Paradigm Biocapital Advisors LP Quant / Systematic

Location: New York, NY

CIK: 0001855655 · Show all filings

Period: Q4 2023 (← Previous) (Next →)

Filing Date: Feb 14, 2024

Total Value: $2.136B (100.0% shares, 0.0% debt)

Holdings (30)

NUVL NUVALENT INC 13.3%

Value $284M Shares 3,858,008 Est. Cost $52.54 Unrealized +17.8%

ACLX ARCELLX INC 9.5%

Value $203M Shares 3,658,624 Est. Cost $33.36 Unrealized +35.2%

ARGX ARGENX SE 7.5%

Value $161M Shares 422,577 Est. Cost $410.13 Unrealized —

IRON DISC MEDICINE INC 6.5%

Value $138M Shares 2,385,857 Est. Cost $50.57 Unrealized +1.2%

LEGN LEGEND BIOTECH CORP 5.3%

Value $114M Shares 1,894,644 Est. Cost $50.58 Unrealized —

OLMA OLEMA PHARMACEUTICALS INC 5.2%

Value $111M Shares 7,903,600 Est. Cost $7.68 Unrealized +74.9%

VRDN VIRIDIAN THERAPEUTICS INC 4.9%

Value $104M Shares 4,794,488 Est. Cost $19.52 Unrealized -19.1%

IMCR IMMUNOCORE HLDGS PLC 4.7%

Value $99.33M Shares 1,453,883 Est. Cost $44.13 Unrealized —

— CEREVEL THERAPEUTICS HLDNG I 4.6%

Value $98.81M Shares 2,330,508 Est. Cost $24.52 Unrealized —

XENE XENON PHARMACEUTICALS INC 4.6%

Value $97.99M Shares 2,127,400 Est. Cost $37.02 Unrealized -4.6%

— MIRATI THERAPEUTICS INC 4.2%

Value $90.66M Shares 1,543,116 Est. Cost $60.31 Unrealized —

CRNX CRINETICS PHARMACEUTICALS IN 3.9%

Value $82.29M Shares 2,312,919 Est. Cost $20.37 Unrealized +50.6%

AUTL AUTOLUS THERAPEUTICS PLC 3.8%

Value $81.22M Shares 12,611,335 Est. Cost $2.36 Unrealized —

BCYC BICYCLE THERAPEUTICS PLC 3.1%

Value $67.02M Shares 3,707,001 Est. Cost $19.84 Unrealized —

— AMBRX BIOPHARMA INC 2.9%

Value $61.98M Shares 4,352,689 Est. Cost $14.24 Unrealized —

— ALPINE IMMUNE SCIENCES INC 2.8%

Value $60.55M Shares 3,176,743 Est. Cost $10.52 Unrealized —

ASND ASCENDIS PHARMA A/S 2.1%

Value $44.3M Shares 351,700 Est. Cost $125.95 Unrealized —

ARVN ARVINAS INC 1.8%

Value $38.33M Shares 931,303 Est. Cost $23.38 Unrealized 0.0%

TGTX TG THERAPEUTICS INC 1.7%

Value $37.09M Shares 2,171,419 Est. Cost $13.94 Unrealized -16.6%

ZLAB ZAI LAB LTD 1.4%

Value $29.84M Shares 1,091,779 Est. Cost $29.52 Unrealized —

IMTX IMMATICS N.V 1.1%

Value $22.5M Shares 2,136,339 Est. Cost $9.42 Unrealized -2.3%

TARS TARSUS PHARMACEUTICALS INC 1.0%

Value $20.76M Shares 1,025,000 Est. Cost $16.70 Unrealized 0.0%

CMPS COMPASS PATHWAYS PLC 0.9%

Value $19.83M Shares 2,265,988 Est. Cost $7.94 Unrealized —

KURA KURA ONCOLOGY INC 0.9%

Value $18.16M Shares 1,262,828 Est. Cost $11.47 Unrealized -14.3%

CRBU CARIBOU BIOSCIENCES INC 0.8%

Value $16.75M Shares 2,923,851 Est. Cost $6.20 Unrealized -20.3%

— VOR BIOPHARMA INC 0.7%

Value $14.53M Shares 6,457,293 Est. Cost $6.84 Unrealized —

— CARGO THERAPEUTICS INC 0.4%

Value $7.717M Shares 333,333 Est. Cost $23.15 Unrealized —

ZNTL ZENTALIS PHARMACEUTICALS INC 0.3%

Value $6.06M Shares 400,000 Est. Cost $14.59 Unrealized 0.0%

— AEROVATE THERAPEUTICS INC 0.2%

Value $3.241M Shares 143,235 Est. Cost $22.63 Unrealized —

— AMBRX BIOPHARMA INC 0.1%

Value $2.136M Shares 150,000 Est. Cost $14.24 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
NUVL	NUVALENT INC	3,858,008	$284M	13.3%	$52.54	+17.8%	COM	670703107
ACLX	ARCELLX INC	3,658,624	$203M	9.5%	$33.36	+35.2%	COMMON STOCK	03940C100
ARGX	ARGENX SE	422,577	$161M	7.5%	$410.13	—	SPONSORED ADR	04016X101
IRON	DISC MEDICINE INC	2,385,857	$138M	6.5%	$50.57	+1.2%	COM	254604101
LEGN	LEGEND BIOTECH CORP	1,894,644	$114M	5.3%	$50.58	—	SPONSORED ADS	52490G102
OLMA	OLEMA PHARMACEUTICALS INC	7,903,600	$111M	5.2%	$7.68	+74.9%	COM	68062P106
VRDN	VIRIDIAN THERAPEUTICS INC	4,794,488	$104M	4.9%	$19.52	-19.1%	COM	92790C104
IMCR	IMMUNOCORE HLDGS PLC	1,453,883	$99.33M	4.7%	$44.13	—	ADS	45258D105
—	CEREVEL THERAPEUTICS HLDNG I	2,330,508	$98.81M	4.6%	$24.52	—	COM	15678U128
XENE	XENON PHARMACEUTICALS INC	2,127,400	$97.99M	4.6%	$37.02	-4.6%	COM	98420N105
—	MIRATI THERAPEUTICS INC	1,543,116	$90.66M	4.2%	$60.31	—	COM	60468T105
CRNX	CRINETICS PHARMACEUTICALS IN	2,312,919	$82.29M	3.9%	$20.37	+50.6%	COM	22663K107
AUTL	AUTOLUS THERAPEUTICS PLC	12,611,335	$81.22M	3.8%	$2.36	—	SPON ADS	05280R100
BCYC	BICYCLE THERAPEUTICS PLC	3,707,001	$67.02M	3.1%	$19.84	—	SPONSORED ADS	088786108
—	AMBRX BIOPHARMA INC	4,352,689	$61.98M	2.9%	$14.24	—	COM	641871108
—	ALPINE IMMUNE SCIENCES INC	3,176,743	$60.55M	2.8%	$10.52	—	COM	02083G100
ASND	ASCENDIS PHARMA A/S	351,700	$44.3M	2.1%	$125.95	—	SPONSORED ADR	04351P101
ARVN	ARVINAS INC	931,303	$38.33M	1.8%	$23.38	0.0%	COM	04335A105
TGTX	TG THERAPEUTICS INC	2,171,419	$37.09M	1.7%	$13.94	-16.6%	COM	88322Q108
ZLAB	ZAI LAB LTD	1,091,779	$29.84M	1.4%	$29.52	—	ADR	98887Q104
IMTX	IMMATICS N.V	2,136,339	$22.5M	1.1%	$9.42	-2.3%	SHS	N44445109
TARS	TARSUS PHARMACEUTICALS INC	1,025,000	$20.76M	1.0%	$16.70	0.0%	COM	87650L103
CMPS	COMPASS PATHWAYS PLC	2,265,988	$19.83M	0.9%	$7.94	—	SPONSORED ADS	20451W101
KURA	KURA ONCOLOGY INC	1,262,828	$18.16M	0.9%	$11.47	-14.3%	COM	50127T109
CRBU	CARIBOU BIOSCIENCES INC	2,923,851	$16.75M	0.8%	$6.20	-20.3%	COM	142038108
—	VOR BIOPHARMA INC	6,457,293	$14.53M	0.7%	$6.84	—	COM	929033108
—	CARGO THERAPEUTICS INC	333,333	$7.717M	0.4%	$23.15	—	COM	14179K101
ZNTL	ZENTALIS PHARMACEUTICALS INC	400,000	$6.06M	0.3%	$14.59	0.0%	COM	98943L107
—	AEROVATE THERAPEUTICS INC	143,235	$3.241M	0.2%	$22.63	—	COM	008064107
—	AMBRX BIOPHARMA INC	150,000	$2.136M	0.1%	$14.24	—	Call	641871108