ALTO NEUROSCIENCE INC

Institution	Shares	Value ($000)
Commodore Capital LP	1,823,196	$32,453
Vivo Capital, LLC	1,035,551	$18,433
AdvisorShares Investments LLC	44,077	$785
Artia Global Partners LP	29,192	$520
683 Capital Management, LLC	64,782	$1,153
DRIEHAUS CAPITAL MANAGEMENT LLC	336,762	$5,994
Qube Research & Technologies Ltd	112,792	$2,008
D. E. Shaw & Co., Inc.	124,795	$2,221
ALPS ADVISORS INC	25,505	$454
Hudson Bay Capital Management LP	34,789	$619
ExodusPoint Capital Management, LP	18,786	$334
WELLINGTON MANAGEMENT GROUP LLP	69,016	$1,228
AlphaQuest LLC	3,821	$68
OMERS ADMINISTRATION Corp	12,400	$221
DIMENSIONAL FUND ADVISORS LP	31,176	$555
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	17,064	$304
CITIGROUP INC	12,566	$224
BALYASNY ASSET MANAGEMENT L.P.	11,120	$198
AMERICAN CENTURY COMPANIES INC	10,360	$184
SIGNATUREFD, LLC	1,065	$19

Increased Positions (26)

Vestal Point Capital, LP

Value ($000) $44,233 (+1058.2%) Shares 2,485,000 (+161.6%)

Ikarian Capital, LLC

Value ($000) $9,167 (+1973.0%) Shares 515,000 (+368.2%)

PERCEPTIVE ADVISORS LLC

Value ($000) $31,762 (+4985.4%) Shares 1,784,393 (+1048.5%)

BOOTHBAY FUND MANAGEMENT, LLC

Value ($000) $2,480 (+1799.5%) Shares 139,304 (+329.0%)

Point72 Asset Management, L.P.

Value ($000) $28,604 (+434.0%) Shares 1,606,954 (+20.6%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $11,214 (+783.4%) Shares 629,985 (+99.5%)

VANGUARD GROUP INC

Value ($000) $24,312 (+447.1%) Shares 1,365,847 (+23.6%)

BlackRock, Inc.

Value ($000) $10,820 (+631.6%) Shares 607,874 (+65.2%)

JANE STREET GROUP, LLC

Value ($000) $3,454 (+1676.4%) Shares 194,041 (+301.2%)

AlphaCore Capital LLC

Value ($000) $356 (+785.6%) Shares 20,000 (+100.0%)

GOLDMAN SACHS GROUP INC

Value ($000) $2,782 (+666.9%) Shares 156,319 (+73.2%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $5,118 (+434.9%) Shares 287,435 (+20.8%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $592 (+28534.2%) Shares 33,235 (+6366.0%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $2,498 (+432.9%) Shares 140,317 (+20.4%)

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $1,734 (+469.2%) Shares 97,399 (+28.5%)

STATE STREET CORP

Value ($000) $2,326 (+460.7%) Shares 130,665 (+26.6%)

XTX Topco Ltd

Value ($000) $371 (+485.6%) Shares 20,824 (+32.2%)

IEQ CAPITAL, LLC

Value ($000) $1,340 (+429.4%) Shares 75,294 (+19.6%)

NORTHERN TRUST CORP

Value ($000) $8,444 (+355.3%) Shares 474,373 (+2.8%)

TWO SIGMA ADVISERS, LP

Value ($000) $2,850 (+372.9%) Shares 160,100 (+6.8%)

Institution	Prev Shares	Curr Shares	Change
Vestal Point Capital, LP	950,000	2,485,000	+1,535,000 (+161.6%)
Ikarian Capital, LLC	110,000	515,000	+405,000 (+368.2%)
PERCEPTIVE ADVISORS LLC	155,366	1,784,393	+1,629,027 (+1048.5%)
BOOTHBAY FUND MANAGEMENT, LLC	32,472	139,304	+106,832 (+329.0%)
Point72 Asset Management, L.P.	1,332,437	1,606,954	+274,517 (+20.6%)
MILLENNIUM MANAGEMENT LLC	315,758	629,985	+314,227 (+99.5%)
VANGUARD GROUP INC	1,105,407	1,365,847	+260,440 (+23.6%)
BlackRock, Inc.	367,879	607,874	+239,995 (+65.2%)
JANE STREET GROUP, LLC	48,366	194,041	+145,675 (+301.2%)
AlphaCore Capital LLC	10,000	20,000	+10,000 (+100.0%)
GOLDMAN SACHS GROUP INC	90,251	156,319	+66,068 (+73.2%)
GEODE CAPITAL MANAGEMENT, LLC	237,900	287,435	+49,535 (+20.8%)
BNP PARIBAS ARBITRAGE, SA	514	33,235	+32,721 (+6366.0%)
TWO SIGMA INVESTMENTS, LP	116,579	140,317	+23,738 (+20.4%)
RENAISSANCE TECHNOLOGIES LLC	75,772	97,399	+21,627 (+28.5%)
STATE STREET CORP	103,185	130,665	+27,480 (+26.6%)
XTX Topco Ltd	15,746	20,824	+5,078 (+32.2%)
IEQ CAPITAL, LLC	62,979	75,294	+12,315 (+19.6%)
NORTHERN TRUST CORP	461,285	474,373	+13,088 (+2.8%)
TWO SIGMA ADVISERS, LP	149,900	160,100	+10,200 (+6.8%)

Decreased Positions (25)

Peapod Lane Capital LLC

Value ($000) $4,521 (+297.9%) Shares 253,992 (-9.9%)

Almitas Capital LLC

Value ($000) $1,398 (+78.2%) Shares 78,520 (-59.8%)

AWM Investment Company, Inc.

Value ($000) $4,005 (+255.2%) Shares 225,000 (-19.8%)

ARMISTICE CAPITAL, LLC

Value ($000) $27,341 (+315.7%) Shares 1,536,000 (-6.1%)

ORBIMED ADVISORS LLC

Value ($000) $2,225 (+121.4%) Shares 125,000 (-50.0%)

Integral Health Asset Management, LLC

Value ($000) $6,675 (+315.1%) Shares 375,000 (-6.3%)

MARSHALL WACE, LLP

Value ($000) $3,437 (+3.6%) Shares 193,109 (-76.6%)

SCS Capital Management LLC

Value ($000) $594 (+121.4%) Shares 33,389 (-50.0%)

UBS Group AG

Value ($000) $329 (-41.1%) Shares 18,489 (-86.7%)

FRANKLIN RESOURCES INC

Value ($000) $19,928 (+326.4%) Shares 1,119,578 (-3.7%)

STIFEL FINANCIAL CORP

Value ($000) $1,552 (+216.3%) Shares 87,164 (-28.6%)

CITIZENS FINANCIAL GROUP INC/RI

Value ($000) $502 (+212.1%) Shares 28,190 (-29.5%)

SUSQUEHANNA INTERNATIONAL GROUP, LLP

Value ($000) $2,103 (+236.1%) Shares 118,156 (-24.1%)

CITADEL ADVISORS LLC

Value ($000) $231 (+54.6%) Shares 12,973 (-65.1%)

FEDERATED HERMES, INC.

Value ($000) $14 (+1.9%) Shares 770 (-77.0%)

FMR LLC

Value ($000) $113 (+267.7%) Shares 6,374 (-17.0%)

GROUP ONE TRADING, L.P.

Value ($000) $25 (+135.4%) Shares 1,413 (-46.8%)

Vanguard Personalized Indexing Management, LLC

Value ($000) $293 (+328.2%) Shares 16,485 (-3.3%)

Tower Research Capital LLC (TRC)

Value ($000) $35 (+268.1%) Shares 1,987 (-16.9%)

ROYAL BANK OF CANADA

Value ($000) $1 (0.0%) Shares 34 (-82.6%)

Institution	Prev Shares	Curr Shares	Change
Peapod Lane Capital LLC	281,963	253,992	-27,971 (-9.9%)
Almitas Capital LLC	195,145	78,520	-116,625 (-59.8%)
AWM Investment Company, Inc.	280,483	225,000	-55,483 (-19.8%)
ARMISTICE CAPITAL, LLC	1,636,000	1,536,000	-100,000 (-6.1%)
ORBIMED ADVISORS LLC	250,000	125,000	-125,000 (-50.0%)
Integral Health Asset Management, LLC	400,000	375,000	-25,000 (-6.3%)
MARSHALL WACE, LLP	825,225	193,109	-632,116 (-76.6%)
SCS Capital Management LLC	66,777	33,389	-33,388 (-50.0%)
UBS Group AG	139,031	18,489	-120,542 (-86.7%)
FRANKLIN RESOURCES INC	1,162,608	1,119,578	-43,030 (-3.7%)
STIFEL FINANCIAL CORP	122,000	87,164	-34,836 (-28.6%)
CITIZENS FINANCIAL GROUP INC/RI	40,000	28,190	-11,810 (-29.5%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP	155,676	118,156	-37,520 (-24.1%)
CITADEL ADVISORS LLC	37,152	12,973	-24,179 (-65.1%)
FEDERATED HERMES, INC.	3,347	770	-2,577 (-77.0%)
FMR LLC	7,676	6,374	-1,302 (-17.0%)
GROUP ONE TRADING, L.P.	2,658	1,413	-1,245 (-46.8%)
Vanguard Personalized Indexing Management, LLC	17,045	16,485	-560 (-3.3%)
Tower Research Capital LLC (TRC)	2,390	1,987	-403 (-16.9%)
ROYAL BANK OF CANADA	195	34	-161 (-82.6%)

Exited Positions (9)

Bowie Capital Management, LLC

Value ($000) $78 Shares 19,484

PRELUDE CAPITAL MANAGEMENT, LLC

Value ($000) $46 Shares 11,401

AQR CAPITAL MANAGEMENT LLC

Value ($000) $122 Shares 30,412

Squarepoint Ops LLC

Value ($000) $92 Shares 22,816

NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO

Value ($000) $6 Shares 1,450

Advisory Services Network, LLC

Value ($000) $3 Shares 802

True Wealth Design, LLC

Value ($000) $1 Shares 126

OSAIC HOLDINGS, INC.

Value ($000) $0 Shares 47

Cloud Capital Management, LLC

Value ($000) $0 Shares 8

Institution	Prev Shares	Prev Value ($000)
Bowie Capital Management, LLC	19,484	$78
PRELUDE CAPITAL MANAGEMENT, LLC	11,401	$46
AQR CAPITAL MANAGEMENT LLC	30,412	$122
Squarepoint Ops LLC	22,816	$92
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	1,450	$6
Advisory Services Network, LLC	802	$3
True Wealth Design, LLC	126	$1
OSAIC HOLDINGS, INC.	47	$0
Cloud Capital Management, LLC	8	$0