COM	01345P106
LRMR	LARIMAR THERAPEUTICS INC	1,273,635	$5,260	1.0%	$2.60	+31.1%	COM	517125100
URGN	UROGEN PHARMA LTD	560,000	$4,967	1.0%	$15.60	-39.3%	COM	M96088105
—	PRECISION BIOSCIENCES INC	3,801,305	$4,524	0.9%	$1.48	—	COM	74019P108
—	GRACELL BIOTECHNOLOGIES INC	1,962,399	$4,514	0.9%	$2.51	—	SPONSORED ADS	38406L103
—	GENERATION BIO CO	1,022,537	$4,019	0.8%	$5.04	—	COM	37148K100
EOLS	EVOLUS INC	190,329	$1,429	0.3%	$7.74	0.0%	COM	30052C107
ALKS	ALKERMES PLC	46,185	$1,207	0.2%	$27.94	-14.4%	SHS	G01767105
IMUX	IMMUNIC INC	632,184	$885	0.2%	$2.73	0.0%	COM	4525EP101
ANAB	ANAPTYSBIO INC	15,000	$465	0.1%	$28.24	0.0%	COM	032724106