Paradigm Biocapital Advisors LP Quant / Systematic

CIK: 0001855655 · Show all filings

Period: Q1 2022 (← Previous) (Next →)

Filing Date: May 16, 2022

Total Value ($000): $378,175 (100.0% shares, 0.0% debt)

Holdings (25)

ASND ASCENDIS PHARMA A/S 10.0%

Value ($000) $37,745 Shares 321,621 Est. Cost $129.01 Unrealized —

— GLOBAL BLOOD THERAPEUTICS IN 8.9%

Value ($000) $33,491 Shares 966,827 Est. Cost $30.31 Unrealized —

ARVN ARVINAS INC 8.7%

Value ($000) $33,067 Shares 491,333 Est. Cost $75.38 Unrealized -9.6%

LEGN LEGEND BIOTECH CORP 8.0%

Value ($000) $30,225 Shares 831,728 Est. Cost $41.11 Unrealized —

— SIERRA ONCOLOGY INC 6.5%

Value ($000) $24,721 Shares 771,314 Est. Cost $25.70 Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 6.1%

Value ($000) $23,224 Shares 1,256,051 Est. Cost $18.65 Unrealized +3.0%

INCY INCYTE CORP 4.9%

Value ($000) $18,618 Shares 234,419 Est. Cost $72.74 Unrealized 0.0%

— IVERIC BIO INC 4.1%

Value ($000) $15,322 Shares 910,416 Est. Cost $16.73 Unrealized —

IOVA IOVANCE BIOTHERAPEUTICS INC 4.0%

Value ($000) $15,109 Shares 907,428 Est. Cost $21.56 Unrealized -28.3%

IMCR IMMUNOCORE HLDGS PLC 3.9%

Value ($000) $14,926 Shares 499,190 Est. Cost $31.07 Unrealized —

— HORIZON THERAPEUTICS PUB L 3.8%

Value ($000) $14,334 Shares 136,243 Est. Cost $105.21 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 3.6%

Value ($000) $13,570 Shares 75,635 Est. Cost $190.51 Unrealized 0.0%

ZNTL ZENTALIS PHARMACEUTICALS INC 3.5%

Value ($000) $13,269 Shares 287,577 Est. Cost $77.38 Unrealized -30.3%

SNDX SYNDAX PHARMACEUTICALS INC 3.2%

Value ($000) $12,190 Shares 701,356 Est. Cost $17.90 Unrealized -5.9%

CCCC C4 THERAPEUTICS INC 3.2%

Value ($000) $12,118 Shares 499,496 Est. Cost $32.19 Unrealized -24.6%

— OYSTER PT PHARMA INC 3.0%

Value ($000) $11,497 Shares 987,698 Est. Cost $13.68 Unrealized —

PRTA PROTHENA CORP PLC 2.6%

Value ($000) $9,799 Shares 267,946 Est. Cost $36.05 Unrealized 0.0%

KYMR KYMERA THERAPEUTICS INC 2.5%

Value ($000) $9,608 Shares 227,034 Est. Cost $51.11 Unrealized -17.4%

— MIRATI THERAPEUTICS INC 2.1%

Value ($000) $8,089 Shares 98,383 Est. Cost $146.69 Unrealized —

— MERUS N V 1.7%

Value ($000) $6,603 Shares 249,738 Est. Cost $26.44 Unrealized —

— VOR BIOPHARMA INC 1.4%

Value ($000) $5,402 Shares 894,404 Est. Cost $9.97 Unrealized —

ESPR ESPERION THERAPEUTICS INC NE 1.4%

Value ($000) $5,370 Shares 1,157,246 Est. Cost $6.99 Unrealized -38.6%

FULC FULCRUM THERAPEUTICS INC 1.3%

Value ($000) $5,037 Shares 212,961 Est. Cost $14.15 Unrealized 0.0%

— ALPINE IMMUNE SCIENCES INC 0.8%

Value ($000) $3,016 Shares 336,229 Est. Cost $8.97 Unrealized —

— GRACELL BIOTECHNOLOGIES INC 0.5%

Value ($000) $1,825 Shares 783,445 Est. Cost $4.91 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
ASND	ASCENDIS PHARMA A/S	321,621	$37,745	10.0%	$129.01	—	SPONSORED ADR	04351P101
—	GLOBAL BLOOD THERAPEUTICS IN	966,827	$33,491	8.9%	$30.31	—	COM	37890U108
ARVN	ARVINAS INC	491,333	$33,067	8.7%	$75.38	-9.6%	COM	04335A105
LEGN	LEGEND BIOTECH CORP	831,728	$30,225	8.0%	$41.11	—	SPONSORED ADS	52490G102
—	SIERRA ONCOLOGY INC	771,314	$24,721	6.5%	$25.70	—	COM NEW	82640U404
VRDN	VIRIDIAN THERAPEUTICS INC	1,256,051	$23,224	6.1%	$18.65	+3.0%	COM	92790C104
INCY	INCYTE CORP	234,419	$18,618	4.9%	$72.74	0.0%	COM	45337C102
—	IVERIC BIO INC	910,416	$15,322	4.1%	$16.73	—	COM	46583P102
IOVA	IOVANCE BIOTHERAPEUTICS INC	907,428	$15,109	4.0%	$21.56	-28.3%	COM	462260100
IMCR	IMMUNOCORE HLDGS PLC	499,190	$14,926	3.9%	$31.07	—	ADS	45258D105
—	HORIZON THERAPEUTICS PUB L	136,243	$14,334	3.8%	$105.21	—	SHS	G46188101
UTHR	UNITED THERAPEUTICS CORP DEL	75,635	$13,570	3.6%	$190.51	0.0%	COM	91307C102
ZNTL	ZENTALIS PHARMACEUTICALS INC	287,577	$13,269	3.5%	$77.38	-30.3%	COM	98943L107
SNDX	SYNDAX PHARMACEUTICALS INC	701,356	$12,190	3.2%	$17.90	-5.9%	COM	87164F105
CCCC	C4 THERAPEUTICS INC	499,496	$12,118	3.2%	$32.19	-24.6%	COM STK	12529R107
—	OYSTER PT PHARMA INC	987,698	$11,497	3.0%	$13.68	—	COM	69242L106
PRTA	PROTHENA CORP PLC	267,946	$9,799	2.6%	$36.05	0.0%	SHS	G72800108
KYMR	KYMERA THERAPEUTICS INC	227,034	$9,608	2.5%	$51.11	-17.4%	COM	501575104
—	MIRATI THERAPEUTICS INC	98,383	$8,089	2.1%	$146.69	—	COM	60468T105
—	MERUS N V	249,738	$6,603	1.7%	$26.44	—	COM	N5749R100
—	VOR BIOPHARMA INC	894,404	$5,402	1.4%	$9.97	—	COM	929033108
ESPR	ESPERION THERAPEUTICS INC NE	1,157,246	$5,370	1.4%	$6.99	-38.6%	COM	29664W105
FULC	FULCRUM THERAPEUTICS INC	212,961	$5,037	1.3%	$14.15	0.0%	COM	359616109
—	ALPINE IMMUNE SCIENCES INC	336,229	$3,016	0.8%	$8.97	—	COM	02083G100
—	GRACELL BIOTECHNOLOGIES INC	783,445	$1,825	0.5%	$4.91	—	SPONSORED ADS	38406L103