Catalio Capital Management, LP Quant / Systematic

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
GILD	GILEAD SCIENCES INC	289,312	$35,510	6.3%	$120.88	0.0%	COM	375558103
BMY	BRISTOL-MYERS SQUIBB CO	647,899	$34,948	6.2%	$47.53	0.0%	COM	110122108
BBOT	BRIDGEBIO ONCOLOGY THERAPEUT	410,700	$31,414	5.6%	$76.49	—	COM NEW	107924102
JNJ	JOHNSON & JOHNSON	120,840	$25,008	4.4%	$197.01	0.0%	COM	478160104
EW	EDWARDS LIFESCIENCES CORP	187,048	$15,946	2.8%	$82.07	0.0%	COM	28176E108
MLYS	MINERALYS THERAPEUTICS INC	331,849	$12,043	2.1%	$40.10	0.0%	COM	603170101
ACLX	ARCELLX INC	156,109	$10,178	1.8%	$79.78	0.0%	COMMON STOCK	03940C100
DYN	DYNE THERAPEUTICS INC	519,715	$10,166	1.8%	$18.94	0.0%	COM	26818M108
OCUL	OCULAR THERAPEUTIX INC	714,501	$8,674	1.5%	$12.15	0.0%	COM	67576A100
OLMA	OLEMA PHARMACEUTICALS INC	267,058	$6,676	1.2%	$17.79	0.0%	COM	68062P106
TERN	TERNS PHARMACEUTICALS INC	136,958	$5,533	1.0%	$23.11	0.0%	COM	880881107
HTFL	HEARTFLOW INC	113,857	$3,319	0.6%	$32.19	0.0%	COM	42238D107
FULC	FULCRUM THERAPEUTICS INC	201,301	$2,277	0.4%	$10.18	0.0%	COM	359616109
BLLN	BILLIONTOONE INC	25,505	$2,087	0.4%	$101.40	0.0%	CL A	090168105

Increased Positions (5)

QURE UNIQURE NV 1.2%

Value ($000) $6,900 (-58.2%) Shares 288,345 (+1.9%) Est. Cost $9.19 Unrealized +319.7%

BSX BOSTON SCIENTIFIC CORP 6.1%

Value ($000) $34,367 (+33.9%) Shares 360,428 (+37.1%) Est. Cost $100.56 Unrealized -2.5%

GUTS FRACTYL HEALTH INC 2.1%

Value ($000) $12,082 (+45.7%) Shares 5,491,866 (+5.3%) Est. Cost $1.35 Unrealized +18.9%

ELDN ELEDON PHARMACEUTICALS INC 0.3%

Value ($000) $1,902 (-30.8%) Shares 1,259,820 (+18.7%) Est. Cost $2.84 Unrealized -16.2%

HYPR HYPERFINE INC 0.2%

Value ($000) $1,293 (+30.2%) Shares 1,320,041 (+92.8%) Est. Cost $1.08 Unrealized +11.7%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
QURE	UNIQURE NV	288,345 (+1.9%)	$6,900 (-58.2%)	1.2%	$9.19	+319.7%	SHS	N90064101
BSX	BOSTON SCIENTIFIC CORP	360,428 (+37.1%)	$34,367 (+33.9%)	6.1%	$100.56	-2.5%	COM	101137107
GUTS	FRACTYL HEALTH INC	5,491,866 (+5.3%)	$12,082 (+45.7%)	2.1%	$1.35	+18.9%	COM	35168W103
ELDN	ELEDON PHARMACEUTICALS INC	1,259,820 (+18.7%)	$1,902 (-30.8%)	0.3%	$2.84	-16.2%	COM	28617K101
HYPR	HYPERFINE INC	1,320,041 (+92.8%)	$1,293 (+30.2%)	0.2%	$1.08	+11.7%	COM CL A	44916K106

Exited Positions (7)

ABBV ABBVIE INC 6.3%

Value ($000) $35,850 Shares 154,834 Est. Cost $201.95 Unrealized +12.7%

BBIO BRIDGEBIO PHARMA INC 5.7%

Value ($000) $32,345 Shares 622,729 Est. Cost $26.37 Unrealized +148.9%

EXAS EXACT SCIENCES CORP 2.4%

Value ($000) $13,622 Shares 248,987 Est. Cost $49.96 Unrealized +60.7%

RNA AVIDITY BIOSCIENCES INC 2.0%

Value ($000) $11,470 Shares 263,256 Est. Cost $40.43 Unrealized +59.8%

— CIDARA THERAPEUTICS INC 0.9%

Value ($000) $5,107 Shares 53,333 Est. Cost $95.76 Unrealized —

KYTX KYVERNA THERAPEUTICS INC 0.6%

Value ($000) $3,521 Shares 586,909 Est. Cost $4.79 Unrealized +55.0%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 0.2%

Value ($000) $955 Shares 133,131 Est. Cost $42.39 Unrealized -72.2%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
ABBV	ABBVIE INC	154,834	$35,850	6.3%	$201.95	+12.7%	—	00287Y109
BBIO	BRIDGEBIO PHARMA INC	622,729	$32,345	5.7%	$26.37	+148.9%	—	10806X102
EXAS	EXACT SCIENCES CORP	248,987	$13,622	2.4%	$49.96	+60.7%	—	30063P105
RNA	AVIDITY BIOSCIENCES INC	263,256	$11,470	2.0%	$40.43	+59.8%	—	05370A108
—	CIDARA THERAPEUTICS INC	53,333	$5,107	0.9%	$95.76	—	—	171757206
KYTX	KYVERNA THERAPEUTICS INC	586,909	$3,521	0.6%	$4.79	+55.0%	—	501976104
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	133,131	$955	0.2%	$42.39	-72.2%	—	61559X104

Decreased Positions (20)

ISRG INTUITIVE SURGICAL INC 2.7%

Value ($000) $15,410 (-51.7%) Shares 27,209 (-61.9%) Est. Cost $513.00 Unrealized +3.8%

LLY ELI LILLY & CO 4.9%

Value ($000) $27,859 (-36.4%) Shares 25,923 (-54.8%) Est. Cost $793.52 Unrealized +20.4%

SLNO SOLENO THERAPEUTICS INC 2.9%

Value ($000) $16,684 (-41.0%) Shares 360,340 (-13.8%) Est. Cost $64.77 Unrealized -15.3%

NTRA NATERA INC 2.5%

Value ($000) $14,266 (-40.3%) Shares 62,273 (-58.0%) Est. Cost $156.65 Unrealized +33.2%

CYTK CYTOKINETICS INC 2.9%

Value ($000) $16,418 (-33.9%) Shares 258,381 (-42.8%) Est. Cost $50.21 Unrealized +23.9%

GRAL GRAIL INC 0.5%

Value ($000) $2,594 (-68.2%) Shares 30,313 (-78.0%) Est. Cost $38.21 Unrealized +126.1%

IRON DISC MEDICINE INC 1.5%

Value ($000) $8,769 (-38.7%) Shares 110,427 (-49.0%) Est. Cost $57.71 Unrealized +46.4%

RARE ULTRAGENYX PHARMACEUTICAL IN 0.7%

Value ($000) $3,739 (-57.3%) Shares 162,550 (-44.2%) Est. Cost $34.43 Unrealized -4.5%

ASND ASCENDIS PHARMA A/S 4.5%

Value ($000) $25,432 (-11.8%) Shares 119,265 (-17.7%) Est. Cost $137.67 Unrealized —

REGN REGENERON PHARMACEUTICALS 4.1%

Value ($000) $22,999 (+15.7%) Shares 29,797 (-15.7%) Est. Cost $564.28 Unrealized +20.3%

PHAT PHATHOM PHARMACEUTICALS INC 2.0%

Value ($000) $11,596 (-12.7%) Shares 698,996 (-38.1%) Est. Cost $7.47 Unrealized +91.2%

TARA PROTARA THERAPEUTICS INC 1.4%

Value ($000) $7,709 (+18.1%) Shares 1,446,254 (-3.6%) Est. Cost $3.30 Unrealized +68.3%

SUPN SUPERNUS PHARMACEUTICALS INC 2.3%

Value ($000) $12,796 (-6.7%) Shares 257,465 (-10.3%) Est. Cost $40.27 Unrealized +20.7%

DNTH DIANTHUS THERAPEUTICS INC 4.8%

Value ($000) $26,934 (+2.5%) Shares 653,572 (-2.1%) Est. Cost $25.71 Unrealized +50.8%

GPCR STRUCTURE THERAPEUTICS INC 3.1%

Value ($000) $17,589 (-3.6%) Shares 252,901 (-61.2%) Est. Cost $25.23 Unrealized —

ABVX ABIVAX SA 2.3%

Value ($000) $13,285 (-3.5%) Shares 98,514 (-39.2%) Est. Cost $84.90 Unrealized —

PVLA PALVELLA THERAPEUTICS INC NE 0.2%

Value ($000) $1,094 (+45.3%) Shares 10,452 (-13.0%) Est. Cost $44.59 Unrealized +91.3%

SNDX SYNDAX PHARMACEUTICALS INC 4.4%

Value ($000) $25,145 (+1.2%) Shares 1,196,807 (-25.9%) Est. Cost $13.56 Unrealized +28.7%

ADMA ADMA BIOLOGICS INC 1.8%

Value ($000) $10,296 (+2.6%) Shares 564,461 (-17.5%) Est. Cost $19.85 Unrealized -15.1%

ADPT ADAPTIVE BIOTECHNOLOGIES COR 2.4%

Value ($000) $13,336 (+0.7%) Shares 821,195 (-7.2%) Est. Cost $8.47 Unrealized +92.7%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
ISRG	INTUITIVE SURGICAL INC	27,209 (-61.9%)	$15,410 (-51.7%)	2.7%	$513.00	+3.8%	COM NEW	46120E602
LLY	ELI LILLY & CO	25,923 (-54.8%)	$27,859 (-36.4%)	4.9%	$793.52	+20.4%	COM	532457108
SLNO	SOLENO THERAPEUTICS INC	360,340 (-13.8%)	$16,684 (-41.0%)	2.9%	$64.77	-15.3%	COM	834203309
NTRA	NATERA INC	62,273 (-58.0%)	$14,266 (-40.3%)	2.5%	$156.65	+33.2%	COM	632307104
CYTK	CYTOKINETICS INC	258,381 (-42.8%)	$16,418 (-33.9%)	2.9%	$50.21	+23.9%	COM NEW	23282W605
GRAL	GRAIL INC	30,313 (-78.0%)	$2,594 (-68.2%)	0.5%	$38.21	+126.1%	COM	384747101
IRON	DISC MEDICINE INC	110,427 (-49.0%)	$8,769 (-38.7%)	1.5%	$57.71	+46.4%	COM	254604101
RARE	ULTRAGENYX PHARMACEUTICAL IN	162,550 (-44.2%)	$3,739 (-57.3%)	0.7%	$34.43	-4.5%	COM	90400D108
ASND	ASCENDIS PHARMA A/S	119,265 (-17.7%)	$25,432 (-11.8%)	4.5%	$137.67	—	SPONSORED ADR	04351P101
REGN	REGENERON PHARMACEUTICALS	29,797 (-15.7%)	$22,999 (+15.7%)	4.1%	$564.28	+20.3%	COM	75886F107
PHAT	PHATHOM PHARMACEUTICALS INC	698,996 (-38.1%)	$11,596 (-12.7%)	2.0%	$7.47	+91.2%	COM	71722W107
TARA	PROTARA THERAPEUTICS INC	1,446,254 (-3.6%)	$7,709 (+18.1%)	1.4%	$3.30	+68.3%	COM STK	74365U107
SUPN	SUPERNUS PHARMACEUTICALS INC	257,465 (-10.3%)	$12,796 (-6.7%)	2.3%	$40.27	+20.7%	COM	868459108
DNTH	DIANTHUS THERAPEUTICS INC	653,572 (-2.1%)	$26,934 (+2.5%)	4.8%	$25.71	+50.8%	COM	252828108
GPCR	STRUCTURE THERAPEUTICS INC	252,901 (-61.2%)	$17,589 (-3.6%)	3.1%	$25.23	—	SPONSORED ADS	86366E106
ABVX	ABIVAX SA	98,514 (-39.2%)	$13,285 (-3.5%)	2.3%	$84.90	—	SPONSORED ADS	00370M103
PVLA	PALVELLA THERAPEUTICS INC NE	10,452 (-13.0%)	$1,094 (+45.3%)	0.2%	$44.59	+91.3%	COM	697947109
SNDX	SYNDAX PHARMACEUTICALS INC	1,196,807 (-25.9%)	$25,145 (+1.2%)	4.4%	$13.56	+28.7%	COM	87164F105
ADMA	ADMA BIOLOGICS INC	564,461 (-17.5%)	$10,296 (+2.6%)	1.8%	$19.85	-15.1%	COM	000899104
ADPT	ADAPTIVE BIOTECHNOLOGIES COR	821,195 (-7.2%)	$13,336 (+0.7%)	2.4%	$8.47	+92.7%	COM	00650F109

Unchanged Positions (6)

SEPN SEPTERNA INC 1.5%

Value ($000) $8,207 Shares 294,360 Est. Cost $23.65 Unrealized +1.0%

OM OUTSET MED INC 0.1%

Value ($000) $439 Shares 118,279 Est. Cost $11.92 Unrealized -28.1%

MGX METAGENOMI INC 0.2%

Value ($000) $857 Shares 528,993 Est. Cost $2.41 Unrealized -10.3%

— ATAI BECKLEY NV 0.1%

Value ($000) $805 Shares 196,858 Est. Cost $1.33 Unrealized —

KPTI KARYOPHARM THERAPEUTICS INC 0.2%

Value ($000) $1,052 Shares 142,984 Est. Cost $8.54 Unrealized -28.4%

SNSE SENSEI BIOTHERAPEUTICS INC 0.0%

Value ($000) $157 Shares 14,718 Est. Cost $7.18 Unrealized +34.6%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
SEPN	SEPTERNA INC	294,360	$8,207	1.5%	$23.65	+1.0%	COM	81734D104
OM	OUTSET MED INC	118,279	$439	0.1%	$11.92	-28.1%	COM NEW	690145206
MGX	METAGENOMI INC	528,993	$857	0.2%	$2.41	-10.3%	COM	59102M104
—	ATAI BECKLEY NV	196,858	$805	0.1%	$1.33	—	SHS	N0731H103
KPTI	KARYOPHARM THERAPEUTICS INC	142,984	$1,052	0.2%	$8.54	-28.4%	COM NEW	48576U205
SNSE	SENSEI BIOTHERAPEUTICS INC	14,718	$157	0.0%	$7.18	+34.6%	COM NEW	81728A207