Paradigm Biocapital Advisors LP Quant / Systematic

CIK: 0001855655 · Show all filings

Period: Q3 2023 (← Previous) (Next →)

Filing Date: Nov 14, 2023

Total Value ($000): $1,473,653 (100.0% shares, 0.0% debt)

Holdings (31)

LEGN LEGEND BIOTECH CORP 9.2%

Value ($000) $136,051 Shares 2,025,480 Est. Cost $50.58 Unrealized —

ARGX ARGENX SE 8.7%

Value ($000) $128,533 Shares 261,443 Est. Cost $428.43 Unrealized —

ACLX ARCELLX INC 7.2%

Value ($000) $105,958 Shares 2,953,122 Est. Cost $30.55 Unrealized +12.8%

OLMA OLEMA PHARMACEUTICALS INC 6.5%

Value ($000) $96,374 Shares 7,803,600 Est. Cost $7.61 Unrealized +34.0%

NUVL NUVALENT INC 5.1%

Value ($000) $75,306 Shares 1,638,147 Est. Cost $39.88 Unrealized +11.3%

BCYC BICYCLE THERAPEUTICS PLC 5.0%

Value ($000) $73,174 Shares 3,642,307 Est. Cost $19.87 Unrealized —

— MIRATI THERAPEUTICS INC 4.9%

Value ($000) $72,663 Shares 1,668,116 Est. Cost $60.31 Unrealized —

IMCR IMMUNOCORE HLDGS PLC 4.9%

Value ($000) $71,865 Shares 1,384,686 Est. Cost $42.92 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 4.7%

Value ($000) $69,413 Shares 307,314 Est. Cost $218.41 Unrealized +5.5%

CRNX CRINETICS PHARMACEUTICALS IN 4.4%

Value ($000) $64,796 Shares 2,178,737 Est. Cost $19.73 Unrealized +4.4%

IRON DISC MEDICINE INC 4.1%

Value ($000) $59,772 Shares 1,272,279 Est. Cost $50.02 Unrealized 0.0%

VRDN VIRIDIAN THERAPEUTICS INC 3.8%

Value ($000) $56,478 Shares 3,681,747 Est. Cost $20.65 Unrealized -7.6%

— CEREVEL THERAPEUTICS HLDNG I 3.8%

Value ($000) $55,295 Shares 2,532,972 Est. Cost $24.52 Unrealized —

INCY INCYTE CORP 3.6%

Value ($000) $52,715 Shares 912,497 Est. Cost $74.99 Unrealized -15.9%

XENE XENON PHARMACEUTICALS INC 3.5%

Value ($000) $50,961 Shares 1,491,835 Est. Cost $37.73 Unrealized -0.9%

— AMBRX BIOPHARMA INC 2.7%

Value ($000) $40,119 Shares 3,488,596 Est. Cost $13.85 Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC 2.4%

Value ($000) $34,704 Shares 2,390,077 Est. Cost $21.25 Unrealized -11.0%

AUTL AUTOLUS THERAPEUTICS PLC 2.3%

Value ($000) $33,568 Shares 14,406,782 Est. Cost $2.36 Unrealized —

TGTX TG THERAPEUTICS INC 2.1%

Value ($000) $30,255 Shares 3,619,015 Est. Cost $13.94 Unrealized 0.0%

ZLAB ZAI LAB LTD 1.9%

Value ($000) $27,771 Shares 1,142,383 Est. Cost $29.52 Unrealized —

— ALPINE IMMUNE SCIENCES INC 1.9%

Value ($000) $27,729 Shares 2,421,743 Est. Cost $7.85 Unrealized —

IMTX IMMATICS N.V 1.6%

Value ($000) $23,837 Shares 2,058,447 Est. Cost $9.43 Unrealized +26.6%

— VERONA PHARMA PLC 1.0%

Value ($000) $15,101 Shares 926,432 Est. Cost $19.95 Unrealized —

CRBU CARIBOU BIOSCIENCES INC 1.0%

Value ($000) $14,075 Shares 2,944,513 Est. Cost $6.20 Unrealized 0.0%

— VOR BIOPHARMA INC 0.9%

Value ($000) $13,698 Shares 6,461,467 Est. Cost $6.84 Unrealized —

ROIV ROIVANT SCIENCES LTD 0.9%

Value ($000) $12,635 Shares 1,081,767 Est. Cost $11.31 Unrealized 0.0%

KURA KURA ONCOLOGY INC 0.8%

Value ($000) $11,061 Shares 1,212,828 Est. Cost $11.54 Unrealized -12.0%

CMPS COMPASS PATHWAYS PLC 0.7%

Value ($000) $10,054 Shares 1,358,709 Est. Cost $7.40 Unrealized —

— 89BIO INC 0.3%

Value ($000) $5,081 Shares 329,100 Est. Cost — Unrealized —

— AMBRX BIOPHARMA INC 0.2%

Value ($000) $2,410 Shares 209,600 Est. Cost $13.85 Unrealized —

COGT COGENT BIOSCIENCES INC 0.1%

Value ($000) $2,200 Shares 225,605 Est. Cost $11.86 Unrealized 0.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
LEGN	LEGEND BIOTECH CORP	2,025,480	$136,051	9.2%	$50.58	—	SPONSORED ADS	52490G102
ARGX	ARGENX SE	261,443	$128,533	8.7%	$428.43	—	SPONSORED ADR	04016X101
ACLX	ARCELLX INC	2,953,122	$105,958	7.2%	$30.55	+12.8%	COMMON STOCK	03940C100
OLMA	OLEMA PHARMACEUTICALS INC	7,803,600	$96,374	6.5%	$7.61	+34.0%	COM	68062P106
NUVL	NUVALENT INC	1,638,147	$75,306	5.1%	$39.88	+11.3%	COM	670703107
BCYC	BICYCLE THERAPEUTICS PLC	3,642,307	$73,174	5.0%	$19.87	—	SPONSORED ADS	088786108
—	MIRATI THERAPEUTICS INC	1,668,116	$72,663	4.9%	$60.31	—	COM	60468T105
IMCR	IMMUNOCORE HLDGS PLC	1,384,686	$71,865	4.9%	$42.92	—	ADS	45258D105
UTHR	UNITED THERAPEUTICS CORP DEL	307,314	$69,413	4.7%	$218.41	+5.5%	COM	91307C102
CRNX	CRINETICS PHARMACEUTICALS IN	2,178,737	$64,796	4.4%	$19.73	+4.4%	COM	22663K107
IRON	DISC MEDICINE INC	1,272,279	$59,772	4.1%	$50.02	0.0%	COM	254604101
VRDN	VIRIDIAN THERAPEUTICS INC	3,681,747	$56,478	3.8%	$20.65	-7.6%	COM	92790C104
—	CEREVEL THERAPEUTICS HLDNG I	2,532,972	$55,295	3.8%	$24.52	—	COM	15678U128
INCY	INCYTE CORP	912,497	$52,715	3.6%	$74.99	-15.9%	COM	45337C102
XENE	XENON PHARMACEUTICALS INC	1,491,835	$50,961	3.5%	$37.73	-0.9%	COM	98420N105
—	AMBRX BIOPHARMA INC	3,488,596	$40,119	2.7%	$13.85	—	SPONSORED ADS	02290A102
SNDX	SYNDAX PHARMACEUTICALS INC	2,390,077	$34,704	2.4%	$21.25	-11.0%	COM	87164F105
AUTL	AUTOLUS THERAPEUTICS PLC	14,406,782	$33,568	2.3%	$2.36	—	SPON ADS	05280R100
TGTX	TG THERAPEUTICS INC	3,619,015	$30,255	2.1%	$13.94	0.0%	COM	88322Q108
ZLAB	ZAI LAB LTD	1,142,383	$27,771	1.9%	$29.52	—	ADR	98887Q104
—	ALPINE IMMUNE SCIENCES INC	2,421,743	$27,729	1.9%	$7.85	—	COM	02083G100
IMTX	IMMATICS N.V	2,058,447	$23,837	1.6%	$9.43	+26.6%	SHS	N44445109
—	VERONA PHARMA PLC	926,432	$15,101	1.0%	$19.95	—	SPONSORED ADS	925050106
CRBU	CARIBOU BIOSCIENCES INC	2,944,513	$14,075	1.0%	$6.20	0.0%	COM	142038108
—	VOR BIOPHARMA INC	6,461,467	$13,698	0.9%	$6.84	—	COM	929033108
ROIV	ROIVANT SCIENCES LTD	1,081,767	$12,635	0.9%	$11.31	0.0%	SHS	G76279101
KURA	KURA ONCOLOGY INC	1,212,828	$11,061	0.8%	$11.54	-12.0%	COM	50127T109
CMPS	COMPASS PATHWAYS PLC	1,358,709	$10,054	0.7%	$7.40	—	SPONSORED ADS	20451W101
—	89BIO INC	329,100	$5,081	0.3%	—	—	Call	282559103
—	AMBRX BIOPHARMA INC	209,600	$2,410	0.2%	$13.85	—	Call	02290A102
COGT	COGENT BIOSCIENCES INC	225,605	$2,200	0.1%	$11.86	0.0%	COM	19240Q201