Octagon Capital Advisors LP Quant / Systematic

Location: New York, NY

CIK: 0001839435 · Show all filings

Period: Q4 2022 (← Previous) (Next →)

Filing Date: Feb 14, 2023

Total Value: $642M (100.0% shares, 0.0% debt)

Holdings (32)

APLS APELLIS PHARMACEUTICALS INC 25.4%

Value $163M Shares 3,160,000 Est. Cost $48.04 Unrealized +10.4%

— CHINOOK THERAPEUTICS INC 10.4%

Value $66.85M Shares 2,551,703 Est. Cost $16.88 Unrealized —

— VERONA PHARMA PLC 10.0%

Value $64.49M Shares 2,468,000 Est. Cost $17.59 Unrealized —

RCUS ARCUS BIOSCIENCES INC 8.0%

Value $51.34M Shares 2,482,700 Est. Cost $33.27 Unrealized -17.3%

— MIRATI THERAPEUTICS INC 5.3%

Value $33.98M Shares 750,000 Est. Cost $52.54 Unrealized —

CLDX CELLDEX THERAPEUTICS INC NEW 5.3%

Value $33.94M Shares 761,398 Est. Cost $25.60 Unrealized +39.5%

— IVERIC BIO INC 4.3%

Value $27.36M Shares 1,278,000 Est. Cost $21.41 Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 3.7%

Value $24.07M Shares 824,200 Est. Cost $23.04 Unrealized 0.0%

TNDM TANDEM DIABETES CARE INC 3.3%

Value $21.35M Shares 474,929 Est. Cost $54.82 Unrealized -17.4%

— AEROVATE THERAPEUTICS INC 2.8%

Value $18.22M Shares 621,712 Est. Cost $29.30 Unrealized —

XBI SPDR SER TR 2.6%

Value $16.55M Shares 199,417 Est. Cost $77.85 Unrealized —

VERA VERA THERAPEUTICS INC 2.0%

Value $12.87M Shares 665,156 Est. Cost $16.05 Unrealized +12.8%

— INTRA-CELLULAR THERAPIES INC 1.8%

Value $11.69M Shares 220,953 Est. Cost $46.53 Unrealized —

— CYMABAY THERAPEUTICS INC 1.8%

Value $11.66M Shares 1,859,200 Est. Cost $6.27 Unrealized —

FDMT 4D MOLECULAR THERAPEUTICS IN 1.7%

Value $11.1M Shares 499,996 Est. Cost $30.23 Unrealized -48.9%

— ALPINE IMMUNE SCIENCES INC 1.4%

Value $9.004M Shares 1,225,000 Est. Cost $7.20 Unrealized —

— ITEOS THERAPEUTICS INC 1.4%

Value $8.691M Shares 445,000 Est. Cost $19.53 Unrealized —

VKTX VIKING THERAPEUTICS INC 1.3%

Value $8.183M Shares 870,500 Est. Cost $4.46 Unrealized 0.0%

RNAM AVIDITY BIOSCIENCES INC 1.1%

Value $7.204M Shares 324,629 Est. Cost $27.48 Unrealized -45.7%

BBIO BRIDGEBIO PHARMA INC 1.1%

Value $7.115M Shares 933,743 Est. Cost $38.67 Unrealized -75.2%

STOK STOKE THERAPEUTICS INC 1.1%

Value $7.047M Shares 763,456 Est. Cost $27.91 Unrealized -62.7%

XLO XILIO THERAPEUTICS INC 1.0%

Value $6.523M Shares 2,425,000 Est. Cost $2.77 Unrealized -13.1%

— 89BIO INC 0.8%

Value $4.837M Shares 380,000 Est. Cost $12.73 Unrealized —

GOSS GOSSAMER BIO INC 0.7%

Value $4.249M Shares 1,958,069 Est. Cost $9.60 Unrealized -14.2%

MIRM MIRUM PHARMACEUTICALS INC 0.3%

Value $1.95M Shares 100,000 Est. Cost $24.08 Unrealized -17.9%

— PRAXIS PRECISION MEDICINES I 0.3%

Value $1.904M Shares 800,000 Est. Cost $2.38 Unrealized —

DXCM DEXCOM INC 0.3%

Value $1.699M Shares 15,000 Est. Cost $84.70 Unrealized +29.6%

— PROMETHEUS BIOSCIENCES INC 0.3%

Value $1.65M Shares 15,000 Est. Cost $110.00 Unrealized —

— JOUNCE THERAPEUTICS INC 0.2%

Value $1.554M Shares 1,400,000 Est. Cost $2.34 Unrealized —

MREO MEREO BIOPHARMA GROUP PLC 0.1%

Value $750K Shares 1,000,000 Est. Cost $1.12 Unrealized —

NUVL NUVALENT INC 0.1%

Value $745K Shares 25,000 Est. Cost $16.74 Unrealized +66.6%

IPSC CENTURY THERAPEUTICS INC 0.0%

Value $231K Shares 45,000 Est. Cost $24.92 Unrealized -62.1%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
APLS	APELLIS PHARMACEUTICALS INC	3,160,000	$163M	25.4%	$48.04	+10.4%	COM	03753U106
—	CHINOOK THERAPEUTICS INC	2,551,703	$66.85M	10.4%	$16.88	—	COM	16961L106
—	VERONA PHARMA PLC	2,468,000	$64.49M	10.0%	$17.59	—	SPONSORED ADS	925050106
RCUS	ARCUS BIOSCIENCES INC	2,482,700	$51.34M	8.0%	$33.27	-17.3%	COM	03969F109
—	MIRATI THERAPEUTICS INC	750,000	$33.98M	5.3%	$52.54	—	COM	60468T105
CLDX	CELLDEX THERAPEUTICS INC NEW	761,398	$33.94M	5.3%	$25.60	+39.5%	COM NEW	15117B202
—	IVERIC BIO INC	1,278,000	$27.36M	4.3%	$21.41	—	COM	46583P102
VRDN	VIRIDIAN THERAPEUTICS INC	824,200	$24.07M	3.7%	$23.04	0.0%	COM	92790C104
TNDM	TANDEM DIABETES CARE INC	474,929	$21.35M	3.3%	$54.82	-17.4%	COM NEW	875372203
—	AEROVATE THERAPEUTICS INC	621,712	$18.22M	2.8%	$29.30	—	COM	008064107
XBI	SPDR SER TR	199,417	$16.55M	2.6%	$77.85	—	S&P BIOTECH	78464A870
VERA	VERA THERAPEUTICS INC	665,156	$12.87M	2.0%	$16.05	+12.8%	CL A	92337R101
—	INTRA-CELLULAR THERAPIES INC	220,953	$11.69M	1.8%	$46.53	—	COM	46116X101
—	CYMABAY THERAPEUTICS INC	1,859,200	$11.66M	1.8%	$6.27	—	COM	23257D103
FDMT	4D MOLECULAR THERAPEUTICS IN	499,996	$11.1M	1.7%	$30.23	-48.9%	COM	35104E100
—	ALPINE IMMUNE SCIENCES INC	1,225,000	$9.004M	1.4%	$7.20	—	COM	02083G100
—	ITEOS THERAPEUTICS INC	445,000	$8.691M	1.4%	$19.53	—	COM	46565G104
VKTX	VIKING THERAPEUTICS INC	870,500	$8.183M	1.3%	$4.46	0.0%	COM	92686J106
RNAM	AVIDITY BIOSCIENCES INC	324,629	$7.204M	1.1%	$27.48	-45.7%	COM	05370A108
BBIO	BRIDGEBIO PHARMA INC	933,743	$7.115M	1.1%	$38.67	-75.2%	COM	10806X102
STOK	STOKE THERAPEUTICS INC	763,456	$7.047M	1.1%	$27.91	-62.7%	COM	86150R107
XLO	XILIO THERAPEUTICS INC	2,425,000	$6.523M	1.0%	$2.77	-13.1%	COM	98422T100
—	89BIO INC	380,000	$4.837M	0.8%	$12.73	—	COM	282559103
GOSS	GOSSAMER BIO INC	1,958,069	$4.249M	0.7%	$9.60	-14.2%	COM	38341P102
MIRM	MIRUM PHARMACEUTICALS INC	100,000	$1.95M	0.3%	$24.08	-17.9%	COM	604749101
—	PRAXIS PRECISION MEDICINES I	800,000	$1.904M	0.3%	$2.38	—	COM	74006W108
DXCM	DEXCOM INC	15,000	$1.699M	0.3%	$84.70	+29.6%	COM	252131107
—	PROMETHEUS BIOSCIENCES INC	15,000	$1.65M	0.3%	$110.00	—	COM	74349U108
—	JOUNCE THERAPEUTICS INC	1,400,000	$1.554M	0.2%	$2.34	—	COM	481116101
MREO	MEREO BIOPHARMA GROUP PLC	1,000,000	$750K	0.1%	$1.12	—	SPON ADS	589492107
NUVL	NUVALENT INC	25,000	$745K	0.1%	$16.74	+66.6%	COM	670703107
IPSC	CENTURY THERAPEUTICS INC	45,000	$231K	0.0%	$24.92	-62.1%	COM	15673T100