| BlackRock, Inc. | 9,164,538 | $1,034,768 |
| VANGUARD GROUP INC | 6,020,492 | $679,774 |
| PRIMECAP MANAGEMENT CO/CA/ | 3,376,928 | $381,289 |
| JANUS HENDERSON GROUP PLC | 3,018,787 | $340,855 |
| STATE STREET CORP | 2,122,402 | $239,640 |
| AMERIPRISE FINANCIAL INC | 2,104,294 | $237,596 |
| ALLIANCEBERNSTEIN L.P. | 1,643,448 | $185,562 |
| MILLENNIUM MANAGEMENT LLC | 1,609,699 | $181,751 |
| GOLDMAN SACHS GROUP INC | 1,350,425 | $152,476 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,317,648 | $148,800 |
| Holocene Advisors, LP | 1,299,294 | $146,703 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,106,918 | $124,982 |
| BRAIDWELL LP | 921,979 | $104,101 |
| UBS Group AG | 873,942 | $98,677 |
| Capital World Investors | 850,893 | $96,074 |
| Invesco Ltd. | 780,267 | $88,100 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 714,026 | $80,621 |
| Artisan Partners Limited Partnership | 702,818 | $79,355 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 672,958 | $75,984 |
| MORGAN STANLEY | 670,778 | $75,738 |
| NORTHERN TRUST CORP | 587,130 | $66,293 |
| D. E. Shaw & Co., Inc. | 558,290 | $63,037 |
| JPMORGAN CHASE & CO | 556,479 | $62,832 |
| BANK OF AMERICA CORP /DE/ | 538,678 | $60,822 |
| NORGES BANK | 536,143 | $60,536 |
| RIVERBRIDGE PARTNERS LLC | 535,169 | $60,426 |
| Capital International Investors | 511,510 | $57,755 |
| WELLINGTON MANAGEMENT GROUP LLP | 486,824 | $54,967 |
| AustralianSuper Pty Ltd | 449,846 | $50,792 |
| LOOMIS SAYLES & CO L P | 447,805 | $50,562 |
| Nuveen, LLC | 406,046 | $45,847 |
| Bank of New York Mellon Corp | 355,840 | $40,178 |
| Allspring Global Investments Holdings, LLC | 355,279 | $39,336 |
| Champlain Investment Partners, LLC | 333,264 | $37,629 |
| BROWN CAPITAL MANAGEMENT LLC | 326,579 | $36,874 |
| FRED ALGER MANAGEMENT, LLC | 325,540 | $36,757 |
| Integral Health Asset Management, LLC | 325,000 | $36,696 |
| EVENTIDE ASSET MANAGEMENT, LLC | 289,275 | $32,662 |
| Sofinnova Investments, Inc. | 288,128 | $32,533 |
| PRINCIPAL FINANCIAL GROUP INC | 274,565 | $31,001 |
| Bellevue Group AG | 261,935 | $29,575 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 250,000 | $28,228 |
| Rhenman & Partners Asset Management AB | 210,000 | $23,711 |
| C WorldWide Group Holding A/S | 207,212 | $23 |
| DIMENSIONAL FUND ADVISORS LP | 205,461 | $23,202 |
| PFM Health Sciences, LP | 201,676 | $22,771 |
| Public Sector Pension Investment Board | 198,817 | $22,448 |
| ROYAL BANK OF CANADA | 191,900 | $21,667 |
| Voya Investment Management LLC | 189,832 | $21,434 |
| Qube Research & Technologies Ltd | 188,735 | $21,310 |
| Assenagon Asset Management S.A. | 182,393 | $20,594 |
| SEI INVESTMENTS CO | 181,853 | $20,533 |
| Legal & General Group Plc | 179,698 | $20,290 |
| Point72 Asset Management, L.P. | 161,596 | $18,246 |
| ALGERT GLOBAL LLC | 155,546 | $18 |
| GILDER GAGNON HOWE & CO LLC | 154,442 | $17,438 |
| RHUMBLINE ADVISERS | 151,467 | $17,102 |
| Eversept Partners, LP | 147,471 | $16,651 |
| UBS ASSET MANAGEMENT AMERICAS INC | 143,192 | $16,168 |
| KEYBANK NATIONAL ASSOCIATION/OH | 142,506 | $16,090 |
| PERCEPTIVE ADVISORS LLC | 140,000 | $15,807 |
| SEGALL BRYANT & HAMILL, LLC | 131,404 | $14,837 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 122,169 | $14 |
| Granite Investment Partners, LLC | 119,343 | $13,475 |
| Swiss National Bank | 113,100 | $12,770 |
| Clearbridge Investments, LLC | 112,022 | $12,648 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 104,279 | $11,774 |
| OSTERWEIS CAPITAL MANAGEMENT INC | 101,613 | $11,473 |
| RAYMOND JAMES FINANCIAL INC | 98,768 | $11,250 |
| TWO SIGMA INVESTMENTS, LP | 98,651 | $11,139 |
| WCM INVESTMENT MANAGEMENT, LLC | 97,367 | $11,123 |
| Defilade Capital Management, L.P. | 91,703 | $10,354 |
| BARCLAYS PLC | 91,127 | $10,289 |
| BALYASNY ASSET MANAGEMENT L.P. | 87,171 | $9,842 |
| DnB Asset Management AS | 82,320 | $9,295 |
| VICTORY CAPITAL MANAGEMENT INC | 80,102 | $9,044 |
| NEW YORK STATE COMMON RETIREMENT FUND | 79,610 | $8,989 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 72,340 | $8,168 |
| WELLS FARGO & COMPANY/MN | 69,175 | $7,810 |
| TWO SIGMA ADVISERS, LP | 69,000 | $7,791 |
| SIT INVESTMENT ASSOCIATES INC | 66,970 | $8 |
| SG Americas Securities, LLC | 60,232 | $7 |
| Capricorn Fund Managers Ltd | 60,000 | $6,775 |
| Allianz Asset Management GmbH | 55,996 | $6,323 |
| Baird Financial Group, Inc. | 55,434 | $6,259 |
| EFG International AG | 55,340 | $6,249 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 54,563 | $6,161 |
| NEUBERGER BERMAN GROUP LLC | 53,778 | $6,072 |
| PRUDENTIAL FINANCIAL INC | 53,557 | $6,047 |
| ENVESTNET ASSET MANAGEMENT INC | 51,833 | $5,852 |
| CANADA PENSION PLAN INVESTMENT BOARD | 51,600 | $5,826 |
| GREAT WEST LIFE ASSURANCE CO /CAN/ | 50,101 | $6 |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 48,243 | $5 |
| THORNBURG INVESTMENT MANAGEMENT INC | 47,725 | $5,389 |
| DEUTSCHE BANK AG\ | 46,731 | $5,276 |
| CITIGROUP INC | 44,623 | $5,038 |
| INTECH INVESTMENT MANAGEMENT LLC | 43,615 | $4,925 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 42,996 | $4,855 |
| Resolute Capital Asset Partners LLC | 40,500 | $4,573 |
| Thrivent Financial for Lutherans | 39,465 | $4 |
| 229 other institutions | 1,573,553 | $162,358 |