EcoR1 Capital, LLC Quant / Systematic

CIK: 0001587114 · Show all filings

Period: Q1 2019 (← Previous) (Next →)

Filing Date: May 15, 2019

Total Value ($000): $1,084,777 (100.0% shares, 0.0% debt)

Holdings (41)

ARGX ARGENX SE 9.5%

Value ($000) $103,004 Shares 825,087 Est. Cost $96.07 Unrealized —

KURA KURA ONCOLOGY INC 8.1%

Value ($000) $87,541 Shares 5,276,753 Est. Cost $10.87 Unrealized +41.7%

— MIRATI THERAPEUTICS INC 6.8%

Value ($000) $73,300 Shares 1,000,000 Est. Cost $53.32 Unrealized —

CRSP CRISPR THERAPEUTICS AG 6.2%

Value ($000) $67,092 Shares 1,878,277 Est. Cost $36.55 Unrealized -5.4%

XNCR XENCOR INC 5.9%

Value ($000) $63,966 Shares 2,059,429 Est. Cost $34.92 Unrealized -4.7%

— SPARK THERAPEUTICS INC 5.6%

Value ($000) $60,243 Shares 529,000 Est. Cost $50.49 Unrealized —

IRWD IRONWOOD PHARMACEUTICALS INC 5.5%

Value ($000) $59,494 Shares 4,397,168 Est. Cost $11.86 Unrealized -5.8%

— FIBROGEN INC 5.0%

Value ($000) $54,350 Shares 1,000,000 Est. Cost — Unrealized —

— DICERNA PHARMACEUTICALS INC 4.5%

Value ($000) $48,585 Shares 3,316,407 Est. Cost $9.60 Unrealized —

ASND ASCENDIS PHARMA A S 3.9%

Value ($000) $42,468 Shares 360,819 Est. Cost $26.79 Unrealized —

— ASCENDIS PHARMA A S 3.9%

Value ($000) $42,372 Shares 360,000 Est. Cost — Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL INC 3.2%

Value ($000) $34,534 Shares 497,899 Est. Cost $57.14 Unrealized 0.0%

— MIRATI THERAPEUTICS INC 2.4%

Value ($000) $25,574 Shares 348,900 Est. Cost — Unrealized —

— MYOKARDIA INC 2.3%

Value ($000) $24,881 Shares 478,574 Est. Cost $50.46 Unrealized —

— FIBROGEN INC 2.2%

Value ($000) $23,957 Shares 440,800 Est. Cost — Unrealized —

— ASSEMBLY BIOSCIENCES INC 2.1%

Value ($000) $22,714 Shares 1,153,599 Est. Cost $8.38 Unrealized —

— EIGER BIOPHARMACEUTICALS INC 2.1%

Value ($000) $22,307 Shares 1,595,643 Est. Cost $11.49 Unrealized —

— MAGENTA THERAPEUTICS INC 1.9%

Value ($000) $21,045 Shares 1,277,787 Est. Cost $13.50 Unrealized —

GOSS GOSSAMER BIO INC 1.5%

Value ($000) $16,731 Shares 772,096 Est. Cost $20.85 Unrealized 0.0%

— CHIASMA INC 1.5%

Value ($000) $15,828 Shares 3,043,827 Est. Cost $5.00 Unrealized —

— KEZAR LIFE SCIENCES INC 1.4%

Value ($000) $15,194 Shares 856,471 Est. Cost $17.35 Unrealized —

— IRONWOOD PHARMACUTICALS INC 1.4%

Value ($000) $14,675 Shares 1,084,600 Est. Cost — Unrealized —

— HARPOON THERAPEUTICS INC 1.2%

Value ($000) $12,656 Shares 1,336,423 Est. Cost $9.47 Unrealized —

RCUS ARCUS BIOSCIENCES INC 1.1%

Value ($000) $12,367 Shares 990,146 Est. Cost $16.66 Unrealized -34.8%

— MERSANA THERAPEUTICS INC 1.1%

Value ($000) $12,098 Shares 2,300,000 Est. Cost $5.26 Unrealized —

— RUBIUS THERAPEUTICS INC 1.1%

Value ($000) $11,697 Shares 646,228 Est. Cost $23.51 Unrealized —

RYTM RHYTHM PHARMACEUTICALS INC 1.0%

Value ($000) $10,987 Shares 400,838 Est. Cost $27.64 Unrealized +4.0%

— SURFACE ONCOLOGY INC 1.0%

Value ($000) $10,797 Shares 2,263,488 Est. Cost $10.40 Unrealized —

— FIBROGEN INC 0.8%

Value ($000) $9,152 Shares 168,382 Est. Cost $36.02 Unrealized —

PRTA PROTHENA CORP PLC 0.8%

Value ($000) $8,813 Shares 726,519 Est. Cost $11.89 Unrealized +5.0%

RCKT ROCKET PHARMACEUTICALS INC 0.7%

Value ($000) $7,893 Shares 450,000 Est. Cost $16.60 Unrealized -4.9%

ABUS ARBUTUS BIOPHARMA CORP 0.7%

Value ($000) $7,779 Shares 2,172,883 Est. Cost $6.80 Unrealized -43.6%

— ADURO BIOTECH INC 0.7%

Value ($000) $7,719 Shares 1,939,390 Est. Cost $3.98 Unrealized —

— UNITY BIOTECHNOLOGY INC 0.7%

Value ($000) $7,353 Shares 906,614 Est. Cost $15.06 Unrealized —

SRRK SCHOLAR ROCK HOLDING CORP 0.6%

Value ($000) $6,364 Shares 338,668 Est. Cost $18.88 Unrealized -6.8%

— AQUINOX PHARMACEUTICALS INC 0.6%

Value ($000) $6,107 Shares 2,265,880 Est. Cost $2.79 Unrealized —

— CURIS INC 0.5%

Value ($000) $5,935 Shares 2,982,208 Est. Cost $0.69 Unrealized —

ZLAB ZAI LAB LTD 0.2%

Value ($000) $2,317 Shares 78,519 Est. Cost $20.92 Unrealized —

VCEL VERICEL CORP 0.2%

Value ($000) $2,294 Shares 131,001 Est. Cost $18.29 Unrealized 0.0%

SNNAQ SIENNA BIOPHARMACEUTICALS INC 0.2%

Value ($000) $1,856 Shares 800,000 Est. Cost $2.71 Unrealized 0.0%

ARVN ARVINAS INC 0.1%

Value ($000) $738 Shares 50,000 Est. Cost $16.46 Unrealized +7.8%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
ARGX	ARGENX SE	825,087	$103,004	9.5%	$96.07	—	SPONSORED ADR	04016X101
KURA	KURA ONCOLOGY INC	5,276,753	$87,541	8.1%	$10.87	+41.7%	COM	50127T109
—	MIRATI THERAPEUTICS INC	1,000,000	$73,300	6.8%	$53.32	—	COM	60468T105
CRSP	CRISPR THERAPEUTICS AG	1,878,277	$67,092	6.2%	$36.55	-5.4%	COM	H17182108
XNCR	XENCOR INC	2,059,429	$63,966	5.9%	$34.92	-4.7%	COM	98401F105
—	SPARK THERAPEUTICS INC	529,000	$60,243	5.6%	$50.49	—	COM	84652J103
IRWD	IRONWOOD PHARMACEUTICALS INC	4,397,168	$59,494	5.5%	$11.86	-5.8%	COM	46333X108
—	FIBROGEN INC	1,000,000	$54,350	5.0%	—	—	Put	31572Q958
—	DICERNA PHARMACEUTICALS INC	3,316,407	$48,585	4.5%	$9.60	—	COM	253031108
ASND	ASCENDIS PHARMA A S	360,819	$42,468	3.9%	$26.79	—	SPONSORED ADR	04351P101
—	ASCENDIS PHARMA A S	360,000	$42,372	3.9%	—	—	Put	04351P951
RARE	ULTRAGENYX PHARMACEUTICAL INC	497,899	$34,534	3.2%	$57.14	0.0%	COM	90400D108
—	MIRATI THERAPEUTICS INC	348,900	$25,574	2.4%	—	—	Call	60468T905
—	MYOKARDIA INC	478,574	$24,881	2.3%	$50.46	—	COM	62857M105
—	FIBROGEN INC	440,800	$23,957	2.2%	—	—	Call	31572Q908
—	ASSEMBLY BIOSCIENCES INC	1,153,599	$22,714	2.1%	$8.38	—	COM	045396108
—	EIGER BIOPHARMACEUTICALS INC	1,595,643	$22,307	2.1%	$11.49	—	COM	28249U105
—	MAGENTA THERAPEUTICS INC	1,277,787	$21,045	1.9%	$13.50	—	COM	55910K108
GOSS	GOSSAMER BIO INC	772,096	$16,731	1.5%	$20.85	0.0%	COM	38341P102
—	CHIASMA INC	3,043,827	$15,828	1.5%	$5.00	—	COM	16706W102
—	KEZAR LIFE SCIENCES INC	856,471	$15,194	1.4%	$17.35	—	COM	49372L100
—	IRONWOOD PHARMACUTICALS INC	1,084,600	$14,675	1.4%	—	—	Call	46333X908
—	HARPOON THERAPEUTICS INC	1,336,423	$12,656	1.2%	$9.47	—	COM	41358P106
RCUS	ARCUS BIOSCIENCES INC	990,146	$12,367	1.1%	$16.66	-34.8%	COM	03969F109
—	MERSANA THERAPEUTICS INC	2,300,000	$12,098	1.1%	$5.26	—	COM	59045L106
—	RUBIUS THERAPEUTICS INC	646,228	$11,697	1.1%	$23.51	—	COM	78116T103
RYTM	RHYTHM PHARMACEUTICALS INC	400,838	$10,987	1.0%	$27.64	+4.0%	COM	76243J105
—	SURFACE ONCOLOGY INC	2,263,488	$10,797	1.0%	$10.40	—	COM	86877M209
—	FIBROGEN INC	168,382	$9,152	0.8%	$36.02	—	COM	31572Q808
PRTA	PROTHENA CORP PLC	726,519	$8,813	0.8%	$11.89	+5.0%	COM	G72800108
RCKT	ROCKET PHARMACEUTICALS INC	450,000	$7,893	0.7%	$16.60	-4.9%	COM	77313F106
ABUS	ARBUTUS BIOPHARMA CORP	2,172,883	$7,779	0.7%	$6.80	-43.6%	COM	03879J100
—	ADURO BIOTECH INC	1,939,390	$7,719	0.7%	$3.98	—	COM	00739L101
—	UNITY BIOTECHNOLOGY INC	906,614	$7,353	0.7%	$15.06	—	COM	91381U101
SRRK	SCHOLAR ROCK HOLDING CORP	338,668	$6,364	0.6%	$18.88	-6.8%	COM	80706P103
—	AQUINOX PHARMACEUTICALS INC	2,265,880	$6,107	0.6%	$2.79	—	COM	03842B101
—	CURIS INC	2,982,208	$5,935	0.5%	$0.69	—	COM	231269200
ZLAB	ZAI LAB LTD	78,519	$2,317	0.2%	$20.92	—	SPONSORED ADR	98887Q104
VCEL	VERICEL CORP	131,001	$2,294	0.2%	$18.29	0.0%	COM	92346J108
SNNAQ	SIENNA BIOPHARMACEUTICALS INC	800,000	$1,856	0.2%	$2.71	0.0%	COM	82622H108
ARVN	ARVINAS INC	50,000	$738	0.1%	$16.46	+7.8%	COM	04335A105