GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q2 2022 (← Previous) (Next →)

Filing Date: Aug 15, 2022

Total Value ($000): $416,964 (100.0% shares, 0.0% debt)

Holdings (35)

XENE XENON PHARMACEUTICALS INC 8.1%

Value ($000) $33,594 Shares 1,104,334 Est. Cost $22.27 Unrealized +35.8%

JAZZ JAZZ PHARMACEUTICALS PLC 7.1%

Value ($000) $29,642 Shares 190,000 Est. Cost $146.74 Unrealized +4.9%

CYTK CYTOKINETICS INC 5.7%

Value ($000) $23,967 Shares 610,000 Est. Cost $32.25 Unrealized +24.8%

TVTX TRAVERE THERAPEUTICS INC 5.6%

Value ($000) $23,533 Shares 971,233 Est. Cost $25.28 Unrealized -0.5%

ALNY ALNYLAM PHARMACEUTICALS INC 5.2%

Value ($000) $21,878 Shares 150,000 Est. Cost — Unrealized —

PCVX VAXCYTE INC 5.1%

Value ($000) $21,437 Shares 985,153 Est. Cost $22.79 Unrealized +1.5%

GLPG GALAPAGOS NV 4.8%

Value ($000) $20,088 Shares 360,000 Est. Cost $56.28 Unrealized —

— KARUNA THERAPEUTICS INC 4.5%

Value ($000) $18,850 Shares 149,000 Est. Cost $126.51 Unrealized —

— POINT BIOPHARMA GLOBAL INC 4.0%

Value ($000) $16,484 Shares 2,420,501 Est. Cost $7.61 Unrealized —

ACRS ACLARIS THERAPEUTICS INC 3.6%

Value ($000) $15,119 Shares 1,083,000 Est. Cost $15.21 Unrealized -7.9%

KALV KALVISTA PHARMACEUTICALS INC 3.6%

Value ($000) $15,055 Shares 1,530,000 Est. Cost $13.36 Unrealized -17.4%

SRPT SAREPTA THERAPEUTICS INC 3.5%

Value ($000) $14,535 Shares 193,900 Est. Cost $73.57 Unrealized 0.0%

RLMD RELMADA THERAPEUTICS INC 3.2%

Value ($000) $13,293 Shares 700,000 Est. Cost $22.09 Unrealized -1.3%

— CINCOR PHARMA INC 3.0%

Value ($000) $12,608 Shares 669,200 Est. Cost $18.68 Unrealized —

— NEKTAR THERAPEUTICS 2.9%

Value ($000) $11,970 Shares 3,150,000 Est. Cost $3.80 Unrealized —

— KINIKSA PHARMACEUTICALS LTD 2.8%

Value ($000) $11,667 Shares 1,204,028 Est. Cost $10.59 Unrealized —

— TRICIDA INC 2.7%

Value ($000) $11,275 Shares 1,164,763 Est. Cost $4.49 Unrealized —

ALKS ALKERMES PLC 2.6%

Value ($000) $10,773 Shares 361,636 Est. Cost $28.72 Unrealized 0.0%

— PRECISION BIOSCIENCES INC 2.2%

Value ($000) $9,209 Shares 5,755,396 Est. Cost $1.60 Unrealized —

ANAB ANAPTYSBIO INC 2.2%

Value ($000) $9,198 Shares 453,118 Est. Cost $25.71 Unrealized -13.9%

NBIX NEUROCRINE BIOSCIENCES INC 1.8%

Value ($000) $7,311 Shares 75,000 Est. Cost $92.29 Unrealized 0.0%

RNAM AVIDITY BIOSCIENCES INC 1.7%

Value ($000) $7,265 Shares 500,000 Est. Cost $23.88 Unrealized -37.7%

URGN UROGEN PHARMA LTD 1.7%

Value ($000) $7,153 Shares 873,424 Est. Cost $15.60 Unrealized -56.0%

ABOS ACUMEN PHARMACEUTICALS INC 1.7%

Value ($000) $7,121 Shares 1,515,000 Est. Cost $4.79 Unrealized -21.5%

— KARUNA THERAPEUTICS INC 1.7%

Value ($000) $6,945 Shares 54,900 Est. Cost $126.51 Unrealized —

— CHINOOK THERAPEUTICS INC 1.4%

Value ($000) $5,889 Shares 336,731 Est. Cost $16.35 Unrealized —

VTYX VENTYX BIOSCIENCES INC 1.1%

Value ($000) $4,760 Shares 389,223 Est. Cost $13.58 Unrealized +10.1%

SLN SILENCE THERAPEUTICS PLC 1.1%

Value ($000) $4,757 Shares 401,449 Est. Cost $23.89 Unrealized —

— PIERIS PHARMACEUTICALS INC 1.1%

Value ($000) $4,698 Shares 2,512,500 Est. Cost $3.35 Unrealized —

— ALPINE IMMUNE SCIENCES INC 1.1%

Value ($000) $4,585 Shares 538,819 Est. Cost $8.51 Unrealized —

— 89BIO INC 1.1%

Value ($000) $4,508 Shares 1,400,000 Est. Cost $3.22 Unrealized —

PLRX PLIANT THERAPEUTICS INC 0.7%

Value ($000) $2,862 Shares 357,263 Est. Cost $6.40 Unrealized 0.0%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 0.5%

Value ($000) $2,268 Shares 432,000 Est. Cost $6.29 Unrealized 0.0%

— MAGENTA THERAPEUTICS INC 0.3%

Value ($000) $1,404 Shares 1,170,000 Est. Cost $9.65 Unrealized —

— AEGLEA BIOTHERAPEUTICS INC 0.3%

Value ($000) $1,263 Shares 2,500,000 Est. Cost $0.51 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
XENE	XENON PHARMACEUTICALS INC	1,104,334	$33,594	8.1%	$22.27	+35.8%	COM	98420N105
JAZZ	JAZZ PHARMACEUTICALS PLC	190,000	$29,642	7.1%	$146.74	+4.9%	SHS USD	G50871105
CYTK	CYTOKINETICS INC	610,000	$23,967	5.7%	$32.25	+24.8%	COM NEW	23282W605
TVTX	TRAVERE THERAPEUTICS INC	971,233	$23,533	5.6%	$25.28	-0.5%	COM	89422G107
ALNY	ALNYLAM PHARMACEUTICALS INC	150,000	$21,878	5.2%	—	—	Put	02043Q107
PCVX	VAXCYTE INC	985,153	$21,437	5.1%	$22.79	+1.5%	COM	92243G108
GLPG	GALAPAGOS NV	360,000	$20,088	4.8%	$56.28	—	SPON ADR	36315X101
—	KARUNA THERAPEUTICS INC	149,000	$18,850	4.5%	$126.51	—	COM	48576A100
—	POINT BIOPHARMA GLOBAL INC	2,420,501	$16,484	4.0%	$7.61	—	COM	730541109
ACRS	ACLARIS THERAPEUTICS INC	1,083,000	$15,119	3.6%	$15.21	-7.9%	COM	00461U105
KALV	KALVISTA PHARMACEUTICALS INC	1,530,000	$15,055	3.6%	$13.36	-17.4%	COM	483497103
SRPT	SAREPTA THERAPEUTICS INC	193,900	$14,535	3.5%	$73.57	0.0%	COM	803607100
RLMD	RELMADA THERAPEUTICS INC	700,000	$13,293	3.2%	$22.09	-1.3%	COM	75955J402
—	CINCOR PHARMA INC	669,200	$12,608	3.0%	$18.68	—	COM	17240Y109
—	NEKTAR THERAPEUTICS	3,150,000	$11,970	2.9%	$3.80	—	COM	640268108
—	KINIKSA PHARMACEUTICALS LTD	1,204,028	$11,667	2.8%	$10.59	—	COM CL A	G5269C101
—	TRICIDA INC	1,164,763	$11,275	2.7%	$4.49	—	COM	89610F101
ALKS	ALKERMES PLC	361,636	$10,773	2.6%	$28.72	0.0%	SHS	G01767105
—	PRECISION BIOSCIENCES INC	5,755,396	$9,209	2.2%	$1.60	—	COM	74019P108
ANAB	ANAPTYSBIO INC	453,118	$9,198	2.2%	$25.71	-13.9%	COM	032724106
NBIX	NEUROCRINE BIOSCIENCES INC	75,000	$7,311	1.8%	$92.29	0.0%	COM	64125C109
RNAM	AVIDITY BIOSCIENCES INC	500,000	$7,265	1.7%	$23.88	-37.7%	COM	05370A108
URGN	UROGEN PHARMA LTD	873,424	$7,153	1.7%	$15.60	-56.0%	COM	M96088105
ABOS	ACUMEN PHARMACEUTICALS INC	1,515,000	$7,121	1.7%	$4.79	-21.5%	COM	00509G209
—	KARUNA THERAPEUTICS INC	54,900	$6,945	1.7%	$126.51	—	Put	48576A100
—	CHINOOK THERAPEUTICS INC	336,731	$5,889	1.4%	$16.35	—	COM	16961L106
VTYX	VENTYX BIOSCIENCES INC	389,223	$4,760	1.1%	$13.58	+10.1%	COM	92332V107
SLN	SILENCE THERAPEUTICS PLC	401,449	$4,757	1.1%	$23.89	—	ADS	82686Q101
—	PIERIS PHARMACEUTICALS INC	2,512,500	$4,698	1.1%	$3.35	—	COM	720795103
—	ALPINE IMMUNE SCIENCES INC	538,819	$4,585	1.1%	$8.51	—	COM	02083G100
—	89BIO INC	1,400,000	$4,508	1.1%	$3.22	—	COM	282559103
PLRX	PLIANT THERAPEUTICS INC	357,263	$2,862	0.7%	$6.40	0.0%	COM	729139105
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	432,000	$2,268	0.5%	$6.29	0.0%	CLASS A ORD	61559X104
—	MAGENTA THERAPEUTICS INC	1,170,000	$1,404	0.3%	$9.65	—	COM	55910K108
—	AEGLEA BIOTHERAPEUTICS INC	2,500,000	$1,263	0.3%	$0.51	—	COM	00773J103