| VANGUARD GROUP INC | 6,539,482 | $271,519 |
| Decheng Capital LLC | 6,371,669 | $264,552 |
| WELLINGTON MANAGEMENT GROUP LLP | 5,999,790 | $249,111 |
| BlackRock, Inc. | 4,843,242 | $201,091 |
| FMR LLC | 4,298,173 | $178,460 |
| TCG Crossover Management, LLC | 3,670,206 | $152,387 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,443,144 | $143 |
| STATE STREET CORP | 2,996,695 | $124,423 |
| Foresite Capital Management VI LLC | 2,221,474 | $92,236 |
| RTW INVESTMENTS, LP | 2,012,127 | $83,544 |
| UBS Group AG | 1,923,746 | $79,874 |
| BRAIDWELL LP | 1,870,571 | $77,666 |
| ALLIANCEBERNSTEIN L.P. | 1,613,425 | $66,989 |
| FRANKLIN RESOURCES INC | 1,561,574 | $64,837 |
| ORBIMED ADVISORS LLC | 1,516,550 | $62,967 |
| Seven Fleet Capital Management LP | 1,515,151 | $62,909 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,511,533 | $62,773 |
| Avidity Partners Management LP | 1,472,699 | $61,146 |
| DV Trading LLC | 1,439,393 | $59,764 |
| Pictet Asset Management Holding SA | 1,349,527 | $56,032 |
| GOLDMAN SACHS GROUP INC | 1,324,603 | $54,998 |
| BANK OF AMERICA CORP /DE/ | 1,190,053 | $49,411 |
| ACORN CAPITAL ADVISORS, LLC | 1,131,501 | $46,980 |
| Polar Capital Holdings Plc | 1,098,662 | $45,616 |
| UBS ASSET MANAGEMENT AMERICAS INC | 1,090,894 | $45,294 |
| Foresite Capital Management V, LLC | 1,004,050 | $41,688 |
| Kynam Capital Management, LP | 945,830 | $39,271 |
| Candriam S.C.A. | 797,615 | $33,118 |
| EcoR1 Capital, LLC | 772,000 | $32,053 |
| Clearbridge Investments, LLC | 705,014 | $29,272 |
| CITADEL ADVISORS LLC | 681,186 | $28,283 |
| JPMORGAN CHASE & CO | 586,829 | $24,365 |
| MORGAN STANLEY | 545,019 | $22,629 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 542,695 | $22,533 |
| Ensign Peak Advisors, Inc | 530,758 | $22,037 |
| Elmind Capital, LP | 492,500 | $20,449 |
| Woodline Partners LP | 492,500 | $20,449 |
| NORTHERN TRUST CORP | 481,940 | $20,010 |
| DIMENSIONAL FUND ADVISORS LP | 461,132 | $19,146 |
| TimesSquare Capital Management, LLC | 426,019 | $17,688 |
| Opaleye Management Inc. | 410,000 | $17,023 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 361,158 | $14,995 |
| EVENTIDE ASSET MANAGEMENT, LLC | 312,445 | $12,972 |
| Eversept Partners, LP | 308,466 | $12,808 |
| Caption Management, LLC | 306,846 | $12,740 |
| Rosalind Advisors, Inc. | 300,000 | $12,456 |
| JENNISON ASSOCIATES LLC | 282,506 | $11,730 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 281,059 | $11,290 |
| MARSHALL WACE, LLP | 261,110 | $10,841 |
| ADAR1 Capital Management, LLC | 258,139 | $10,718 |
| ArrowMark Colorado Holdings LLC | 245,832 | $10,207 |
| AMERIPRISE FINANCIAL INC | 240,477 | $9,985 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 201,918 | $8,384 |
| Logos Global Management LP | 200,000 | $8,304 |
| Ikarian Capital, LLC | 199,473 | $8,282 |
| BARCLAYS PLC | 187,510 | $7,785 |
| TD Asset Management Inc | 186,448 | $7,741 |
| FIRST TRUST ADVISORS LP | 181,798 | $7,548 |
| Soleus Capital Management, L.P. | 170,000 | $7,058 |
| PFM Health Sciences, LP | 163,967 | $6,808 |
| Davern Capital Partners, LP | 162,005 | $6,726 |
| Bank of New York Mellon Corp | 155,156 | $6,442 |
| Point72 Asset Management, L.P. | 151,363 | $6,285 |
| DEUTSCHE BANK AG\ | 150,188 | $6,236 |
| Russell Investments Group, Ltd. | 143,346 | $5,952 |
| Nuveen, LLC | 134,692 | $5,592 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 128,478 | $5,202 |
| LORD, ABBETT & CO. LLC | 125,636 | $5 |
| AMERICAN CENTURY COMPANIES INC | 124,544 | $5,171 |
| AQR CAPITAL MANAGEMENT LLC | 112,349 | $4,665 |
| Nantahala Capital Management, LLC | 109,449 | $4,544 |
| Rafferty Asset Management, LLC | 106,052 | $4,403 |
| BNP PARIBAS ARBITRAGE, SA | 96,103 | $3,990 |
| MILLENNIUM MANAGEMENT LLC | 91,454 | $3,797 |
| Swiss National Bank | 84,400 | $3,504 |
| RHUMBLINE ADVISERS | 70,601 | $2,931 |
| CenterBook Partners LP | 69,224 | $2,874 |
| ALPS ADVISORS INC | 66,038 | $2,742 |
| WELLS FARGO & COMPANY/MN | 62,552 | $2,597 |
| BOOTHBAY FUND MANAGEMENT, LLC | 59,400 | $2,466 |
| BNP Paribas Investment Partners S.A. | 58,118 | $2 |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt | 55,151 | $2,290 |
| SECTOR GAMMA AS | 52,039 | $2,161 |
| SummitTX Capital, L.P. | 49,928 | $2,073 |
| Legal & General Group Plc | 45,147 | $1,875 |
| Voya Investment Management LLC | 43,721 | $1,815 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 43,127 | $1,782 |
| T. Rowe Price Investment Management, Inc. | 41,850 | $2 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,658 | $1,730 |
| AMI ASSET MANAGEMENT CORP | 41,209 | $1,711 |
| PDT Partners, LLC | 39,967 | $1,659 |
| PROFUND ADVISORS LLC | 39,319 | $1,633 |
| AlphaQuest LLC | 38,894 | $1,615 |
| Invesco Ltd. | 38,140 | $1,584 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 37,834 | $1,571 |
| Cinctive Capital Management LP | 37,171 | $1,543 |
| NEOS Investment Management LLC | 36,597 | $1,520 |
| TEMA ETFS LLC | 36,057 | $1,497 |
| Sivik Global Healthcare LLC | 35,000 | $1 |
| XTX Topco Ltd | 33,710 | $1,400 |
| 92 other institutions | 675,409 | $24,585 |