TCG Crossover Management, LLC Diversified Active

Location: Palo Alto, CA

CIK: 0001839948 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 17, 2025

Total Value: $2.033B (100.0% shares, 0.0% debt)

Holdings (40)

ABVX ABIVAX SA AMERICAN DEPOSITARY SHARES 29.7%

Value $604M Shares 7,111,596 Est. Cost $23.46 Unrealized —

CGON CG ONCOLOGY INC 7.3%

Value $148M Shares 3,670,206 Est. Cost $40.67 Unrealized -28.5%

COGT COGENT BIOSCIENCES INC 4.8%

Value $97.62M Shares 6,798,162 Est. Cost $9.05 Unrealized +30.9%

AMLX AMYLYX PHARMACEUTICALS INC 4.2%

Value $84.85M Shares 6,243,812 Est. Cost $2.86 Unrealized +228.5%

CNTA CENTESSA PHARMACEUTICALS PLC 3.7%

Value $76.06M Shares 3,136,480 Est. Cost $8.56 Unrealized —

TNGX TANGO THERAPEUTICS INC 3.5%

Value $71.7M Shares 8,536,196 Est. Cost $4.64 Unrealized +45.8%

OCUL OCULAR THERAPEUTIX INC 3.5%

Value $71.51M Shares 6,117,232 Est. Cost $7.73 Unrealized +54.7%

DNTH DIANTHUS THERAPEUTICS INC 3.2%

Value $65.98M Shares 1,676,624 Est. Cost $25.70 Unrealized -0.5%

— TOURMALINE BIO INC 3.1%

Value $62.74M Shares 1,311,783 Est. Cost $25.14 Unrealized —

DYN DYNE THERAPEUTICS INC 2.9%

Value $58.38M Shares 4,615,144 Est. Cost $14.30 Unrealized -20.3%

AGIO AGIOS PHARMACEUTICALS INC 2.8%

Value $57.4M Shares 1,430,041 Est. Cost $34.05 Unrealized +10.5%

EYPT EYEPOINT PHARMACEUTICALS INC 2.5%

Value $50.87M Shares 3,572,335 Est. Cost $10.51 Unrealized +9.5%

FULC FULCRUM THERAPEUTICS INC 2.4%

Value $48.3M Shares 5,250,000 Est. Cost $7.42 Unrealized -2.5%

SVRA SAVARA INC 2.2%

Value $44.13M Shares 12,362,205 Est. Cost $3.73 Unrealized -20.8%

RAPT RAPT THERAPEUTICS INC 2.1%

Value $42.2M Shares 1,636,275 Est. Cost $7.63 Unrealized +71.5%

TYRA TYRA BIOSCIENCES INC 2.0%

Value $40.54M Shares 2,898,103 Est. Cost $12.78 Unrealized -10.8%

UPB UPSTREAM BIO INC 2.0%

Value $39.82M Shares 2,117,103 Est. Cost $22.33 Unrealized -30.4%

LQDA LIQUIDIA TECHNOLOGIES INC 1.9%

Value $38.89M Shares 1,710,084 Est. Cost $21.69 Unrealized 0.0%

IRON DISC MEDICINE INC 1.5%

Value $30.74M Shares 465,257 Est. Cost $33.98 Unrealized +75.1%

GPCR STRUCTURE THERAPEUTICS INC 1.5%

Value $29.76M Shares 1,063,000 Est. Cost $43.45 Unrealized —

XNCR XENCOR INC 1.4%

Value $28.76M Shares 2,452,138 Est. Cost $18.82 Unrealized -53.9%

LBRX LB PHARMACEUTICALS INC 1.4%

Value $27.55M Shares 1,745,016 Est. Cost $15.87 Unrealized 0.0%

RVMD REVOLUTION MEDICINES INC 1.0%

Value $20.38M Shares 436,473 Est. Cost $39.15 Unrealized 0.0%

— ASTRIA THERAPEUTICS INC 1.0%

Value $20.11M Shares 2,761,861 Est. Cost $14.07 Unrealized —

KRRO KORRO BIO INC 1.0%

Value $19.94M Shares 416,301 Est. Cost $22.19 Unrealized 0.0%

KOD KODIAK SCIENCES INC 0.9%

Value $18.75M Shares 1,145,538 Est. Cost $4.16 Unrealized +107.0%

SYRE SPYRE THERAPEUTICS INC 0.9%

Value $18.45M Shares 1,100,582 Est. Cost $16.31 Unrealized 0.0%

SLN SILENCE THERAPEUTICS PLC 0.8%

Value $15.74M Shares 3,033,560 Est. Cost $14.21 Unrealized —

URGN UROGEN PHARMA LTD 0.7%

Value $14.31M Shares 717,347 Est. Cost $17.96 Unrealized 0.0%

ARVN ARVINAS HOLDING CO LLC 0.7%

Value $13.78M Shares 1,617,365 Est. Cost $7.58 Unrealized 0.0%

MNPR MONOPAR THERAPEUTICS INC 0.6%

Value $12.5M Shares 153,000 Est. Cost $44.70 Unrealized 0.0%

MBX MBX BIOSCIENCES INC 0.6%

Value $11.38M Shares 650,000 Est. Cost $22.87 Unrealized -41.5%

VTGN VISTAGEN THERAPEUTICS INC 0.5%

Value $9.502M Shares 2,676,580 Est. Cost $3.41 Unrealized -12.4%

RLAY RELAY THERAPEUTICS INC 0.5%

Value $9.45M Shares 1,810,351 Est. Cost $3.81 Unrealized 0.0%

— ADVERUM BIOTECHNOLOGIES INC 0.4%

Value $7.557M Shares 1,668,174 Est. Cost $7.02 Unrealized —

AVTX AVALO THERAPEUTICS INC 0.3%

Value $6.139M Shares 483,000 Est. Cost $10.31 Unrealized -16.6%

ADCT ADC THERAPEUTICS SA 0.3%

Value $5.561M Shares 1,390,175 Est. Cost $3.15 Unrealized 0.0%

PEPG PEPGEN INC 0.3%

Value $5.544M Shares 1,200,000 Est. Cost $1.61 Unrealized 0.0%

TRDA ENTRADA THERAPEUTICS INC 0.2%

Value $3.393M Shares 584,955 Est. Cost $17.12 Unrealized —

VTYX VENTYX BIOSCIENCES INC 0.0%

Value $983K Shares 316,195 Est. Cost $29.94 Unrealized -91.2%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ABVX	ABIVAX SA AMERICAN DEPOSITARY SHARES	7,111,596	$604M	29.7%	$23.46	—	ADRS	00370M103
CGON	CG ONCOLOGY INC	3,670,206	$148M	7.3%	$40.67	-28.5%	COMM	156944100
COGT	COGENT BIOSCIENCES INC	6,798,162	$97.62M	4.8%	$9.05	+30.9%	COMM	19240Q201
AMLX	AMYLYX PHARMACEUTICALS INC	6,243,812	$84.85M	4.2%	$2.86	+228.5%	COMM	03237H101
CNTA	CENTESSA PHARMACEUTICALS PLC	3,136,480	$76.06M	3.7%	$8.56	—	ADRS	152309100
TNGX	TANGO THERAPEUTICS INC	8,536,196	$71.7M	3.5%	$4.64	+45.8%	COMM	87583X109
OCUL	OCULAR THERAPEUTIX INC	6,117,232	$71.51M	3.5%	$7.73	+54.7%	COMM	67576A100
DNTH	DIANTHUS THERAPEUTICS INC	1,676,624	$65.98M	3.2%	$25.70	-0.5%	COMM	252828108
—	TOURMALINE BIO INC	1,311,783	$62.74M	3.1%	$25.14	—	COMM	89157D105
DYN	DYNE THERAPEUTICS INC	4,615,144	$58.38M	2.9%	$14.30	-20.3%	COMM	26818M108
AGIO	AGIOS PHARMACEUTICALS INC	1,430,041	$57.4M	2.8%	$34.05	+10.5%	COMM	00847X104
EYPT	EYEPOINT PHARMACEUTICALS INC	3,572,335	$50.87M	2.5%	$10.51	+9.5%	COMM	30233G209
FULC	FULCRUM THERAPEUTICS INC	5,250,000	$48.3M	2.4%	$7.42	-2.5%	COMM	359616109
SVRA	SAVARA INC	12,362,205	$44.13M	2.2%	$3.73	-20.8%	COMM	805111101
RAPT	RAPT THERAPEUTICS INC	1,636,275	$42.2M	2.1%	$7.63	+71.5%	COMM	75382E208
TYRA	TYRA BIOSCIENCES INC	2,898,103	$40.54M	2.0%	$12.78	-10.8%	COMM	90240B106
UPB	UPSTREAM BIO INC	2,117,103	$39.82M	2.0%	$22.33	-30.4%	COMM	91678A107
LQDA	LIQUIDIA TECHNOLOGIES INC	1,710,084	$38.89M	1.9%	$21.69	0.0%	COMM	53635D202
IRON	DISC MEDICINE INC	465,257	$30.74M	1.5%	$33.98	+75.1%	COMM	254604101
GPCR	STRUCTURE THERAPEUTICS INC	1,063,000	$29.76M	1.5%	$43.45	—	ADRS	86366E106
XNCR	XENCOR INC	2,452,138	$28.76M	1.4%	$18.82	-53.9%	COMM	98401F105
LBRX	LB PHARMACEUTICALS INC	1,745,016	$27.55M	1.4%	$15.87	0.0%	COMM	50180M108
RVMD	REVOLUTION MEDICINES INC	436,473	$20.38M	1.0%	$39.15	0.0%	COMM	76155X100
—	ASTRIA THERAPEUTICS INC	2,761,861	$20.11M	1.0%	$14.07	—	COMM	04635X102
KRRO	KORRO BIO INC	416,301	$19.94M	1.0%	$22.19	0.0%	COMM	500946108
KOD	KODIAK SCIENCES INC	1,145,538	$18.75M	0.9%	$4.16	+107.0%	COMM	50015M109
SYRE	SPYRE THERAPEUTICS INC	1,100,582	$18.45M	0.9%	$16.31	0.0%	COMM	00773J202
SLN	SILENCE THERAPEUTICS PLC	3,033,560	$15.74M	0.8%	$14.21	—	ADRS	82686Q101
URGN	UROGEN PHARMA LTD	717,347	$14.31M	0.7%	$17.96	0.0%	COMM	M96088105
ARVN	ARVINAS HOLDING CO LLC	1,617,365	$13.78M	0.7%	$7.58	0.0%	COMM	04335A105
MNPR	MONOPAR THERAPEUTICS INC	153,000	$12.5M	0.6%	$44.70	0.0%	COMM	61023L207
MBX	MBX BIOSCIENCES INC	650,000	$11.38M	0.6%	$22.87	-41.5%	COMM	55287L101
VTGN	VISTAGEN THERAPEUTICS INC	2,676,580	$9.502M	0.5%	$3.41	-12.4%	COMM	92840H400
RLAY	RELAY THERAPEUTICS INC	1,810,351	$9.45M	0.5%	$3.81	0.0%	COMM	75943R102
—	ADVERUM BIOTECHNOLOGIES INC	1,668,174	$7.557M	0.4%	$7.02	—	COMM	00773U207
AVTX	AVALO THERAPEUTICS INC	483,000	$6.139M	0.3%	$10.31	-16.6%	COMM	05338F306
ADCT	ADC THERAPEUTICS SA	1,390,175	$5.561M	0.3%	$3.15	0.0%	COMM	H0036K147
PEPG	PEPGEN INC	1,200,000	$5.544M	0.3%	$1.61	0.0%	COMM	713317105
TRDA	ENTRADA THERAPEUTICS INC	584,955	$3.393M	0.2%	$17.12	—	COMM	29384C108
VTYX	VENTYX BIOSCIENCES INC	316,195	$983K	0.0%	$29.94	-91.2%	COMM	92332V107