DIADEMA PARTNERS LP Hedge Fund

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
VRTX	VERTEX PHARMACEUTICALS INC	88,300	$40,032	6.9%	$431.03	0.0%	CALL	92532F100
XBI	SPDR SERIES TRUST	250,000	$30,483	5.3%	—	—	PUT	78464A870
QQQ	INVESCO QQQ TR	30,000	$18,429	3.2%	—	—	PUT	46090E103
BBIO	BRIDGEBIO PHARMA INC	200,000	$15,298	2.6%	$65.64	0.0%	PUT	10806X102
JNJ	JOHNSON & JOHNSON	66,444	$13,751	2.4%	$197.01	0.0%	COM	478160104
GPCR	STRUCTURE THERAPEUTICS INC	191,700	$13,333	2.3%	—	—	CALL	86366E106
VKTX	VIKING THERAPEUTICS INC	316,700	$11,142	1.9%	$31.80	+11.4%	PUT	92686J106
JNJ	JOHNSON & JOHNSON	50,000	$10,348	1.8%	$197.01	0.0%	CALL	478160104
INCY	INCYTE CORP	100,000	$9,877	1.7%	—	—	PUT	45337C102
INSM	INSMED INC	52,800	$9,189	1.6%	—	—	CALL	457669307
—	INDIVIOR PLC	220,300	$7,904	1.4%	$24.11	—	CALL	G4766E116
CAPR	CAPRICOR THERAPEUTICS INC	200,000	$5,772	1.0%	$13.06	0.0%	PUT	14070B309
BBIO	BRIDGEBIO PHARMA INC	70,000	$5,354	0.9%	$65.64	0.0%	COM	10806X102
UTHR	UNITED THERAPEUTICS CORP DEL	10,000	$4,873	0.8%	$465.69	0.0%	COM	91307C102
CAPR	CAPRICOR THERAPEUTICS INC	158,075	$4,562	0.8%	$13.06	0.0%	COM NEW	14070B309
VRTX	VERTEX PHARMACEUTICALS INC	10,000	$4,534	0.8%	$431.03	0.0%	COM	92532F100
REGN	REGENERON PHARMACEUTICALS	5,000	$3,859	0.7%	$586.61	+15.7%	CALL	75886F107
BIOA	BIOAGE LABS INC	271,164	$3,588	0.6%	$8.86	0.0%	COM	09077V100
CORT	CORCEPT THERAPEUTICS INC	97,445	$3,391	0.6%	$78.55	0.0%	COM	218352102
TGTX	TG THERAPEUTICS INC	100,000	$2,981	0.5%	$33.61	-2.8%	PUT	88322Q108
TENX	TENAX THERAPEUTICS INC	243,170	$2,964	0.5%	$8.70	0.0%	COM NEW	88032L605
NTLA	INTELLIA THERAPEUTICS INC	316,900	$2,849	0.5%	—	—	PUT	45826J105
IRWD	IRONWOOD PHARMACEUTICALS INC	683,611	$2,304	0.4%	$2.60	0.0%	COM CL A	46333X108
BHVN	BIOHAVEN LTD	200,000	$2,258	0.4%	—	—	CALL	G1110E107
CNTA	CENTESSA PHARMACEUTICALS PLC	90,000	$2,251	0.4%	$25.01	—	SPONSORED ADS	152309100
REPL	REPLIMUNE GROUP INC	230,997	$2,245	0.4%	$8.50	0.0%	COM	76029N106
AQST	AQUESTIVE THERAPEUTICS INC	337,700	$2,182	0.4%	—	—	PUT	03843E104
LLY	ELI LILLY & CO	2,000	$2,149	0.4%	$955.55	0.0%	COM	532457108
LPCN	LIPOCINE INC NEW	260,939	$2,095	0.4%	$3.36	0.0%	COM NEW	53630X203
RLMD	RELMADA THERAPEUTICS INC	389,395	$1,881	0.3%	$3.35	0.0%	COM	75955J402
VNDA	VANDA PHARMACEUTICALS INC	200,000	$1,764	0.3%	—	—	CALL	921659108
ANNX	ANNEXON INC	350,000	$1,757	0.3%	$3.82	0.0%	COM	03589W102
IVA	INVENTIVA SA	334,251	$1,554	0.3%	$4.65	—	ADS	46124U107
ANNX	ANNEXON INC	309,100	$1,552	0.3%	$3.82	0.0%	CALL	03589W102
LEGN	LEGEND BIOTECH CORP	69,000	$1,500	0.3%	—	—	CALL	52490G102
BCRX	BIOCRYST PHARMACEUTICALS INC	190,928	$1,489	0.3%	$7.23	0.0%	COM	09058V103
AQST	AQUESTIVE THERAPEUTICS INC	211,100	$1,364	0.2%	—	—	CALL	03843E104
RIGL	RIGEL PHARMACEUTICALS INC	30,000	$1,285	0.2%	$37.70	0.0%	COM	766559702
MPLT	MAPLIGHT THERAPEUTICS INC	63,791	$1,120	0.2%	$16.75	0.0%	COM	56565P103
QURE	UNIQURE NV	45,000	$1,077	0.2%	$38.59	0.0%	SHS	N90064101
ENTA	ENANTA PHARMACEUTICALS INC	65,138	$1,027	0.2%	$12.70	0.0%	COM	29251M106
PRTA	PROTHENA CORP PLC	106,539	$1,017	0.2%	$10.18	0.0%	SHS	G72800108
GLUE	MONTE ROSA THERAPEUTICS INC	62,281	$977	0.2%	$13.48	0.0%	COM	61225M102
DSGN	DESIGN THERAPEUTICS INC	100,320	$941	0.2%	$7.83	0.0%	COM	25056L103
INO	INOVIO PHARMACEUTICALS INC	533,682	$929	0.2%	$2.20	0.0%	COM SHS	45773H409
MLYS	MINERALYS THERAPEUTICS INC	25,000	$907	0.2%	$40.10	0.0%	COM	603170101
EOLS	EVOLUS INC	118,800	$790	0.1%	—	—	CALL	30052C107
LQDA	LIQUIDIA CORPORATION	21,881	$755	0.1%	$28.47	0.0%	COM NEW	53635D202
EWTX	EDGEWISE THERAPEUTICS INC	30,000	$744	0.1%	$20.07	0.0%	COM	28036F105
VRDN	VIRIDIAN THERAPEUTICS INC	21,114	$657	0.1%	$27.43	0.0%	COM	92790C104
VIR	VIR BIOTECHNOLOGY INC	100,000	$603	0.1%	$5.95	0.0%	COM	92764N102
LGND	LIGAND PHARMACEUTICALS INC	2,987	$565	0.1%	$192.14	0.0%	COM NEW	53220K504
ZYME	ZYMEWORKS INC	21,400	$563	0.1%	—	—	PUT	98985Y108
UPB	UPSTREAM BIO INC	20,500	$557	0.1%	$24.89	0.0%	COM	91678A107
STOK	STOKE THERAPEUTICS INC	17,181	$545	0.1%	$30.06	0.0%	COM	86150R107
VIR	VIR BIOTECHNOLOGY INC	89,200	$538	0.1%	$5.95	0.0%	CALL	92764N102
CNTA	CENTESSA PHARMACEUTICALS PLC	21,100	$528	0.1%	$25.01	—	CALL	152309100
IMNM	IMMUNOME INC	22,500	$483	0.1%	$17.55	0.0%	COM	45257U108
BDTX	BLACK DIAMOND THERAPEUTICS I	190,400	$463	0.1%	—	—	CALL	09203E105
JANX	JANUX THERAPEUTICS INC	30,000	$414	0.1%	—	—	CALL	47103J105
PALI	PALISADE BIO INC	166,049	$390	0.1%	$1.92	0.0%	COM	696389402
BIOA	BIOAGE LABS INC	22,600	$299	0.1%	$8.86	0.0%	CALL	09077V100
AARD	AARDVARK THERAPEUTICS INC	15,882	$208	0.0%	$12.48	0.0%	COM	002942100
PLRX	PLIANT THERAPEUTICS INC	144,914	$177	0.0%	$1.50	0.0%	COM	729139105
INO	INOVIO PHARMACEUTICALS INC	100,000	$174	0.0%	$2.20	0.0%	CALL	45773H409
ONC	BEONE MEDICINES LTD	7,500	$173	0.0%	$23.04	—	SPONSORED ADS	07725L102
TLPH	TALPHERA INC	136,923	$156	0.0%	$1.21	0.0%	COM NEW	00444T209
RVPH	REVIVA PHARMACEUTCLS HLDGS I	500,000	$140	0.0%	$0.97	-42.5%	CALL	76152G100
LYEL	LYELL IMMUNOPHARMA INC	3,800	$117	0.0%	—	—	PUT	55083R203
INBX	INHIBRX BIOSCIENCES INC	1,299	$103	0.0%	$68.13	0.0%	COM	45720N103
EDSA	EDESA BIOTECH INC	54,025	$77	0.0%	$1.96	0.0%	COM NEW	27966L306

Increased Positions (44)

RNA AVIDITY BIOSCIENCES INC 4.1%

Value ($000) $23,659 (+171.4%) Shares 328,000 (+63.9%) Est. Cost $40.43 Unrealized +59.8%

VKTX VIKING THERAPEUTICS INC 4.2%

Value ($000) $24,236 (+127.6%) Shares 688,900 (+70.1%) Est. Cost $31.80 Unrealized +11.4%

TERN TERNS PHARMACEUTICALS INC 2.4%

Value ($000) $13,974 (+475.8%) Shares 345,880 (+7.0%) Est. Cost $5.58 Unrealized +314.1%

APGE APOGEE THERAPEUTICS INC 2.7%

Value ($000) $15,934 (+214.8%) Shares 211,100 (+65.7%) Est. Cost $40.29 Unrealized +56.3%

CAPR CAPRICOR THERAPEUTICS INC 1.6%

Value ($000) $9,013 (+316.7%) Shares 312,300 (+4.1%) Est. Cost $13.06 Unrealized 0.0%

VKTX VIKING THERAPEUTICS INC 2.0%

Value ($000) $11,850 (+132.8%) Shares 336,849 (+73.9%) Est. Cost $31.80 Unrealized +11.4%

ABVX ABIVAX SA 1.8%

Value ($000) $10,201 (+190.4%) Shares 75,644 (+81.7%) Est. Cost $107.10 Unrealized —

OCUL OCULAR THERAPEUTIX INC 1.1%

Value ($000) $6,619 (+314.2%) Shares 545,200 (+298.8%) Est. Cost — Unrealized —

JAZZ JAZZ PHARMACEUTICALS PLC 3.1%

Value ($000) $17,901 (+35.8%) Shares 105,300 (+5.3%) Est. Cost $125.07 Unrealized +22.6%

BBIO BRIDGEBIO PHARMA INC 1.8%

Value ($000) $10,678 (+56.5%) Shares 139,600 (+6.2%) Est. Cost $65.64 Unrealized 0.0%

COGT COGENT BIOSCIENCES INC 0.8%

Value ($000) $4,683 (+233.4%) Shares 131,852 (+34.8%) Est. Cost $13.44 Unrealized +109.2%

ZYME ZYMEWORKS INC 1.1%

Value ($000) $6,335 (+88.8%) Shares 240,600 (+22.4%) Est. Cost — Unrealized —

CORT CORCEPT THERAPEUTICS INC 0.8%

Value ($000) $4,691 (+113.0%) Shares 134,800 (+408.7%) Est. Cost $78.55 Unrealized 0.0%

ROIV ROIVANT SCIENCES LTD 1.2%

Value ($000) $6,916 (+52.4%) Shares 318,700 (+6.2%) Est. Cost $12.38 Unrealized +59.4%

MREO MEREO BIOPHARMA GROUP PLC 0.1%

Value ($000) $833 (-73.4%) Shares 1,999,500 (+31.5%) Est. Cost — Unrealized —

TVTX TRAVERE THERAPEUTICS INC 0.3%

Value ($000) $1,922 (+26705.6%) Shares 50,300 (+16666.7%) Est. Cost — Unrealized —

IONS IONIS PHARMACEUTICALS INC 1.4%

Value ($000) $8,401 (+28.4%) Shares 106,200 (+6.2%) Est. Cost — Unrealized —

VTYX VENTYX BIOSCIENCES INC 0.3%

Value ($000) $1,806 (+715.6%) Shares 200,000 (+180.9%) Est. Cost $5.76 Unrealized +29.8%

OLMA OLEMA PHARMACEUTICALS INC 0.4%

Value ($000) $2,403 (+171.2%) Shares 96,100 (+6.2%) Est. Cost — Unrealized —

TGTX TG THERAPEUTICS INC 0.6%

Value ($000) $3,675 (+67.5%) Shares 123,283 (+102.9%) Est. Cost $33.61 Unrealized -2.8%

ANIP ANI PHARMACEUTICALS INC 0.7%

Value ($000) $4,212 (+46.4%) Shares 53,354 (+69.9%) Est. Cost $83.62 Unrealized +3.5%

SLS SELLAS LIFE SCIENCES GROUP I 0.3%

Value ($000) $1,602 (+148.7%) Shares 424,900 (+6.2%) Est. Cost — Unrealized —

SLNO SOLENO THERAPEUTICS INC 0.4%

Value ($000) $2,459 (-27.3%) Shares 53,100 (+6.2%) Est. Cost $67.08 Unrealized -18.3%

XERS XERIS BIOPHARMA HOLDINGS INC 0.2%

Value ($000) $1,339 (+120.0%) Shares 170,568 (+128.2%) Est. Cost $7.33 Unrealized +7.3%

CRMD CORMEDIX INC 0.3%

Value ($000) $1,849 (+59.0%) Shares 159,000 (+59.0%) Est. Cost — Unrealized —

MNKD MANNKIND CORP 0.3%

Value ($000) $1,712 (+50.1%) Shares 302,000 (+42.1%) Est. Cost $4.72 Unrealized +16.7%

GOSS GOSSAMER BIO INC 0.5%

Value ($000) $2,719 (+25.3%) Shares 877,100 (+6.3%) Est. Cost — Unrealized —

PTHS PELTHOS THERAPEUTICS INC 0.1%

Value ($000) $775 (+163.7%) Shares 25,000 (+138.1%) Est. Cost $26.93 Unrealized +7.1%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 0.1%

Value ($000) $622 (+232.4%) Shares 47,200 (+80.8%) Est. Cost — Unrealized —

TRVI TREVI THERAPEUTICS INC 0.2%

Value ($000) $1,217 (+54.9%) Shares 97,184 (+13.2%) Est. Cost $5.60 Unrealized +106.3%

EDIT EDITAS MEDICINE INC 0.1%

Value ($000) $653 (-37.2%) Shares 318,700 (+6.2%) Est. Cost — Unrealized —

RXRX RECURSION PHARMACEUTICALS IN 0.5%

Value ($000) $3,034 (-11.0%) Shares 741,900 (+6.2%) Est. Cost — Unrealized —

KOD KODIAK SCIENCES INC 0.1%

Value ($000) $828 (+81.9%) Shares 29,600 (+6.5%) Est. Cost — Unrealized —

ABUS ARBUTUS BIOPHARMA CORP 0.5%

Value ($000) $2,639 (+12.6%) Shares 548,600 (+6.3%) Est. Cost — Unrealized —

VTGN VISTAGEN THERAPEUTICS INC 0.0%

Value ($000) $70 (-80.2%) Shares 106,500 (+6.3%) Est. Cost $2.82 Unrealized +28.2%

AYTU AYTU BIOPHARMA INC 0.1%

Value ($000) $795 (+55.1%) Shares 305,788 (+12.1%) Est. Cost $2.30 Unrealized -2.6%

EQ EQUILLIUM INC 0.1%

Value ($000) $538 (+25.5%) Shares 347,393 (+15.8%) Est. Cost $1.08 Unrealized +12.8%

NEUP NEUPHORIA THERAPEUTICS INC 0.0%

Value ($000) $194 (-23.3%) Shares 50,000 (+133.1%) Est. Cost $8.04 Unrealized -11.6%

CRVS CORVUS PHARMACEUTICALS INC 0.1%

Value ($000) $409 (+11.0%) Shares 53,100 (+6.2%) Est. Cost — Unrealized —

ALT ALTIMMUNE INC 0.3%

Value ($000) $1,775 (+1.7%) Shares 491,800 (+6.2%) Est. Cost — Unrealized —

PRTC PURETECH HEALTH PLC 0.0%

Value ($000) $124 (-8.6%) Shares 7,442 (+1.6%) Est. Cost $17.24 Unrealized —

— APPLIED THERAPEUTICS INC 0.0%

Value ($000) $2 (-82.4%) Shares 20,200 (+6.3%) Est. Cost — Unrealized —

SAVA CASSAVA SCIENCES INC 0.0%

Value ($000) $21 (-27.1%) Shares 10,600 (+7.1%) Est. Cost — Unrealized —

PRQR PROQR THRAPEUTICS N V 0.1%

Value ($000) $338 (+0.8%) Shares 167,532 (+6.2%) Est. Cost $2.89 Unrealized -19.1%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
RNA	AVIDITY BIOSCIENCES INC	328,000 (+63.9%)	$23,659 (+171.4%)	4.1%	$40.43	+59.8%	CALL	05370A108
VKTX	VIKING THERAPEUTICS INC	688,900 (+70.1%)	$24,236 (+127.6%)	4.2%	$31.80	+11.4%	CALL	92686J106
TERN	TERNS PHARMACEUTICALS INC	345,880 (+7.0%)	$13,974 (+475.8%)	2.4%	$5.58	+314.1%	COM	880881107
APGE	APOGEE THERAPEUTICS INC	211,100 (+65.7%)	$15,934 (+214.8%)	2.7%	$40.29	+56.3%	CALL	03770N101
CAPR	CAPRICOR THERAPEUTICS INC	312,300 (+4.1%)	$9,013 (+316.7%)	1.6%	$13.06	0.0%	CALL	14070B309
VKTX	VIKING THERAPEUTICS INC	336,849 (+73.9%)	$11,850 (+132.8%)	2.0%	$31.80	+11.4%	COM	92686J106
ABVX	ABIVAX SA	75,644 (+81.7%)	$10,201 (+190.4%)	1.8%	$107.10	—	SPONSORED ADS	00370M103
OCUL	OCULAR THERAPEUTIX INC	545,200 (+298.8%)	$6,619 (+314.2%)	1.1%	—	—	CALL	67576A100
JAZZ	JAZZ PHARMACEUTICALS PLC	105,300 (+5.3%)	$17,901 (+35.8%)	3.1%	$125.07	+22.6%	CALL	G50871105
BBIO	BRIDGEBIO PHARMA INC	139,600 (+6.2%)	$10,678 (+56.5%)	1.8%	$65.64	0.0%	CALL	10806X102
COGT	COGENT BIOSCIENCES INC	131,852 (+34.8%)	$4,683 (+233.4%)	0.8%	$13.44	+109.2%	COM	19240Q201
ZYME	ZYMEWORKS INC	240,600 (+22.4%)	$6,335 (+88.8%)	1.1%	—	—	CALL	98985Y108
CORT	CORCEPT THERAPEUTICS INC	134,800 (+408.7%)	$4,691 (+113.0%)	0.8%	$78.55	0.0%	PUT	218352102
ROIV	ROIVANT SCIENCES LTD	318,700 (+6.2%)	$6,916 (+52.4%)	1.2%	$12.38	+59.4%	PUT	G76279101
MREO	MEREO BIOPHARMA GROUP PLC	1,999,500 (+31.5%)	$833 (-73.4%)	0.1%	—	—	CALL	589492107
TVTX	TRAVERE THERAPEUTICS INC	50,300 (+16666.7%)	$1,922 (+26705.6%)	0.3%	—	—	PUT	89422G107
IONS	IONIS PHARMACEUTICALS INC	106,200 (+6.2%)	$8,401 (+28.4%)	1.4%	—	—	CALL	462222100
VTYX	VENTYX BIOSCIENCES INC	200,000 (+180.9%)	$1,806 (+715.6%)	0.3%	$5.76	+29.8%	COM	92332V107
OLMA	OLEMA PHARMACEUTICALS INC	96,100 (+6.2%)	$2,403 (+171.2%)	0.4%	—	—	CALL	68062P106
TGTX	TG THERAPEUTICS INC	123,283 (+102.9%)	$3,675 (+67.5%)	0.6%	$33.61	-2.8%	COM	88322Q108
ANIP	ANI PHARMACEUTICALS INC	53,354 (+69.9%)	$4,212 (+46.4%)	0.7%	$83.62	+3.5%	COM	00182C103
SLS	SELLAS LIFE SCIENCES GROUP I	424,900 (+6.2%)	$1,602 (+148.7%)	0.3%	—	—	CALL	81642T209
SLNO	SOLENO THERAPEUTICS INC	53,100 (+6.2%)	$2,459 (-27.3%)	0.4%	$67.08	-18.3%	CALL	834203309
XERS	XERIS BIOPHARMA HOLDINGS INC	170,568 (+128.2%)	$1,339 (+120.0%)	0.2%	$7.33	+7.3%	COM	98422E103
CRMD	CORMEDIX INC	159,000 (+59.0%)	$1,849 (+59.0%)	0.3%	—	—	PUT	21900C308
MNKD	MANNKIND CORP	302,000 (+42.1%)	$1,712 (+50.1%)	0.3%	$4.72	+16.7%	COM NEW	56400P706
GOSS	GOSSAMER BIO INC	877,100 (+6.3%)	$2,719 (+25.3%)	0.5%	—	—	CALL	38341P102
PTHS	PELTHOS THERAPEUTICS INC	25,000 (+138.1%)	$775 (+163.7%)	0.1%	$26.93	+7.1%	COM SHS	171126204
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	47,200 (+80.8%)	$622 (+232.4%)	0.1%	—	—	CALL	61559X104
TRVI	TREVI THERAPEUTICS INC	97,184 (+13.2%)	$1,217 (+54.9%)	0.2%	$5.60	+106.3%	COM	89532M101
EDIT	EDITAS MEDICINE INC	318,700 (+6.2%)	$653 (-37.2%)	0.1%	—	—	CALL	28106W103
RXRX	RECURSION PHARMACEUTICALS IN	741,900 (+6.2%)	$3,034 (-11.0%)	0.5%	—	—	CALL	75629V104
KOD	KODIAK SCIENCES INC	29,600 (+6.5%)	$828 (+81.9%)	0.1%	—	—	CALL	50015M109
ABUS	ARBUTUS BIOPHARMA CORP	548,600 (+6.3%)	$2,639 (+12.6%)	0.5%	—	—	CALL	03879J100
VTGN	VISTAGEN THERAPEUTICS INC	106,500 (+6.3%)	$70 (-80.2%)	0.0%	$2.82	+28.2%	CALL	92840H400
AYTU	AYTU BIOPHARMA INC	305,788 (+12.1%)	$795 (+55.1%)	0.1%	$2.30	-2.6%	COM	054754858
EQ	EQUILLIUM INC	347,393 (+15.8%)	$538 (+25.5%)	0.1%	$1.08	+12.8%	COM	29446K106
NEUP	NEUPHORIA THERAPEUTICS INC	50,000 (+133.1%)	$194 (-23.3%)	0.0%	$8.04	-11.6%	COM	64136E102
CRVS	CORVUS PHARMACEUTICALS INC	53,100 (+6.2%)	$409 (+11.0%)	0.1%	—	—	PUT	221015100
ALT	ALTIMMUNE INC	491,800 (+6.2%)	$1,775 (+1.7%)	0.3%	—	—	CALL	02155H200
PRTC	PURETECH HEALTH PLC	7,442 (+1.6%)	$124 (-8.6%)	0.0%	$17.24	—	ADS	746237106
—	APPLIED THERAPEUTICS INC	20,200 (+6.3%)	$2 (-82.4%)	0.0%	—	—	CALL	03828A101
SAVA	CASSAVA SCIENCES INC	10,600 (+7.1%)	$21 (-27.1%)	0.0%	—	—	PUT	14817C107
PRQR	PROQR THRAPEUTICS N V	167,532 (+6.2%)	$338 (+0.8%)	0.1%	$2.89	-19.1%	SHS EURO	N71542109

Exited Positions (56)

SPY SPDR S&P 500 ETF TR 2.3%

Value ($000) $13,324 Shares 20,000 Est. Cost — Unrealized —

AGIO AGIOS PHARMACEUTICALS INC 1.5%

Value ($000) $8,915 Shares 222,100 Est. Cost — Unrealized —

INCY INCYTE CORP 1.5%

Value ($000) $8,481 Shares 100,000 Est. Cost — Unrealized —

BMY BRISTOL-MYERS SQUIBB CO 1.4%

Value ($000) $8,118 Shares 180,000 Est. Cost $45.51 Unrealized +4.4%

LLY ELI LILLY & CO 1.3%

Value ($000) $7,630 Shares 10,000 Est. Cost $955.55 Unrealized 0.0%

SLNO SOLENO THERAPEUTICS INC 1.2%

Value ($000) $6,760 Shares 100,000 Est. Cost $67.08 Unrealized -18.3%

JAZZ JAZZ PHARMACEUTICALS PLC 1.1%

Value ($000) $6,590 Shares 50,000 Est. Cost $125.07 Unrealized +22.6%

BMY BRISTOL-MYERS SQUIBB CO 1.0%

Value ($000) $5,863 Shares 130,000 Est. Cost $45.51 Unrealized +4.4%

NBIX NEUROCRINE BIOSCIENCES INC 0.9%

Value ($000) $5,300 Shares 37,754 Est. Cost $122.62 Unrealized +18.1%

NKTR NEKTAR THERAPEUTICS 0.7%

Value ($000) $4,268 Shares 75,000 Est. Cost $33.10 Unrealized +69.1%

HRMY HARMONY BIOSCIENCES HLDGS IN 0.7%

Value ($000) $4,134 Shares 150,000 Est. Cost $34.45 Unrealized -4.6%

UPB UPSTREAM BIO INC 0.6%

Value ($000) $3,762 Shares 200,000 Est. Cost $24.89 Unrealized 0.0%

SRRK SCHOLAR ROCK HLDG CORP 0.6%

Value ($000) $3,724 Shares 100,000 Est. Cost — Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL IN 0.6%

Value ($000) $3,709 Shares 123,300 Est. Cost $36.05 Unrealized -8.8%

JAZZ JAZZ PHARMACEUTICALS PLC 0.5%

Value ($000) $3,050 Shares 23,140 Est. Cost $125.07 Unrealized +22.6%

COGT COGENT BIOSCIENCES INC 0.5%

Value ($000) $2,872 Shares 200,000 Est. Cost $13.44 Unrealized +109.2%

ARCT ARCTURUS THERAPEUTICS HLDGS 0.5%

Value ($000) $2,781 Shares 150,900 Est. Cost $16.06 Unrealized -32.8%

MRNA MODERNA INC 0.5%

Value ($000) $2,637 Shares 102,100 Est. Cost $27.90 Unrealized -2.6%

— SCPHARMACEUTICALS INC 0.5%

Value ($000) $2,620 Shares 462,000 Est. Cost — Unrealized —

MRNA MODERNA INC 0.4%

Value ($000) $2,583 Shares 100,000 Est. Cost $27.90 Unrealized -2.6%

REPL REPLIMUNE GROUP INC 0.4%

Value ($000) $2,566 Shares 612,300 Est. Cost $8.50 Unrealized 0.0%

APGE APOGEE THERAPEUTICS INC 0.4%

Value ($000) $2,553 Shares 64,250 Est. Cost $40.29 Unrealized +56.3%

ALKS ALKERMES PLC 0.4%

Value ($000) $2,162 Shares 72,079 Est. Cost $28.20 Unrealized +6.2%

ACAD ACADIA PHARMACEUTICALS INC 0.3%

Value ($000) $1,899 Shares 89,000 Est. Cost — Unrealized —

ROIV ROIVANT SCIENCES LTD 0.3%

Value ($000) $1,816 Shares 120,000 Est. Cost $12.38 Unrealized +59.4%

MBX MBX BIOSCIENCES INC 0.3%

Value ($000) $1,750 Shares 100,000 Est. Cost — Unrealized —

SMMT SUMMIT THERAPEUTICS INC 0.3%

Value ($000) $1,543 Shares 74,700 Est. Cost — Unrealized —

NVAX NOVAVAX INC 0.3%

Value ($000) $1,504 Shares 173,500 Est. Cost — Unrealized —

NVO NOVO-NORDISK A S 0.2%

Value ($000) $1,387 Shares 25,000 Est. Cost $55.49 Unrealized —

HRMY HARMONY BIOSCIENCES HLDGS IN 0.2%

Value ($000) $1,381 Shares 50,100 Est. Cost $34.45 Unrealized -4.6%

AMLX AMYLYX PHARMACEUTICALS INC 0.2%

Value ($000) $1,359 Shares 100,000 Est. Cost $9.41 Unrealized +44.3%

RNA AVIDITY BIOSCIENCES INC 0.2%

Value ($000) $1,307 Shares 30,000 Est. Cost $40.43 Unrealized +59.8%

— MIND MEDICINE MINDMED INC 0.2%

Value ($000) $1,248 Shares 105,891 Est. Cost $6.49 Unrealized —

SKYE SKYE BIOSCIENCE INC 0.2%

Value ($000) $1,179 Shares 300,000 Est. Cost — Unrealized —

SUPN SUPERNUS PHARMACEUTICALS INC 0.2%

Value ($000) $1,068 Shares 22,348 Est. Cost $40.27 Unrealized +20.7%

FOLD AMICUS THERAPEUTICS INC 0.2%

Value ($000) $1,035 Shares 131,400 Est. Cost — Unrealized —

CPRX CATALYST PHARMACEUTICALS INC 0.2%

Value ($000) $985 Shares 50,000 Est. Cost $20.57 Unrealized +8.3%

RVPH REVIVA PHARMACEUTCLS HLDGS I 0.2%

Value ($000) $924 Shares 2,506,921 Est. Cost $0.97 Unrealized -42.5%

ARCT ARCTURUS THERAPEUTICS HLDGS 0.2%

Value ($000) $900 Shares 48,811 Est. Cost $16.06 Unrealized -32.8%

CTMX CYTOMX THERAPEUTICS INC 0.1%

Value ($000) $591 Shares 185,286 Est. Cost $2.25 Unrealized +68.7%

MRNA MODERNA INC 0.1%

Value ($000) $517 Shares 20,000 Est. Cost $27.90 Unrealized -2.6%

TNYA TENAYA THERAPEUTICS INC 0.1%

Value ($000) $511 Shares 315,519 Est. Cost $1.01 Unrealized +35.0%

ALEC ALECTOR INC 0.1%

Value ($000) $403 Shares 136,023 Est. Cost $2.75 Unrealized -35.4%

PYXS PYXIS ONCOLOGY INC 0.1%

Value ($000) $333 Shares 150,000 Est. Cost $1.44 Unrealized +144.9%

CCCC C4 THERAPEUTICS INC 0.1%

Value ($000) $312 Shares 140,700 Est. Cost — Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL IN 0.0%

Value ($000) $276 Shares 9,189 Est. Cost $36.05 Unrealized -8.8%

CLYM CLIMB BIO INC 0.0%

Value ($000) $274 Shares 136,488 Est. Cost $2.67 Unrealized -10.0%

OVID OVID THERAPEUTICS INC 0.0%

Value ($000) $244 Shares 187,739 Est. Cost $0.87 Unrealized +77.7%

RLAY RELAY THERAPEUTICS INC 0.0%

Value ($000) $228 Shares 43,616 Est. Cost $5.44 Unrealized +31.1%

RCEL AVITA MEDICAL INC 0.0%

Value ($000) $128 Shares 25,100 Est. Cost — Unrealized —

ANAB ANAPTYSBIO INC 0.0%

Value ($000) $101 Shares 3,295 Est. Cost $22.95 Unrealized +69.9%

TVRD TVARDI THERAPEUTICS INC 0.0%

Value ($000) $85 Shares 2,185 Est. Cost $28.47 Unrealized -68.5%

MREO MEREO BIOPHARMA GROUP PLC 0.0%

Value ($000) $81 Shares 39,400 Est. Cost — Unrealized —

KOD KODIAK SCIENCES INC 0.0%

Value ($000) $18 Shares 1,100 Est. Cost — Unrealized —

PMVP PMV PHARMACEUTICALS INC 0.0%

Value ($000) $16 Shares 11,300 Est. Cost $1.38 Unrealized -3.2%

AUPH AURINIA PHARMACEUTICALS INC 0.0%

Value ($000) $8 Shares 700 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
SPY	SPDR S&P 500 ETF TR	20,000	$13,324	2.3%	—	—	PUT	78462F103
AGIO	AGIOS PHARMACEUTICALS INC	222,100	$8,915	1.5%	—	—	CALL	00847X104
INCY	INCYTE CORP	100,000	$8,481	1.5%	—	—	CALL	45337C102
BMY	BRISTOL-MYERS SQUIBB CO	180,000	$8,118	1.4%	$45.51	+4.4%	CALL	110122108
LLY	ELI LILLY & CO	10,000	$7,630	1.3%	$955.55	0.0%	PUT	532457108
SLNO	SOLENO THERAPEUTICS INC	100,000	$6,760	1.2%	$67.08	-18.3%	PUT	834203309
JAZZ	JAZZ PHARMACEUTICALS PLC	50,000	$6,590	1.1%	$125.07	+22.6%	PUT	G50871105
BMY	BRISTOL-MYERS SQUIBB CO	130,000	$5,863	1.0%	$45.51	+4.4%	—	110122108
NBIX	NEUROCRINE BIOSCIENCES INC	37,754	$5,300	0.9%	$122.62	+18.1%	—	64125C109
NKTR	NEKTAR THERAPEUTICS	75,000	$4,268	0.7%	$33.10	+69.1%	—	640268306
HRMY	HARMONY BIOSCIENCES HLDGS IN	150,000	$4,134	0.7%	$34.45	-4.6%	CALL	413197104
UPB	UPSTREAM BIO INC	200,000	$3,762	0.6%	$24.89	0.0%	CALL	91678A107
SRRK	SCHOLAR ROCK HLDG CORP	100,000	$3,724	0.6%	—	—	CALL	80706P103
RARE	ULTRAGENYX PHARMACEUTICAL IN	123,300	$3,709	0.6%	$36.05	-8.8%	PUT	90400D108
JAZZ	JAZZ PHARMACEUTICALS PLC	23,140	$3,050	0.5%	$125.07	+22.6%	—	G50871105
COGT	COGENT BIOSCIENCES INC	200,000	$2,872	0.5%	$13.44	+109.2%	CALL	19240Q201
ARCT	ARCTURUS THERAPEUTICS HLDGS	150,900	$2,781	0.5%	$16.06	-32.8%	PUT	03969T109
MRNA	MODERNA INC	102,100	$2,637	0.5%	$27.90	-2.6%	CALL	60770K107
—	SCPHARMACEUTICALS INC	462,000	$2,620	0.5%	—	—	CALL	810648105
MRNA	MODERNA INC	100,000	$2,583	0.4%	$27.90	-2.6%	PUT	60770K107
REPL	REPLIMUNE GROUP INC	612,300	$2,566	0.4%	$8.50	0.0%	CALL	76029N106
APGE	APOGEE THERAPEUTICS INC	64,250	$2,553	0.4%	$40.29	+56.3%	—	03770N101
ALKS	ALKERMES PLC	72,079	$2,162	0.4%	$28.20	+6.2%	—	G01767105
ACAD	ACADIA PHARMACEUTICALS INC	89,000	$1,899	0.3%	—	—	CALL	004225108
ROIV	ROIVANT SCIENCES LTD	120,000	$1,816	0.3%	$12.38	+59.4%	—	G76279101
MBX	MBX BIOSCIENCES INC	100,000	$1,750	0.3%	—	—	CALL	55287L101
SMMT	SUMMIT THERAPEUTICS INC	74,700	$1,543	0.3%	—	—	CALL	86627T108
NVAX	NOVAVAX INC	173,500	$1,504	0.3%	—	—	CALL	670002401
NVO	NOVO-NORDISK A S	25,000	$1,387	0.2%	$55.49	—	—	670100205
HRMY	HARMONY BIOSCIENCES HLDGS IN	50,100	$1,381	0.2%	$34.45	-4.6%	PUT	413197104
AMLX	AMYLYX PHARMACEUTICALS INC	100,000	$1,359	0.2%	$9.41	+44.3%	—	03237H101
RNA	AVIDITY BIOSCIENCES INC	30,000	$1,307	0.2%	$40.43	+59.8%	—	05370A108
—	MIND MEDICINE MINDMED INC	105,891	$1,248	0.2%	$6.49	—	—	60255C885
SKYE	SKYE BIOSCIENCE INC	300,000	$1,179	0.2%	—	—	CALL	83086J200
SUPN	SUPERNUS PHARMACEUTICALS INC	22,348	$1,068	0.2%	$40.27	+20.7%	—	868459108
FOLD	AMICUS THERAPEUTICS INC	131,400	$1,035	0.2%	—	—	CALL	03152W109
CPRX	CATALYST PHARMACEUTICALS INC	50,000	$985	0.2%	$20.57	+8.3%	—	14888U101
RVPH	REVIVA PHARMACEUTCLS HLDGS I	2,506,921	$924	0.2%	$0.97	-42.5%	—	76152G100
ARCT	ARCTURUS THERAPEUTICS HLDGS	48,811	$900	0.2%	$16.06	-32.8%	—	03969T109
CTMX	CYTOMX THERAPEUTICS INC	185,286	$591	0.1%	$2.25	+68.7%	—	23284F105
MRNA	MODERNA INC	20,000	$517	0.1%	$27.90	-2.6%	—	60770K107
TNYA	TENAYA THERAPEUTICS INC	315,519	$511	0.1%	$1.01	+35.0%	—	87990A106
ALEC	ALECTOR INC	136,023	$403	0.1%	$2.75	-35.4%	—	014442107
PYXS	PYXIS ONCOLOGY INC	150,000	$333	0.1%	$1.44	+144.9%	—	747324101
CCCC	C4 THERAPEUTICS INC	140,700	$312	0.1%	—	—	CALL	12529R107
RARE	ULTRAGENYX PHARMACEUTICAL IN	9,189	$276	0.0%	$36.05	-8.8%	—	90400D108
CLYM	CLIMB BIO INC	136,488	$274	0.0%	$2.67	-10.0%	—	28658R106
OVID	OVID THERAPEUTICS INC	187,739	$244	0.0%	$0.87	+77.7%	—	690469101
RLAY	RELAY THERAPEUTICS INC	43,616	$228	0.0%	$5.44	+31.1%	—	75943R102
RCEL	AVITA MEDICAL INC	25,100	$128	0.0%	—	—	CALL	05380C102
ANAB	ANAPTYSBIO INC	3,295	$101	0.0%	$22.95	+69.9%	—	032724106
TVRD	TVARDI THERAPEUTICS INC	2,185	$85	0.0%	$28.47	-68.5%	—	140755307
MREO	MEREO BIOPHARMA GROUP PLC	39,400	$81	0.0%	—	—	PUT	589492107
KOD	KODIAK SCIENCES INC	1,100	$18	0.0%	—	—	PUT	50015M109
PMVP	PMV PHARMACEUTICALS INC	11,300	$16	0.0%	$1.38	-3.2%	—	69353Y103
AUPH	AURINIA PHARMACEUTICALS INC	700	$8	0.0%	—	—	PUT	05156V102

Decreased Positions (24)

SLNO SOLENO THERAPEUTICS INC 0.2%

Value ($000) $1,245 (-89.6%) Shares 26,892 (-84.8%) Est. Cost $67.08 Unrealized -18.3%

REGN REGENERON PHARMACEUTICALS 1.4%

Value ($000) $7,950 (-53.1%) Shares 10,300 (-65.8%) Est. Cost $586.61 Unrealized +15.7%

PCVX VAXCYTE INC 0.2%

Value ($000) $1,060 (-86.5%) Shares 22,972 (-89.5%) Est. Cost $53.66 Unrealized -16.7%

NTLA INTELLIA THERAPEUTICS INC 0.3%

Value ($000) $1,909 (-76.5%) Shares 212,400 (-54.8%) Est. Cost — Unrealized —

— INDIVIOR PLC 0.1%

Value ($000) $621 (-89.9%) Shares 17,320 (-93.2%) Est. Cost $24.11 Unrealized —

ASND ASCENDIS PHARMA A/S 0.3%

Value ($000) $1,459 (-73.4%) Shares 6,840 (-75.2%) Est. Cost $198.81 Unrealized —

NVO NOVO-NORDISK A S 0.5%

Value ($000) $2,702 (-51.3%) Shares 53,100 (-46.9%) Est. Cost $55.49 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 1.5%

Value ($000) $8,698 (-24.6%) Shares 146,361 (-31.2%) Est. Cost $60.81 Unrealized -10.5%

MNKD MANNKIND CORP 0.5%

Value ($000) $3,132 (-43.9%) Shares 552,300 (-46.9%) Est. Cost $4.72 Unrealized +16.7%

ALNY ALNYLAM PHARMACEUTICALS INC 0.4%

Value ($000) $2,124 (-53.4%) Shares 5,341 (-46.6%) Est. Cost $407.20 Unrealized +8.7%

RARE ULTRAGENYX PHARMACEUTICAL IN 0.4%

Value ($000) $2,300 (-49.0%) Shares 100,000 (-33.3%) Est. Cost $36.05 Unrealized -8.8%

IMCR IMMUNOCORE HLDGS PLC 0.4%

Value ($000) $2,440 (-46.0%) Shares 70,300 (-43.5%) Est. Cost $30.84 Unrealized —

PTGX PROTAGONIST THERAPEUTICS INC 0.3%

Value ($000) $1,983 (-41.7%) Shares 22,700 (-55.7%) Est. Cost $47.99 Unrealized +70.5%

URGN UROGEN PHARMA LTD 0.1%

Value ($000) $511 (-71.6%) Shares 21,810 (-75.8%) Est. Cost $10.57 Unrealized +105.1%

VTGN VISTAGEN THERAPEUTICS INC 0.0%

Value ($000) $66 (-94.7%) Shares 100,000 (-71.4%) Est. Cost $2.82 Unrealized +28.2%

HRMY HARMONY BIOSCIENCES HLDGS IN 0.0%

Value ($000) $281 (-79.6%) Shares 7,500 (-85.0%) Est. Cost $34.45 Unrealized -4.6%

TERN TERNS PHARMACEUTICALS INC 0.5%

Value ($000) $2,614 (+54.6%) Shares 64,700 (-71.3%) Est. Cost $5.58 Unrealized +314.1%

ARDX ARDELYX INC 0.3%

Value ($000) $1,470 (-33.3%) Shares 252,198 (-37.0%) Est. Cost $5.43 Unrealized +2.5%

PBYI PUMA BIOTECHNOLOGY INC 0.0%

Value ($000) $201 (-72.1%) Shares 33,800 (-75.1%) Est. Cost — Unrealized —

PCRX PACIRA BIOSCIENCES INC 0.2%

Value ($000) $1,243 (-18.2%) Shares 48,025 (-18.5%) Est. Cost $24.37 Unrealized -2.4%

RVMD REVOLUTION MEDICINES INC 0.5%

Value ($000) $2,949 (+6.9%) Shares 37,020 (-37.3%) Est. Cost $38.42 Unrealized +70.7%

ATYR ATYR PHARMA INC 0.0%

Value ($000) $12 (-86.9%) Shares 15,500 (-88.0%) Est. Cost — Unrealized —

FHTX FOGHORN THERAPEUTICS INC 0.0%

Value ($000) $165 (-32.4%) Shares 30,630 (-38.7%) Est. Cost $5.30 Unrealized -14.5%

ATYR ATYR PHARMA INC 0.0%

Value ($000) $9 (-83.2%) Shares 11,800 (-84.5%) Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
SLNO	SOLENO THERAPEUTICS INC	26,892 (-84.8%)	$1,245 (-89.6%)	0.2%	$67.08	-18.3%	COM	834203309
REGN	REGENERON PHARMACEUTICALS	10,300 (-65.8%)	$7,950 (-53.1%)	1.4%	$586.61	+15.7%	COM	75886F107
PCVX	VAXCYTE INC	22,972 (-89.5%)	$1,060 (-86.5%)	0.2%	$53.66	-16.7%	COM	92243G108
NTLA	INTELLIA THERAPEUTICS INC	212,400 (-54.8%)	$1,909 (-76.5%)	0.3%	—	—	CALL	45826J105
—	INDIVIOR PLC	17,320 (-93.2%)	$621 (-89.9%)	0.1%	$24.11	—	ORD	G4766E116
ASND	ASCENDIS PHARMA A/S	6,840 (-75.2%)	$1,459 (-73.4%)	0.3%	$198.81	—	SPONSORED ADR	04351P101
NVO	NOVO-NORDISK A S	53,100 (-46.9%)	$2,702 (-51.3%)	0.5%	$55.49	—	PUT	670100205
BMRN	BIOMARIN PHARMACEUTICAL INC	146,361 (-31.2%)	$8,698 (-24.6%)	1.5%	$60.81	-10.5%	COM	09061G101
MNKD	MANNKIND CORP	552,300 (-46.9%)	$3,132 (-43.9%)	0.5%	$4.72	+16.7%	CALL	56400P706
ALNY	ALNYLAM PHARMACEUTICALS INC	5,341 (-46.6%)	$2,124 (-53.4%)	0.4%	$407.20	+8.7%	COM	02043Q107
RARE	ULTRAGENYX PHARMACEUTICAL IN	100,000 (-33.3%)	$2,300 (-49.0%)	0.4%	$36.05	-8.8%	CALL	90400D108
IMCR	IMMUNOCORE HLDGS PLC	70,300 (-43.5%)	$2,440 (-46.0%)	0.4%	$30.84	—	ADS	45258D105
PTGX	PROTAGONIST THERAPEUTICS INC	22,700 (-55.7%)	$1,983 (-41.7%)	0.3%	$47.99	+70.5%	COM	74366E102
URGN	UROGEN PHARMA LTD	21,810 (-75.8%)	$511 (-71.6%)	0.1%	$10.57	+105.1%	COM	M96088105
VTGN	VISTAGEN THERAPEUTICS INC	100,000 (-71.4%)	$66 (-94.7%)	0.0%	$2.82	+28.2%	COM	92840H400
HRMY	HARMONY BIOSCIENCES HLDGS IN	7,500 (-85.0%)	$281 (-79.6%)	0.0%	$34.45	-4.6%	COM	413197104
TERN	TERNS PHARMACEUTICALS INC	64,700 (-71.3%)	$2,614 (+54.6%)	0.5%	$5.58	+314.1%	CALL	880881107
ARDX	ARDELYX INC	252,198 (-37.0%)	$1,470 (-33.3%)	0.3%	$5.43	+2.5%	COM	039697107
PBYI	PUMA BIOTECHNOLOGY INC	33,800 (-75.1%)	$201 (-72.1%)	0.0%	—	—	CALL	74587V107
PCRX	PACIRA BIOSCIENCES INC	48,025 (-18.5%)	$1,243 (-18.2%)	0.2%	$24.37	-2.4%	COM	695127100
RVMD	REVOLUTION MEDICINES INC	37,020 (-37.3%)	$2,949 (+6.9%)	0.5%	$38.42	+70.7%	COM	76155X100
ATYR	ATYR PHARMA INC	15,500 (-88.0%)	$12 (-86.9%)	0.0%	—	—	CALL	002120202
FHTX	FOGHORN THERAPEUTICS INC	30,630 (-38.7%)	$165 (-32.4%)	0.0%	$5.30	-14.5%	COM	344174107
ATYR	ATYR PHARMA INC	11,800 (-84.5%)	$9 (-83.2%)	0.0%	—	—	PUT	002120202

Unchanged Positions (6)

PRAX PRAXIS PRECISION MEDICINES I 5.1%

Value ($000) $29,651 Shares 100,600 Est. Cost — Unrealized —

QURE UNIQURE NV 1.2%

Value ($000) $7,222 Shares 301,800 Est. Cost $38.59 Unrealized 0.0%

CRSP CRISPR THERAPEUTICS AG 1.0%

Value ($000) $5,910 Shares 112,700 Est. Cost — Unrealized —

AVXL ANAVEX LIFE SCIENCES CORP 0.1%

Value ($000) $501 Shares 140,600 Est. Cost — Unrealized —

TECX TECTONIC THERAPEUTIC INC 0.4%

Value ($000) $2,099 Shares 100,600 Est. Cost — Unrealized —

JBIO JADE BIOSCIENCES INC 0.0%

Value ($000) $3 Shares 1,046 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
PRAX	PRAXIS PRECISION MEDICINES I	100,600	$29,651	5.1%	—	—	PUT	74006W207
QURE	UNIQURE NV	301,800	$7,222	1.2%	$38.59	0.0%	PUT	N90064101
CRSP	CRISPR THERAPEUTICS AG	112,700	$5,910	1.0%	—	—	CALL	H17182108
AVXL	ANAVEX LIFE SCIENCES CORP	140,600	$501	0.1%	—	—	CALL	032797300
TECX	TECTONIC THERAPEUTIC INC	100,600	$2,099	0.4%	—	—	CALL	878972108
JBIO	JADE BIOSCIENCES INC	1,046	$3	0.0%	—	—	PUT	008064206