Octagon Capital Advisors LP Quant / Systematic

Location: New York, NY

CIK: 0001839435 · Show all filings

Period: Q3 2022 (← Previous) (Next →)

Filing Date: Nov 14, 2022

Total Value: $579M (100.0% shares, 0.0% debt)

Holdings (35)

APLS APELLIS PHARMACEUTICALS INC 29.5%

Value $171M Shares 2,503,059 Est. Cost $46.73 Unrealized +26.6%

RCUS ARCUS BIOSCIENCES INC 12.0%

Value $69.8M Shares 2,668,316 Est. Cost $33.27 Unrealized -20.5%

— CHINOOK THERAPEUTICS INC 8.7%

Value $50.17M Shares 2,551,703 Est. Cost $16.88 Unrealized —

— HORIZON THERAPEUTICS PUB L 6.7%

Value $38.65M Shares 624,500 Est. Cost $75.41 Unrealized —

GOSS GOSSAMER BIO INC 4.2%

Value $24.5M Shares 2,045,442 Est. Cost $9.60 Unrealized +29.3%

TNDM TANDEM DIABETES CARE INC 3.9%

Value $22.73M Shares 474,929 Est. Cost $54.82 Unrealized 0.0%

CLDX CELLDEX THERAPEUTICS INC NEW 3.7%

Value $21.4M Shares 761,398 Est. Cost $25.60 Unrealized +19.8%

XBI SPDR SER TR 3.3%

Value $19.31M Shares 243,400 Est. Cost $77.85 Unrealized —

— MIRATI THERAPEUTICS INC 2.7%

Value $15.44M Shares 221,000 Est. Cost $69.84 Unrealized —

— VERONA PHARMA PLC 2.3%

Value $13.54M Shares 1,324,868 Est. Cost $10.22 Unrealized —

VERA VERA THERAPEUTICS INC 2.0%

Value $11.36M Shares 533,264 Est. Cost $15.54 Unrealized +20.5%

HRMY HARMONY BIOSCIENCES HLDGS IN 1.9%

Value $10.79M Shares 243,500 Est. Cost $48.78 Unrealized 0.0%

— INTRA-CELLULAR THERAPIES INC 1.8%

Value $10.28M Shares 220,953 Est. Cost $46.53 Unrealized —

STOK STOKE THERAPEUTICS INC 1.7%

Value $9.803M Shares 763,456 Est. Cost $27.91 Unrealized -42.9%

BBIO BRIDGEBIO PHARMA INC 1.6%

Value $9.281M Shares 933,743 Est. Cost $38.67 Unrealized -73.1%

— ALPINE IMMUNE SCIENCES INC 1.5%

Value $8.82M Shares 1,225,000 Est. Cost $7.20 Unrealized —

ASND ASCENDIS PHARMA A/S 1.5%

Value $8.622M Shares 83,500 Est. Cost $103.26 Unrealized —

— KARUNA THERAPEUTICS INC 1.3%

Value $7.76M Shares 34,500 Est. Cost $224.93 Unrealized —

ALNY ALNYLAM PHARMACEUTICALS INC 1.3%

Value $7.466M Shares 37,300 Est. Cost $190.74 Unrealized 0.0%

FATE FATE THERAPEUTICS INC 1.3%

Value $7.42M Shares 331,096 Est. Cost $28.89 Unrealized 0.0%

XLO XILIO THERAPEUTICS INC 1.2%

Value $7.057M Shares 2,425,000 Est. Cost $2.77 Unrealized 0.0%

RNAM AVIDITY BIOSCIENCES INC 1.1%

Value $6.199M Shares 379,629 Est. Cost $27.48 Unrealized -30.4%

FDMT 4D MOLECULAR THERAPEUTICS IN 0.7%

Value $4.02M Shares 499,996 Est. Cost $30.23 Unrealized -70.0%

NUVL NUVALENT INC 0.7%

Value $3.888M Shares 200,000 Est. Cost $16.74 Unrealized 0.0%

— JOUNCE THERAPEUTICS INC 0.6%

Value $3.276M Shares 1,400,000 Est. Cost $2.34 Unrealized —

IMVT IMMUNOVANT INC 0.6%

Value $3.231M Shares 579,061 Est. Cost $7.02 Unrealized -30.3%

DXCM DEXCOM INC 0.6%

Value $3.222M Shares 40,000 Est. Cost $84.70 Unrealized 0.0%

— AKERO THERAPEUTICS INC 0.4%

Value $2.554M Shares 75,000 Est. Cost $34.05 Unrealized —

IPSC CENTURY THERAPEUTICS INC 0.4%

Value $2.218M Shares 224,300 Est. Cost $24.92 Unrealized -57.7%

MIRM MIRUM PHARMACEUTICALS INC 0.4%

Value $2.101M Shares 100,000 Est. Cost $24.08 Unrealized 0.0%

ONC BEIGENE LTD 0.3%

Value $1.523M Shares 11,300 Est. Cost $134.78 Unrealized —

MREO MEREO BIOPHARMA GROUP PLC 0.1%

Value $861K Shares 1,000,000 Est. Cost $1.12 Unrealized —

— CONNECT BIOPHARMA HLDGS LTD 0.1%

Value $581K Shares 450,000 Est. Cost $1.29 Unrealized —

BCYC BICYCLE THERAPEUTICS PLC 0.1%

Value $465K Shares 20,000 Est. Cost $23.25 Unrealized —

ADCT ADC THERAPEUTICS SA 0.0%

Value $145K Shares 30,000 Est. Cost $7.24 Unrealized 0.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
APLS	APELLIS PHARMACEUTICALS INC	2,503,059	$171M	29.5%	$46.73	+26.6%	COM	03753U106
RCUS	ARCUS BIOSCIENCES INC	2,668,316	$69.8M	12.0%	$33.27	-20.5%	COM	03969F109
—	CHINOOK THERAPEUTICS INC	2,551,703	$50.17M	8.7%	$16.88	—	COM	16961L106
—	HORIZON THERAPEUTICS PUB L	624,500	$38.65M	6.7%	$75.41	—	SHS	G46188101
GOSS	GOSSAMER BIO INC	2,045,442	$24.5M	4.2%	$9.60	+29.3%	COM	38341P102
TNDM	TANDEM DIABETES CARE INC	474,929	$22.73M	3.9%	$54.82	0.0%	COM NEW	875372203
CLDX	CELLDEX THERAPEUTICS INC NEW	761,398	$21.4M	3.7%	$25.60	+19.8%	COM NEW	15117B202
XBI	SPDR SER TR	243,400	$19.31M	3.3%	$77.85	—	S&P BIOTECH	78464A870
—	MIRATI THERAPEUTICS INC	221,000	$15.44M	2.7%	$69.84	—	COM	60468T105
—	VERONA PHARMA PLC	1,324,868	$13.54M	2.3%	$10.22	—	SPONSORED ADS	925050106
VERA	VERA THERAPEUTICS INC	533,264	$11.36M	2.0%	$15.54	+20.5%	CL A	92337R101
HRMY	HARMONY BIOSCIENCES HLDGS IN	243,500	$10.79M	1.9%	$48.78	0.0%	COM	413197104
—	INTRA-CELLULAR THERAPIES INC	220,953	$10.28M	1.8%	$46.53	—	COM	46116X101
STOK	STOKE THERAPEUTICS INC	763,456	$9.803M	1.7%	$27.91	-42.9%	COM	86150R107
BBIO	BRIDGEBIO PHARMA INC	933,743	$9.281M	1.6%	$38.67	-73.1%	COM	10806X102
—	ALPINE IMMUNE SCIENCES INC	1,225,000	$8.82M	1.5%	$7.20	—	COM	02083G100
ASND	ASCENDIS PHARMA A/S	83,500	$8.622M	1.5%	$103.26	—	SPONSORED ADR	04351P101
—	KARUNA THERAPEUTICS INC	34,500	$7.76M	1.3%	$224.93	—	COM	48576A100
ALNY	ALNYLAM PHARMACEUTICALS INC	37,300	$7.466M	1.3%	$190.74	0.0%	COM	02043Q107
FATE	FATE THERAPEUTICS INC	331,096	$7.42M	1.3%	$28.89	0.0%	COM	31189P102
XLO	XILIO THERAPEUTICS INC	2,425,000	$7.057M	1.2%	$2.77	0.0%	COM	98422T100
RNAM	AVIDITY BIOSCIENCES INC	379,629	$6.199M	1.1%	$27.48	-30.4%	COM	05370A108
FDMT	4D MOLECULAR THERAPEUTICS IN	499,996	$4.02M	0.7%	$30.23	-70.0%	COM	35104E100
NUVL	NUVALENT INC	200,000	$3.888M	0.7%	$16.74	0.0%	COM	670703107
—	JOUNCE THERAPEUTICS INC	1,400,000	$3.276M	0.6%	$2.34	—	COM	481116101
IMVT	IMMUNOVANT INC	579,061	$3.231M	0.6%	$7.02	-30.3%	COM	45258J102
DXCM	DEXCOM INC	40,000	$3.222M	0.6%	$84.70	0.0%	COM	252131107
—	AKERO THERAPEUTICS INC	75,000	$2.554M	0.4%	$34.05	—	COM	00973Y108
IPSC	CENTURY THERAPEUTICS INC	224,300	$2.218M	0.4%	$24.92	-57.7%	COM	15673T100
MIRM	MIRUM PHARMACEUTICALS INC	100,000	$2.101M	0.4%	$24.08	0.0%	COM	604749101
ONC	BEIGENE LTD	11,300	$1.523M	0.3%	$134.78	—	SPONSORED ADR	07725L102
MREO	MEREO BIOPHARMA GROUP PLC	1,000,000	$861K	0.1%	$1.12	—	SPON ADS	589492107
—	CONNECT BIOPHARMA HLDGS LTD	450,000	$581K	0.1%	$1.29	—	ADS	207523101
BCYC	BICYCLE THERAPEUTICS PLC	20,000	$465K	0.1%	$23.25	—	SPONSORED ADS	088786108
ADCT	ADC THERAPEUTICS SA	30,000	$145K	0.0%	$7.24	0.0%	SHS	H0036K147