Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ERAS	ERASCA INC	2,700,000	$49.46M	1.7%	$18.32	—	COM	29479A108
PBLS	PARABILIS MEDICINES INC	1,465,070	$40.1M	1.4%	$27.37	—	COM	698955101
LEGN	LEGEND BIOTECH CORP	1,205,000	$34.8M	1.2%	$28.88	—	SPONSORED ADS	52490G102
UNH	UNITEDHEALTH GROUP INC	80,000	$33.25M	1.1%	$415.63	—	COM	91324P102
PALI	PALISADE BIO INC	13,063,687	$27.3M	0.9%	$2.09	—	COM	696389402
SUPN	SUPERNUS PHARMACEUTICALS	520,000	$24.19M	0.8%	$46.51	—	COM	868459108
NVCT	NUVECTIS PHARMA INC	1,000,000	$18.39M	0.6%	$18.39	—	COM	67080T108
CAPR	CAPRICOR THERAPEUTICS INC	761,737	$18.34M	0.6%	$24.08	—	COM NEW	14070B309
PRLD	PRELUDE THERAPEUTICS INC	3,378,378	$18.01M	0.6%	$5.33	—	COM	74065P101
AVLN	AVALYN PHARMACEUTICALS INC	419,000	$13.79M	0.5%	$32.92	—	COM SHS	05348Y105
SYRE	SPYRE THERAPEUTICS INC	147,000	$13.05M	0.4%	$88.78	—	COM NEW	00773J202
NKTR	NEKTAR THERAPEUTICS	128,362	$8.961M	0.3%	$69.81	—	COM NEW	640268306
AORT	ARTIVION INC	388,000	$8.718M	0.3%	$22.47	—	COM	228903100
BLTE	BELITE BIO INC	50,524	$7.78M	0.3%	$153.99	—	SPONSORED ADS	07782B104
SLN	SILENCE THERAPEUTICS PLC	630,000	$6.917M	0.2%	$10.98	—	ADS	82686Q101
IMUX	IMMUNIC INC	450,000	$6.917M	0.2%	$15.37	—	COM NEW	4525EP200
ANL	ADLAI NORTYE LTD	405,523	$4.664M	0.2%	$11.50	—	SPONSORED ADS	00704R109
ZNTL	ZENTALIS PHARMACEUTICALS INC	950,000	$4.607M	0.2%	$4.85	—	COM	98943L107
AVBP	ARRIVENT BIOPHARMA INC	50,000	$1.737M	0.1%	$34.74	—	COM	04272N102
SLDB	SOLID BIOSCIENCES INC	150,000	$1.498M	0.1%	$9.99	—	COM NEW	83422E204
WGS	GENEDX HOLDINGS CORP	10,000	$687K	0.0%	$68.65	—	COM CL A	81663L200
EQ	EQUILLIUM INC	90,000	$288K	0.0%	$3.20	—	COM	29446K106

Increased Positions (23)

RIGL RIGEL PHARMACEUTICALS INC 2.5%

Value $72.12M (+26570.8%) Shares 1,843,504 (+18335.0%) Est. Cost $38.97 Unrealized —

INSP INSPIRE MED SYS INC 3.0%

Value $86.16M (+189.9%) Shares 1,931,436 (+235.1%) Est. Cost $59.41 Unrealized —

PODD INSULET CORP 5.5%

Value $160M (+35.3%) Shares 1,049,000 (+86.5%) Est. Cost $219.28 Unrealized —

CELC CELCUITY INC 6.1%

Value $178M (+21.6%) Shares 1,704,318 (+32.7%) Est. Cost $53.28 Unrealized —

RCUS ARCUS BIOSCIENCES INC 1.2%

Value $36.03M (+269.1%) Shares 1,168,738 (+158.6%) Est. Cost $26.80 Unrealized —

AVTX AVALO THERAPEUTICS INC 1.1%

Value $30.58M (+363.5%) Shares 1,654,978 (+274.4%) Est. Cost $18.05 Unrealized —

JBIO JADE BIOSCIENCES INC 1.2%

Value $34.46M (+207.8%) Shares 1,550,690 (+94.6%) Est. Cost $27.92 Unrealized —

MBX MBX BIOSCIENCES INC 1.0%

Value $28.44M (+432.6%) Shares 515,279 (+188.0%) Est. Cost $41.92 Unrealized —

NRIX NURIX THERAPEUTICS INC 1.2%

Value $35.54M (+144.4%) Shares 1,465,163 (+56.2%) Est. Cost $20.04 Unrealized —

PRCT PROCEPT BIOROBOTICS CORP 0.8%

Value $22.65M (+466.0%) Shares 1,003,000 (+526.9%) Est. Cost $23.70 Unrealized —

URGN UROGEN PHARMA LTD 1.1%

Value $30.54M (+133.6%) Shares 829,810 (+14.1%) Est. Cost $20.78 Unrealized —

ARGX ARGENX SE 0.6%

Value $18.51M (+624.4%) Shares 19,955 (+470.1%) Est. Cost $877.20 Unrealized —

CNTX CONTEXT THERAPEUTICS INC 0.1%

Value $3.912M (-78.6%) Shares 7,063,141 (+1.4%) Est. Cost $2.03 Unrealized —

TNGX TANGO THERAPEUTICS INC 0.8%

Value $22.16M (+135.4%) Shares 709,000 (+57.6%) Est. Cost $18.84 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 4.2%

Value $122M (+10.1%) Shares 225,587 (+20.5%) Est. Cost $434.56 Unrealized —

ANIP ANI PHARMACEUTICALS INC 2.5%

Value $71.83M (+13.9%) Shares 867,760 (+5.8%) Est. Cost $80.80 Unrealized —

INSM INSMED INC 0.3%

Value $9.622M (+474.1%) Shares 90,250 (+780.5%) Est. Cost $114.55 Unrealized —

BDSX BIODESIX INC 0.5%

Value $13.21M (+118.7%) Shares 585,958 (+40.7%) Est. Cost $13.58 Unrealized —

GERN GERON CORP 1.9%

Value $54.8M (-11.4%) Shares 42,808,659 (+3.1%) Est. Cost $1.48 Unrealized —

PHVS PHARVARIS N V 0.9%

Value $25.27M (+27.4%) Shares 730,907 (+4.1%) Est. Cost $18.69 Unrealized —

KIDS ORTHOPEDIATRICS CORP 0.5%

Value $14.01M (+43.4%) Shares 732,144 (+19.0%) Est. Cost $18.57 Unrealized —

IMVT IMMUNOVANT INC 0.3%

Value $9.71M (+69.9%) Shares 252,000 (+9.6%) Est. Cost $23.72 Unrealized —

GPCR STRUCTURE THERAPEUTICS INC 0.2%

Value $5.743M (+48.9%) Shares 107,000 (+33.8%) Est. Cost $65.54 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
RIGL	RIGEL PHARMACEUTICALS INC	1,843,504 (+18335.0%)	$72.12M (+26570.8%)	2.5%	$38.97	—	COM	766559702
INSP	INSPIRE MED SYS INC	1,931,436 (+235.1%)	$86.16M (+189.9%)	3.0%	$59.41	—	COM	457730109
PODD	INSULET CORP	1,049,000 (+86.5%)	$160M (+35.3%)	5.5%	$219.28	—	COM	45784P101
CELC	CELCUITY INC	1,704,318 (+32.7%)	$178M (+21.6%)	6.1%	$53.28	—	COM	15102K100
RCUS	ARCUS BIOSCIENCES INC	1,168,738 (+158.6%)	$36.03M (+269.1%)	1.2%	$26.80	—	COM	03969F109
AVTX	AVALO THERAPEUTICS INC	1,654,978 (+274.4%)	$30.58M (+363.5%)	1.1%	$18.05	—	COM NEW	05338F306
JBIO	JADE BIOSCIENCES INC	1,550,690 (+94.6%)	$34.46M (+207.8%)	1.2%	$27.92	—	COM NEW	008064206
MBX	MBX BIOSCIENCES INC	515,279 (+188.0%)	$28.44M (+432.6%)	1.0%	$41.92	—	COM	55287L101
NRIX	NURIX THERAPEUTICS INC	1,465,163 (+56.2%)	$35.54M (+144.4%)	1.2%	$20.04	—	COM	67080M103
PRCT	PROCEPT BIOROBOTICS CORP	1,003,000 (+526.9%)	$22.65M (+466.0%)	0.8%	$23.70	—	COM	74276L105
URGN	UROGEN PHARMA LTD	829,810 (+14.1%)	$30.54M (+133.6%)	1.1%	$20.78	—	COM	M96088105
ARGX	ARGENX SE	19,955 (+470.1%)	$18.51M (+624.4%)	0.6%	$877.20	—	SPONSORED ADR	04016X101
CNTX	CONTEXT THERAPEUTICS INC	7,063,141 (+1.4%)	$3.912M (-78.6%)	0.1%	$2.03	—	COM	21077P108
TNGX	TANGO THERAPEUTICS INC	709,000 (+57.6%)	$22.16M (+135.4%)	0.8%	$18.84	—	COM	87583X109
UTHR	UNITED THERAPEUTICS CORP DEL	225,587 (+20.5%)	$122M (+10.1%)	4.2%	$434.56	—	COM	91307C102
ANIP	ANI PHARMACEUTICALS INC	867,760 (+5.8%)	$71.83M (+13.9%)	2.5%	$80.80	—	COM	00182C103
INSM	INSMED INC	90,250 (+780.5%)	$9.622M (+474.1%)	0.3%	$114.55	—	COM PAR $.01	457669307
BDSX	BIODESIX INC	585,958 (+40.7%)	$13.21M (+118.7%)	0.5%	$13.58	—	COM	09075X207
GERN	GERON CORP	42,808,659 (+3.1%)	$54.8M (-11.4%)	1.9%	$1.48	—	COM	374163103
PHVS	PHARVARIS N V	730,907 (+4.1%)	$25.27M (+27.4%)	0.9%	$18.69	—	COM	N69605108
KIDS	ORTHOPEDIATRICS CORP	732,144 (+19.0%)	$14.01M (+43.4%)	0.5%	$18.57	—	COM	68752L100
IMVT	IMMUNOVANT INC	252,000 (+9.6%)	$9.71M (+69.9%)	0.3%	$23.72	—	COM	45258J102
GPCR	STRUCTURE THERAPEUTICS INC	107,000 (+33.8%)	$5.743M (+48.9%)	0.2%	$65.54	—	SPONSORED ADS	86366E106

Exited Positions (18)

PCVX VAXCYTE INC 0.8%

Value $22.4M Shares 385,472 Est. Cost $44.73 Unrealized —

ICLR ICON PLC 0.7%

Value $21.25M Shares 192,000 Est. Cost $156.36 Unrealized —

TVTX TRAVERE THERAPEUTICS INC 0.6%

Value $16.22M Shares 546,000 Est. Cost $31.03 Unrealized —

INBX INHIBRX BIOSCIENCES INC 0.3%

Value $8.807M Shares 131,000 Est. Cost $75.90 Unrealized —

DXCM DEXCOM INC 0.3%

Value $8.792M Shares 140,000 Est. Cost $64.65 Unrealized —

IMUX IMMUNIC INC 0.2%

Value $4.995M Shares 4,500,000 Est. Cost $0.72 Unrealized —

ETON ETON PHARMACEUTICALS INC 0.1%

Value $4.106M Shares 166,381 Est. Cost $15.99 Unrealized —

ARWR ARROWHEAD PHARMACEUTICALS IN 0.1%

Value $1.786M Shares 28,479 Est. Cost $65.73 Unrealized —

CTMX CYTOMX THERAPEUTICS INC. 0.0%

Value $1.41M Shares 300,000 Est. Cost $5.23 Unrealized —

COGT COGENT BIOSCIENCES INC 0.0%

Value $385K Shares 10,000 Est. Cost $28.11 Unrealized —

TYRA TYRA BIOSCIENCES INC 0.0%

Value $383K Shares 10,000 Est. Cost $18.37 Unrealized —

STAA STAAR SURGICAL CO 0.0%

Value $374K Shares 20,000 Est. Cost $19.72 Unrealized —

ANAB ANAPTYSBIO INC 0.0%

Value $333K Shares 6,000 Est. Cost $22.45 Unrealized —

RAPP RAPPORT THERAPEUTICS INC 0.0%

Value $313K Shares 10,000 Est. Cost $27.83 Unrealized —

ZYME ZYMEWORKS INC 0.0%

Value $250K Shares 10,000 Est. Cost $21.81 Unrealized —

LBRX LB PHARMACEUTICALS INC 0.0%

Value $247K Shares 10,000 Est. Cost $15.87 Unrealized —

ORKA ORUKA THERAPEUTICS INC 0.0%

Value $245K Shares 5,000 Est. Cost $27.86 Unrealized —

JSPR JASPER THERAPEUTICS INC 0.0%

Value $242K Shares 276,312 Est. Cost $13.83 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
PCVX	VAXCYTE INC	385,472	$22.4M	0.8%	$44.73	—	—	92243G108
ICLR	ICON PLC	192,000	$21.25M	0.7%	$156.36	—	—	G4705A100
TVTX	TRAVERE THERAPEUTICS INC	546,000	$16.22M	0.6%	$31.03	—	—	89422G107
INBX	INHIBRX BIOSCIENCES INC	131,000	$8.807M	0.3%	$75.90	—	—	45720N103
DXCM	DEXCOM INC	140,000	$8.792M	0.3%	$64.65	—	—	252131107
IMUX	IMMUNIC INC	4,500,000	$4.995M	0.2%	$0.72	—	—	4525EP101
ETON	ETON PHARMACEUTICALS INC	166,381	$4.106M	0.1%	$15.99	—	—	29772L108
ARWR	ARROWHEAD PHARMACEUTICALS IN	28,479	$1.786M	0.1%	$65.73	—	—	04280A100
CTMX	CYTOMX THERAPEUTICS INC.	300,000	$1.41M	0.0%	$5.23	—	—	23284F105
COGT	COGENT BIOSCIENCES INC	10,000	$385K	0.0%	$28.11	—	—	19240Q201
TYRA	TYRA BIOSCIENCES INC	10,000	$383K	0.0%	$18.37	—	—	90240B106
STAA	STAAR SURGICAL CO	20,000	$374K	0.0%	$19.72	—	—	852312305
ANAB	ANAPTYSBIO INC	6,000	$333K	0.0%	$22.45	—	—	032724106
RAPP	RAPPORT THERAPEUTICS INC	10,000	$313K	0.0%	$27.83	—	—	75383L102
ZYME	ZYMEWORKS INC	10,000	$250K	0.0%	$21.81	—	—	98985Y108
LBRX	LB PHARMACEUTICALS INC	10,000	$247K	0.0%	$15.87	—	—	50180M108
ORKA	ORUKA THERAPEUTICS INC	5,000	$245K	0.0%	$27.86	—	—	687604108
JSPR	JASPER THERAPEUTICS INC	276,312	$242K	0.0%	$13.83	—	—	471871202

Decreased Positions (40)

KRYS KRYSTAL BIOTECH INC 12.0%

Value $349M (+17.2%) Shares 939,254 (-18.5%) Est. Cost $176.52 Unrealized —

TWST TWIST BIOSCIENCE CORP 0.4%

Value $10.76M (-81.5%) Shares 104,629 (-91.5%) Est. Cost $31.10 Unrealized —

PRAX PRAXIS PRECISION MEDICINES I 2.0%

Value $59.43M (-44.2%) Shares 177,517 (-46.3%) Est. Cost $59.17 Unrealized —

NVCR NOVOCURE LTD 5.2%

Value $150M (+31.3%) Shares 9,913,401 (-5.5%) Est. Cost $17.68 Unrealized —

ALNY ALNYLAM PHARMACEUTICALS INC 0.3%

Value $9.949M (-77.2%) Shares 33,050 (-74.9%) Est. Cost $381.54 Unrealized —

MIRM MIRUM PHARMACEUTICALS INC 0.3%

Value $8.78M (-76.3%) Shares 75,000 (-81.3%) Est. Cost $64.71 Unrealized —

EWTX EDGEWISE THERAPEUTICS INC 0.6%

Value $18.32M (-59.9%) Shares 450,889 (-68.9%) Est. Cost $23.09 Unrealized —

TGTX TG THERAPEUTICS INC 5.5%

Value $161M (+20.2%) Shares 2,927,895 (-27.3%) Est. Cost $25.09 Unrealized —

GMED GLOBUS MED INC 1.3%

Value $37.05M (-41.1%) Shares 468,922 (-35.7%) Est. Cost $72.27 Unrealized —

NTRA NATERA INC 0.0%

Value $271K (-98.9%) Shares 1,000 (-99.2%) Est. Cost $222.97 Unrealized —

AXGN AXOGEN INC 0.1%

Value $2.634M (-88.3%) Shares 57,036 (-91.6%) Est. Cost $9.23 Unrealized —

MRK MERCK & CO INC 0.2%

Value $6.425M (-73.7%) Shares 50,000 (-75.4%) Est. Cost $114.28 Unrealized —

VCEL VERICEL CORP 2.2%

Value $64.92M (-20.8%) Shares 1,459,152 (-42.8%) Est. Cost $36.97 Unrealized —

LIVN LIVANOVA PLC 0.7%

Value $20.97M (-43.4%) Shares 254,957 (-56.2%) Est. Cost $57.34 Unrealized —

ALKS ALKERMES PLC 1.9%

Value $53.93M (-22.6%) Shares 1,029,252 (-47.8%) Est. Cost $30.74 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 0.7%

Value $21.49M (-41.5%) Shares 375,572 (-42.3%) Est. Cost $62.91 Unrealized —

CERS CERUS CORP 0.3%

Value $7.3M (-62.7%) Shares 2,500,000 (-76.8%) Est. Cost $2.11 Unrealized —

PGNY PROGYNY INC 1.6%

Value $46.19M (+31.6%) Shares 1,602,000 (-22.5%) Est. Cost $23.66 Unrealized —

CORT CORCEPT THERAPEUTICS INC 0.1%

Value $1.709M (-85.2%) Shares 19,653 (-93.1%) Est. Cost $38.80 Unrealized —

KNSA KINIKSA PHARMACEUTICALS INTL 0.5%

Value $15.75M (-37.2%) Shares 246,353 (-52.7%) Est. Cost $35.12 Unrealized —

VCYT VERACYTE INC 0.1%

Value $1.468M (-85.8%) Shares 25,000 (-92.2%) Est. Cost $39.00 Unrealized —

VIR VIR BIOTECHNOLOGY INC 0.4%

Value $10.19M (-43.2%) Shares 1,000,000 (-50.0%) Est. Cost $7.20 Unrealized —

TNDM TANDEM DIABETES CARE INC 0.3%

Value $8.677M (-42.2%) Shares 575,000 (-26.6%) Est. Cost $21.08 Unrealized —

CCCC C4 THERAPEUTICS INC 0.5%

Value $15.78M (+57.7%) Shares 3,377,981 (-11.2%) Est. Cost $7.16 Unrealized —

CGEM CULLINAN THERAPEUTICS INC 0.0%

Value $911K (-84.4%) Shares 50,000 (-87.8%) Est. Cost $11.97 Unrealized —

INDV INDIVIOR PHARMACEUTICALS INC 1.5%

Value $43.66M (+12.4%) Shares 1,064,000 (-16.5%) Est. Cost $34.29 Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC 1.2%

Value $35.59M (-11.8%) Shares 1,628,039 (-5.7%) Est. Cost $15.16 Unrealized —

LRMR LARIMAR THERAPEUTICS INC 0.0%

Value $574K (-88.1%) Shares 188,102 (-82.4%) Est. Cost $3.46 Unrealized —

SION SIONNA THERAPEUTICS INC 0.3%

Value $7.816M (-33.6%) Shares 177,687 (-39.5%) Est. Cost $17.77 Unrealized —

EOLS EVOLUS INC 0.2%

Value $5.708M (-38.2%) Shares 822,428 (-63.4%) Est. Cost $8.02 Unrealized —

IOVA IOVANCE BIOTHERAPEUTICS INC 0.0%

Value $624K (-82.2%) Shares 150,000 (-85.0%) Est. Cost $2.68 Unrealized —

TRVI TREVI THERAPEUTICS INC 0.8%

Value $22M (+13.8%) Shares 1,179,618 (-27.2%) Est. Cost $11.20 Unrealized —

NEO NEOGENOMICS INC 0.0%

Value $146K (-88.8%) Shares 10,000 (-94.3%) Est. Cost $10.79 Unrealized —

CGON CG ONCOLOGY INC 0.0%

Value $355K (-73.8%) Shares 5,000 (-75.0%) Est. Cost $33.75 Unrealized —

XENE XENON PHARMACEUTICALS INC 0.6%

Value $16.12M (-5.1%) Shares 267,000 (-8.6%) Est. Cost $41.98 Unrealized —

ELVN ENLIVEN THERAPEUTICS INC 0.3%

Value $8.408M (-7.1%) Shares 165,677 (-28.2%) Est. Cost $19.92 Unrealized —

SABS SAB BIOTHERAPEUTICS INC 0.1%

Value $3.51M (-12.7%) Shares 900,000 (-14.3%) Est. Cost $4.00 Unrealized —

TECX TECTONIC THERAPEUTIC INC 0.1%

Value $3.495M (-7.1%) Shares 101,684 (-16.4%) Est. Cost $21.10 Unrealized —

SOPH SOPHIA GENETICS SA 0.3%

Value $9.03M (-1.4%) Shares 1,565,000 (-15.4%) Est. Cost $4.99 Unrealized —

MSLE SATELLOS BIOSCIENCE INC 0.1%

Value $2.444M (+4.8%) Shares 314,359 (-24.1%) Est. Cost $5.63 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
KRYS	KRYSTAL BIOTECH INC	939,254 (-18.5%)	$349M (+17.2%)	12.0%	$176.52	—	COM	501147102
TWST	TWIST BIOSCIENCE CORP	104,629 (-91.5%)	$10.76M (-81.5%)	0.4%	$31.10	—	COM	90184D100
PRAX	PRAXIS PRECISION MEDICINES I	177,517 (-46.3%)	$59.43M (-44.2%)	2.0%	$59.17	—	COM NEW	74006W207
NVCR	NOVOCURE LTD	9,913,401 (-5.5%)	$150M (+31.3%)	5.2%	$17.68	—	ORD SHS	G6674U108
ALNY	ALNYLAM PHARMACEUTICALS INC	33,050 (-74.9%)	$9.949M (-77.2%)	0.3%	$381.54	—	COM	02043Q107
MIRM	MIRUM PHARMACEUTICALS INC	75,000 (-81.3%)	$8.78M (-76.3%)	0.3%	$64.71	—	COM	604749101
EWTX	EDGEWISE THERAPEUTICS INC	450,889 (-68.9%)	$18.32M (-59.9%)	0.6%	$23.09	—	COM	28036F105
TGTX	TG THERAPEUTICS INC	2,927,895 (-27.3%)	$161M (+20.2%)	5.5%	$25.09	—	COM	88322Q108
GMED	GLOBUS MED INC	468,922 (-35.7%)	$37.05M (-41.1%)	1.3%	$72.27	—	CL A	379577208
NTRA	NATERA INC	1,000 (-99.2%)	$271K (-98.9%)	0.0%	$222.97	—	COM	632307104
AXGN	AXOGEN INC	57,036 (-91.6%)	$2.634M (-88.3%)	0.1%	$9.23	—	COM	05463X106
MRK	MERCK & CO INC	50,000 (-75.4%)	$6.425M (-73.7%)	0.2%	$114.28	—	COM	58933Y105
VCEL	VERICEL CORP	1,459,152 (-42.8%)	$64.92M (-20.8%)	2.2%	$36.97	—	COM	92346J108
LIVN	LIVANOVA PLC	254,957 (-56.2%)	$20.97M (-43.4%)	0.7%	$57.34	—	SHS	G5509L101
ALKS	ALKERMES PLC	1,029,252 (-47.8%)	$53.93M (-22.6%)	1.9%	$30.74	—	SHS	G01767105
BMRN	BIOMARIN PHARMACEUTICAL INC	375,572 (-42.3%)	$21.49M (-41.5%)	0.7%	$62.91	—	COM	09061G101
CERS	CERUS CORP	2,500,000 (-76.8%)	$7.3M (-62.7%)	0.3%	$2.11	—	COM	157085101
PGNY	PROGYNY INC	1,602,000 (-22.5%)	$46.19M (+31.6%)	1.6%	$23.66	—	COM	74340E103
CORT	CORCEPT THERAPEUTICS INC	19,653 (-93.1%)	$1.709M (-85.2%)	0.1%	$38.80	—	COM	218352102
KNSA	KINIKSA PHARMACEUTICALS INTL	246,353 (-52.7%)	$15.75M (-37.2%)	0.5%	$35.12	—	ORD SHS CL A	G52694109
VCYT	VERACYTE INC	25,000 (-92.2%)	$1.468M (-85.8%)	0.1%	$39.00	—	COM	92337F107
VIR	VIR BIOTECHNOLOGY INC	1,000,000 (-50.0%)	$10.19M (-43.2%)	0.4%	$7.20	—	COM	92764N102
TNDM	TANDEM DIABETES CARE INC	575,000 (-26.6%)	$8.677M (-42.2%)	0.3%	$21.08	—	COM NEW	875372203
CCCC	C4 THERAPEUTICS INC	3,377,981 (-11.2%)	$15.78M (+57.7%)	0.5%	$7.16	—	COM STK	12529R107
CGEM	CULLINAN THERAPEUTICS INC	50,000 (-87.8%)	$911K (-84.4%)	0.0%	$11.97	—	COM	230031106
INDV	INDIVIOR PHARMACEUTICALS INC	1,064,000 (-16.5%)	$43.66M (+12.4%)	1.5%	$34.29	—	COM	45579U109
SNDX	SYNDAX PHARMACEUTICALS INC	1,628,039 (-5.7%)	$35.59M (-11.8%)	1.2%	$15.16	—	COM	87164F105
LRMR	LARIMAR THERAPEUTICS INC	188,102 (-82.4%)	$574K (-88.1%)	0.0%	$3.46	—	COM	517125100
SION	SIONNA THERAPEUTICS INC	177,687 (-39.5%)	$7.816M (-33.6%)	0.3%	$17.77	—	COM	829401108
EOLS	EVOLUS INC	822,428 (-63.4%)	$5.708M (-38.2%)	0.2%	$8.02	—	COM	30052C107
IOVA	IOVANCE BIOTHERAPEUTICS INC	150,000 (-85.0%)	$624K (-82.2%)	0.0%	$2.68	—	COM	462260100
TRVI	TREVI THERAPEUTICS INC	1,179,618 (-27.2%)	$22M (+13.8%)	0.8%	$11.20	—	COM	89532M101
NEO	NEOGENOMICS INC	10,000 (-94.3%)	$146K (-88.8%)	0.0%	$10.79	—	COM NEW	64049M209
CGON	CG ONCOLOGY INC	5,000 (-75.0%)	$355K (-73.8%)	0.0%	$33.75	—	COM	156944100
XENE	XENON PHARMACEUTICALS INC	267,000 (-8.6%)	$16.12M (-5.1%)	0.6%	$41.98	—	COM	98420N105
ELVN	ENLIVEN THERAPEUTICS INC	165,677 (-28.2%)	$8.408M (-7.1%)	0.3%	$19.92	—	COM	29337E102
SABS	SAB BIOTHERAPEUTICS INC	900,000 (-14.3%)	$3.51M (-12.7%)	0.1%	$4.00	—	COM NEW	78397T202
TECX	TECTONIC THERAPEUTIC INC	101,684 (-16.4%)	$3.495M (-7.1%)	0.1%	$21.10	—	COM	878972108
SOPH	SOPHIA GENETICS SA	1,565,000 (-15.4%)	$9.03M (-1.4%)	0.3%	$4.99	—	ORDINARY SHARES	H82027105
MSLE	SATELLOS BIOSCIENCE INC	314,359 (-24.1%)	$2.444M (+4.8%)	0.1%	$5.63	—	COM	80401L803

Unchanged Positions (12)

BBNX BETA BIONICS INC 2.4%

Value $68.85M Shares 4,393,714 Est. Cost $17.70 Unrealized —

EDAP EDAP TMS S A 1.3%

Value $37.86M Shares 7,309,254 Est. Cost $7.34 Unrealized —

NPCE NEUROPACE INC 1.6%

Value $46.26M Shares 2,911,122 Est. Cost $16.66 Unrealized —

IKT INHIBIKASE THERAPEUTICS INC 0.8%

Value $22.08M Shares 10,875,000 Est. Cost $2.12 Unrealized —

IVVD INVIVYD INC 0.2%

Value $6.725M Shares 7,708,727 Est. Cost $2.08 Unrealized —

SEPN SEPTERNA INC 0.3%

Value $9.21M Shares 275,000 Est. Cost $23.81 Unrealized —

KPTI KARYOPHARM THERAPEUTICS INC 0.1%

Value $4.299M Shares 440,000 Est. Cost $6.12 Unrealized —

NSPR INSPIREMD INC 0.0%

Value $732K Shares 1,045,708 Est. Cost $2.04 Unrealized —

ORGO ORGANOGENESIS HLDGS INC 0.8%

Value $24.64M Shares 10,140,951 Est. Cost $4.73 Unrealized —

QNRX QUOIN PHARMACEUTICALS LTD 0.0%

Value $352K Shares 72,730 Est. Cost $9.29 Unrealized —

RLMD RELMADA THERAPEUTICS INC 0.2%

Value $5.827M Shares 842,106 Est. Cost $4.01 Unrealized —

LUNG PULMONX CORP 0.1%

Value $3.625M Shares 2,788,323 Est. Cost $1.84 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
BBNX	BETA BIONICS INC	4,393,714	$68.85M	2.4%	$17.70	—	COM	08659B102
EDAP	EDAP TMS S A	7,309,254	$37.86M	1.3%	$7.34	—	SPONSORED ADR	268311107
NPCE	NEUROPACE INC	2,911,122	$46.26M	1.6%	$16.66	—	COM	641288105
IKT	INHIBIKASE THERAPEUTICS INC	10,875,000	$22.08M	0.8%	$2.12	—	COM NEW	45719W205
IVVD	INVIVYD INC	7,708,727	$6.725M	0.2%	$2.08	—	COM	00534A102
SEPN	SEPTERNA INC	275,000	$9.21M	0.3%	$23.81	—	COM	81734D104
KPTI	KARYOPHARM THERAPEUTICS INC	440,000	$4.299M	0.1%	$6.12	—	COM NEW	48576U205
NSPR	INSPIREMD INC	1,045,708	$732K	0.0%	$2.04	—	COM	45779A846
ORGO	ORGANOGENESIS HLDGS INC	10,140,951	$24.64M	0.8%	$4.73	—	COM	68621F102
QNRX	QUOIN PHARMACEUTICALS LTD	72,730	$352K	0.0%	$9.29	—	SPONSORED ADS	74907L409
RLMD	RELMADA THERAPEUTICS INC	842,106	$5.827M	0.2%	$4.01	—	COM	75955J402
LUNG	PULMONX CORP	2,788,323	$3.625M	0.1%	$1.84	—	COM	745848101