Paradigm Biocapital Advisors LP Quant / Systematic

CIK: 0001855655 · Show all filings

Period: Q1 2024 (← Previous) (Next →)

Filing Date: May 15, 2024

Total Value ($000): $2,840,752 (100.0% shares, 0.0% debt)

Holdings (34)

NUVL NUVALENT INC 11.0%

Value ($000) $313,713 Shares 4,177,830 Est. Cost $54.61 Unrealized +45.7%

ACLX ARCELLX INC 9.3%

Value ($000) $265,549 Shares 3,818,095 Est. Cost $34.61 Unrealized +83.2%

ARGX ARGENX SE 7.7%

Value ($000) $217,381 Shares 552,120 Est. Cost $406.28 Unrealized —

IRON DISC MEDICINE INC 5.2%

Value ($000) $148,795 Shares 2,389,902 Est. Cost $50.57 Unrealized +28.2%

CRNX CRINETICS PHARMACEUTICALS IN 5.1%

Value ($000) $146,270 Shares 3,124,749 Est. Cost $25.24 Unrealized +55.0%

SRPT SAREPTA THERAPEUTICS INC 4.9%

Value ($000) $139,603 Shares 1,078,346 Est. Cost $122.50 Unrealized 0.0%

IMCR IMMUNOCORE HLDGS PLC 4.1%

Value ($000) $116,166 Shares 1,787,176 Est. Cost $48.02 Unrealized —

LEGN LEGEND BIOTECH CORP 3.9%

Value ($000) $111,171 Shares 1,982,006 Est. Cost $50.82 Unrealized —

ARVN ARVINAS INC 3.8%

Value ($000) $107,945 Shares 2,614,935 Est. Cost $36.46 Unrealized +19.8%

XENE XENON PHARMACEUTICALS INC 3.8%

Value ($000) $106,974 Shares 2,484,874 Est. Cost $38.31 Unrealized +20.1%

TARS TARSUS PHARMACEUTICALS INC 3.7%

Value ($000) $104,085 Shares 2,863,406 Est. Cost $24.85 Unrealized +18.3%

— CEREVEL THERAPEUTICS HLDNG I 3.5%

Value ($000) $98,511 Shares 2,330,508 Est. Cost $24.52 Unrealized —

RVMD REVOLUTION MEDICINES INC 3.3%

Value ($000) $93,950 Shares 2,914,975 Est. Cost $29.64 Unrealized 0.0%

OLMA OLEMA PHARMACEUTICALS INC 3.1%

Value ($000) $89,469 Shares 7,903,600 Est. Cost $7.68 Unrealized +68.0%

VRDN VIRIDIAN THERAPEUTICS INC 3.1%

Value ($000) $88,100 Shares 5,031,420 Est. Cost $19.51 Unrealized -0.7%

PCVX VAXCYTE INC 3.0%

Value ($000) $84,704 Shares 1,239,995 Est. Cost $69.25 Unrealized 0.0%

— ALPINE IMMUNE SCIENCES INC 3.0%

Value ($000) $84,083 Shares 2,121,163 Est. Cost $10.52 Unrealized —

BCYC BICYCLE THERAPEUTICS PLC 2.8%

Value ($000) $80,844 Shares 3,246,759 Est. Cost $19.84 Unrealized —

ASND ASCENDIS PHARMA A/S 2.7%

Value ($000) $76,787 Shares 507,952 Est. Cost $133.71 Unrealized —

KURA KURA ONCOLOGY INC 2.4%

Value ($000) $66,878 Shares 3,135,387 Est. Cost $16.23 Unrealized +19.8%

EWTX EDGEWISE THERAPEUTICS INC 1.6%

Value ($000) $44,622 Shares 2,446,373 Est. Cost $15.89 Unrealized 0.0%

AUTL AUTOLUS THERAPEUTICS PLC 1.4%

Value ($000) $40,997 Shares 6,425,803 Est. Cost $2.36 Unrealized —

— Y-MABS THERAPEUTICS INC 1.3%

Value ($000) $36,318 Shares 2,233,610 Est. Cost $16.26 Unrealized —

IMTX IMMATICS N.V 1.0%

Value ($000) $29,627 Shares 2,818,908 Est. Cost $9.96 Unrealized +17.1%

IMVT IMMUNOVANT INC 0.9%

Value ($000) $25,817 Shares 799,054 Est. Cost $36.48 Unrealized 0.0%

CGEM CULLINAN ONCOLOGY INC 0.8%

Value ($000) $22,970 Shares 1,348,015 Est. Cost $15.45 Unrealized 0.0%

APGE APOGEE THERAPEUTICS INC 0.8%

Value ($000) $21,929 Shares 330,000 Est. Cost $43.66 Unrealized 0.0%

CMPS COMPASS PATHWAYS PLC 0.7%

Value ($000) $19,893 Shares 2,390,988 Est. Cost $7.96 Unrealized —

— VOR BIOPHARMA INC 0.5%

Value ($000) $15,304 Shares 6,457,293 Est. Cost $6.84 Unrealized —

ZNTL ZENTALIS PHARMACEUTICALS INC 0.5%

Value ($000) $14,892 Shares 944,917 Est. Cost $14.11 Unrealized -2.5%

AGIO AGIOS PHARMACEUTICALS INC 0.4%

Value ($000) $11,696 Shares 400,000 Est. Cost $26.78 Unrealized 0.0%

CRBU CARIBOU BIOSCIENCES INC 0.4%

Value ($000) $11,167 Shares 2,172,620 Est. Cost $6.20 Unrealized -0.6%

— CARGO THERAPEUTICS INC 0.1%

Value ($000) $3,302 Shares 147,959 Est. Cost $23.15 Unrealized —

KYTX KYVERNA THERAPEUTICS INC 0.0%

Value ($000) $1,242 Shares 50,000 Est. Cost $27.84 Unrealized 0.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
NUVL	NUVALENT INC	4,177,830	$313,713	11.0%	$54.61	+45.7%	COM	670703107
ACLX	ARCELLX INC	3,818,095	$265,549	9.3%	$34.61	+83.2%	COMMON STOCK	03940C100
ARGX	ARGENX SE	552,120	$217,381	7.7%	$406.28	—	SPONSORED ADR	04016X101
IRON	DISC MEDICINE INC	2,389,902	$148,795	5.2%	$50.57	+28.2%	COM	254604101
CRNX	CRINETICS PHARMACEUTICALS IN	3,124,749	$146,270	5.1%	$25.24	+55.0%	COM	22663K107
SRPT	SAREPTA THERAPEUTICS INC	1,078,346	$139,603	4.9%	$122.50	0.0%	COM	803607100
IMCR	IMMUNOCORE HLDGS PLC	1,787,176	$116,166	4.1%	$48.02	—	ADS	45258D105
LEGN	LEGEND BIOTECH CORP	1,982,006	$111,171	3.9%	$50.82	—	SPONSORED ADS	52490G102
ARVN	ARVINAS INC	2,614,935	$107,945	3.8%	$36.46	+19.8%	COM	04335A105
XENE	XENON PHARMACEUTICALS INC	2,484,874	$106,974	3.8%	$38.31	+20.1%	COM	98420N105
TARS	TARSUS PHARMACEUTICALS INC	2,863,406	$104,085	3.7%	$24.85	+18.3%	COM	87650L103
—	CEREVEL THERAPEUTICS HLDNG I	2,330,508	$98,511	3.5%	$24.52	—	COM	15678U128
RVMD	REVOLUTION MEDICINES INC	2,914,975	$93,950	3.3%	$29.64	0.0%	COM	76155X100
OLMA	OLEMA PHARMACEUTICALS INC	7,903,600	$89,469	3.1%	$7.68	+68.0%	COM	68062P106
VRDN	VIRIDIAN THERAPEUTICS INC	5,031,420	$88,100	3.1%	$19.51	-0.7%	COM	92790C104
PCVX	VAXCYTE INC	1,239,995	$84,704	3.0%	$69.25	0.0%	COM	92243G108
—	ALPINE IMMUNE SCIENCES INC	2,121,163	$84,083	3.0%	$10.52	—	COM	02083G100
BCYC	BICYCLE THERAPEUTICS PLC	3,246,759	$80,844	2.8%	$19.84	—	SPONSORED ADS	088786108
ASND	ASCENDIS PHARMA A/S	507,952	$76,787	2.7%	$133.71	—	SPONSORED ADR	04351P101
KURA	KURA ONCOLOGY INC	3,135,387	$66,878	2.4%	$16.23	+19.8%	COM	50127T109
EWTX	EDGEWISE THERAPEUTICS INC	2,446,373	$44,622	1.6%	$15.89	0.0%	COM	28036F105
AUTL	AUTOLUS THERAPEUTICS PLC	6,425,803	$40,997	1.4%	$2.36	—	SPON ADS	05280R100
—	Y-MABS THERAPEUTICS INC	2,233,610	$36,318	1.3%	$16.26	—	COM	984241109
IMTX	IMMATICS N.V	2,818,908	$29,627	1.0%	$9.96	+17.1%	SHS	N44445109
IMVT	IMMUNOVANT INC	799,054	$25,817	0.9%	$36.48	0.0%	COM	45258J102
CGEM	CULLINAN ONCOLOGY INC	1,348,015	$22,970	0.8%	$15.45	0.0%	COM	230031106
APGE	APOGEE THERAPEUTICS INC	330,000	$21,929	0.8%	$43.66	0.0%	COM	03770N101
CMPS	COMPASS PATHWAYS PLC	2,390,988	$19,893	0.7%	$7.96	—	SPONSORED ADS	20451W101
—	VOR BIOPHARMA INC	6,457,293	$15,304	0.5%	$6.84	—	COM	929033108
ZNTL	ZENTALIS PHARMACEUTICALS INC	944,917	$14,892	0.5%	$14.11	-2.5%	COM	98943L107
AGIO	AGIOS PHARMACEUTICALS INC	400,000	$11,696	0.4%	$26.78	0.0%	COM	00847X104
CRBU	CARIBOU BIOSCIENCES INC	2,172,620	$11,167	0.4%	$6.20	-0.6%	COM	142038108
—	CARGO THERAPEUTICS INC	147,959	$3,302	0.1%	$23.15	—	COM	14179K101
KYTX	KYVERNA THERAPEUTICS INC	50,000	$1,242	0.0%	$27.84	0.0%	COM	501976104