Opaleye Management Inc. Quant / Systematic

CIK: 0001595855 · Show all filings

Period: Q3 2023 (← Previous) (Next →)

Filing Date: Nov 15, 2023

Total Value ($000): $307,380 (100.0% shares, 0.0% debt)

Holdings (40)

HROW HARROW HEALTH INC 17.7%

Value ($000) $54,534 Shares 3,795,000 Est. Cost $6.06 Unrealized +188.4%

— ACELYRIN INC 13.7%

Value ($000) $42,166 Shares 4,146,138 Est. Cost $20.90 Unrealized —

OCUL OCULAR THERAPEUTIX INC 6.6%

Value ($000) $20,310 Shares 6,468,000 Est. Cost $4.90 Unrealized -16.5%

TGTX TG THERAPEUTICS INC 5.1%

Value ($000) $15,800 Shares 1,890,000 Est. Cost $13.94 Unrealized 0.0%

RYTM RHYTHM PHARMACEUTICALS INC 4.9%

Value ($000) $14,970 Shares 653,000 Est. Cost $12.73 Unrealized +75.9%

CPRX CATALYST PHARMACEUTICALS INC 4.6%

Value ($000) $14,086 Shares 1,205,000 Est. Cost $13.38 Unrealized 0.0%

KROS KEROS THERAPEUTICS INC 3.7%

Value ($000) $11,490 Shares 360,400 Est. Cost $47.35 Unrealized -21.2%

BHVN BIOHAVEN LTD 3.7%

Value ($000) $11,418 Shares 439,000 Est. Cost $14.12 Unrealized +47.2%

CRNX CRINETICS PHARMACEUTICALS INC 3.6%

Value ($000) $11,004 Shares 370,000 Est. Cost $20.62 Unrealized -0.0%

ETON ETON PHARMACEUTICALS INC 3.3%

Value ($000) $10,134 Shares 2,430,270 Est. Cost $5.89 Unrealized -34.5%

IDYA IDEAYA BIOSCIENCES INC 2.7%

Value ($000) $8,404 Shares 311,500 Est. Cost $17.38 Unrealized +45.9%

— MORPHOSYS AG 2.6%

Value ($000) $8,127 Shares 1,209,380 Est. Cost $3.87 Unrealized —

TELA TELA BIO INC 2.0%

Value ($000) $6,000 Shares 750,000 Est. Cost $9.44 Unrealized -1.6%

EWTX EDGEWISE THERAPEUTICS INC 1.6%

Value ($000) $5,016 Shares 875,405 Est. Cost $10.13 Unrealized -32.9%

KALV KALVISTA PHARMACEUTICALS INC 1.6%

Value ($000) $4,815 Shares 500,000 Est. Cost $5.36 Unrealized +90.7%

— MARINUS PHARMACEUTICALS INC 1.5%

Value ($000) $4,701 Shares 584,000 Est. Cost $3.98 Unrealized —

PCVX VAXCYTE INC 1.5%

Value ($000) $4,588 Shares 90,000 Est. Cost $38.73 Unrealized +27.4%

TARA PROTARA THERAPEUTICS INC 1.5%

Value ($000) $4,497 Shares 2,692,594 Est. Cost $29.10 Unrealized -92.1%

URGN UROGEN PHARMA LTD 1.5%

Value ($000) $4,483 Shares 320,000 Est. Cost $8.22 Unrealized +95.4%

GERN GERON CORP 1.3%

Value ($000) $4,060 Shares 1,915,000 Est. Cost $2.85 Unrealized -4.6%

GOSS GOSSAMER BIO INC 1.3%

Value ($000) $3,959 Shares 4,754,200 Est. Cost $1.22 Unrealized -5.4%

FDMT 4D MOLECULAR THERAPEUTICS INC 1.3%

Value ($000) $3,927 Shares 308,500 Est. Cost $19.77 Unrealized -15.4%

XOMA XOMA CORP DEL 1.3%

Value ($000) $3,868 Shares 274,500 Est. Cost $11.26 Unrealized +39.2%

TRVI TREVI THERAPEUTICS INC 1.2%

Value ($000) $3,719 Shares 1,705,900 Est. Cost $2.31 Unrealized -2.2%

LQDA LIQUIDIA CORPORATION 1.2%

Value ($000) $3,618 Shares 570,700 Est. Cost $5.52 Unrealized +30.4%

LRMR LARIMAR THERAPEUTICS INC 1.1%

Value ($000) $3,352 Shares 848,500 Est. Cost $7.31 Unrealized -48.3%

NYXH NYXOAH S A 1.0%

Value ($000) $3,115 Shares 441,896 Est. Cost $7.81 Unrealized +0.3%

— GOSSAMER BIO INC 1.0%

Value ($000) $3,099 Shares 8,000,000 Est. Cost $0.39 Unrealized —

— BIODESIX 1.0%

Value ($000) $3,038 Shares 455,573 Est. Cost $6.67 Unrealized —

IOVA IOVANCE BIOTHERAPEUTICS INC 0.9%

Value ($000) $2,776 Shares 610,000 Est. Cost $6.78 Unrealized -3.8%

— APPLIED THERAPEUTICS 0.7%

Value ($000) $2,224 Shares 893,000 Est. Cost $2.49 Unrealized —

— IGM BIOSCIIENCES INC 0.7%

Value ($000) $2,179 Shares 261,000 Est. Cost $8.56 Unrealized —

CDXS CODEXIS INC 0.7%

Value ($000) $2,115 Shares 1,118,900 Est. Cost $3.11 Unrealized -24.9%

VSTM VERASTEM INC 0.6%

Value ($000) $1,719 Shares 211,400 Est. Cost $8.32 Unrealized +15.4%

PGEN PRECIGEN INC 0.4%

Value ($000) $1,318 Shares 928,500 Est. Cost $1.42 Unrealized 0.0%

— TRACON PHARMACEUTICALS INC 0.3%

Value ($000) $848 Shares 4,764,508 Est. Cost $4.42 Unrealized —

XERS XERIS BIOPHARMA HOLDINGS INC 0.2%

Value ($000) $725 Shares 390,000 Est. Cost $2.29 Unrealized 0.0%

— FORTRESS BIOTECH INC 0.2%

Value ($000) $581 Shares 2,000,000 Est. Cost $1.66 Unrealized —

— KEZAR LIFE SCIENCES INC 0.2%

Value ($000) $506 Shares 425,000 Est. Cost $1.64 Unrealized —

RLMD RELMADA THERAPEUTICS INC 0.0%

Value ($000) $90 Shares 30,000 Est. Cost $2.97 Unrealized 0.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
HROW	HARROW HEALTH INC	3,795,000	$54,534	17.7%	$6.06	+188.4%	COM	415858109
—	ACELYRIN INC	4,146,138	$42,166	13.7%	$20.90	—	COM	00445A100
OCUL	OCULAR THERAPEUTIX INC	6,468,000	$20,310	6.6%	$4.90	-16.5%	COM	67576A100
TGTX	TG THERAPEUTICS INC	1,890,000	$15,800	5.1%	$13.94	0.0%	COM	88322Q108
RYTM	RHYTHM PHARMACEUTICALS INC	653,000	$14,970	4.9%	$12.73	+75.9%	COM	76243J105
CPRX	CATALYST PHARMACEUTICALS INC	1,205,000	$14,086	4.6%	$13.38	0.0%	COM	14888U101
KROS	KEROS THERAPEUTICS INC	360,400	$11,490	3.7%	$47.35	-21.2%	COM	492327101
BHVN	BIOHAVEN LTD	439,000	$11,418	3.7%	$14.12	+47.2%	COM	G1110E107
CRNX	CRINETICS PHARMACEUTICALS INC	370,000	$11,004	3.6%	$20.62	-0.0%	COM	22663K107
ETON	ETON PHARMACEUTICALS INC	2,430,270	$10,134	3.3%	$5.89	-34.5%	COM	29772L108
IDYA	IDEAYA BIOSCIENCES INC	311,500	$8,404	2.7%	$17.38	+45.9%	COM	45166A102
—	MORPHOSYS AG	1,209,380	$8,127	2.6%	$3.87	—	SPONSORED ADS	617760202
TELA	TELA BIO INC	750,000	$6,000	2.0%	$9.44	-1.6%	COM	872381108
EWTX	EDGEWISE THERAPEUTICS INC	875,405	$5,016	1.6%	$10.13	-32.9%	COM	28036F105
KALV	KALVISTA PHARMACEUTICALS INC	500,000	$4,815	1.6%	$5.36	+90.7%	COM	483497103
—	MARINUS PHARMACEUTICALS INC	584,000	$4,701	1.5%	$3.98	—	COM NEW	56854Q200
PCVX	VAXCYTE INC	90,000	$4,588	1.5%	$38.73	+27.4%	COM	92243G108
TARA	PROTARA THERAPEUTICS INC	2,692,594	$4,497	1.5%	$29.10	-92.1%	COM STK	74365U107
URGN	UROGEN PHARMA LTD	320,000	$4,483	1.5%	$8.22	+95.4%	COM	M96088105
GERN	GERON CORP	1,915,000	$4,060	1.3%	$2.85	-4.6%	COM	374163103
GOSS	GOSSAMER BIO INC	4,754,200	$3,959	1.3%	$1.22	-5.4%	COM	38341P102
FDMT	4D MOLECULAR THERAPEUTICS INC	308,500	$3,927	1.3%	$19.77	-15.4%	COM	35104E100
XOMA	XOMA CORP DEL	274,500	$3,868	1.3%	$11.26	+39.2%	COM NEW	98419J206
TRVI	TREVI THERAPEUTICS INC	1,705,900	$3,719	1.2%	$2.31	-2.2%	COM	89532M101
LQDA	LIQUIDIA CORPORATION	570,700	$3,618	1.2%	$5.52	+30.4%	COM NEW	53635D202
LRMR	LARIMAR THERAPEUTICS INC	848,500	$3,352	1.1%	$7.31	-48.3%	COM	517125100
NYXH	NYXOAH S A	441,896	$3,115	1.0%	$7.81	+0.3%	SHS	B6S7WD106
—	GOSSAMER BIO INC	8,000,000	$3,099	1.0%	$0.39	—	NOTE 5.000% 6/0	38341PAA0
—	BIODESIX	455,573	$3,038	1.0%	$6.67	—	COM	09075X108
IOVA	IOVANCE BIOTHERAPEUTICS INC	610,000	$2,776	0.9%	$6.78	-3.8%	COM	462260100
—	APPLIED THERAPEUTICS	893,000	$2,224	0.7%	$2.49	—	COM	03828A101
—	IGM BIOSCIIENCES INC	261,000	$2,179	0.7%	$8.56	—	COM	449585108
CDXS	CODEXIS INC	1,118,900	$2,115	0.7%	$3.11	-24.9%	COM	192005106
VSTM	VERASTEM INC	211,400	$1,719	0.6%	$8.32	+15.4%	COM NEW	92337C203
PGEN	PRECIGEN INC	928,500	$1,318	0.4%	$1.42	0.0%	COM	74017N105
—	TRACON PHARMACEUTICALS INC	4,764,508	$848	0.3%	$4.42	—	COM NEW	89237H209
XERS	XERIS BIOPHARMA HOLDINGS INC	390,000	$725	0.2%	$2.29	0.0%	COM	98422E103
—	FORTRESS BIOTECH INC	2,000,000	$581	0.2%	$1.66	—	COM	34960Q109
—	KEZAR LIFE SCIENCES INC	425,000	$506	0.2%	$1.64	—	COM	49372L100
RLMD	RELMADA THERAPEUTICS INC	30,000	$90	0.0%	$2.97	0.0%	COM	75955J402