GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q2 2023 (← Previous) (Next →)

Filing Date: Aug 14, 2023

Total Value ($000): $510,830 (100.0% shares, 0.0% debt)

Holdings (40)

— ALPINE IMMUNE SCIENCES INC 6.8%

Value ($000) $34,579 Shares 3,363,688 Est. Cost $7.41 Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL IN 6.1%

Value ($000) $31,250 Shares 677,426 Est. Cost $41.10 Unrealized +12.9%

PCVX VAXCYTE INC 5.8%

Value ($000) $29,425 Shares 589,211 Est. Cost $26.90 Unrealized +76.2%

PLRX PLIANT THERAPEUTICS INC 5.5%

Value ($000) $28,089 Shares 1,550,184 Est. Cost $17.73 Unrealized +33.5%

— RAPT THERAPEUTICS INC 5.4%

Value ($000) $27,398 Shares 1,465,151 Est. Cost $20.58 Unrealized —

— POINT BIOPHARMA GLOBAL INC 5.3%

Value ($000) $27,180 Shares 3,000,000 Est. Cost $7.55 Unrealized —

ZURA ZURA BIO LTD 5.3%

Value ($000) $27,019 Shares 3,295,000 Est. Cost $8.03 Unrealized 0.0%

AMLX AMYLYX PHARMACEUTICALS INC 4.1%

Value ($000) $20,897 Shares 968,795 Est. Cost $33.41 Unrealized -19.2%

XENE XENON PHARMACEUTICALS INC 4.0%

Value ($000) $20,405 Shares 530,000 Est. Cost $22.27 Unrealized +78.5%

ACRS ACLARIS THERAPEUTICS INC 3.9%

Value ($000) $20,134 Shares 1,941,581 Est. Cost $12.61 Unrealized -28.2%

CYTK CYTOKINETICS INC 3.8%

Value ($000) $19,572 Shares 600,000 Est. Cost $40.16 Unrealized -7.9%

ANAB ANAPTYSBIO INC 3.6%

Value ($000) $18,191 Shares 894,333 Est. Cost $23.96 Unrealized -15.4%

IMCR IMMUNOCORE HLDGS PLC 3.5%

Value ($000) $17,813 Shares 297,082 Est. Cost $50.92 Unrealized —

EOLS EVOLUS INC 3.5%

Value ($000) $17,696 Shares 2,434,048 Est. Cost $8.90 Unrealized -3.1%

— AEROVATE THERAPEUTICS INC 3.1%

Value ($000) $15,987 Shares 932,158 Est. Cost $23.31 Unrealized —

SRPT SAREPTA THERAPEUTICS INC 2.8%

Value ($000) $14,155 Shares 123,600 Est. Cost $128.81 Unrealized 0.0%

ALKS ALKERMES PLC 2.5%

Value ($000) $12,878 Shares 411,453 Est. Cost $30.28 Unrealized 0.0%

RYTM RHYTHM PHARMACEUTICALS INC 2.5%

Value ($000) $12,730 Shares 772,000 Est. Cost $18.94 Unrealized -4.7%

— OPTINOSE INC 2.1%

Value ($000) $10,873 Shares 8,839,939 Est. Cost $1.78 Unrealized —

VKTX VIKING THERAPEUTICS INC 1.9%

Value ($000) $9,702 Shares 598,550 Est. Cost $4.46 Unrealized +369.3%

MLYS MINERALYS THERAPEUTICS INC 1.8%

Value ($000) $9,310 Shares 546,059 Est. Cost $16.83 Unrealized -11.2%

FOLD AMICUS THERAPEUTICS INC 1.7%

Value ($000) $8,809 Shares 701,392 Est. Cost $12.12 Unrealized -2.1%

— GRACELL BIOTECHNOLOGIES INC 1.7%

Value ($000) $8,641 Shares 2,268,057 Est. Cost $2.26 Unrealized —

APLS APELLIS PHARMACEUTICALS INC 1.7%

Value ($000) $8,627 Shares 94,700 Est. Cost — Unrealized —

— RENEO PHARMACEUTICALS INC 1.4%

Value ($000) $7,107 Shares 1,083,317 Est. Cost $6.50 Unrealized —

— INTERCEPT PHARMACEUTICALS IN 1.3%

Value ($000) $6,651 Shares 601,322 Est. Cost $11.06 Unrealized —

FDMT 4D MOLECULAR THERAPEUTICS IN 1.2%

Value ($000) $6,325 Shares 350,000 Est. Cost $18.41 Unrealized 0.0%

— GENERATION BIO CO 1.1%

Value ($000) $5,624 Shares 1,022,537 Est. Cost $5.04 Unrealized —

HRTX HERON THERAPEUTICS INC 1.1%

Value ($000) $5,495 Shares 4,737,368 Est. Cost $3.84 Unrealized -53.5%

ABOS ACUMEN PHARMACEUTICALS INC 1.0%

Value ($000) $5,057 Shares 1,051,267 Est. Cost $4.79 Unrealized -0.0%

— IGM BIOSCIENCES INC 0.9%

Value ($000) $4,615 Shares 500,000 Est. Cost $9.23 Unrealized —

— SERES THERAPEUTICS INC 0.9%

Value ($000) $4,493 Shares 938,067 Est. Cost $4.79 Unrealized —

— PRECISION BIOSCIENCES INC 0.8%

Value ($000) $3,929 Shares 7,469,736 Est. Cost $1.10 Unrealized —

SLDB SOLID BIOSCIENCES INC 0.6%

Value ($000) $3,063 Shares 584,458 Est. Cost $5.77 Unrealized -2.4%

ACRS ACLARIS THERAPEUTICS INC 0.5%

Value ($000) $2,644 Shares 255,000 Est. Cost $12.61 Unrealized -28.2%

— TALARIS THERAPEUTICS INC 0.4%

Value ($000) $2,025 Shares 666,033 Est. Cost $3.04 Unrealized —

ACLX ARCELLX INC 0.2%

Value ($000) $1,186 Shares 37,500 Est. Cost $30.34 Unrealized +26.0%

TVTX TRAVERE THERAPEUTICS INC 0.2%

Value ($000) $922 Shares 60,000 Est. Cost $23.16 Unrealized -21.5%

— MERSANA THERAPEUTICS INC 0.0%

Value ($000) $230 Shares 70,000 Est. Cost — Unrealized —

XENE XENON PHARMACEUTICALS INC 0.0%

Value ($000) $104 Shares 2,700 Est. Cost $22.27 Unrealized +78.5%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	ALPINE IMMUNE SCIENCES INC	3,363,688	$34,579	6.8%	$7.41	—	COM	02083G100
RARE	ULTRAGENYX PHARMACEUTICAL IN	677,426	$31,250	6.1%	$41.10	+12.9%	COM	90400D108
PCVX	VAXCYTE INC	589,211	$29,425	5.8%	$26.90	+76.2%	COM	92243G108
PLRX	PLIANT THERAPEUTICS INC	1,550,184	$28,089	5.5%	$17.73	+33.5%	COM	729139105
—	RAPT THERAPEUTICS INC	1,465,151	$27,398	5.4%	$20.58	—	COM	75382E109
—	POINT BIOPHARMA GLOBAL INC	3,000,000	$27,180	5.3%	$7.55	—	COM	730541109
ZURA	ZURA BIO LTD	3,295,000	$27,019	5.3%	$8.03	0.0%	CLASS A ORD SHS	G9TY5A101
AMLX	AMYLYX PHARMACEUTICALS INC	968,795	$20,897	4.1%	$33.41	-19.2%	COM	03237H101
XENE	XENON PHARMACEUTICALS INC	530,000	$20,405	4.0%	$22.27	+78.5%	COM	98420N105
ACRS	ACLARIS THERAPEUTICS INC	1,941,581	$20,134	3.9%	$12.61	-28.2%	COM	00461U105
CYTK	CYTOKINETICS INC	600,000	$19,572	3.8%	$40.16	-7.9%	COM NEW	23282W605
ANAB	ANAPTYSBIO INC	894,333	$18,191	3.6%	$23.96	-15.4%	COM	032724106
IMCR	IMMUNOCORE HLDGS PLC	297,082	$17,813	3.5%	$50.92	—	ADS	45258D105
EOLS	EVOLUS INC	2,434,048	$17,696	3.5%	$8.90	-3.1%	COM	30052C107
—	AEROVATE THERAPEUTICS INC	932,158	$15,987	3.1%	$23.31	—	COM	008064107
SRPT	SAREPTA THERAPEUTICS INC	123,600	$14,155	2.8%	$128.81	0.0%	COM	803607100
ALKS	ALKERMES PLC	411,453	$12,878	2.5%	$30.28	0.0%	SHS	G01767105
RYTM	RHYTHM PHARMACEUTICALS INC	772,000	$12,730	2.5%	$18.94	-4.7%	COM	76243J105
—	OPTINOSE INC	8,839,939	$10,873	2.1%	$1.78	—	COM	68404V100
VKTX	VIKING THERAPEUTICS INC	598,550	$9,702	1.9%	$4.46	+369.3%	COM	92686J106
MLYS	MINERALYS THERAPEUTICS INC	546,059	$9,310	1.8%	$16.83	-11.2%	COM	603170101
FOLD	AMICUS THERAPEUTICS INC	701,392	$8,809	1.7%	$12.12	-2.1%	COM	03152W109
—	GRACELL BIOTECHNOLOGIES INC	2,268,057	$8,641	1.7%	$2.26	—	SPONSORED ADS	38406L103
APLS	APELLIS PHARMACEUTICALS INC	94,700	$8,627	1.7%	—	—	Put	03753U106
—	RENEO PHARMACEUTICALS INC	1,083,317	$7,107	1.4%	$6.50	—	COM	75974E103
—	INTERCEPT PHARMACEUTICALS IN	601,322	$6,651	1.3%	$11.06	—	COM	45845P108
FDMT	4D MOLECULAR THERAPEUTICS IN	350,000	$6,325	1.2%	$18.41	0.0%	COM	35104E100
—	GENERATION BIO CO	1,022,537	$5,624	1.1%	$5.04	—	COM	37148K100
HRTX	HERON THERAPEUTICS INC	4,737,368	$5,495	1.1%	$3.84	-53.5%	COM	427746102
ABOS	ACUMEN PHARMACEUTICALS INC	1,051,267	$5,057	1.0%	$4.79	-0.0%	COM	00509G209
—	IGM BIOSCIENCES INC	500,000	$4,615	0.9%	$9.23	—	COM	449585108
—	SERES THERAPEUTICS INC	938,067	$4,493	0.9%	$4.79	—	COM	81750R102
—	PRECISION BIOSCIENCES INC	7,469,736	$3,929	0.8%	$1.10	—	COM	74019P108
SLDB	SOLID BIOSCIENCES INC	584,458	$3,063	0.6%	$5.77	-2.4%	COM NEW	83422E204
ACRS	ACLARIS THERAPEUTICS INC	255,000	$2,644	0.5%	$12.61	-28.2%	Put	00461U105
—	TALARIS THERAPEUTICS INC	666,033	$2,025	0.4%	$3.04	—	COM	87410C104
ACLX	ARCELLX INC	37,500	$1,186	0.2%	$30.34	+26.0%	COMMON STOCK	03940C100
TVTX	TRAVERE THERAPEUTICS INC	60,000	$922	0.2%	$23.16	-21.5%	COM	89422G107
—	MERSANA THERAPEUTICS INC	70,000	$230	0.0%	—	—	Call	59045L106
XENE	XENON PHARMACEUTICALS INC	2,700	$104	0.0%	$22.27	+78.5%	Put	98420N105