Paradigm Biocapital Advisors LP Quant / Systematic

CIK: 0001855655 · Show all filings

Period: Q3 2022 (← Previous) (Next →)

Filing Date: Nov 14, 2022

Total Value ($000): $750,139 (100.0% shares, 0.0% debt)

Holdings (28)

— GLOBAL BLOOD THERAPEUTICS IN 10.7%

Value ($000) $80,077 Shares 1,175,879 Est. Cost $30.85 Unrealized —

— MIRATI THERAPEUTICS INC 7.9%

Value ($000) $59,391 Shares 850,385 Est. Cost $76.94 Unrealized —

INCY INCYTE CORP 6.9%

Value ($000) $51,518 Shares 773,082 Est. Cost $74.39 Unrealized -0.7%

ASND ASCENDIS PHARMA A/S 6.8%

Value ($000) $51,356 Shares 497,347 Est. Cost $117.62 Unrealized —

LEGN LEGEND BIOTECH CORP 5.9%

Value ($000) $43,925 Shares 1,076,591 Est. Cost $42.97 Unrealized —

BIIB BIOGEN INC 5.5%

Value ($000) $41,280 Shares 154,605 Est. Cost $212.38 Unrealized 0.0%

BIIB BIOGEN INC 5.3%

Value ($000) $40,050 Shares 150,000 Est. Cost $212.38 Unrealized 0.0%

IMCR IMMUNOCORE HLDGS PLC 4.8%

Value ($000) $36,288 Shares 773,079 Est. Cost $34.60 Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 4.5%

Value ($000) $33,559 Shares 1,636,211 Est. Cost $18.35 Unrealized -2.0%

ARGX ARGENX SE 4.2%

Value ($000) $31,879 Shares 90,297 Est. Cost $378.46 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 3.9%

Value ($000) $29,431 Shares 140,561 Est. Cost $197.37 Unrealized +13.3%

— AKERO THERAPEUTICS INC 3.8%

Value ($000) $28,373 Shares 833,265 Est. Cost $34.05 Unrealized —

BCYC BICYCLE THERAPEUTICS PLC 3.6%

Value ($000) $26,951 Shares 1,158,686 Est. Cost $17.40 Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC 3.5%

Value ($000) $26,076 Shares 1,085,142 Est. Cost $18.57 Unrealized +20.8%

AXSM AXSOME THERAPEUTICS INC 3.1%

Value ($000) $23,206 Shares 520,080 Est. Cost $49.97 Unrealized 0.0%

— HORIZON THERAPEUTICS PUB L 2.9%

Value ($000) $21,748 Shares 351,405 Est. Cost $61.89 Unrealized —

— ALPINE IMMUNE SCIENCES INC 2.1%

Value ($000) $15,946 Shares 2,214,722 Est. Cost $7.76 Unrealized —

PRTA PROTHENA CORP PLC 1.9%

Value ($000) $14,298 Shares 235,826 Est. Cost $31.61 Unrealized 0.0%

ARVN ARVINAS INC 1.7%

Value ($000) $12,625 Shares 283,777 Est. Cost $74.11 Unrealized -34.5%

ESPR ESPERION THERAPEUTICS INC NE 1.5%

Value ($000) $11,523 Shares 1,719,831 Est. Cost $6.77 Unrealized +1.4%

— MERUS N V 1.5%

Value ($000) $11,301 Shares 564,214 Est. Cost $23.80 Unrealized —

— G1 THERAPEUTICS INC 1.5%

Value ($000) $11,048 Shares 884,574 Est. Cost $12.49 Unrealized —

CRNX CRINETICS PHARMACEUTICALS IN 1.4%

Value ($000) $10,198 Shares 519,256 Est. Cost $20.39 Unrealized 0.0%

— OYSTER PT PHARMA INC 1.2%

Value ($000) $9,264 Shares 1,648,316 Est. Cost $10.18 Unrealized —

TGTX TG THERAPEUTICS INC 1.2%

Value ($000) $8,912 Shares 1,505,479 Est. Cost $6.24 Unrealized +5.0%

— POSEIDA THERAPEUTICS INC 1.0%

Value ($000) $7,307 Shares 2,070,108 Est. Cost $3.53 Unrealized —

— VOR BIOPHARMA INC 0.9%

Value ($000) $6,781 Shares 1,703,645 Est. Cost $7.36 Unrealized —

MIST MILESTONE PHARMACEUTICALS IN 0.8%

Value ($000) $5,828 Shares 634,211 Est. Cost $7.58 Unrealized 0.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	GLOBAL BLOOD THERAPEUTICS IN	1,175,879	$80,077	10.7%	$30.85	—	COM	37890U108
—	MIRATI THERAPEUTICS INC	850,385	$59,391	7.9%	$76.94	—	COM	60468T105
INCY	INCYTE CORP	773,082	$51,518	6.9%	$74.39	-0.7%	COM	45337C102
ASND	ASCENDIS PHARMA A/S	497,347	$51,356	6.8%	$117.62	—	SPONSORED ADR	04351P101
LEGN	LEGEND BIOTECH CORP	1,076,591	$43,925	5.9%	$42.97	—	SPONSORED ADS	52490G102
BIIB	BIOGEN INC	154,605	$41,280	5.5%	$212.38	0.0%	COM	09062X103
BIIB	BIOGEN INC	150,000	$40,050	5.3%	$212.38	0.0%	Call	09062X103
IMCR	IMMUNOCORE HLDGS PLC	773,079	$36,288	4.8%	$34.60	—	ADS	45258D105
VRDN	VIRIDIAN THERAPEUTICS INC	1,636,211	$33,559	4.5%	$18.35	-2.0%	COM	92790C104
ARGX	ARGENX SE	90,297	$31,879	4.2%	$378.46	—	SPONSORED ADR	04016X101
UTHR	UNITED THERAPEUTICS CORP DEL	140,561	$29,431	3.9%	$197.37	+13.3%	COM	91307C102
—	AKERO THERAPEUTICS INC	833,265	$28,373	3.8%	$34.05	—	COM	00973Y108
BCYC	BICYCLE THERAPEUTICS PLC	1,158,686	$26,951	3.6%	$17.40	—	SPONSORED ADS	088786108
SNDX	SYNDAX PHARMACEUTICALS INC	1,085,142	$26,076	3.5%	$18.57	+20.8%	COM	87164F105
AXSM	AXSOME THERAPEUTICS INC	520,080	$23,206	3.1%	$49.97	0.0%	COM	05464T104
—	HORIZON THERAPEUTICS PUB L	351,405	$21,748	2.9%	$61.89	—	SHS	G46188101
—	ALPINE IMMUNE SCIENCES INC	2,214,722	$15,946	2.1%	$7.76	—	COM	02083G100
PRTA	PROTHENA CORP PLC	235,826	$14,298	1.9%	$31.61	0.0%	SHS	G72800108
ARVN	ARVINAS INC	283,777	$12,625	1.7%	$74.11	-34.5%	COM	04335A105
ESPR	ESPERION THERAPEUTICS INC NE	1,719,831	$11,523	1.5%	$6.77	+1.4%	COM	29664W105
—	MERUS N V	564,214	$11,301	1.5%	$23.80	—	COM	N5749R100
—	G1 THERAPEUTICS INC	884,574	$11,048	1.5%	$12.49	—	COM	3621LQ109
CRNX	CRINETICS PHARMACEUTICALS IN	519,256	$10,198	1.4%	$20.39	0.0%	COM	22663K107
—	OYSTER PT PHARMA INC	1,648,316	$9,264	1.2%	$10.18	—	COM	69242L106
TGTX	TG THERAPEUTICS INC	1,505,479	$8,912	1.2%	$6.24	+5.0%	COM	88322Q108
—	POSEIDA THERAPEUTICS INC	2,070,108	$7,307	1.0%	$3.53	—	COM	73730P108
—	VOR BIOPHARMA INC	1,703,645	$6,781	0.9%	$7.36	—	COM	929033108
MIST	MILESTONE PHARMACEUTICALS IN	634,211	$5,828	0.8%	$7.58	0.0%	COM	59935V107