Octagon Capital Advisors LP Quant / Systematic

Location: New York, NY

CIK: 0001839435 · Show all filings

Period: Q2 2023 (← Previous) (Next →)

Filing Date: Aug 14, 2023

Total Value: $719M (100.0% shares, 0.0% debt)

Holdings (41)

APLS APELLIS PHARMACEUTICALS INC 33.2%

Value $239M Shares 2,618,300 Est. Cost $48.31 Unrealized +78.6%

— VERONA PHARMA PLC 7.3%

Value $52.17M Shares 2,468,000 Est. Cost $17.59 Unrealized —

— CYMABAY THERAPEUTICS INC 7.0%

Value $50.05M Shares 4,570,918 Est. Cost $7.72 Unrealized —

RCUS ARCUS BIOSCIENCES INC 5.6%

Value $39.97M Shares 1,968,000 Est. Cost $33.27 Unrealized -42.8%

ROIV ROIVANT SCIENCES LTD 5.5%

Value $39.35M Shares 3,904,000 Est. Cost $8.23 Unrealized +8.6%

— MIRATI THERAPEUTICS INC 3.8%

Value $27.1M Shares 750,000 Est. Cost $52.54 Unrealized —

CLDX CELLDEX THERAPEUTICS INC NEW 3.6%

Value $25.78M Shares 759,898 Est. Cost $25.60 Unrealized +31.7%

VRDN VIRIDIAN THERAPEUTICS INC 3.1%

Value $21.96M Shares 923,000 Est. Cost $25.79 Unrealized -0.5%

BBIO BRIDGEBIO PHARMA INC 2.9%

Value $20.97M Shares 1,219,200 Est. Cost $30.51 Unrealized -50.7%

— 89BIO INC 2.8%

Value $20.22M Shares 1,066,784 Est. Cost $16.66 Unrealized —

IRON DISC MEDICINE INC 2.6%

Value $18.43M Shares 415,000 Est. Cost $35.48 Unrealized 0.0%

VIR VIR BIOTECHNOLOGY INC 2.2%

Value $15.95M Shares 650,100 Est. Cost $25.11 Unrealized 0.0%

— RENEO PHARMACEUTICALS INC 2.2%

Value $15.54M Shares 2,368,587 Est. Cost $6.46 Unrealized —

TNDM TANDEM DIABETES CARE INC 1.6%

Value $11.65M Shares 474,929 Est. Cost $54.82 Unrealized -41.3%

— AEROVATE THERAPEUTICS INC 1.5%

Value $10.66M Shares 621,712 Est. Cost $29.30 Unrealized —

— ITEOS THERAPEUTICS INC 1.1%

Value $7.891M Shares 596,000 Est. Cost $18.03 Unrealized —

DYN DYNE THERAPEUTICS INC 1.1%

Value $7.796M Shares 692,945 Est. Cost $12.99 Unrealized -9.2%

INSM INSMED INC 1.1%

Value $7.744M Shares 367,000 Est. Cost $18.97 Unrealized 0.0%

— ALPINE IMMUNE SCIENCES INC 1.1%

Value $7.71M Shares 750,000 Est. Cost $7.20 Unrealized —

TVTX TRAVERE THERAPEUTICS INC 1.1%

Value $7.603M Shares 495,000 Est. Cost $21.26 Unrealized -14.4%

GERN GERON CORP 1.0%

Value $7.312M Shares 2,278,000 Est. Cost $2.84 Unrealized +0.2%

XLO XILIO THERAPEUTICS INC 0.9%

Value $6.354M Shares 2,425,000 Est. Cost $2.77 Unrealized +9.5%

ANTX AN2 THERAPEUTICS INC 0.9%

Value $6.128M Shares 720,900 Est. Cost $7.19 Unrealized 0.0%

— JASPER THERAPEUTICS INC 0.9%

Value $6.121M Shares 4,468,114 Est. Cost $1.81 Unrealized —

VKTX VIKING THERAPEUTICS INC 0.8%

Value $6.079M Shares 375,000 Est. Cost $4.46 Unrealized +369.3%

ANNX ANNEXON INC 0.8%

Value $5.843M Shares 1,660,000 Est. Cost $5.18 Unrealized -15.6%

— GLYCOMIMETICS INC 0.7%

Value $5.22M Shares 3,000,000 Est. Cost $1.26 Unrealized —

GOSS GOSSAMER BIO INC 0.7%

Value $4.75M Shares 3,958,069 Est. Cost $5.38 Unrealized -76.8%

LXRX LEXICON PHARMACEUTICALS INC 0.6%

Value $4.404M Shares 1,923,076 Est. Cost $2.65 Unrealized 0.0%

GPCR STRUCTURE THERAPEUTICS INC 0.4%

Value $3.118M Shares 75,000 Est. Cost $23.79 Unrealized —

PMVP PMV PHARMACEUTICALS INC 0.4%

Value $2.942M Shares 470,000 Est. Cost $5.24 Unrealized 0.0%

CNTA CENTESSA PHARMACEUTICALS PLC 0.4%

Value $2.55M Shares 411,928 Est. Cost $3.94 Unrealized —

ORIC ORIC PHARMACEUTICALS INC 0.3%

Value $2.15M Shares 277,000 Est. Cost $5.68 Unrealized 0.0%

STOK STOKE THERAPEUTICS INC 0.3%

Value $1.974M Shares 185,669 Est. Cost $27.91 Unrealized -61.9%

— IVERIC BIO INC 0.3%

Value $1.967M Shares 50,000 Est. Cost — Unrealized —

— HEPION PHARMACEUTICALS INC 0.2%

Value $1.627M Shares 155,000 Est. Cost $10.50 Unrealized —

VERA VERA THERAPEUTICS INC 0.2%

Value $1.123M Shares 70,000 Est. Cost $14.69 Unrealized -38.5%

— PIERIS PHARMACEUTICALS INC 0.2%

Value $1.092M Shares 6,600,000 Est. Cost $0.20 Unrealized —

— MAGENTA THERAPEUTICS INC 0.1%

Value $417K Shares 550,000 Est. Cost $0.76 Unrealized —

— INOZYME PHARMA INC 0.0%

Value $277K Shares 49,702 Est. Cost $5.57 Unrealized —

GLUE MONTE ROSA THERAPEUTICS INC 0.0%

Value $136K Shares 19,900 Est. Cost $6.47 Unrealized 0.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
APLS	APELLIS PHARMACEUTICALS INC	2,618,300	$239M	33.2%	$48.31	+78.6%	COM	03753U106
—	VERONA PHARMA PLC	2,468,000	$52.17M	7.3%	$17.59	—	SPONSORED ADS	925050106
—	CYMABAY THERAPEUTICS INC	4,570,918	$50.05M	7.0%	$7.72	—	COM	23257D103
RCUS	ARCUS BIOSCIENCES INC	1,968,000	$39.97M	5.6%	$33.27	-42.8%	COM	03969F109
ROIV	ROIVANT SCIENCES LTD	3,904,000	$39.35M	5.5%	$8.23	+8.6%	SHS	G76279101
—	MIRATI THERAPEUTICS INC	750,000	$27.1M	3.8%	$52.54	—	COM	60468T105
CLDX	CELLDEX THERAPEUTICS INC NEW	759,898	$25.78M	3.6%	$25.60	+31.7%	COM NEW	15117B202
VRDN	VIRIDIAN THERAPEUTICS INC	923,000	$21.96M	3.1%	$25.79	-0.5%	COM	92790C104
BBIO	BRIDGEBIO PHARMA INC	1,219,200	$20.97M	2.9%	$30.51	-50.7%	COM	10806X102
—	89BIO INC	1,066,784	$20.22M	2.8%	$16.66	—	COM	282559103
IRON	DISC MEDICINE INC	415,000	$18.43M	2.6%	$35.48	0.0%	COM	254604101
VIR	VIR BIOTECHNOLOGY INC	650,100	$15.95M	2.2%	$25.11	0.0%	COM	92764N102
—	RENEO PHARMACEUTICALS INC	2,368,587	$15.54M	2.2%	$6.46	—	COM	75974E103
TNDM	TANDEM DIABETES CARE INC	474,929	$11.65M	1.6%	$54.82	-41.3%	COM NEW	875372203
—	AEROVATE THERAPEUTICS INC	621,712	$10.66M	1.5%	$29.30	—	COM	008064107
—	ITEOS THERAPEUTICS INC	596,000	$7.891M	1.1%	$18.03	—	COM	46565G104
DYN	DYNE THERAPEUTICS INC	692,945	$7.796M	1.1%	$12.99	-9.2%	COM	26818M108
INSM	INSMED INC	367,000	$7.744M	1.1%	$18.97	0.0%	COM PAR $.01	457669307
—	ALPINE IMMUNE SCIENCES INC	750,000	$7.71M	1.1%	$7.20	—	COM	02083G100
TVTX	TRAVERE THERAPEUTICS INC	495,000	$7.603M	1.1%	$21.26	-14.4%	COM	89422G107
GERN	GERON CORP	2,278,000	$7.312M	1.0%	$2.84	+0.2%	COM	374163103
XLO	XILIO THERAPEUTICS INC	2,425,000	$6.354M	0.9%	$2.77	+9.5%	COM	98422T100
ANTX	AN2 THERAPEUTICS INC	720,900	$6.128M	0.9%	$7.19	0.0%	COM	037326105
—	JASPER THERAPEUTICS INC	4,468,114	$6.121M	0.9%	$1.81	—	COM	471871103
VKTX	VIKING THERAPEUTICS INC	375,000	$6.079M	0.8%	$4.46	+369.3%	COM	92686J106
ANNX	ANNEXON INC	1,660,000	$5.843M	0.8%	$5.18	-15.6%	COM	03589W102
—	GLYCOMIMETICS INC	3,000,000	$5.22M	0.7%	$1.26	—	COM	38000Q102
GOSS	GOSSAMER BIO INC	3,958,069	$4.75M	0.7%	$5.38	-76.8%	COM	38341P102
LXRX	LEXICON PHARMACEUTICALS INC	1,923,076	$4.404M	0.6%	$2.65	0.0%	COM NEW	528872302
GPCR	STRUCTURE THERAPEUTICS INC	75,000	$3.118M	0.4%	$23.79	—	SPONSORED ADS	86366E106
PMVP	PMV PHARMACEUTICALS INC	470,000	$2.942M	0.4%	$5.24	0.0%	COM	69353Y103
CNTA	CENTESSA PHARMACEUTICALS PLC	411,928	$2.55M	0.4%	$3.94	—	SPONSORED ADS	152309100
ORIC	ORIC PHARMACEUTICALS INC	277,000	$2.15M	0.3%	$5.68	0.0%	COM	68622P109
STOK	STOKE THERAPEUTICS INC	185,669	$1.974M	0.3%	$27.91	-61.9%	COM	86150R107
—	IVERIC BIO INC	50,000	$1.967M	0.3%	—	—	Put	46583P102
—	HEPION PHARMACEUTICALS INC	155,000	$1.627M	0.2%	$10.50	—	COM NEW	426897302
VERA	VERA THERAPEUTICS INC	70,000	$1.123M	0.2%	$14.69	-38.5%	CL A	92337R101
—	PIERIS PHARMACEUTICALS INC	6,600,000	$1.092M	0.2%	$0.20	—	COM	720795103
—	MAGENTA THERAPEUTICS INC	550,000	$417K	0.1%	$0.76	—	COM	55910K108
—	INOZYME PHARMA INC	49,702	$277K	0.0%	$5.57	—	COM	45790W108
GLUE	MONTE ROSA THERAPEUTICS INC	19,900	$136K	0.0%	$6.47	0.0%	COM	61225M102