Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
ABVX	ABIVAX SA AMERICAN DEPOSITARY SHARES	7,111,596	$959M	31.7%	$134.86	$23.46	—	ADRS	00370M103
COGT	COGENT BIOSCIENCES INC	5,868,162	$208M	6.9%	$35.52 *	$9.05	+210.6%	COMM	19240Q201
CGON	CG ONCOLOGY INC	3,670,206	$152M	5.0%	$41.52	$40.67	+1.7%	COMM	156944100
TNGX	TANGO THERAPEUTICS INC	12,762,094	$113M	3.7%	$8.86 *	$5.96	+44.6%	COMM	87583X109
CNTA	CENTESSA PHARMACEUTICALS PLC	4,286,480	$107M	3.5%	$25.01	$12.97	—	ADRS	152309100
DYN	DYNE THERAPEUTICS INC	4,615,144	$90.27M	3.0%	$19.56 *	$14.30	+32.4%	COMM	26818M108
RAPT	RAPT THERAPEUTICS INC	2,582,408	$87.47M	2.9%	$33.87 *	$16.21	+91.6%	COMM	75382E208
TYRA	TYRA BIOSCIENCES INC	2,898,103	$76.19M	2.5%	$26.29 *	$12.78	+43.7%	COMM	90240B106
AMLX	AMYLYX PHARMACEUTICALS INC	6,243,812	$75.43M	2.5%	$12.08 *	$2.86	+374.1%	COMM	03237H101
SVRA	SAVARA INC	12,362,205	$74.54M	2.5%	$6.03 *	$3.73	+31.2%	COMM	805111101
GLUE	MONTE ROSA THERAPEUTICS INC	4,622,151	$72.48M	2.4%	$15.68 *	$13.48	0.0%	COMM	61225M102
OCUL	OCULAR THERAPEUTIX INC	5,740,231	$69.69M	2.3%	$12.14	$7.73	+57.1%	COMM	67576A100
DNTH	DIANTHUS THERAPEUTICS INC	1,676,624	$69.09M	2.3%	$41.21 *	$25.70	+50.9%	COMM	252828108
EYPT	EYEPOINT PHARMACEUTICALS INC	3,572,335	$65.27M	2.2%	$18.27 *	$10.51	+34.8%	COMM	30233G209
GPCR	STRUCTURE THERAPEUTICS INC	920,857	$64.05M	2.1%	$69.55	$43.45	—	ADRS	86366E106
SYRE	SPYRE THERAPEUTICS INC	1,900,582	$62.26M	2.1%	$32.76 *	$20.44	+27.8%	COMM	00773J202
FULC	FULCRUM THERAPEUTICS INC	5,250,000	$59.38M	2.0%	$11.31 *	$7.42	+37.2%	COMM	359616109
LQDA	LIQUIDIA TECHNOLOGIES INC	1,710,084	$58.98M	2.0%	$34.49 *	$21.69	+31.2%	COMM	53635D202
BHVN	BIOHAVEN LTD	4,631,317	$52.29M	1.7%	$11.29 *	$12.39	0.0%	COMM	G1110E107
IMVT	IMMUNOVANT INC	1,660,933	$42.22M	1.4%	$25.42 *	$22.30	0.0%	COMM	45258J102
KOD	KODIAK SCIENCES INC	1,445,538	$40.42M	1.3%	$27.96 *	$7.55	+171.3%	COMM	50015M109
ADCT	ADC THERAPEUTICS SA	11,390,175	$40.21M	1.3%	$3.53 *	$3.95	+2.8%	COMM	H0036K147
LBRX	LB PHARMACEUTICALS INC	1,745,015	$38.84M	1.3%	$22.26 *	$15.87	+10.1%	COMM	50180M108
XNCR	XENCOR INC	2,452,138	$37.54M	1.2%	$15.31 *	$18.82	-20.6%	COMM	98401F105
RVMD	REVOLUTION MEDICINES INC	436,473	$34.77M	1.2%	$79.65 *	$39.15	+67.5%	COMM	76155X100
AGIO	AGIOS PHARMACEUTICALS INC	1,181,841	$32.17M	1.1%	$27.22 *	$34.05	+3.0%	COMM	00847X104
ARVN	ARVINAS HOLDING CO LLC	2,666,216	$31.62M	1.0%	$11.86 *	$8.90	+22.7%	COMM	04335A105
RLAY	RELAY THERAPEUTICS INC	3,220,186	$27.24M	0.9%	$8.46 *	$5.27	+35.5%	COMM	75943R102
JANX	JANUX THERAPEUTICS INC	1,789,617	$24.7M	0.8%	$13.80 *	$23.52	0.0%	COMM	47103J105
TRDA	ENTRADA THERAPEUTICS INC	2,088,392	$21.47M	0.7%	$10.28	$12.20	—	COMM	29384C108
MBX	MBX BIOSCIENCES INC	650,000	$20.5M	0.7%	$31.54 *	$22.87	+6.1%	COMM	55287L101
UPB	UPSTREAM BIO INC	743,886	$20.2M	0.7%	$27.15 *	$22.33	+11.5%	COMM	91678A107
SLN	SILENCE THERAPEUTICS PLC	3,033,560	$18.44M	0.6%	$6.08	$14.21	—	ADRS	82686Q101
URGN	UROGEN PHARMA LTD	717,347	$16.8M	0.6%	$23.42 *	$17.96	+20.8%	COMM	M96088105
ALEC	ALECTOR INC	10,000,000	$15.6M	0.5%	$1.56 *	$1.77	0.0%	COMM	014442107
MNPR	MONOPAR THERAPEUTICS INC	141,915	$9.267M	0.3%	$65.30 *	$44.70	+82.8%	COMM	61023L207
AVTX	AVALO THERAPEUTICS INC	483,000	$8.771M	0.3%	$18.16 *	$10.31	+63.7%	COMM	05338F306
MAZE	MAZE THERAPEUTICS INC	173,816	$7.201M	0.2%	$41.43 *	$34.37	0.0%	COMM	578784100
MIRM	MIRUM PHARMACEUTICALS INC	62,049	$4.901M	0.2%	$78.99 *	$71.78	0.0%	COMM	604749101
LONA	Athira Pharma, Inc.	464,398	$3.349M	0.1%	$7.21 *	$4.58	0.0%	COMM	04746L203
KRRO	KORRO BIO INC	416,301	$3.335M	0.1%	$8.01 *	$22.19	+5.3%	COMM	500946108
VTYX	VENTYX BIOSCIENCES INC	316,195	$2.855M	0.1%	$9.03 *	$29.94	-75.0%	COMM	92332V107
VTGN	VISTAGEN THERAPEUTICS INC	2,676,580	$1.772M	0.1%	$0.66 *	$3.41	+5.9%	COMM	92840H400