GREAT POINT PARTNERS LLC Quant / Systematic

Location: Greenwich, CT

CIK: 0001281446 · Show all filings

Period: Q3 2023 (← Previous) (Next →)

Filing Date: Nov 14, 2023

Total Value: $549M (100.0% shares, 0.0% debt)

Holdings (42)

URGN UROGEN PHARMA LTD 6.7%

Value $36.71M Shares 2,620,545 Est. Cost $16.05 Unrealized 0.0%

— ALPINE IMMUNE SCIENCES INC 6.4%

Value $35.25M Shares 3,078,633 Est. Cost $7.41 Unrealized —

PLRX PLIANT THERAPEUTICS INC 5.5%

Value $30.43M Shares 1,755,184 Est. Cost $17.68 Unrealized -2.0%

PCVX VAXCYTE INC 4.9%

Value $27.08M Shares 531,211 Est. Cost $26.90 Unrealized +83.4%

RARE ULTRAGENYX PHARMACEUTICAL IN 4.7%

Value $25.93M Shares 727,426 Est. Cost $41.00 Unrealized -3.4%

ALKS ALKERMES PLC 4.5%

Value $24.51M Shares 875,044 Est. Cost $29.77 Unrealized -1.5%

— RAPT THERAPEUTICS INC 4.4%

Value $24.23M Shares 1,458,070 Est. Cost $20.58 Unrealized —

ZURA ZURA BIO LTD 4.0%

Value $21.75M Shares 3,295,000 Est. Cost $8.03 Unrealized -16.8%

SRPT SAREPTA THERAPEUTICS INC 3.6%

Value $20.03M Shares 165,200 Est. Cost $124.83 Unrealized -9.5%

EOLS EVOLUS INC 3.6%

Value $19.99M Shares 2,186,934 Est. Cost $8.90 Unrealized +0.8%

— POINT BIOPHARMA GLOBAL INC 3.5%

Value $19.41M Shares 2,909,960 Est. Cost $7.55 Unrealized —

CYTK CYTOKINETICS INC 3.2%

Value $17.68M Shares 600,000 Est. Cost $40.16 Unrealized -17.1%

XENE XENON PHARMACEUTICALS INC 3.1%

Value $17.08M Shares 500,001 Est. Cost $22.27 Unrealized +68.0%

ANAB ANAPTYSBIO INC 2.9%

Value $16.06M Shares 894,333 Est. Cost $23.96 Unrealized -20.4%

IMCR IMMUNOCORE HLDGS PLC 2.8%

Value $15.1M Shares 290,917 Est. Cost $50.92 Unrealized —

— AEROVATE THERAPEUTICS INC 2.7%

Value $14.81M Shares 1,091,233 Est. Cost $21.89 Unrealized —

— INTRA-CELLULAR THERAPIES INC 2.1%

Value $11.72M Shares 225,000 Est. Cost $52.09 Unrealized —

ACRS ACLARIS THERAPEUTICS INC 2.1%

Value $11.59M Shares 1,691,768 Est. Cost $12.61 Unrealized -32.2%

SRPT SAREPTA THERAPEUTICS INC 2.1%

Value $11.52M Shares 95,000 Est. Cost $124.83 Unrealized -9.5%

PTCT PTC THERAPEUTICS INC 2.0%

Value $11.21M Shares 500,000 Est. Cost $37.19 Unrealized 0.0%

REPL REPLIMUNE GROUP INC 2.0%

Value $10.92M Shares 638,495 Est. Cost $19.64 Unrealized 0.0%

— OPTINOSE INC 2.0%

Value $10.87M Shares 8,839,939 Est. Cost $1.78 Unrealized —

FOLD AMICUS THERAPEUTICS INC 1.9%

Value $10.42M Shares 857,000 Est. Cost $12.26 Unrealized +5.2%

ACLX ARCELLX INC 1.9%

Value $10.32M Shares 287,500 Est. Cost $33.94 Unrealized +1.6%

— KARUNA THERAPEUTICS INC 1.9%

Value $10.23M Shares 60,500 Est. Cost $169.09 Unrealized —

— AKERO THERAPEUTICS INC 1.8%

Value $10.04M Shares 198,500 Est. Cost $50.58 Unrealized —

INSM INSMED INC 1.8%

Value $9.971M Shares 394,872 Est. Cost $22.87 Unrealized 0.0%

— RENEO PHARMACEUTICALS INC 1.6%

Value $8.887M Shares 1,167,061 Est. Cost $6.58 Unrealized —

APGE APOGEE THERAPEUTICS INC 1.6%

Value $8.52M Shares 400,000 Est. Cost $22.03 Unrealized 0.0%

GOSS GOSSAMER BIO INC 0.9%

Value $5.189M Shares 6,230,272 Est. Cost $1.15 Unrealized 0.0%

— IGM BIOSCIENCES INC 0.9%

Value $5.138M Shares 615,317 Est. Cost $9.07 Unrealized —

HRTX HERON THERAPEUTICS INC 0.9%

Value $4.879M Shares 4,737,368 Est. Cost $3.84 Unrealized -62.9%

ACRS ACLARIS THERAPEUTICS INC 0.9%

Value $4.795M Shares 700,000 Est. Cost $12.61 Unrealized -32.2%

— CEREVEL THERAPEUTICS HLDNG I 0.9%

Value $4.693M Shares 215,000 Est. Cost $21.83 Unrealized —

ABOS ACUMEN PHARMACEUTICALS INC 0.8%

Value $4.458M Shares 1,074,101 Est. Cost $4.82 Unrealized +28.2%

— GENERATION BIO CO 0.7%

Value $3.875M Shares 1,022,537 Est. Cost $5.04 Unrealized —

— MIRATI THERAPEUTICS INC 0.7%

Value $3.759M Shares 86,302 Est. Cost $43.56 Unrealized —

TERN TERNS PHARMACEUTICALS INC 0.6%

Value $3.249M Shares 645,899 Est. Cost $6.35 Unrealized 0.0%

— TALARIS THERAPEUTICS INC 0.5%

Value $2.81M Shares 1,000,000 Est. Cost $2.96 Unrealized —

— GRACELL BIOTECHNOLOGIES INC 0.3%

Value $1.669M Shares 579,667 Est. Cost $2.26 Unrealized —

SLDB SOLID BIOSCIENCES INC 0.2%

Value $1.135M Shares 450,403 Est. Cost $5.77 Unrealized -32.7%

— AMBRX BIOPHARMA INC 0.2%

Value $1.124M Shares 97,700 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
URGN	UROGEN PHARMA LTD	2,620,545	$36.71M	6.7%	$16.05	0.0%	COM	M96088105
—	ALPINE IMMUNE SCIENCES INC	3,078,633	$35.25M	6.4%	$7.41	—	COM	02083G100
PLRX	PLIANT THERAPEUTICS INC	1,755,184	$30.43M	5.5%	$17.68	-2.0%	COM	729139105
PCVX	VAXCYTE INC	531,211	$27.08M	4.9%	$26.90	+83.4%	COM	92243G108
RARE	ULTRAGENYX PHARMACEUTICAL IN	727,426	$25.93M	4.7%	$41.00	-3.4%	COM	90400D108
ALKS	ALKERMES PLC	875,044	$24.51M	4.5%	$29.77	-1.5%	SHS	G01767105
—	RAPT THERAPEUTICS INC	1,458,070	$24.23M	4.4%	$20.58	—	COM	75382E109
ZURA	ZURA BIO LTD	3,295,000	$21.75M	4.0%	$8.03	-16.8%	CLASS A ORD SHS	G9TY5A101
SRPT	SAREPTA THERAPEUTICS INC	165,200	$20.03M	3.6%	$124.83	-9.5%	COM	803607100
EOLS	EVOLUS INC	2,186,934	$19.99M	3.6%	$8.90	+0.8%	COM	30052C107
—	POINT BIOPHARMA GLOBAL INC	2,909,960	$19.41M	3.5%	$7.55	—	COM	730541109
CYTK	CYTOKINETICS INC	600,000	$17.68M	3.2%	$40.16	-17.1%	COM NEW	23282W605
XENE	XENON PHARMACEUTICALS INC	500,001	$17.08M	3.1%	$22.27	+68.0%	COM	98420N105
ANAB	ANAPTYSBIO INC	894,333	$16.06M	2.9%	$23.96	-20.4%	COM	032724106
IMCR	IMMUNOCORE HLDGS PLC	290,917	$15.1M	2.8%	$50.92	—	ADS	45258D105
—	AEROVATE THERAPEUTICS INC	1,091,233	$14.81M	2.7%	$21.89	—	COM	008064107
—	INTRA-CELLULAR THERAPIES INC	225,000	$11.72M	2.1%	$52.09	—	COM	46116X101
ACRS	ACLARIS THERAPEUTICS INC	1,691,768	$11.59M	2.1%	$12.61	-32.2%	COM	00461U105
SRPT	SAREPTA THERAPEUTICS INC	95,000	$11.52M	2.1%	$124.83	-9.5%	Put	803607100
PTCT	PTC THERAPEUTICS INC	500,000	$11.21M	2.0%	$37.19	0.0%	COM	69366J200
REPL	REPLIMUNE GROUP INC	638,495	$10.92M	2.0%	$19.64	0.0%	COM	76029N106
—	OPTINOSE INC	8,839,939	$10.87M	2.0%	$1.78	—	COM	68404V100
FOLD	AMICUS THERAPEUTICS INC	857,000	$10.42M	1.9%	$12.26	+5.2%	COM	03152W109
ACLX	ARCELLX INC	287,500	$10.32M	1.9%	$33.94	+1.6%	COMMON STOCK	03940C100
—	KARUNA THERAPEUTICS INC	60,500	$10.23M	1.9%	$169.09	—	COM	48576A100
—	AKERO THERAPEUTICS INC	198,500	$10.04M	1.8%	$50.58	—	COM	00973Y108
INSM	INSMED INC	394,872	$9.971M	1.8%	$22.87	0.0%	COM PAR $.01	457669307
—	RENEO PHARMACEUTICALS INC	1,167,061	$8.887M	1.6%	$6.58	—	COM	75974E103
APGE	APOGEE THERAPEUTICS INC	400,000	$8.52M	1.6%	$22.03	0.0%	COM	03770N101
GOSS	GOSSAMER BIO INC	6,230,272	$5.189M	0.9%	$1.15	0.0%	COM	38341P102
—	IGM BIOSCIENCES INC	615,317	$5.138M	0.9%	$9.07	—	COM	449585108
HRTX	HERON THERAPEUTICS INC	4,737,368	$4.879M	0.9%	$3.84	-62.9%	COM	427746102
ACRS	ACLARIS THERAPEUTICS INC	700,000	$4.795M	0.9%	$12.61	-32.2%	Call	00461U105
—	CEREVEL THERAPEUTICS HLDNG I	215,000	$4.693M	0.9%	$21.83	—	COM	15678U128
ABOS	ACUMEN PHARMACEUTICALS INC	1,074,101	$4.458M	0.8%	$4.82	+28.2%	COM	00509G209
—	GENERATION BIO CO	1,022,537	$3.875M	0.7%	$5.04	—	COM	37148K100
—	MIRATI THERAPEUTICS INC	86,302	$3.759M	0.7%	$43.56	—	COM	60468T105
TERN	TERNS PHARMACEUTICALS INC	645,899	$3.249M	0.6%	$6.35	0.0%	COM	880881107
—	TALARIS THERAPEUTICS INC	1,000,000	$2.81M	0.5%	$2.96	—	COM	87410C104
—	GRACELL BIOTECHNOLOGIES INC	579,667	$1.669M	0.3%	$2.26	—	SPONSORED ADS	38406L103
SLDB	SOLID BIOSCIENCES INC	450,403	$1.135M	0.2%	$5.77	-32.7%	COM NEW	83422E204
—	AMBRX BIOPHARMA INC	97,700	$1.124M	0.2%	—	—	Call	02290A102