Location: Baltimore, MD
CIK: 0001595725 · Show all filings
Period: Q4 2024 (← Previous) (Next →)
Filing Date: Feb 14, 2025
Total Value: $2.627B (99.8% shares, 0.2% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| ARGX | ARGENX SE | 229,600 | $141M | 5.4% | $160.49 | — | SPONSORED ADR | 04016X101 |
| ISRG | INTUITIVE SURGICAL INC | 216,000 | $113M | 4.3% | $264.69 | +96.8% | COM NEW | 46120E602 |
| LLY | ELI LILLY & CO | 144,500 | $112M | 4.2% | $681.09 | +20.6% | COM | 532457108 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 720,500 | $98.35M | 3.7% | $78.19 | +58.2% | COM | 64125C109 |
| — | BLUEPRINT MEDICINES CORP | 1,096,899 | $95.67M | 3.6% | $70.25 | — | COM | 09627Y109 |
| UNH | UNITEDHEALTH GROUP INC | 176,000 | $89.03M | 3.4% | $279.63 | +97.7% | COM | 91324P102 |
| TVTX | TRAVERE THERAPEUTICS INC | 4,973,649 | $86.64M | 3.3% | $13.21 | +33.9% | COM | 89422G107 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 265,212 | $81.84M | 3.1% | $118.06 | +138.2% | COM | 558868105 |
| RARE | ULTRAGENYX PHARMACEUTICAL IN | 1,739,813 | $73.19M | 2.8% | $58.22 | -14.8% | COM | 90400D108 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 1,162,718 | $65.09M | 2.5% | $15.80 | +249.7% | COM | 76243J105 |
| MIRM | MIRUM PHARMACEUTICALS INC | 1,471,564 | $60.85M | 2.3% | $14.67 | +184.1% | COM | 604749101 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 256,200 | $60.29M | 2.3% | $107.54 | +144.6% | COM | 02043Q107 |
| PEN | PENUMBRA INC | 240,000 | $57M | 2.2% | $179.03 | +27.0% | COM | 70975L107 |
| WST | WEST PHARMACEUTICAL SVSC INC | 168,750 | $55.28M | 2.1% | $299.09 | +4.8% | COM | 955306105 |
| RVMD | REVOLUTION MEDICINES INC | 1,213,257 | $53.07M | 2.0% | $31.11 | +62.2% | COM | 76155X100 |
| PHR | PHREESIA INC | 2,040,000 | $51.33M | 2.0% | $25.92 | -17.6% | COM | 71944F106 |
| XENE | XENON PHARMACEUTICALS INC | 1,251,859 | $49.07M | 1.9% | $24.19 | +70.9% | COM | 98420N105 |
| FRPT | FRESHPET INC | 327,500 | $48.51M | 1.8% | $60.72 | +140.0% | COM | 358039105 |
| ASND | ASCENDIS PHARMA A/S | 305,000 | $41.99M | 1.6% | $92.14 | — | SPONSORED ADR | 04351P101 |
| KYMR | KYMERA THERAPEUTICS INC | 1,034,137 | $41.6M | 1.6% | $30.84 | +46.5% | COM | 501575104 |
| BSX | BOSTON SCIENTIFIC CORP | 460,000 | $41.09M | 1.6% | $52.45 | +67.8% | COM | 101137107 |
| EW | EDWARDS LIFESCIENCES CORP | 545,000 | $40.35M | 1.5% | $63.05 | +11.0% | COM | 28176E108 |
| INSM | INSMED INC | 550,000 | $37.97M | 1.4% | $38.78 | +85.7% | COM PAR $.01 | 457669307 |
| — | MERUS N V | 892,549 | $37.53M | 1.4% | $29.98 | — | COM | N5749R100 |
| SRPT | SAREPTA THERAPEUTICS INC | 307,500 | $37.39M | 1.4% | $68.51 | +78.9% | COM | 803607100 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 397,500 | $35.84M | 1.4% | $74.37 | +5.7% | COM | 450056106 |
| ZLAB | ZAI LAB LTD | 1,305,337 | $34.19M | 1.3% | $51.35 | — | ADR | 98887Q104 |
| NUVL | NUVALENT INC | 429,994 | $33.66M | 1.3% | $78.38 | +19.2% | COM | 670703107 |
| MREO | MEREO BIOPHARMA GROUP PLC | 9,599,170 | $33.6M | 1.3% | $2.75 | — | SPON ADS | 589492107 |
| SRRK | SCHOLAR ROCK HLDG CORP | 716,782 | $30.98M | 1.2% | $32.56 | 0.0% | COM | 80706P103 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 1,222,182 | $30.88M | 1.2% | $32.64 | -16.8% | COM NEW | 15117B202 |
| PODD | INSULET CORP | 114,250 | $29.83M | 1.1% | $183.83 | +37.0% | COM | 45784P101 |
| GPCR | STRUCTURE THERAPEUTICS INC | 1,080,963 | $29.32M | 1.1% | $40.17 | — | SPONSORED ADS | 86366E106 |
| DXCM | DEXCOM INC | 353,000 | $27.45M | 1.0% | $96.66 | -23.4% | COM | 252131107 |
| — | AKERO THERAPEUTICS INC | 946,499 | $26.33M | 1.0% | $29.53 | — | COM | 00973Y108 |
| EXAS | EXACT SCIENCES CORP | 450,000 | $25.29M | 1.0% | $54.63 | +13.9% | COM | 30063P105 |
| FOLD | AMICUS THERAPEUTICS INC | 2,599,425 | $24.49M | 0.9% | $10.92 | -4.8% | COM | 03152W109 |
| INSP | INSPIRE MED SYS INC | 130,000 | $24.1M | 0.9% | $200.97 | -3.4% | COM | 457730109 |
| AZTA | AZENTA INC | 475,000 | $23.75M | 0.9% | $61.73 | -26.2% | COM | 114340102 |
| EVH | EVOLENT HEALTH INC | 2,060,000 | $23.18M | 0.9% | $25.07 | -29.9% | CL A | 30050B101 |
| ACHC | ACADIA HEALTHCARE COMPANY IN | 583,500 | $23.14M | 0.9% | $57.08 | -21.0% | COM | 00404A109 |
| IMVT | IMMUNOVANT INC | 909,103 | $22.52M | 0.9% | $28.81 | -1.5% | COM | 45258J102 |
| WRBY | WARBY PARKER INC | 920,000 | $22.27M | 0.8% | $29.52 | -30.8% | CL A COM | 93403J106 |
| VERA | VERA THERAPEUTICS INC | 487,863 | $20.63M | 0.8% | $37.82 | +17.1% | CL A | 92337R101 |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 2,677,996 | $20.14M | 0.8% | $9.01 | -15.7% | COM | 09058V103 |
| NAMS | NEWAMSTERDAM PHARMA COMPANY | 767,522 | $19.73M | 0.8% | $19.43 | +9.3% | ORDINARY SHARES | N62509109 |
| SMMT | SUMMIT THERAPEUTICS INC | 1,054,000 | $18.81M | 0.7% | $14.06 | +37.9% | COM | 86627T108 |
| LFST | LIFESTANCE HEALTH GROUP INC | 2,550,000 | $18.79M | 0.7% | $13.69 | -47.6% | COM | 53228F101 |
| LEGN | LEGEND BIOTECH CORP | 512,132 | $16.66M | 0.6% | $41.82 | — | SPONSORED ADS | 52490G102 |
| THC | TENET HEALTHCARE CORP | 129,200 | $16.31M | 0.6% | $148.69 | 0.0% | COM NEW | 88033G407 |
| AGIO | AGIOS PHARMACEUTICALS INC | 471,086 | $15.48M | 0.6% | $40.40 | +16.3% | COM | 00847X104 |
| ACRS | ACLARIS THERAPEUTICS INC | 6,204,309 | $15.39M | 0.6% | $6.19 | -59.8% | COM | 00461U105 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 294,100 | $15.04M | 0.6% | $39.40 | +42.0% | COM | 22663K107 |
| PHVS | PHARVARIS N V | 775,131 | $14.86M | 0.6% | $26.42 | -22.1% | COM | N69605108 |
| AGL | AGILON HEALTH INC | 7,463,300 | $14.18M | 0.5% | $31.45 | -92.3% | COM | 00857U107 |
| OSCR | OSCAR HEALTH INC | 1,050,000 | $14.11M | 0.5% | $11.50 | +39.9% | CL A | 687793109 |
| — | SPRINGWORKS THERAPEUTICS INC | 328,911 | $11.88M | 0.5% | $37.07 | — | COM | 85205L107 |
| DYN | DYNE THERAPEUTICS INC | 474,528 | $11.18M | 0.4% | $22.94 | +28.9% | COM | 26818M108 |
| JANX | JANUX THERAPEUTICS INC | 204,466 | $10.95M | 0.4% | $52.89 | 0.0% | COM | 47103J105 |
| — | INOZYME PHARMA INC | 3,861,983 | $10.7M | 0.4% | $9.07 | — | COM | 45790W108 |
| NMRA | NEUMORA THERAPEUTICS INC. | 955,106 | $10.12M | 0.4% | $14.60 | -17.9% | COM | 640979100 |
| JSPR | JASPER THERAPEUTICS INC | 463,088 | $9.901M | 0.4% | $18.02 | +15.5% | COM NEW | 471871202 |
| ELVN | ENLIVEN THERAPEUTICS INC | 428,571 | $9.643M | 0.4% | $15.34 | +69.0% | COM | 29337E102 |
| XNCR | XENCOR INC | 401,013 | $9.215M | 0.4% | $18.77 | +22.4% | COM | 98401F105 |
| CGEM | CULLINAN THERAPEUTICS INC | 742,114 | $9.039M | 0.3% | $20.91 | -31.3% | COM | 230031106 |
| PRTA | PROTHENA CORP PLC | 644,601 | $8.928M | 0.3% | $17.57 | -10.2% | SHS | G72800108 |
| CMPX | COMPASS THERAPEUTICS INC | 5,779,575 | $8.38M | 0.3% | $3.23 | -48.5% | COM | 20454B104 |
| BCAX | BICARA THERAPEUTICS INC | 445,975 | $7.769M | 0.3% | $25.50 | -18.4% | COM | 055477103 |
| ARDX | ARDELYX INC | 1,463,629 | $7.421M | 0.3% | $5.52 | 0.0% | COM | 039697107 |
| ZBIO | ZENAS BIOPHARMA INC | 878,667 | $7.196M | 0.3% | $17.98 | -13.2% | COM | 98937L105 |
| BEAM | BEAM THERAPEUTICS INC | 252,223 | $6.255M | 0.2% | $32.29 | -21.0% | COM | 07373V105 |
| TARS | TARSUS PHARMACEUTICALS INC | 110,889 | $6.14M | 0.2% | $45.42 | 0.0% | COM | 87650L103 |
| — | NEVRO CORP | 1,648,100 | $6.131M | 0.2% | $49.31 | — | COM | 64157F103 |
| SLNO | SOLENO THERAPEUTICS INC | 124,095 | $5.578M | 0.2% | $51.81 | 0.0% | COM | 834203309 |
| PLRX | PLIANT THERAPEUTICS INC | 404,796 | $5.331M | 0.2% | $27.75 | -50.8% | COM | 729139105 |
| LUNG | PULMONX CORP | 772,151 | $5.243M | 0.2% | $39.33 | -83.3% | COM | 745848101 |
| NVAX | NOVAVAX INC | 650,000 | $5.226M | 0.2% | $31.79 | -69.7% | COM NEW | 670002401 |
| — | GOSSAMER BIO INC | 9,573,000 | $5.07M | 0.2% | $1.01 | — | NOTE 5.000% 6/0 | 38341PAA0 |
| — | MERSANA THERAPEUTICS INC | 3,431,684 | $4.907M | 0.2% | $11.74 | — | COM | 59045L106 |
| BHVN | BIOHAVEN LTD | 129,858 | $4.85M | 0.2% | $49.46 | -5.7% | COM | G1110E107 |
| — | 89BIO INC | 552,741 | $4.322M | 0.2% | $7.82 | — | COM | 282559103 |
| CYPH | LEAP THERAPEUTICS INC | 1,266,546 | $3.641M | 0.1% | $4.22 | -29.6% | COM NEW | 52187K200 |
| SGMT | SAGIMET BIOSCIENCES INC | 787,808 | $3.545M | 0.1% | $12.87 | -60.6% | COM SER A | 786700104 |
| EDAP | EDAP TMS S A | 1,591,800 | $3.518M | 0.1% | $7.23 | — | SPONSORED ADR | 268311107 |
| MGNX | MACROGENICS INC | 1,053,647 | $3.424M | 0.1% | $16.70 | -78.4% | COM | 556099109 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 1,838,916 | $3.163M | 0.1% | $6.18 | -61.0% | COM | 00509G209 |
| GOSS | GOSSAMER BIO INC | 3,266,960 | $2.955M | 0.1% | $2.62 | -67.3% | COM | 38341P102 |
| XLO | XILIO THERAPEUTICS INC | 3,003,259 | $2.868M | 0.1% | $7.63 | -87.1% | COM | 98422T100 |
| APLS | APELLIS PHARMACEUTICALS INC | 80,000 | $2.553M | 0.1% | $45.29 | -33.6% | COM | 03753U106 |
| AUTL | AUTOLUS THERAPEUTICS PLC | 1,032,988 | $2.428M | 0.1% | $6.38 | — | SPON ADS | 05280R100 |
| NGNE | NEUROGENE INC | 95,407 | $2.181M | 0.1% | $37.21 | 0.0% | COM | 64135M105 |
| ATEC | ALPHATEC HLDGS INC | 200,000 | $1.836M | 0.1% | $7.98 | 0.0% | COM NEW | 02081G201 |
| — | APPLIED THERAPEUTICS INC | 1,917,191 | $1.641M | 0.1% | $13.35 | — | COM | 03828A101 |
| CGEN | COMPUGEN LTD | 989,990 | $1.515M | 0.1% | $6.12 | -73.4% | ORD | M25722105 |
| CATX | PERSPECTIVE THERAPEUTICS INC | 444,383 | $1.418M | 0.1% | $14.00 | -41.7% | COM NEW | 46489V302 |
| KRRO | KORRO BIO INC | 35,719 | $1.36M | 0.1% | $55.25 | -7.0% | COM | 500946108 |
| ADAPY | ADAPTIMMUNE THERAPEUTICS PLC | 2,483,468 | $1.338M | 0.1% | $6.95 | — | SPONDS ADR | 00653A107 |
| — | ALLAKOS INC | 1,100,409 | $1.331M | 0.1% | $1.00 | — | COM | 01671P100 |
| — | SPRUCE BIOSCIENCES INC | 2,609,125 | $1.096M | 0.0% | $15.23 | — | COM | 85209E109 |
| LENZ | LENZ THERAPEUTICS INC | 29,305 | $846K | 0.0% | $30.48 | 0.0% | COM | 52635N103 |
| — | VIGIL NEUROSCIENCE INC | 471,958 | $802K | 0.0% | $7.03 | — | COM | 92673K108 |
| BMEA | BIOMEA FUSION INC | 181,147 | $703K | 0.0% | $15.37 | -48.2% | COM | 09077A106 |
| KYTX | KYVERNA THERAPEUTICS INC | 178,963 | $669K | 0.0% | $27.84 | -82.8% | COM | 501976104 |
| — | NEVRO CORP | 500,000 | $489K | 0.0% | $1.37 | — | NOTE 2.750% 4/0 | 64157FAC7 |
| — | VINCERX PHARMA INC | 891,719 | $234K | 0.0% | $12.19 | — | COM NEW | 92731L106 |
| TLPH | TALPHERA INC | 316,460 | $166K | 0.0% | $2.81 | -72.2% | COM NEW | 00444T209 |
| — | NUVATION BIO INC | 134,028 | $30,826 | 0.0% | $2.67 | — | *W EXP 02/10/202 | 67080N119 |