TCG Crossover Management, LLC Diversified Active

Location: Palo Alto, CA

CIK: 0001839948 · Show all filings

Period: Q4 2024 (← Previous) (Next →)

Filing Date: Feb 14, 2025

Total Value: $1.023B (100.0% shares, 0.0% debt)

Holdings (38)

CGON CG ONCOLOGY INC 10.3%

Value $105M Shares 3,670,206 Share Price $28.68 * Est. Cost/Share $40.67 Unrealized @ Report Date -15.9%

DYN DYNE THERAPEUTICS INC 6.1%

Value $62.44M Shares 2,650,150 Share Price $23.56 * Est. Cost/Share $16.62 Unrealized @ Report Date +78.0%

XNCR XENCOR INC 5.5%

Value $56.35M Shares 2,452,138 Share Price $22.98 Est. Cost/Share $18.82 Unrealized @ Report Date +22.1%

COGT COGENT BIOSCIENCES INC 5.3%

Value $54.32M Shares 6,964,375 Share Price $7.80 * Est. Cost/Share $9.05 Unrealized @ Report Date +10.1%

CNTA CENTESSA PHARMACEUTICALS PLC 4.7%

Value $48.42M Shares 2,890,816 Share Price $16.75 Est. Cost/Share $7.22 Unrealized @ Report Date —

OCUL OCULAR THERAPEUTIX INC 4.4%

Value $45.43M Shares 5,319,148 Share Price $8.54 * Est. Cost/Share $7.10 Unrealized @ Report Date +37.5%

UPB UPSTREAM BIO INC 4.4%

Value $44.86M Shares 2,801,763 Share Price $16.01 * Est. Cost/Share $22.33 Unrealized @ Report Date 0.0%

ABVX ABIVAX SA AMERICAN DEPOSITARY SHARES 4.3%

Value $44.33M Shares 6,056,596 Share Price $7.32 Est. Cost/Share $12.76 Unrealized @ Report Date —

SVRA SAVARA INC 3.7%

Value $37.95M Shares 12,362,205 Share Price $3.07 * Est. Cost/Share $3.73 Unrealized @ Report Date -6.6%

TNGX TANGO THERAPEUTICS INC 3.2%

Value $33.17M Shares 10,736,000 Share Price $3.09 * Est. Cost/Share $4.64 Unrealized @ Report Date 0.0%

DNTH DIANTHUS THERAPEUTICS INC 3.2%

Value $32.74M Shares 1,501,624 Share Price $21.80 * Est. Cost/Share $25.71 Unrealized @ Report Date 0.0%

IRON DISC MEDICINE INC 3.0%

Value $30.87M Shares 486,957 Share Price $63.40 * Est. Cost/Share $33.98 Unrealized @ Report Date +70.2%

MLYS MINERALYS THERAPEUTICS INC 3.0%

Value $30.41M Shares 2,470,265 Share Price $12.31 * Est. Cost/Share $12.35 Unrealized @ Report Date +5.9%

— TOURMALINE BIO INC 2.9%

Value $29.97M Shares 1,477,593 Share Price $20.28 Est. Cost/Share $25.14 Unrealized @ Report Date —

GPCR STRUCTURE THERAPEUTICS INC 2.8%

Value $28.83M Shares 1,063,000 Share Price $27.12 Est. Cost/Share $43.45 Unrealized @ Report Date —

TYRA TYRA BIOSCIENCES INC 2.7%

Value $27.65M Shares 1,989,103 Share Price $13.90 * Est. Cost/Share $12.71 Unrealized @ Report Date +42.8%

EYPT EYEPOINT PHARMACEUTICALS INC 2.6%

Value $26.61M Shares 3,572,335 Share Price $7.45 * Est. Cost/Share $10.51 Unrealized @ Report Date -11.4%

— Cidara Therapeutics, Inc. 2.5%

Value $26.09M Shares 1,005,901 Share Price $25.94 Est. Cost/Share $25.94 Unrealized @ Report Date —

— THIRD HARMONIC BIO INC 2.5%

Value $25.78M Shares 2,505,424 Share Price $10.29 Est. Cost/Share $13.43 Unrealized @ Report Date —

SLNO SOLENO THERAPEUTICS INC 2.4%

Value $24.72M Shares 550,000 Share Price $44.95 * Est. Cost/Share $47.87 Unrealized @ Report Date +8.2%

— ASTRIA THERAPEUTICS INC 2.4%

Value $24.69M Shares 2,761,861 Share Price $8.94 Est. Cost/Share $14.07 Unrealized @ Report Date —

FULC FULCRUM THERAPEUTICS INC 2.4%

Value $24.68M Shares 5,250,000 Share Price $4.70 * Est. Cost/Share $7.42 Unrealized @ Report Date -50.3%

SLN SILENCE THERAPEUTICS PLC 2.0%

Value $20.87M Shares 3,033,560 Share Price $6.88 Est. Cost/Share $14.21 Unrealized @ Report Date —

— RAPT Therapeutics, Inc. 1.9%

Value $19.75M Shares 13,135,260 Share Price $1.50 Est. Cost/Share $1.50 Unrealized @ Report Date —

AMLX AMYLYX PHARMACEUTICALS INC 1.7%

Value $17.55M Shares 4,643,812 Share Price $3.78 * Est. Cost/Share $2.25 Unrealized @ Report Date +109.3%

CMPS COMPASS PATHWAYS LTD 1.4%

Value $14.58M Shares 3,858,000 Share Price $3.78 Est. Cost/Share $7.40 Unrealized @ Report Date —

KURA KURA ONCOLOGY INC 1.2%

Value $12.4M Shares 1,423,642 Share Price $8.71 * Est. Cost/Share $14.54 Unrealized @ Report Date -1.1%

MBX MBX BIOSCIENCES INC 1.2%

Value $11.98M Shares 650,000 Share Price $18.43 * Est. Cost/Share $22.87 Unrealized @ Report Date -6.8%

KOD KODIAK SCIENCES INC 1.1%

Value $11.4M Shares 1,145,538 Share Price $9.95 * Est. Cost/Share $4.16 Unrealized @ Report Date +38.1%

TRDA ENTRADA THERAPEUTICS INC 1.0%

Value $10.11M Shares 584,955 Share Price $17.29 Est. Cost/Share $17.12 Unrealized @ Report Date —

KROS KEROS THERAPEUTICS INC 0.9%

Value $8.707M Shares 550,000 Share Price $15.83 * Est. Cost/Share $59.30 Unrealized @ Report Date -12.4%

— ADVERUM BIOTECHNOLOGIES INC 0.8%

Value $8.39M Shares 1,796,482 Share Price $4.67 Est. Cost/Share $7.02 Unrealized @ Report Date —

VTGN VISTAGEN THERAPEUTICS INC 0.8%

Value $7.896M Shares 2,676,580 Share Price $2.95 * Est. Cost/Share $3.41 Unrealized @ Report Date -17.5%

— AEROVATE THERAPEUTICS INC 0.6%

Value $5.938M Shares 2,240,809 Share Price $2.65 Est. Cost/Share $15.50 Unrealized @ Report Date —

— NEKTAR THERAPEUTICS 0.4%

Value $3.72M Shares 4,000,000 Share Price $0.93 Est. Cost/Share $0.93 Unrealized @ Report Date —

AVTX AVALO THERAPEUTICS INC 0.4%

Value $3.589M Shares 483,000 Share Price $7.43 * Est. Cost/Share $10.31 Unrealized @ Report Date +3.7%

VTYX VENTYX BIOSCIENCES INC 0.1%

Value $692K Shares 316,195 Share Price $2.19 * Est. Cost/Share $29.94 Unrealized @ Report Date -92.4%

CABA CABALETTA BIO INC 0.0%

Value $197K Shares 86,795 Share Price $2.27 * Est. Cost/Share $3.64 Unrealized @ Report Date -3.6%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
CGON	CG ONCOLOGY INC	3,670,206	$105M	10.3%	$28.68 *	$40.67	-15.9%	COMM	156944100
DYN	DYNE THERAPEUTICS INC	2,650,150	$62.44M	6.1%	$23.56 *	$16.62	+78.0%	COMM	26818M108
XNCR	XENCOR INC	2,452,138	$56.35M	5.5%	$22.98	$18.82	+22.1%	COMM	98401F105
COGT	COGENT BIOSCIENCES INC	6,964,375	$54.32M	5.3%	$7.80 *	$9.05	+10.1%	COMM	19240Q201
CNTA	CENTESSA PHARMACEUTICALS PLC	2,890,816	$48.42M	4.7%	$16.75	$7.22	—	ADRS	152309100
OCUL	OCULAR THERAPEUTIX INC	5,319,148	$45.43M	4.4%	$8.54 *	$7.10	+37.5%	COMM	67576A100
UPB	UPSTREAM BIO INC	2,801,763	$44.86M	4.4%	$16.01 *	$22.33	0.0%	COMM	91678A107
ABVX	ABIVAX SA AMERICAN DEPOSITARY SHARES	6,056,596	$44.33M	4.3%	$7.32	$12.76	—	ADRS	00370M103
SVRA	SAVARA INC	12,362,205	$37.95M	3.7%	$3.07 *	$3.73	-6.6%	COMM	805111101
TNGX	TANGO THERAPEUTICS INC	10,736,000	$33.17M	3.2%	$3.09 *	$4.64	0.0%	COMM	87583X109
DNTH	DIANTHUS THERAPEUTICS INC	1,501,624	$32.74M	3.2%	$21.80 *	$25.71	0.0%	COMM	252828108
IRON	DISC MEDICINE INC	486,957	$30.87M	3.0%	$63.40 *	$33.98	+70.2%	COMM	254604101
MLYS	MINERALYS THERAPEUTICS INC	2,470,265	$30.41M	3.0%	$12.31 *	$12.35	+5.9%	COMM	603170101
—	TOURMALINE BIO INC	1,477,593	$29.97M	2.9%	$20.28	$25.14	—	COMM	89157D105
GPCR	STRUCTURE THERAPEUTICS INC	1,063,000	$28.83M	2.8%	$27.12	$43.45	—	ADRS	86366E106
TYRA	TYRA BIOSCIENCES INC	1,989,103	$27.65M	2.7%	$13.90 *	$12.71	+42.8%	COMM	90240B106
EYPT	EYEPOINT PHARMACEUTICALS INC	3,572,335	$26.61M	2.6%	$7.45 *	$10.51	-11.4%	COMM	30233G209
—	Cidara Therapeutics, Inc.	1,005,901	$26.09M	2.5%	$25.94	$25.94	—	COMM	171757206
—	THIRD HARMONIC BIO INC	2,505,424	$25.78M	2.5%	$10.29	$13.43	—	COMM	88427A107
SLNO	SOLENO THERAPEUTICS INC	550,000	$24.72M	2.4%	$44.95 *	$47.87	+8.2%	COMM	834203309
—	ASTRIA THERAPEUTICS INC	2,761,861	$24.69M	2.4%	$8.94	$14.07	—	COMM	04635X102
FULC	FULCRUM THERAPEUTICS INC	5,250,000	$24.68M	2.4%	$4.70 *	$7.42	-50.3%	COMM	359616109
SLN	SILENCE THERAPEUTICS PLC	3,033,560	$20.87M	2.0%	$6.88	$14.21	—	ADRS	82686Q101
—	RAPT Therapeutics, Inc.	13,135,260	$19.75M	1.9%	$1.50	$1.50	—	COMM	75382E109
AMLX	AMYLYX PHARMACEUTICALS INC	4,643,812	$17.55M	1.7%	$3.78 *	$2.25	+109.3%	COMM	03237H101
CMPS	COMPASS PATHWAYS LTD	3,858,000	$14.58M	1.4%	$3.78	$7.40	—	ADRS	20451W101
KURA	KURA ONCOLOGY INC	1,423,642	$12.4M	1.2%	$8.71 *	$14.54	-1.1%	COMM	50127T109
MBX	MBX BIOSCIENCES INC	650,000	$11.98M	1.2%	$18.43 *	$22.87	-6.8%	COMM	55287L101
KOD	KODIAK SCIENCES INC	1,145,538	$11.4M	1.1%	$9.95 *	$4.16	+38.1%	COMM	50015M109
TRDA	ENTRADA THERAPEUTICS INC	584,955	$10.11M	1.0%	$17.29	$17.12	—	COMM	29384C108
KROS	KEROS THERAPEUTICS INC	550,000	$8.707M	0.9%	$15.83 *	$59.30	-12.4%	COMM	492327101
—	ADVERUM BIOTECHNOLOGIES INC	1,796,482	$8.39M	0.8%	$4.67	$7.02	—	COMM	00773U207
VTGN	VISTAGEN THERAPEUTICS INC	2,676,580	$7.896M	0.8%	$2.95 *	$3.41	-17.5%	COMM	92840H400
—	AEROVATE THERAPEUTICS INC	2,240,809	$5.938M	0.6%	$2.65	$15.50	—	COMM	008064107
—	NEKTAR THERAPEUTICS	4,000,000	$3.72M	0.4%	$0.93	$0.93	—	COMM	640268108
AVTX	AVALO THERAPEUTICS INC	483,000	$3.589M	0.4%	$7.43 *	$10.31	+3.7%	COMM	05338F306
VTYX	VENTYX BIOSCIENCES INC	316,195	$692K	0.1%	$2.19 *	$29.94	-92.4%	COMM	92332V107
CABA	CABALETTA BIO INC	86,795	$197K	0.0%	$2.27 *	$3.64	-3.6%	COMM	12674W109