TCG Crossover Management, LLC Diversified Active

Location: Palo Alto, CA

CIK: 0001839948 · Show all filings

Period: Q2 2025 (← Previous) (Next →)

Filing Date: Aug 14, 2025

Total Value: $876M (100.0% shares, 0.0% debt)

Holdings (37)

CGON CG ONCOLOGY INC 10.9%

Value $95.43M Shares 3,670,206 Share Price $26.00 * Est. Cost/Share $40.67 Unrealized @ Report Date -40.8%

TNGX TANGO THERAPEUTICS INC 6.3%

Value $54.97M Shares 10,736,000 Share Price $5.12 * Est. Cost/Share $4.64 Unrealized @ Report Date -46.8%

COGT COGENT BIOSCIENCES INC 5.7%

Value $50M Shares 6,964,375 Share Price $7.18 * Est. Cost/Share $9.05 Unrealized @ Report Date -38.7%

OCUL OCULAR THERAPEUTIX INC 5.6%

Value $49.36M Shares 5,319,148 Share Price $9.28 * Est. Cost/Share $7.10 Unrealized @ Report Date +10.3%

— CIDARA THERAPEUTICS INC 5.6%

Value $49M Shares 1,005,901 Share Price $48.71 Est. Cost/Share $25.94 Unrealized @ Report Date —

ABVX ABIVAX SA AMERICAN DEPOSITARY SHARES 5.3%

Value $46.33M Shares 6,056,596 Share Price $7.65 Est. Cost/Share $12.76 Unrealized @ Report Date —

AMLX AMYLYX PHARMACEUTICALS INC 4.4%

Value $38.1M Shares 5,943,812 Share Price $6.41 * Est. Cost/Share $2.53 Unrealized @ Report Date +91.9%

CNTA CENTESSA PHARMACEUTICALS PLC 4.3%

Value $37.99M Shares 2,890,816 Share Price $13.14 Est. Cost/Share $7.22 Unrealized @ Report Date —

FULC FULCRUM THERAPEUTICS INC 4.1%

Value $36.12M Shares 5,250,000 Share Price $6.88 * Est. Cost/Share $7.42 Unrealized @ Report Date -27.9%

DYN DYNE THERAPEUTICS INC 4.1%

Value $35.86M Shares 3,766,660 Share Price $9.52 * Est. Cost/Share $14.96 Unrealized @ Report Date -26.4%

EYPT EYEPOINT PHARMACEUTICALS INC 3.8%

Value $33.62M Shares 3,572,335 Share Price $9.41 * Est. Cost/Share $10.51 Unrealized @ Report Date -34.3%

UPB UPSTREAM BIO INC 3.5%

Value $30.76M Shares 2,801,763 Share Price $10.98 * Est. Cost/Share $22.33 Unrealized @ Report Date -58.6%

SVRA SAVARA INC 3.2%

Value $28.19M Shares 12,362,205 Share Price $2.28 * Est. Cost/Share $3.73 Unrealized @ Report Date -27.2%

DNTH DIANTHUS THERAPEUTICS INC 3.2%

Value $27.98M Shares 1,501,624 Share Price $18.63 Est. Cost/Share $25.71 Unrealized @ Report Date -27.0%

TYRA TYRA BIOSCIENCES INC 3.2%

Value $27.73M Shares 2,898,103 Share Price $9.57 Est. Cost/Share $12.78 Unrealized @ Report Date -25.6%

IRON DISC MEDICINE INC 2.8%

Value $24.64M Shares 465,257 Share Price $52.96 * Est. Cost/Share $33.98 Unrealized @ Report Date +38.2%

— TOURMALINE BIO INC 2.7%

Value $23.63M Shares 1,477,593 Share Price $15.99 Est. Cost/Share $25.14 Unrealized @ Report Date —

AGIO Agios Pharmaceuticals, Inc. 2.6%

Value $23.18M Shares 697,003 Share Price $33.26 * Est. Cost/Share $30.31 Unrealized @ Report Date 0.0%

GPCR STRUCTURE THERAPEUTICS INC 2.5%

Value $22.05M Shares 1,063,000 Share Price $20.74 Est. Cost/Share $43.45 Unrealized @ Report Date —

XNCR XENCOR INC 2.2%

Value $19.27M Shares 2,452,138 Share Price $7.86 * Est. Cost/Share $18.82 Unrealized @ Report Date -52.3%

SLN SILENCE THERAPEUTICS PLC 2.0%

Value $17.59M Shares 3,033,560 Share Price $5.80 Est. Cost/Share $14.21 Unrealized @ Report Date —

SLNO SOLENO THERAPEUTICS INC 1.8%

Value $15.6M Shares 186,250 Share Price $83.78 * Est. Cost/Share $47.87 Unrealized @ Report Date +56.3%

— ASTRIA THERAPEUTICS INC 1.7%

Value $14.8M Shares 2,761,861 Share Price $5.36 Est. Cost/Share $14.07 Unrealized @ Report Date —

RAPT RAPT Therapeutics, Inc. 1.5%

Value $13.09M Shares 1,636,275 Share Price $8.00 * Est. Cost/Share $7.63 Unrealized @ Report Date 0.0%

— THIRD HARMONIC BIO INC 1.2%

Value $10.4M Shares 1,915,424 Share Price $5.43 Est. Cost/Share $13.43 Unrealized @ Report Date —

ELVN Enliven Therapeutics, Inc. 1.1%

Value $9.99M Shares 498,000 Share Price $20.06 * Est. Cost/Share $18.93 Unrealized @ Report Date 0.0%

MBX MBX BIOSCIENCES INC 0.8%

Value $7.417M Shares 650,000 Share Price $11.41 * Est. Cost/Share $22.87 Unrealized @ Report Date -55.5%

NKTR NEKTAR THERAPEUTICS 0.8%

Value $6.891M Shares 266,666 Share Price $25.84 * Est. Cost/Share $11.24 Unrealized @ Report Date 0.0%

VTGN VISTAGEN THERAPEUTICS INC 0.6%

Value $5.353M Shares 2,676,580 Share Price $2.00 * Est. Cost/Share $3.41 Unrealized @ Report Date -33.4%

KOD KODIAK SCIENCES INC 0.5%

Value $4.273M Shares 1,145,538 Share Price $3.73 * Est. Cost/Share $4.16 Unrealized @ Report Date -15.0%

KURA KURA ONCOLOGY INC 0.5%

Value $4.242M Shares 735,184 Share Price $5.77 * Est. Cost/Share $14.54 Unrealized @ Report Date -57.9%

TRDA ENTRADA THERAPEUTICS INC 0.4%

Value $3.931M Shares 584,955 Share Price $6.72 Est. Cost/Share $17.12 Unrealized @ Report Date —

— ADVERUM BIOTECHNOLOGIES INC 0.4%

Value $3.862M Shares 1,796,482 Share Price $2.15 Est. Cost/Share $7.02 Unrealized @ Report Date —

AVTX AVALO THERAPEUTICS INC 0.3%

Value $2.41M Shares 483,000 Share Price $4.99 * Est. Cost/Share $10.31 Unrealized @ Report Date -54.7%

VTYX VENTYX BIOSCIENCES INC 0.1%

Value $677K Shares 316,195 Share Price $2.14 * Est. Cost/Share $29.94 Unrealized @ Report Date -94.6%

JBIO JADE BIOSCIENCES INC 0.1%

Value $640K Shares 64,023 Share Price $9.99 * Est. Cost/Share $33.31 Unrealized @ Report Date 0.0%

CABA CABALETTA BIO INC 0.0%

Value $132K Shares 86,795 Share Price $1.52 Est. Cost/Share $3.64 Unrealized @ Report Date -57.2%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
CGON	CG ONCOLOGY INC	3,670,206	$95.43M	10.9%	$26.00 *	$40.67	-40.8%	COMM	156944100
TNGX	TANGO THERAPEUTICS INC	10,736,000	$54.97M	6.3%	$5.12 *	$4.64	-46.8%	COMM	87583X109
COGT	COGENT BIOSCIENCES INC	6,964,375	$50M	5.7%	$7.18 *	$9.05	-38.7%	COMM	19240Q201
OCUL	OCULAR THERAPEUTIX INC	5,319,148	$49.36M	5.6%	$9.28 *	$7.10	+10.3%	COMM	67576A100
—	CIDARA THERAPEUTICS INC	1,005,901	$49M	5.6%	$48.71	$25.94	—	COMM	171757206
ABVX	ABIVAX SA AMERICAN DEPOSITARY SHARES	6,056,596	$46.33M	5.3%	$7.65	$12.76	—	ADRS	00370M103
AMLX	AMYLYX PHARMACEUTICALS INC	5,943,812	$38.1M	4.4%	$6.41 *	$2.53	+91.9%	COMM	03237H101
CNTA	CENTESSA PHARMACEUTICALS PLC	2,890,816	$37.99M	4.3%	$13.14	$7.22	—	ADRS	152309100
FULC	FULCRUM THERAPEUTICS INC	5,250,000	$36.12M	4.1%	$6.88 *	$7.42	-27.9%	COMM	359616109
DYN	DYNE THERAPEUTICS INC	3,766,660	$35.86M	4.1%	$9.52 *	$14.96	-26.4%	COMM	26818M108
EYPT	EYEPOINT PHARMACEUTICALS INC	3,572,335	$33.62M	3.8%	$9.41 *	$10.51	-34.3%	COMM	30233G209
UPB	UPSTREAM BIO INC	2,801,763	$30.76M	3.5%	$10.98 *	$22.33	-58.6%	COMM	91678A107
SVRA	SAVARA INC	12,362,205	$28.19M	3.2%	$2.28 *	$3.73	-27.2%	COMM	805111101
DNTH	DIANTHUS THERAPEUTICS INC	1,501,624	$27.98M	3.2%	$18.63	$25.71	-27.0%	COMM	252828108
TYRA	TYRA BIOSCIENCES INC	2,898,103	$27.73M	3.2%	$9.57	$12.78	-25.6%	COMM	90240B106
IRON	DISC MEDICINE INC	465,257	$24.64M	2.8%	$52.96 *	$33.98	+38.2%	COMM	254604101
—	TOURMALINE BIO INC	1,477,593	$23.63M	2.7%	$15.99	$25.14	—	COMM	89157D105
AGIO	Agios Pharmaceuticals, Inc.	697,003	$23.18M	2.6%	$33.26 *	$30.31	0.0%	COMM	00847X104
GPCR	STRUCTURE THERAPEUTICS INC	1,063,000	$22.05M	2.5%	$20.74	$43.45	—	ADRS	86366E106
XNCR	XENCOR INC	2,452,138	$19.27M	2.2%	$7.86 *	$18.82	-52.3%	COMM	98401F105
SLN	SILENCE THERAPEUTICS PLC	3,033,560	$17.59M	2.0%	$5.80	$14.21	—	ADRS	82686Q101
SLNO	SOLENO THERAPEUTICS INC	186,250	$15.6M	1.8%	$83.78 *	$47.87	+56.3%	COMM	834203309
—	ASTRIA THERAPEUTICS INC	2,761,861	$14.8M	1.7%	$5.36	$14.07	—	COMM	04635X102
RAPT	RAPT Therapeutics, Inc.	1,636,275	$13.09M	1.5%	$8.00 *	$7.63	0.0%	COMM	75382E208
—	THIRD HARMONIC BIO INC	1,915,424	$10.4M	1.2%	$5.43	$13.43	—	COMM	88427A107
ELVN	Enliven Therapeutics, Inc.	498,000	$9.99M	1.1%	$20.06 *	$18.93	0.0%	COMM	29337E102
MBX	MBX BIOSCIENCES INC	650,000	$7.417M	0.8%	$11.41 *	$22.87	-55.5%	COMM	55287L101
NKTR	NEKTAR THERAPEUTICS	266,666	$6.891M	0.8%	$25.84 *	$11.24	0.0%	COMM	640268306
VTGN	VISTAGEN THERAPEUTICS INC	2,676,580	$5.353M	0.6%	$2.00 *	$3.41	-33.4%	COMM	92840H400
KOD	KODIAK SCIENCES INC	1,145,538	$4.273M	0.5%	$3.73 *	$4.16	-15.0%	COMM	50015M109
KURA	KURA ONCOLOGY INC	735,184	$4.242M	0.5%	$5.77 *	$14.54	-57.9%	COMM	50127T109
TRDA	ENTRADA THERAPEUTICS INC	584,955	$3.931M	0.4%	$6.72	$17.12	—	COMM	29384C108
—	ADVERUM BIOTECHNOLOGIES INC	1,796,482	$3.862M	0.4%	$2.15	$7.02	—	COMM	00773U207
AVTX	AVALO THERAPEUTICS INC	483,000	$2.41M	0.3%	$4.99 *	$10.31	-54.7%	COMM	05338F306
VTYX	VENTYX BIOSCIENCES INC	316,195	$677K	0.1%	$2.14 *	$29.94	-94.6%	COMM	92332V107
JBIO	JADE BIOSCIENCES INC	64,023	$640K	0.1%	$9.99 *	$33.31	0.0%	COMM	008064206
CABA	CABALETTA BIO INC	86,795	$132K	0.0%	$1.52	$3.64	-57.2%	COMM	12674W109